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UniProtKB - P98082 (DAB2_HUMAN)

Entry version 194 (23 Feb 2022)
Sequence version 3 (17 Apr 2007)
Previous versions | rss
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Protein

Disabled homolog 2

Gene

DAB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.

8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation, Endocytosis, Protein transport, Transport, Wnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P98082

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P98082

SIGNOR Signaling Network Open Resource

More...SIGNORi		P98082

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disabled homolog 2
Alternative name(s):
Adaptor molecule disabled-2
Differentially expressed in ovarian carcinoma 2
Short name:
DOC-2
Differentially-expressed protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAB2
Synonyms:DOC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2662, DAB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601236, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P98082

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000153071

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi166F → A: Impairs TGF-beta receptor signaling, no effect on interaction with SMAD2. 1 Publication1
Mutagenesisi684 – 686SYF → AAA: Greatly reduced binding to MYO6. 1 Publication3
Mutagenesisi720R → A: Abolishes interaction with SH3KBP1. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		1601

Open Targets

More...OpenTargetsi		ENSG00000153071

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P98082, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DAB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797702 – 770Disabled homolog 2Add BLAST769

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineBy similarity1
Modified residuei170PhosphotyrosineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei326Phosphoserine; in mitosisBy similarity1
Modified residuei328Phosphoserine; in mitosisBy similarity1
Modified residuei401PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei729PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P98082

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P98082

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P98082

MaxQB - The MaxQuant DataBase

More...MaxQBi		P98082

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P98082

PeptideAtlas

More...PeptideAtlasi		P98082

PRoteomics IDEntifications database

More...PRIDEi		P98082

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57786 [P98082-1]
57787 [P98082-2]
57788 [P98082-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P98082, 5 sites, 1 O-linked glycan (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P98082

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P98082

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P98082

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000153071, Expressed in placenta and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P98082, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P98082, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000153071, Tissue enhanced (kidney, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via NPXY motif) with DAB2 (via PID domain). Can interact (via PID domain) with LDLR, APP, APLP1 and APLP2, and weakly with INPP5D (via NPXY motifs); the interaction is impaired by tyrosine phosphorylation of the respective NPXY motifs. Can weakly interact (via PID domain) with LRP1 (via NPXY motif); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif.

Interacts with LRP2 (via NPXY motif); the interaction is not affected by tyrosine phosphorylation of the NPXY motif.

Interacts with clathrin; in vitro can assemble clathrin triskelia into polyhedral coats.

Interacts with AP2A2, ITGB1, ITGB3, ITGB5, PIAS2, DAB2IP, NOSTRIN, FCHO1, DVL3, EPS15, ITSN1 and EPS15L1.

Interacts with SH3KBP1 (via SH3 domains).

Interacts with GRB2; competes with SOS1 for binding to GRB2 and the interaction is enhanced by EGF and NT-3 stimulation.

Interacts with MAP3K7; the interaction is induced by TGF-beta stimulation and may mediate TGF-beta stimulated JNK activation.

Interacts with AXIN1 and PPP1CA; the interactions are mutually exclusive.

Interacts with the globular tail of MYO6.

Interacts (via DPF motifs) with FCHO2; the interaction is direct and required for DAB2-mediated LDLR endocytosis.

Interacts with LRP6; the interaction involves LRP6 phosphorylation by CK2 and sequesters LRP6 towards clathrin-mediated endocytosis. Associates with the TGF-beta receptor complex (Probable).

Interacts with SMAD2 and SMAD3; the interactions are enhanced upon TGF-beta stimulation.

Interacts with GRB2; the interaction is enhanced by EGF and NT-3 stimulation.

Interacts with SRC; the interaction is enhanced by EGF stimulation.

Curated9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107971, 116 interactors

Database of interacting proteins

More...DIPi		DIP-45617N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P98082

Protein interaction database and analysis system

More...IntActi		P98082, 67 interactors

Molecular INTeraction database

More...MINTi		P98082

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000313391

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P98082

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P98082, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1770
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P98082

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P98082

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 196PIDPROSITE-ProRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni230 – 447Required for localization to clathrin-coated pitsBy similarityAdd BLAST218
Regioni284 – 482DisorderedSequence analysisAdd BLAST199
Regioni604 – 732Sufficient for interaction with GRB2By similarityAdd BLAST129
Regioni604 – 629DisorderedSequence analysisAdd BLAST26
Regioni619 – 627Required for interaction with CSKBy similarity9
Regioni649 – 770Required for interaction with MYO6By similarityAdd BLAST122
Regioni663 – 671Required for interaction with GRB2 and CSKBy similarity9
Regioni709 – 725Sufficient for interaction with SH3KBP1 SH3 domainBy similarityAdd BLAST17
Regioni742 – 770DisorderedSequence analysisAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi293 – 295DPF 13
Motifi298 – 300DPF 23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Polar residuesSequence analysisAdd BLAST18
Compositional biasi21 – 38Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi300 – 335Polar residuesSequence analysisAdd BLAST36
Compositional biasi344 – 397Polar residuesSequence analysisAdd BLAST54
Compositional biasi407 – 430Polar residuesSequence analysisAdd BLAST24
Compositional biasi466 – 482Polar residuesSequence analysisAdd BLAST17
Compositional biasi615 – 629Pro residuesSequence analysisAdd BLAST15
Compositional biasi742 – 760Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PID domain binds to predominantly non-phosphorylated NPXY internalization motifs present in members of the LDLR and APP family; it also mediates simultaneous binding to phosphatidylinositol 4,5-bisphosphate.By similarity
The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of EPS15, EPS15R and ITSN1.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3535, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155567

