UniProtKB - P98082 (DAB2_HUMAN)
Disabled homolog 2
DAB2
Functioni
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.
8 PublicationsGO - Molecular functioni
- cargo receptor activity Source: UniProtKB
- clathrin adaptor activity Source: UniProtKB
- low-density lipoprotein particle receptor binding Source: Ensembl
- protein C-terminus binding Source: UniProtKB
- SMAD binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to epidermal growth factor stimulus Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- clathrin coat assembly Source: Ensembl
- leading edge cell differentiation Source: UniProtKB
- negative regulation of androgen receptor signaling pathway Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- negative regulation of cell growth Source: Ensembl
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of ERK1 and ERK2 cascade Source: Ensembl
- negative regulation of neuron projection development Source: Ensembl
- negative regulation of protein binding Source: BHF-UCL
- negative regulation of protein localization to plasma membrane Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of aldosterone biosynthetic process Source: Ensembl
- positive regulation of aldosterone secretion Source: Ensembl
- positive regulation of cell migration Source: UniProtKB
- positive regulation of clathrin-dependent endocytosis Source: UniProtKB
- positive regulation of early endosome to late endosome transport Source: UniProtKB
- positive regulation of endocytosis Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
- positive regulation of protein phosphorylation Source: BHF-UCL
- positive regulation of SMAD protein signal transduction Source: UniProtKB
- positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
- protein transport Source: UniProtKB-KW
- receptor-mediated endocytosis Source: GO_Central
- regulation of Rho-dependent protein serine/threonine kinase activity Source: Ensembl
- response to salt Source: Ensembl
- response to steroid hormone Source: Ensembl
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Apoptosis, Differentiation, Endocytosis, Protein transport, Transport, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | P98082 |
Reactomei | R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P98082 |
SIGNORi | P98082 |
Names & Taxonomyi
Protein namesi | Recommended name: Disabled homolog 2Alternative name(s): Adaptor molecule disabled-2 Differentially expressed in ovarian carcinoma 2 Short name: DOC-2 Differentially-expressed protein 2 |
Gene namesi | Name:DAB2 Synonyms:DOC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2662, DAB2 |
MIMi | 601236, gene |
neXtProti | NX_P98082 |
VEuPathDBi | HostDB:ENSG00000153071 |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
Note: Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.
Cytosol
- cytosol Source: Reactome
Lysosome
- lysosomal membrane Source: Reactome
Nucleus
- fibrillar center Source: HPA
Plasma Membrane
- clathrin-coated pit Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- clathrin-coated vesicle Source: UniProtKB
- clathrin-coated vesicle membrane Source: UniProtKB-SubCell
- cytoplasm Source: GO_Central
- focal adhesion Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
Coated pit, Cytoplasm, Cytoplasmic vesicle, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 166 | F → A: Impairs TGF-beta receptor signaling, no effect on interaction with SMAD2. 1 Publication | 1 | |
Mutagenesisi | 684 – 686 | SYF → AAA: Greatly reduced binding to MYO6. 1 Publication | 3 | |
Mutagenesisi | 720 | R → A: Abolishes interaction with SH3KBP1. 1 Publication | 1 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 1601 |
OpenTargetsi | ENSG00000153071 |
PharmGKBi | PA27132 |
Miscellaneous databases
Pharosi | P98082, Tbio |
Genetic variation databases
BioMutai | DAB2 |
DMDMi | 145559465 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000079770 | 2 – 770 | Disabled homolog 2Add BLAST | 769 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 170 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 193 | PhosphoserineBy similarity | 1 | |
Modified residuei | 326 | Phosphoserine; in mitosisBy similarity | 1 | |
Modified residuei | 328 | Phosphoserine; in mitosisBy similarity | 1 | |
Modified residuei | 401 | PhosphoserineCombined sources | 1 | |
Modified residuei | 675 | PhosphoserineCombined sources | 1 | |
Modified residuei | 723 | PhosphoserineCombined sources | 1 | |
Modified residuei | 729 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P98082 |
jPOSTi | P98082 |
MassIVEi | P98082 |
MaxQBi | P98082 |
PaxDbi | P98082 |
PeptideAtlasi | P98082 |
PRIDEi | P98082 |
ProteomicsDBi | 57786 [P98082-1] 57787 [P98082-2] 57788 [P98082-3] |
PTM databases
GlyGeni | P98082, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | P98082 |
MetOSitei | P98082 |
PhosphoSitePlusi | P98082 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000153071, Expressed in placenta and 240 other tissues |
ExpressionAtlasi | P98082, baseline and differential |
Genevisiblei | P98082, HS |
Organism-specific databases
HPAi | ENSG00000153071, Tissue enhanced (kidney, placenta) |
Interactioni
Subunit structurei
Interacts (via NPXY motif) with DAB2 (via PID domain). Can interact (via PID domain) with LDLR, APP, APLP1 and APLP2, and weakly with INPP5D (via NPXY motifs); the interaction is impaired by tyrosine phosphorylation of the respective NPXY motifs. Can weakly interact (via PID domain) with LRP1 (via NPXY motif); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif.
