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Entry version 194 (22 Apr 2020)
Sequence version 3 (27 May 2002)
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Protein

SHC-transforming protein 1

Gene

Shc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Growth regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1250196 SHC1 events in ERBB2 signaling [P98083-3]
R-MMU-1250347 SHC1 events in ERBB4 signaling [P98083-3]
R-MMU-167044 Signalling to RAS [P98083-3]
R-MMU-180336 SHC1 events in EGFR signaling [P98083-3]
R-MMU-210993 Tie2 Signaling [P98083-3]
R-MMU-2424491 DAP12 signaling [P98083-3]
R-MMU-2428933 SHC-related events triggered by IGF1R [P98083-3]
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization [P98083-3]
R-MMU-2871796 FCERI mediated MAPK activation [P98083-3]
R-MMU-2871809 FCERI mediated Ca+2 mobilization [P98083-3]
R-MMU-354192 Integrin signaling [P98083-3]
R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling [P98083-3]
R-MMU-5654688 SHC-mediated cascade:FGFR1 [P98083-3]
R-MMU-5654699 SHC-mediated cascade:FGFR2 [P98083-3]
R-MMU-5654704 SHC-mediated cascade:FGFR3 [P98083-3]
R-MMU-5654719 SHC-mediated cascade:FGFR4 [P98083-3]
R-MMU-5673001 RAF/MAP kinase cascade [P98083-3]
R-MMU-74749 Signal attenuation [P98083-3]
R-MMU-74751 Insulin receptor signalling cascade [P98083-3]
R-MMU-8851805 MET activates RAS signaling [P98083-3]
R-MMU-8853659 RET signaling [P98083-3]
R-MMU-8983432 Interleukin-15 signaling [P98083-3]
R-MMU-9009391 Extra-nuclear estrogen signaling [P98083-3]
R-MMU-9020558 Interleukin-2 signaling [P98083-3]
R-MMU-9027284 Erythropoietin activates RAS [P98083-3]
R-MMU-912526 Interleukin receptor SHC signaling [P98083-3]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SHC-transforming protein 1
Alternative name(s):
SHC-transforming protein A
Src homology 2 domain-containing-transforming protein C1
Short name:
SH2 domain protein C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shc1
Synonyms:Shc, ShcA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98296 Shc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000223391 – 579SHC-transforming protein 1Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei36Phosphoserine1 Publication1
Modified residuei139PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei349PhosphotyrosineBy similarity1
Modified residuei350PhosphotyrosineBy similarity1
Modified residuei423PhosphotyrosineCombined sources1
Modified residuei449PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to FLT4 signaling (By similarity). Tyrosine phosphorylated by ligand-activated PDGFRB (By similarity). May be tyrosine phosphorylated by activated PTK2/FAK1 (By similarity). Tyrosine phosphorylated by TEK/TIE2 (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Isoform p47Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light. FLT3 signaling promotes tyrosine phosphorylation of isoform p47Shc and isoform p52Shc. Also tyrosine phosphorylated by ligand-activated ALK.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P98083

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P98083

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98083

PeptideAtlas

More...
PeptideAtlasi
P98083

PRoteomics IDEntifications database

More...
PRIDEi
P98083

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P98083

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P98083

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in neural stem cells but absent in mature neurons.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042626 Expressed in lens of camera-type eye and 269 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P98083 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P98083 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (By similarity).

Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2.

Interacts with tyrosine-phosphorylated DDR2 and CD3T.

Interacts with the N-terminal region of APS.

Interacts with GRB7 and KIT (By similarity).

Interacts with PTK2/FAK1 (By similarity).

Interacts with phosphorylated LRP1 and IRS4.

Interacts with FLT4 (tyrosine-phosphorylated) (By similarity).

Interacts with PDGFRB (tyrosine-phosphorylated).

Interacts with ERBB4 (By similarity).

Interacts with TEK/TIE2 (tyrosine-phosphorylated) (By similarity).

Interacts with ALK, GAB2, TRIM31, INPP5D/SHIP1 and INPPL1/SHIP2.

Interacts with PTPN6/SHP (tyrosine phosphorylated).

Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN.

Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration.

Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner.

Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity) (PubMed:15467833).

Interacts (via PID domain) with PEAK1 (when phosphorylated at 'Tyr-1177') (By similarity).

Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity).

