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Protein

Amyloid-beta A4 precursor protein-binding family A member 2

Gene

Apba2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.

Caution

Was originally thought to be the ortholog of human X11 (APBA1).1 Publication

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • in utero embryonic development Source: MGI
  • locomotory behavior Source: MGI
  • multicellular organism growth Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of gene expression Source: MGI
  • regulation of synaptic vesicle exocytosis Source: SynGO

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family A member 2
Alternative name(s):
Adapter protein X11beta
Neuron-specific X11L protein
Neuronal Munc18-1-interacting protein 2
Short name:
Mint-2
Gene namesi
Name:Apba2
Synonyms:X11l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1261791 Apba2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646171 – 750Amyloid-beta A4 precursor protein-binding family A member 2Add BLAST750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP98084
PaxDbiP98084
PRIDEiP98084

PTM databases

iPTMnetiP98084
PhosphoSitePlusiP98084

Expressioni

Tissue specificityi

Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei.

Gene expression databases

BgeeiENSMUSG00000030519 Expressed in 160 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP98084 baseline and differential
GenevisibleiP98084 MM

Interactioni

Subunit structurei

Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid-beta protein, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

IntActiP98084, 5 interactors
MINTiP98084
STRINGi10090.ENSMUSP00000032732

Structurei

3D structure databases

ProteinModelPortaliP98084
SMRiP98084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini367 – 556PIDPROSITE-ProRule annotationAdd BLAST190
Domaini569 – 654PDZ 1PROSITE-ProRule annotationAdd BLAST86
Domaini660 – 736PDZ 2PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 271STXBP1-bindingAdd BLAST87

Domaini

Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3605 Eukaryota
ENOG410XSBD LUCA
GeneTreeiENSGT00390000013578
HOGENOMiHOG000033981
HOVERGENiHBG050523
InParanoidiP98084
KOiK20055
OMAiYPAEANG
OrthoDBiEOG091G0PDJ
PhylomeDBiP98084
TreeFamiTF315245

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030529 Apba2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR12345:SF12 PTHR12345:SF12, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P98084-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHRKRQSTA SSMLDHRARP GPIPHDQEPE SEDTELPLES YVPTGLELGT
60 70 80 90 100
LRPESPTPEE QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGVTYY
110 120 130 140 150
IRYCPEDDSY LEGMDCNGEE YIAHGAHPVD TDECQEAVED WTDSVGPHTH
160 170 180 190 200
SHGAENSQEY PDGHLPIPED DPTVLEVHDQ EEDGHYCSSK ESYQDYYPPE
210 220 230 240 250
TNGNTGGASP YRMRRGDGDL EEQEEDIDQI VAEIKMSLSM TSITSASEAS
260 270 280 290 300
PEHMPELDPG DSTEACPPSD TGHGPGRQEA RPKSLNLPPE VKHPGDLQRG
310 320 330 340 350
LKTKTRTPEE RPKWPQEQVC NGLEQPRKQQ RSDLNGPTDN NNIPETKKVA
360 370 380 390 400
SFPSFVAVPG PCEAEDLIDG IIFAANYLGS TQLLSERNPS KNIRMMQAQE
410 420 430 440 450
AVSRVKRMQK AAKIKKKANS EGDAQTLTEV DLFISTQRIK VLNADTQETM
460 470 480 490 500
MDHALRTISY IADIGNIVVL MARRRMPRSA SQDCIETTPG AQEGKKQYKM
510 520 530 540 550
ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS QKEYSDIINT
560 570 580 590 600
QEMYNDDLIH FSNSENCKEL QLEKHKGEIL GVVVVESGWG SILPTVILAN
610 620 630 640 650
MMNGGPAARS GKLSIGDQIM SINGTSLVGL PLATCQGIIK GLKNQTQVKL
660 670 680 690 700
NIVSCPPVTT VLIKRPDLKY QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR
710 720 730 740 750
IIEINGQSVV ATAHEKIVQA LSNSVGEIHM KTMPAAMFRL LTGQETPLYI
Length:750
Mass (Da):82,758
Last modified:July 19, 2005 - v2
Checksum:iFC231C966DB467DE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RPM0A0A0U1RPM0_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba2
738Annotation score:
A0A0U1RQ68A0A0U1RQ68_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba2
81Annotation score:
A0A0U1RQ78A0A0U1RQ78_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba2
102Annotation score:
A0A0U1RPS9A0A0U1RPS9_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba2
79Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313K → M in AAA73936 (PubMed:7719031).Curated1
Sequence conflicti388N → T in AAA73936 (PubMed:7719031).Curated1
Sequence conflicti402V → A in AAA73936 (PubMed:7719031).Curated1
Sequence conflicti677 – 679QNG → RW in AAA73936 (PubMed:7719031).Curated3
Sequence conflicti688 – 690GIA → VLQ in AAA73936 (PubMed:7719031).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060269 mRNA Translation: AAH60269.1
BC057620 mRNA Translation: AAH57620.1
L34676 mRNA Translation: AAA73936.1
CCDSiCCDS21335.1
RefSeqiNP_001278095.1, NM_001291166.1
NP_001278096.1, NM_001291167.1
NP_031487.1, NM_007461.2
XP_006540636.1, XM_006540573.3
XP_006540637.1, XM_006540574.3
XP_017177434.1, XM_017321945.1
UniGeneiMm.4657

Genome annotation databases

EnsembliENSMUST00000032732; ENSMUSP00000032732; ENSMUSG00000030519
GeneIDi11784
KEGGimmu:11784
UCSCiuc009hgj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060269 mRNA Translation: AAH60269.1
BC057620 mRNA Translation: AAH57620.1
L34676 mRNA Translation: AAA73936.1
CCDSiCCDS21335.1
RefSeqiNP_001278095.1, NM_001291166.1
NP_001278096.1, NM_001291167.1
NP_031487.1, NM_007461.2
XP_006540636.1, XM_006540573.3
XP_006540637.1, XM_006540574.3
XP_017177434.1, XM_017321945.1
UniGeneiMm.4657

3D structure databases

ProteinModelPortaliP98084
SMRiP98084
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP98084, 5 interactors
MINTiP98084
STRINGi10090.ENSMUSP00000032732

PTM databases

iPTMnetiP98084
PhosphoSitePlusiP98084

Proteomic databases

MaxQBiP98084
PaxDbiP98084
PRIDEiP98084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032732; ENSMUSP00000032732; ENSMUSG00000030519
GeneIDi11784
KEGGimmu:11784
UCSCiuc009hgj.2 mouse

Organism-specific databases

CTDi321
MGIiMGI:1261791 Apba2

Phylogenomic databases

eggNOGiKOG3605 Eukaryota
ENOG410XSBD LUCA
GeneTreeiENSGT00390000013578
HOGENOMiHOG000033981
HOVERGENiHBG050523
InParanoidiP98084
KOiK20055
OMAiYPAEANG
OrthoDBiEOG091G0PDJ
PhylomeDBiP98084
TreeFamiTF315245

Miscellaneous databases

ChiTaRSiApba2 mouse
PROiPR:P98084
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030519 Expressed in 160 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP98084 baseline and differential
GenevisibleiP98084 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030529 Apba2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR12345:SF12 PTHR12345:SF12, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPBA2_MOUSE
AccessioniPrimary (citable) accession number: P98084
Secondary accession number(s): Q6PAJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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