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Protein

Complement C1q subcomponent subunit A

Gene

C1qa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Biological processi

  • complement activation, classical pathway Source: MGI
  • innate immune response Source: UniProtKB-KW
  • response to iron ion Source: Ensembl

Keywordsi

Biological processComplement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166663 Initial triggering of complement
R-MMU-173623 Classical antibody-mediated complement activation
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q subcomponent subunit A
Gene namesi
Name:C1qa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88223 C1qa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000351823 – 245Complement C1q subcomponent subunit AAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26Interchain (with C-29 in B chain)By similarity
Modified residuei394-hydroxyprolineBy similarity1
Modified residuei454-hydroxyprolineBy similarity1
Modified residuei485-hydroxylysine; alternateBy similarity1
Glycosylationi48O-linked (Gal...) hydroxylysine; alternateBy similarity1
Modified residuei544-hydroxyprolineBy similarity1
Modified residuei675-hydroxylysine; alternateBy similarity1
Glycosylationi67O-linked (Gal...) hydroxylysine; alternateBy similarity1
Modified residuei794-hydroxyprolineBy similarity1
Modified residuei854-hydroxyprolineBy similarity1
Modified residuei1005-hydroxylysine; alternateBy similarity1
Glycosylationi100O-linked (Gal...) hydroxylysine; alternateBy similarity1
Glycosylationi146N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

O-linked glycans are Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.By similarity
Proline residues in the collagen-like domain motif, GXPG, are typically 4-hydroxylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP98086
PeptideAtlasiP98086
PRIDEiP98086

PTM databases

iPTMnetiP98086
PhosphoSitePlusiP98086

Expressioni

Gene expression databases

BgeeiENSMUSG00000036887 Expressed in 237 organ(s), highest expression level in stroma of bone marrow
GenevisibleiP98086 MM

Interactioni

Subunit structurei

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

Binary interactionsi

WithEntry#Exp.IntActNotes
FZD8Q9H4613EBI-299840,EBI-6254212From Homo sapiens.

Protein-protein interaction databases

BioGridi198412, 2 interactors
IntActiP98086, 6 interactors
STRINGi10090.ENSMUSP00000048836

Structurei

3D structure databases

ProteinModelPortaliP98086
SMRiP98086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 109Collagen-likeAdd BLAST79
Domaini110 – 245C1qPROSITE-ProRule annotationAdd BLAST136

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IK45 Eukaryota
ENOG410YJJD LUCA
GeneTreeiENSGT00900000140911
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiP98086
KOiK03986
OMAiYYYFTFQ
OrthoDBiEOG091G0L3Y
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR037572 Complement_C1q_A
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR45066 PTHR45066, 1 hit
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSQGWLVA CVLTMTLVWT VAEDVCRAPN GKDGAPGNPG RPGRPGLKGE
60 70 80 90 100
RGEPGAAGIR TGIRGFKGDP GESGPPGKPG NVGLPGPSGP LGDSGPQGLK
110 120 130 140 150
GVKGNPGNIR DQPRPAFSAI RQNPMTLGNV VIFDKVLTNQ ESPYQNHTGR
160 170 180 190 200
FICAVPGFYY FNFQVISKWD LCLFIKSSSG GQPRDSLSFS NTNNKGLFQV
210 220 230 240
LAGGTVLQLR RGDEVWIEKD PAKGRIYQGT EADSIFSGFL IFPSA
Length:245
Mass (Da):25,974
Last modified:October 3, 2012 - v2
Checksum:i41C2066D49592020
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16T → I in CAA41664 (PubMed:1940381).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58861 mRNA Translation: CAA41664.1
AK002655 mRNA Translation: BAB22262.1
AK136737 mRNA Translation: BAE23115.1
AK159210 mRNA Translation: BAE34901.1
AL627214 Genomic DNA Translation: CAM46146.1
CH466552 Genomic DNA Translation: EDL29926.1
BC002086 mRNA Translation: AAH02086.1
CCDSiCCDS18812.1
PIRiS19018
RefSeqiNP_031598.2, NM_007572.2
UniGeneiMm.439957

Genome annotation databases

EnsembliENSMUST00000046285; ENSMUSP00000048836; ENSMUSG00000036887
GeneIDi12259
KEGGimmu:12259
UCSCiuc008vir.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58861 mRNA Translation: CAA41664.1
AK002655 mRNA Translation: BAB22262.1
AK136737 mRNA Translation: BAE23115.1
AK159210 mRNA Translation: BAE34901.1
AL627214 Genomic DNA Translation: CAM46146.1
CH466552 Genomic DNA Translation: EDL29926.1
BC002086 mRNA Translation: AAH02086.1
CCDSiCCDS18812.1
PIRiS19018
RefSeqiNP_031598.2, NM_007572.2
UniGeneiMm.439957

3D structure databases

ProteinModelPortaliP98086
SMRiP98086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198412, 2 interactors
IntActiP98086, 6 interactors
STRINGi10090.ENSMUSP00000048836

PTM databases

iPTMnetiP98086
PhosphoSitePlusiP98086

Proteomic databases

PaxDbiP98086
PeptideAtlasiP98086
PRIDEiP98086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046285; ENSMUSP00000048836; ENSMUSG00000036887
GeneIDi12259
KEGGimmu:12259
UCSCiuc008vir.1 mouse

Organism-specific databases

CTDi712
MGIiMGI:88223 C1qa

Phylogenomic databases

eggNOGiENOG410IK45 Eukaryota
ENOG410YJJD LUCA
GeneTreeiENSGT00900000140911
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiP98086
KOiK03986
OMAiYYYFTFQ
OrthoDBiEOG091G0L3Y
TreeFamiTF329591

Enzyme and pathway databases

ReactomeiR-MMU-166663 Initial triggering of complement
R-MMU-173623 Classical antibody-mediated complement activation
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRSiC1qa mouse
PROiPR:P98086
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036887 Expressed in 237 organ(s), highest expression level in stroma of bone marrow
GenevisibleiP98086 MM

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR037572 Complement_C1q_A
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR45066 PTHR45066, 1 hit
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC1QA_MOUSE
AccessioniPrimary (citable) accession number: P98086
Secondary accession number(s): Q9DCM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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