By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203215, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P98083

Database of interacting proteins

More...
DIPi
DIP-271N

Protein interaction database and analysis system

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IntActi
P98083, 29 interactors

Molecular INTeraction database

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MINTi
P98083

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091940

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P98083 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P98083

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 339PIDPROSITE-ProRule annotationAdd BLAST184
Domaini484 – 575SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni340 – 483CH1Add BLAST144

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi408 – 470Pro-richAdd BLAST63

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In response to a variety of growth factors, isoform p47Shc and isoform p52 bind to phosphorylated receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif. Isoform p47Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation.

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3697 Eukaryota
ENOG410XTJN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182870

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_029532_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P98083

KEGG Orthology (KO)

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KOi
K06279

Identification of Orthologs from Complete Genome Data

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OMAi
FFPKMAN

Database of Orthologous Groups

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OrthoDBi
1351843at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P98083

TreeFam database of animal gene trees

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TreeFami
TF315807

Family and domain databases

Conserved Domains Database

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CDDi
cd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029586 Shc1/ShcA
IPR035676 SHC_SH2

The PANTHER Classification System

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PANTHERi
PTHR10337:SF13 PTHR10337:SF13, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Note: In human, it is alternative promoter usage that produces such isoforms.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform p66Shc (identifier: P98083-1) [UniParc]FASTAAdd to basket
Also known as: p66

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP
60 70 80 90 100
GDDSPTTLCS FFPRMSNLKL ANPAGGRLGP KGEPGKAAED GEGSAGAALR
110 120 130 140 150
DSGLLPLLQD MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH
160 170 180 190 200
PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP
210 220 230 240 250
GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ
260 270 280 290 300
IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
310 320 330 340 350
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY
360 370 380 390 400
NDFPGKEPPL GGVVDMRLRE GAARPTLPSA QMSSHLGATL PIGQHAAGDH
410 420 430 440 450
EVRKQMLPPP PCPGRELFDD PSYVNIQNLD KARQAGGGAG PPNPSLNGSA
460 470 480 490 500
PRDLFDMKPF EDALRVPPPP QSMSMAEQLQ GEPWFHGKLS RREAEALLQL
510 520 530 540 550
NGDFLVREST TTPGQYVLTG LQSGQPKHLL LVDPEGVVRT KDHRFESVSH
560 570
LISYHMDNHL PIISAGSELC LQQPVDRKV
Length:579
Mass (Da):62,608
Last modified:May 27, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99C22E64412B6236
GO
Isoform p52Shc (identifier: P98083-2) [UniParc]FASTAAdd to basket
Also known as: p52

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:469
Mass (Da):51,409
Checksum:iDF33594E80107A3E
GO
Isoform p47Shc (identifier: P98083-3) [UniParc]FASTAAdd to basket
Also known as: p47

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Note: Produced by alternative initiation at Met-46 of isoform p52.Curated
Show »
Length:424
Mass (Da):46,467
Checksum:i5064FFF6CE5BD930
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2I8D3Z2I8_MOUSE
SHC-transforming protein 1
Shc1
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5U6D3Z5U6_MOUSE
SHC-transforming protein 1
Shc1
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YXZ9D3YXZ9_MOUSE
SHC-transforming protein 1
Shc1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZV5D3YZV5_MOUSE
SHC-transforming protein 1
Shc1
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187921 – 155Missing in isoform p47Shc. CuratedAdd BLAST155
Alternative sequenceiVSP_0187911 – 110Missing in isoform p52Shc. 3 PublicationsAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U46956 Genomic DNA Translation: AAA91777.2
U15784 mRNA Translation: AAC52146.1
AK049357 mRNA Translation: BAC33706.1
AK155158 mRNA Translation: BAE33083.1
BC036172 mRNA Translation: AAH36172.1
AF455140 Genomic DNA Translation: AAM61857.1
AF455140 Genomic DNA Translation: AAM61858.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17508.1 [P98083-2]
CCDS50962.1 [P98083-1]

Protein sequence database of the Protein Information Resource

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PIRi
A55484

NCBI Reference Sequences

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RefSeqi
NP_001106802.1, NM_001113331.2 [P98083-1]
NP_035498.2, NM_011368.5 [P98083-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000039110; ENSMUSP00000035361; ENSMUSG00000042626 [P98083-2]
ENSMUST00000094378; ENSMUSP00000091940; ENSMUSG00000042626 [P98083-1]
ENSMUST00000107417; ENSMUSP00000103040; ENSMUSG00000042626 [P98083-3]
ENSMUST00000191485; ENSMUSP00000140336; ENSMUSG00000042626 [P98083-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
20416

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20416

UCSC genome browser

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UCSCi
uc008pzm.2 mouse [P98083-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46956 Genomic DNA Translation: AAA91777.2
U15784 mRNA Translation: AAC52146.1
AK049357 mRNA Translation: BAC33706.1
AK155158 mRNA Translation: BAE33083.1
BC036172 mRNA Translation: AAH36172.1
AF455140 Genomic DNA Translation: AAM61857.1
AF455140 Genomic DNA Translation: AAM61858.1
CCDSiCCDS17508.1 [P98083-2]
CCDS50962.1 [P98083-1]
PIRiA55484
RefSeqiNP_001106802.1, NM_001113331.2 [P98083-1]
NP_035498.2, NM_011368.5 [P98083-2]

3D structure databases

SMRiP98083
ModBaseiSearch...

Protein-protein interaction databases

BioGridi203215, 30 interactors
CORUMiP98083
DIPiDIP-271N
IntActiP98083, 29 interactors
MINTiP98083
STRINGi10090.ENSMUSP00000091940

PTM databases

iPTMnetiP98083
PhosphoSitePlusiP98083

Proteomic databases

jPOSTiP98083
MaxQBiP98083
PaxDbiP98083
PeptideAtlasiP98083
PRIDEiP98083

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
731 1127 antibodies

Genome annotation databases

EnsembliENSMUST00000039110; ENSMUSP00000035361; ENSMUSG00000042626 [P98083-2]
ENSMUST00000094378; ENSMUSP00000091940; ENSMUSG00000042626 [P98083-1]
ENSMUST00000107417; ENSMUSP00000103040; ENSMUSG00000042626 [P98083-3]
ENSMUST00000191485; ENSMUSP00000140336; ENSMUSG00000042626 [P98083-2]
GeneIDi20416
KEGGimmu:20416
UCSCiuc008pzm.2 mouse [P98083-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6464
MGIiMGI:98296 Shc1

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00950000182870
HOGENOMiCLU_029532_2_0_1
InParanoidiP98083
KOiK06279
OMAiFFPKMAN
OrthoDBi1351843at2759
PhylomeDBiP98083
TreeFamiTF315807

Enzyme and pathway databases

ReactomeiR-MMU-1250196 SHC1 events in ERBB2 signaling [P98083-3]
R-MMU-1250347 SHC1 events in ERBB4 signaling [P98083-3]
R-MMU-167044 Signalling to RAS [P98083-3]
R-MMU-180336 SHC1 events in EGFR signaling [P98083-3]
R-MMU-210993 Tie2 Signaling [P98083-3]
R-MMU-2424491 DAP12 signaling [P98083-3]
R-MMU-2428933 SHC-related events triggered by IGF1R [P98083-3]
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization [P98083-3]
R-MMU-2871796 FCERI mediated MAPK activation [P98083-3]
R-MMU-2871809 FCERI mediated Ca+2 mobilization [P98083-3]
R-MMU-354192 Integrin signaling [P98083-3]
R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling [P98083-3]
R-MMU-5654688 SHC-mediated cascade:FGFR1 [P98083-3]
R-MMU-5654699 SHC-mediated cascade:FGFR2 [P98083-3]
R-MMU-5654704 SHC-mediated cascade:FGFR3 [P98083-3]
R-MMU-5654719 SHC-mediated cascade:FGFR4 [P98083-3]
R-MMU-5673001 RAF/MAP kinase cascade [P98083-3]
R-MMU-74749 Signal attenuation [P98083-3]
R-MMU-74751 Insulin receptor signalling cascade [P98083-3]
R-MMU-8851805 MET activates RAS signaling [P98083-3]
R-MMU-8853659 RET signaling [P98083-3]
R-MMU-8983432 Interleukin-15 signaling [P98083-3]
R-MMU-9009391 Extra-nuclear estrogen signaling [P98083-3]
R-MMU-9020558 Interleukin-2 signaling [P98083-3]
R-MMU-9027284 Erythropoietin activates RAS [P98083-3]
R-MMU-912526 Interleukin receptor SHC signaling [P98083-3]

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Shc1 mouse

Protein Ontology

More...
PROi
PR:P98083
RNActiP98083 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042626 Expressed in lens of camera-type eye and 269 other tissues
ExpressionAtlasiP98083 baseline and differential
GenevisibleiP98083 MM

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029586 Shc1/ShcA
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF13 PTHR10337:SF13, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98083
Secondary accession number(s): Q3U2Q7
, Q8BFY3, Q8K4C6, Q8K4C7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 27, 2002
Last modified: April 22, 2020
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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