UniProtKB - P98086 (C1QA_MOUSE)
Protein
Complement C1q subcomponent subunit A
Gene
C1qa
Organism
Mus musculus (Mouse)
Status
Functioni
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
GO - Biological processi
- aging Source: ARUK-UCL
- astrocyte activation Source: ARUK-UCL
- complement activation, classical pathway Source: MGI
- complement-mediated synapse pruning Source: ARUK-UCL
- innate immune response Source: UniProtKB-KW
- microglial cell activation Source: ARUK-UCL
- neuron remodeling Source: ARUK-UCL
- positive regulation of neuron death Source: ARUK-UCL
- response to iron ion Source: Ensembl
- synapse organization Source: ARUK-UCL
- synapse pruning Source: ARUK-UCL
- vertebrate eye-specific patterning Source: ARUK-UCL
Keywordsi
Biological process | Complement pathway, Immunity, Innate immunity |
Enzyme and pathway databases
Reactomei | R-MMU-166663, Initial triggering of complement R-MMU-173623, Classical antibody-mediated complement activation R-MMU-977606, Regulation of Complement cascade |
Names & Taxonomyi
Protein namesi | Recommended name: Complement C1q subcomponent subunit A |
Gene namesi | Name:C1qa |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88223, C1qa |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Other locations
- collagen trimer Source: UniProtKB-KW
- postsynapse Source: ARUK-UCL
- synapse Source: ARUK-UCL
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | By similarityAdd BLAST | 22 | |
ChainiPRO_0000003518 | 23 – 245 | Complement C1q subcomponent subunit AAdd BLAST | 223 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 | Interchain (with C-29 in B chain)By similarity | ||
Modified residuei | 39 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 45 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 48 | 5-hydroxylysine; alternateBy similarity | 1 | |
Glycosylationi | 48 | O-linked (Gal...) hydroxylysine; alternateBy similarity | 1 | |
Modified residuei | 54 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 67 | 5-hydroxylysine; alternateBy similarity | 1 | |
Glycosylationi | 67 | O-linked (Gal...) hydroxylysine; alternateBy similarity | 1 | |
Modified residuei | 79 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 85 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 100 | 5-hydroxylysine; alternateBy similarity | 1 | |
Glycosylationi | 100 | O-linked (Gal...) hydroxylysine; alternateBy similarity | 1 | |
Glycosylationi | 146 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
O-linked glycans are Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.By similarity
Proline residues in the collagen-like domain motif, GXPG, are typically 4-hydroxylated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
CPTACi | non-CPTAC-3638 non-CPTAC-5581 |
jPOSTi | P98086 |
PaxDbi | P98086 |
PeptideAtlasi | P98086 |
PRIDEi | P98086 |
ProteomicsDBi | 265397 |
PTM databases
GlyConnecti | 2223, 7 N-Linked glycans (1 site) |
GlyGeni | P98086, 4 sites |
iPTMneti | P98086 |
PhosphoSitePlusi | P98086 |
SwissPalmi | P98086 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000036887, Expressed in stroma of bone marrow and 253 other tissues |
ExpressionAtlasi | P98086, baseline and differential |
Genevisiblei | P98086, MM |
Interactioni
Subunit structurei
C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.
Interacts (via C-terminus) with CD33; this interaction activates CD33 inhibitory motifs.