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020747_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P98082

Identification of Orthologs from Complete Genome Data

More...OMAi		ESQAGPW

Database for complete collections of gene phylogenies

More...PhylomeDBi		P98082

TreeFam database of animal gene trees

More...TreeFami		TF316724

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00640, PID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00462, PTB, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01179, PID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P98082-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNEVETSAT NGQPDQQAAP KAPSKKEKKK GPEKTDEYLL ARFKGDGVKY 
        60         70         80         90        100
KAKLIGIDDV PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS 
       110        120        130        140        150
GIKIIDEKTG VIEHEHPVNK ISFIARDVTD NRAFGYVCGG EGQHQFFAIK 
       160        170        180        190        200
TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK KIEEASKAVE NGSEALMILD 
       210        220        230        240        250
DQTNKLKSGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN SEIDTNQNSL 
       260        270        280        290        300
RENPFLTNGI TSCSLPRPTP QASFLPENAF SANLNFFPTP NPDPFRDDPF 
       310        320        330        340        350
TQPDQSTPSS FDSLKSPDQK KENSSSSSTP LSNGPLNGDV DYFGQQFDQI 
       360        370        380        390        400
SNRTGKQEAQ AGPWPFSSSQ TQPAVRTQNG VSEREQNGFS VKSSPNPFVG 
       410        420        430        440        450
SPPKGLSIQN GVKQDLESSV QSSPHDSIAI IPPPQSTKPG RGRRTAKSSA 
       460        470        480        490        500
NDLLASDIFA PPVSEPSGQA SPTGQPTALQ PNPLDLFKTS APAPVGPLVG 
       510        520        530        540        550
LGGVTVTLPQ AGPWNTASLV FNQSPSMAPG AMMGGQPSGF SQPVIFGTSP 
       560        570        580        590        600
AVSGWNQPSP FAASTPPPVP VVWGPSASVA PNAWSTTSPL GNPFQSNIFP 
       610        620        630        640        650
APAVSTQPPS MHSSLLVTPP QPPPRAGPPK DISSDAFTAL DPLGDKEIKD 
       660        670        680        690        700
VKEMFKDFQL RQPPAVPARK GEQTSSGTLS AFASYFNSKV GIPQENADHD 
       710        720        730        740        750
DFDANQLLNK INEPPKPAPR QVSLPVTKST DNAFENPFFK DSFGSSQASV 
       760        770
ASSQPVSSEM YRDPFGNPFA
Length:770
Mass (Da):82,448
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B2F8B510A580A77
GO
Isoform 2 (identifier: P98082-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-447: Missing.

Show »
Length:552
Mass (Da):58,861
Checksum:i2F25868284E3757F
GO
Isoform 3 (identifier: P98082-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-229: Missing.

Show »
Length:749
Mass (Da):80,228
Checksum:iD52B66BB7CA45240
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REB1D6REB1_HUMAN
Disabled homolog 2
DAB2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFF7D6RFF7_HUMAN
Disabled homolog 2
DAB2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIA5D6RIA5_HUMAN
Disabled homolog 2
DAB2
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGZ1D6RGZ1_HUMAN
Disabled homolog 2
DAB2
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44 – 47KGDG → PRVC in AAA93195 (PubMed:8314147).Curated4
Sequence conflicti82A → R in AAC50824 (PubMed:8660969).Curated1
Sequence conflicti82A → R in AAB19032 (PubMed:8660969).Curated1
Sequence conflicti82A → R in AAA98975 (PubMed:9620555).Curated1
Sequence conflicti82A → R in AAF23161 (PubMed:11161789).Curated1
Sequence conflicti82A → R in AAA93195 (PubMed:8314147).Curated1
Sequence conflicti148A → T in AAA98975 (PubMed:9620555).Curated1
Sequence conflicti197M → R in AAA98975 (PubMed:9620555).Curated1
Sequence conflicti230 – 232ESK → VCF in AAF05540 (PubMed:10340382).Curated3
Sequence conflicti230 – 232ESK → VCF in AAA93195 (PubMed:8314147).Curated3
Sequence conflicti275L → S in AAC50824 (PubMed:8660969).Curated1
Sequence conflicti302 – 304QPD → HTR in AAA93195 (PubMed:8314147).Curated3
Sequence conflicti498L → Q in AAF05540 (PubMed:10340382).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031705586T → I. Corresponds to variant dbSNP:rs700241Ensembl.1
Natural variantiVAR_050942634S → N. Corresponds to variant dbSNP:rs3733801Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038401209 – 229Missing in isoform 3. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_004181230 – 447Missing in isoform 2. CuratedAdd BLAST218

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U39050 mRNA Translation: AAC50824.1
AH003698 Genomic DNA Translation: AAB19032.1
U53446 mRNA Translation: AAA98975.1
AF188298 mRNA Translation: AAF05540.1
AF205890 Genomic DNA Translation: AAF23161.1
AC008916 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55989.1
BC003064 mRNA Translation: AAH03064.1
L16886 mRNA Translation: AAA93195.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34149.1 [P98082-1]
CCDS58946.1 [P98082-3]

Protein sequence database of the Protein Information Resource

More...PIRi		G02228

NCBI Reference Sequences

More...RefSeqi		NP_001231800.1, NM_001244871.1 [P98082-3]
NP_001334.2, NM_001343.3 [P98082-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000320816; ENSP00000313391; ENSG00000153071
ENST00000339788; ENSP00000345508; ENSG00000153071 [P98082-2]
ENST00000509337; ENSP00000426245; ENSG00000153071 [P98082-3]
ENST00000545653; ENSP00000439919; ENSG00000153071 [P98082-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1601

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000320816.11; ENSP00000313391.6; NM_001343.4; NP_001334.2

UCSC genome browser

More...UCSCi		uc003jlw.4, human [P98082-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39050 mRNA Translation: AAC50824.1
AH003698 Genomic DNA Translation: AAB19032.1
U53446 mRNA Translation: AAA98975.1
AF188298 mRNA Translation: AAF05540.1
AF205890 Genomic DNA Translation: AAF23161.1
AC008916 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55989.1
BC003064 mRNA Translation: AAH03064.1
L16886 mRNA Translation: AAA93195.1
CCDSiCCDS34149.1 [P98082-1]
CCDS58946.1 [P98082-3]
PIRiG02228
RefSeqiNP_001231800.1, NM_001244871.1 [P98082-3]
NP_001334.2, NM_001343.3 [P98082-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LSWNMR-A24-58[»]
6O5OX-ray1.75A/B31-191[»]
6OVFX-ray1.95A/B31-191[»]
BMRBiP98082
SMRiP98082
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107971, 116 interactors
DIPiDIP-45617N
ELMiP98082
IntActiP98082, 67 interactors
MINTiP98082
STRINGi9606.ENSP00000313391

Chemistry databases

BindingDBiP98082

PTM databases

GlyGeniP98082, 5 sites, 1 O-linked glycan (5 sites)
iPTMnetiP98082
MetOSiteiP98082
PhosphoSitePlusiP98082

Genetic variation databases

BioMutaiDAB2
DMDMi145559465

Proteomic databases

EPDiP98082
jPOSTiP98082
MassIVEiP98082
MaxQBiP98082
PaxDbiP98082
PeptideAtlasiP98082
PRIDEiP98082
ProteomicsDBi57786 [P98082-1]
57787 [P98082-2]
57788 [P98082-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3987, 311 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		1601

Genome annotation databases

EnsembliENST00000320816; ENSP00000313391; ENSG00000153071
ENST00000339788; ENSP00000345508; ENSG00000153071 [P98082-2]
ENST00000509337; ENSP00000426245; ENSG00000153071 [P98082-3]
ENST00000545653; ENSP00000439919; ENSG00000153071 [P98082-3]
GeneIDi1601
KEGGihsa:1601
MANE-SelectiENST00000320816.11; ENSP00000313391.6; NM_001343.4; NP_001334.2
UCSCiuc003jlw.4, human [P98082-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1601
DisGeNETi1601

GeneCards: human genes, protein and diseases

More...GeneCardsi		DAB2
HGNCiHGNC:2662, DAB2
HPAiENSG00000153071, Tissue enhanced (kidney, placenta)
MIMi601236, gene
neXtProtiNX_P98082
OpenTargetsiENSG00000153071
PharmGKBiPA27132
VEuPathDBiHostDB:ENSG00000153071

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3535, Eukaryota
GeneTreeiENSGT00940000155567
HOGENOMiCLU_020747_1_0_1
InParanoidiP98082
OMAiESQAGPW
PhylomeDBiP98082
TreeFamiTF316724

Enzyme and pathway databases

PathwayCommonsiP98082
ReactomeiR-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
SignaLinkiP98082
SIGNORiP98082

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1601, 6 hits in 1053 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DAB2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DAB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1601
PharosiP98082, Tbio

Protein Ontology

More...PROi		PR:P98082
RNActiP98082, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000153071, Expressed in placenta and 240 other tissues
ExpressionAtlasiP98082, baseline and differential
GenevisibleiP98082, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
PfamiView protein in Pfam
PF00640, PID, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 1 hit
PROSITEiView protein in PROSITE
PS01179, PID, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98082
Secondary accession number(s): A6NES5
, Q13598, Q9BTY0, Q9UK04
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 17, 2007
Last modified: February 23, 2022
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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