Interacts with LRP2 (via NPXY motif); the interaction is not affected by tyrosine phosphorylation of the NPXY motif.
Interacts with clathrin; in vitro can assemble clathrin triskelia into polyhedral coats.
Interacts with AP2A2, ITGB1, ITGB3, ITGB5, PIAS2, DAB2IP, NOSTRIN, FCHO1, DVL3, EPS15, ITSN1 and EPS15L1.
Interacts with SH3KBP1 (via SH3 domains).
Interacts with GRB2; competes with SOS1 for binding to GRB2 and the interaction is enhanced by EGF and NT-3 stimulation.
Interacts with MAP3K7; the interaction is induced by TGF-beta stimulation and may mediate TGF-beta stimulated JNK activation.
Interacts with AXIN1 and PPP1CA; the interactions are mutually exclusive.
Interacts with the globular tail of MYO6.
Interacts (via DPF motifs) with FCHO2; the interaction is direct and required for DAB2-mediated LDLR endocytosis.
Interacts with LRP6; the interaction involves LRP6 phosphorylation by CK2 and sequesters LRP6 towards clathrin-mediated endocytosis. Associates with the TGF-beta receptor complex (Probable).
Interacts with SMAD2 and SMAD3; the interactions are enhanced upon TGF-beta stimulation.
Interacts with GRB2; the interaction is enhanced by EGF and NT-3 stimulation.
Interacts with SRC; the interaction is enhanced by EGF stimulation.
Curated9 PublicationsBinary interactionsi
P98082
Isoform 1 [P98082-1]
With | #Exp. | IntAct |
---|---|---|
MYO6 [Q29122] from Sus scrofa. | 2 | EBI-15804617,EBI-15804516 |
GO - Molecular functioni
- clathrin adaptor activity Source: UniProtKB
- low-density lipoprotein particle receptor binding Source: Ensembl
- protein C-terminus binding Source: UniProtKB
- SMAD binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107971, 116 interactors |
DIPi | DIP-45617N |
ELMi | P98082 |
IntActi | P98082, 67 interactors |
MINTi | P98082 |
STRINGi | 9606.ENSP00000313391 |
Chemistry databases
BindingDBi | P98082 |
Miscellaneous databases
RNActi | P98082, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P98082 |
SMRi | P98082 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 196 | PIDPROSITE-ProRule annotationAdd BLAST | 152 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 230 – 447 | Required for localization to clathrin-coated pitsBy similarityAdd BLAST | 218 | |
Regioni | 284 – 482 | DisorderedSequence analysisAdd BLAST | 199 | |
Regioni | 604 – 732 | Sufficient for interaction with GRB2By similarityAdd BLAST | 129 | |
Regioni | 604 – 629 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 619 – 627 | Required for interaction with CSKBy similarity | 9 | |
Regioni | 649 – 770 | Required for interaction with MYO6By similarityAdd BLAST | 122 | |
Regioni | 663 – 671 | Required for interaction with GRB2 and CSKBy similarity | 9 | |
Regioni | 709 – 725 | Sufficient for interaction with SH3KBP1 SH3 domainBy similarityAdd BLAST | 17 | |
Regioni | 742 – 770 | DisorderedSequence analysisAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 293 – 295 | DPF 1 | 3 | |
Motifi | 298 – 300 | DPF 2 | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 21 – 38 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 300 – 335 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 344 – 397 | Polar residuesSequence analysisAdd BLAST | 54 | |
Compositional biasi | 407 – 430 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 466 – 482 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 615 – 629 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 742 – 760 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Phylogenomic databases
eggNOGi | KOG3535, Eukaryota |
GeneTreei | ENSGT00940000155567 |
HOGENOMi | CLU_020747_1_0_1 |
InParanoidi | P98082 |
OMAi | ESQAGPW |
PhylomeDBi | P98082 |
TreeFami | TF316724 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
Pfami | View protein in Pfam PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNEVETSAT NGQPDQQAAP KAPSKKEKKK GPEKTDEYLL ARFKGDGVKY
60 70 80 90 100
KAKLIGIDDV PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS
110 120 130 140 150
GIKIIDEKTG VIEHEHPVNK ISFIARDVTD NRAFGYVCGG EGQHQFFAIK
160 170 180 190 200
TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK KIEEASKAVE NGSEALMILD
210 220 230 240 250
DQTNKLKSGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN SEIDTNQNSL
260 270 280 290 300
RENPFLTNGI TSCSLPRPTP QASFLPENAF SANLNFFPTP NPDPFRDDPF
310 320 330 340 350
TQPDQSTPSS FDSLKSPDQK KENSSSSSTP LSNGPLNGDV DYFGQQFDQI
360 370 380 390 400
SNRTGKQEAQ AGPWPFSSSQ TQPAVRTQNG VSEREQNGFS VKSSPNPFVG
410 420 430 440 450
SPPKGLSIQN GVKQDLESSV QSSPHDSIAI IPPPQSTKPG RGRRTAKSSA
460 470 480 490 500
NDLLASDIFA PPVSEPSGQA SPTGQPTALQ PNPLDLFKTS APAPVGPLVG
510 520 530 540 550
LGGVTVTLPQ AGPWNTASLV FNQSPSMAPG AMMGGQPSGF SQPVIFGTSP
560 570 580 590 600
AVSGWNQPSP FAASTPPPVP VVWGPSASVA PNAWSTTSPL GNPFQSNIFP
610 620 630 640 650
APAVSTQPPS MHSSLLVTPP QPPPRAGPPK DISSDAFTAL DPLGDKEIKD
660 670 680 690 700
VKEMFKDFQL RQPPAVPARK GEQTSSGTLS AFASYFNSKV GIPQENADHD
710 720 730 740 750
DFDANQLLNK INEPPKPAPR QVSLPVTKST DNAFENPFFK DSFGSSQASV
760 770
ASSQPVSSEM YRDPFGNPFA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REB1 | D6REB1_HUMAN | Disabled homolog 2 | DAB2 | 67 | Annotation score: | ||
D6RFF7 | D6RFF7_HUMAN | Disabled homolog 2 | DAB2 | 116 | Annotation score: | ||
D6RIA5 | D6RIA5_HUMAN | Disabled homolog 2 | DAB2 | 75 | Annotation score: | ||
D6RGZ1 | D6RGZ1_HUMAN | Disabled homolog 2 | DAB2 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 44 – 47 | KGDG → PRVC in AAA93195 (PubMed:8314147).Curated | 4 | |
Sequence conflicti | 82 | A → R in AAC50824 (PubMed:8660969).Curated | 1 | |
Sequence conflicti | 82 | A → R in AAB19032 (PubMed:8660969).Curated | 1 | |
Sequence conflicti | 82 | A → R in AAA98975 (PubMed:9620555).Curated | 1 | |
Sequence conflicti | 82 | A → R in AAF23161 (PubMed:11161789).Curated | 1 | |
Sequence conflicti | 82 | A → R in AAA93195 (PubMed:8314147).Curated | 1 | |
Sequence conflicti | 148 | A → T in AAA98975 (PubMed:9620555).Curated | 1 | |
Sequence conflicti | 197 | M → R in AAA98975 (PubMed:9620555).Curated | 1 | |
Sequence conflicti | 230 – 232 | ESK → VCF in AAF05540 (PubMed:10340382).Curated | 3 | |
Sequence conflicti | 230 – 232 | ESK → VCF in AAA93195 (PubMed:8314147).Curated | 3 | |
Sequence conflicti | 275 | L → S in AAC50824 (PubMed:8660969).Curated | 1 | |
Sequence conflicti | 302 – 304 | QPD → HTR in AAA93195 (PubMed:8314147).Curated | 3 | |
Sequence conflicti | 498 | L → Q in AAF05540 (PubMed:10340382).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031705 | 586 | T → I. Corresponds to variant dbSNP:rs700241Ensembl. | 1 | |
Natural variantiVAR_050942 | 634 | S → N. Corresponds to variant dbSNP:rs3733801Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038401 | 209 – 229 | Missing in isoform 3. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_004181 | 230 – 447 | Missing in isoform 2. CuratedAdd BLAST | 218 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39050 mRNA Translation: AAC50824.1 AH003698 Genomic DNA Translation: AAB19032.1 U53446 mRNA Translation: AAA98975.1 AF188298 mRNA Translation: AAF05540.1 AF205890 Genomic DNA Translation: AAF23161.1 AC008916 Genomic DNA No translation available. CH471119 Genomic DNA Translation: EAW55989.1 BC003064 mRNA Translation: AAH03064.1 L16886 mRNA Translation: AAA93195.1 |
CCDSi | CCDS34149.1 [P98082-1] CCDS58946.1 [P98082-3] |
PIRi | G02228 |
RefSeqi | NP_001231800.1, NM_001244871.1 [P98082-3] NP_001334.2, NM_001343.3 [P98082-1] |
Genome annotation databases
Ensembli | ENST00000320816; ENSP00000313391; ENSG00000153071 ENST00000339788; ENSP00000345508; ENSG00000153071 [P98082-2] ENST00000509337; ENSP00000426245; ENSG00000153071 [P98082-3] ENST00000545653; ENSP00000439919; ENSG00000153071 [P98082-3] |
GeneIDi | 1601 |
KEGGi | hsa:1601 |
MANE-Selecti | ENST00000320816.11; ENSP00000313391.6; NM_001343.4; NP_001334.2 |
UCSCi | uc003jlw.4, human [P98082-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39050 mRNA Translation: AAC50824.1 AH003698 Genomic DNA Translation: AAB19032.1 U53446 mRNA Translation: AAA98975.1 AF188298 mRNA Translation: AAF05540.1 AF205890 Genomic DNA Translation: AAF23161.1 AC008916 Genomic DNA No translation available. CH471119 Genomic DNA Translation: EAW55989.1 BC003064 mRNA Translation: AAH03064.1 L16886 mRNA Translation: AAA93195.1 |
CCDSi | CCDS34149.1 [P98082-1] CCDS58946.1 [P98082-3] |
PIRi | G02228 |
RefSeqi | NP_001231800.1, NM_001244871.1 [P98082-3] NP_001334.2, NM_001343.3 [P98082-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LSW | NMR | - | A | 24-58 | [»] | |
6O5O | X-ray | 1.75 | A/B | 31-191 | [»] | |
6OVF | X-ray | 1.95 | A/B | 31-191 | [»] | |
BMRBi | P98082 | |||||
SMRi | P98082 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107971, 116 interactors |
DIPi | DIP-45617N |
ELMi | P98082 |
IntActi | P98082, 67 interactors |
MINTi | P98082 |
STRINGi | 9606.ENSP00000313391 |
Chemistry databases
BindingDBi | P98082 |
PTM databases
GlyGeni | P98082, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | P98082 |
MetOSitei | P98082 |
PhosphoSitePlusi | P98082 |
Genetic variation databases
BioMutai | DAB2 |
DMDMi | 145559465 |
Proteomic databases
EPDi | P98082 |
jPOSTi | P98082 |
MassIVEi | P98082 |
MaxQBi | P98082 |
PaxDbi | P98082 |
PeptideAtlasi | P98082 |
PRIDEi | P98082 |
ProteomicsDBi | 57786 [P98082-1] 57787 [P98082-2] 57788 [P98082-3] |
Protocols and materials databases
Antibodypediai | 3987, 311 antibodies from 35 providers |
DNASUi | 1601 |
Genome annotation databases
Ensembli | ENST00000320816; ENSP00000313391; ENSG00000153071 ENST00000339788; ENSP00000345508; ENSG00000153071 [P98082-2] ENST00000509337; ENSP00000426245; ENSG00000153071 [P98082-3] ENST00000545653; ENSP00000439919; ENSG00000153071 [P98082-3] |
GeneIDi | 1601 |
KEGGi | hsa:1601 |
MANE-Selecti | ENST00000320816.11; ENSP00000313391.6; NM_001343.4; NP_001334.2 |
UCSCi | uc003jlw.4, human [P98082-1] |
Organism-specific databases
CTDi | 1601 |
DisGeNETi | 1601 |
GeneCardsi | DAB2 |
HGNCi | HGNC:2662, DAB2 |
HPAi | ENSG00000153071, Tissue enhanced (kidney, placenta) |
MIMi | 601236, gene |
neXtProti | NX_P98082 |
OpenTargetsi | ENSG00000153071 |
PharmGKBi | PA27132 |
VEuPathDBi | HostDB:ENSG00000153071 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3535, Eukaryota |
GeneTreei | ENSGT00940000155567 |
HOGENOMi | CLU_020747_1_0_1 |
InParanoidi | P98082 |
OMAi | ESQAGPW |
PhylomeDBi | P98082 |
TreeFami | TF316724 |
Enzyme and pathway databases
PathwayCommonsi | P98082 |
Reactomei | R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P98082 |
SIGNORi | P98082 |
Miscellaneous databases
BioGRID-ORCSi | 1601, 6 hits in 1053 CRISPR screens |
ChiTaRSi | DAB2, human |
GeneWikii | DAB2 |
GenomeRNAii | 1601 |
Pharosi | P98082, Tbio |
PROi | PR:P98082 |
RNActi | P98082, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153071, Expressed in placenta and 240 other tissues |
ExpressionAtlasi | P98082, baseline and differential |
Genevisiblei | P98082, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
Pfami | View protein in Pfam PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DAB2_HUMAN | |
Accessioni | P98082Primary (citable) accession number: P98082 Secondary accession number(s): A6NES5 Q9UK04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | April 17, 2007 | |
Last modified: | February 23, 2022 | |
This is version 194 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references