By similarityBinary interactionsi
P98086
With | #Exp. | IntAct |
---|---|---|
FZD8 [Q9H461] from Homo sapiens. | 3 | EBI-299840,EBI-6254212 |
Protein-protein interaction databases
BioGRIDi | 198412, 5 interactors |
ComplexPortali | CPX-4981, Complement component C1q complex |
IntActi | P98086, 6 interactors |
STRINGi | 10090.ENSMUSP00000048836 |
Miscellaneous databases
RNActi | P98086, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 109 | Collagen-likeAdd BLAST | 79 | |
Domaini | 110 – 245 | C1qPROSITE-ProRule annotationAdd BLAST | 136 |
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502RZM2, Eukaryota |
GeneTreei | ENSGT00940000162143 |
HOGENOMi | CLU_001074_0_2_1 |
InParanoidi | P98086 |
OMAi | VWIEKDP |
OrthoDBi | 1258047at2759 |
TreeFami | TF329591 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR037572, Complement_C1q_A IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR15427:SF26, PTHR15427:SF26, 1 hit |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P98086-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METSQGWLVA CVLTMTLVWT VAEDVCRAPN GKDGAPGNPG RPGRPGLKGE
60 70 80 90 100
RGEPGAAGIR TGIRGFKGDP GESGPPGKPG NVGLPGPSGP LGDSGPQGLK
110 120 130 140 150
GVKGNPGNIR DQPRPAFSAI RQNPMTLGNV VIFDKVLTNQ ESPYQNHTGR
160 170 180 190 200
FICAVPGFYY FNFQVISKWD LCLFIKSSSG GQPRDSLSFS NTNNKGLFQV
210 220 230 240
LAGGTVLQLR RGDEVWIEKD PAKGRIYQGT EADSIFSGFL IFPSA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | T → I in CAA41664 (PubMed:1940381).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58861 mRNA Translation: CAA41664.1 AK002655 mRNA Translation: BAB22262.1 AK136737 mRNA Translation: BAE23115.1 AK159210 mRNA Translation: BAE34901.1 AL627214 Genomic DNA No translation available. CH466552 Genomic DNA Translation: EDL29926.1 BC002086 mRNA Translation: AAH02086.1 |
CCDSi | CCDS18812.1 |
PIRi | S19018 |
RefSeqi | NP_031598.2, NM_007572.2 |
Genome annotation databases
Ensembli | ENSMUST00000046285; ENSMUSP00000048836; ENSMUSG00000036887 |
GeneIDi | 12259 |
KEGGi | mmu:12259 |
UCSCi | uc008vir.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58861 mRNA Translation: CAA41664.1 AK002655 mRNA Translation: BAB22262.1 AK136737 mRNA Translation: BAE23115.1 AK159210 mRNA Translation: BAE34901.1 AL627214 Genomic DNA No translation available. CH466552 Genomic DNA Translation: EDL29926.1 BC002086 mRNA Translation: AAH02086.1 |
CCDSi | CCDS18812.1 |
PIRi | S19018 |
RefSeqi | NP_031598.2, NM_007572.2 |
3D structure databases
SMRi | P98086 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198412, 5 interactors |
ComplexPortali | CPX-4981, Complement component C1q complex |
IntActi | P98086, 6 interactors |
STRINGi | 10090.ENSMUSP00000048836 |
PTM databases
GlyConnecti | 2223, 7 N-Linked glycans (1 site) |
GlyGeni | P98086, 4 sites |
iPTMneti | P98086 |
PhosphoSitePlusi | P98086 |
SwissPalmi | P98086 |
Proteomic databases
CPTACi | non-CPTAC-3638 non-CPTAC-5581 |
jPOSTi | P98086 |
PaxDbi | P98086 |
PeptideAtlasi | P98086 |
PRIDEi | P98086 |
ProteomicsDBi | 265397 |
Protocols and materials databases
Antibodypediai | 707, 408 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000046285; ENSMUSP00000048836; ENSMUSG00000036887 |
GeneIDi | 12259 |
KEGGi | mmu:12259 |
UCSCi | uc008vir.1, mouse |
Organism-specific databases
CTDi | 712 |
MGIi | MGI:88223, C1qa |
Phylogenomic databases
eggNOGi | ENOG502RZM2, Eukaryota |
GeneTreei | ENSGT00940000162143 |
HOGENOMi | CLU_001074_0_2_1 |
InParanoidi | P98086 |
OMAi | VWIEKDP |
OrthoDBi | 1258047at2759 |
TreeFami | TF329591 |
Enzyme and pathway databases
Reactomei | R-MMU-166663, Initial triggering of complement R-MMU-173623, Classical antibody-mediated complement activation R-MMU-977606, Regulation of Complement cascade |
Miscellaneous databases
BioGRID-ORCSi | 12259, 0 hits in 52 CRISPR screens |
ChiTaRSi | C1qa, mouse |
PROi | PR:P98086 |
RNActi | P98086, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036887, Expressed in stroma of bone marrow and 253 other tissues |
ExpressionAtlasi | P98086, baseline and differential |
Genevisiblei | P98086, MM |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR037572, Complement_C1q_A IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR15427:SF26, PTHR15427:SF26, 1 hit |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C1QA_MOUSE | |
Accessioni | P98086Primary (citable) accession number: P98086 Secondary accession number(s): Q9DCM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 3, 2012 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot