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Entry version 158 (03 Jul 2019)
Sequence version 2 (24 May 2005)
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Protein

Protein disabled

Gene

Dab

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with Abl, involved in embryonic neural development. May have a role in eye development. Acts as an adapter protein for SH2-domain containing proteins during sevenless (sev) signaling.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • sevenless binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-190873 Gap junction degradation
R-DME-196025 Formation of annular gap junctions
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P98081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein disabled
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dab
ORF Names:CG9695
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000414 Dab

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi120S → A: Greatly reduces sev binding and sev signaling. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797731 – 2224Protein disabledAdd BLAST2224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei112Phosphotyrosine; by ABL1 Publication1
Modified residuei483Phosphotyrosine; by ABL1 Publication1
Modified residuei998Phosphoserine1 Publication1
Modified residuei1336Phosphoserine1 Publication1
Modified residuei1339Phosphoserine1 Publication1
Modified residuei1344Phosphoserine1 Publication1
Modified residuei1348Phosphoserine1 Publication1
Modified residuei1604Phosphotyrosine; by ABL1 Publication1
Modified residuei1609Phosphotyrosine; by ABL1 Publication1
Modified residuei1643Phosphotyrosine; by ABL1 Publication1
Modified residuei1646Phosphotyrosine; by ABL1 Publication1
Modified residuei1655Phosphotyrosine; by ABL1 Publication1
Modified residuei1681Phosphotyrosine; by ABL1 Publication1
Modified residuei1700Phosphoserine1 Publication1
Modified residuei1713Phosphoserine1 Publication1
Modified residuei1716Phosphoserine1 Publication1
Modified residuei1768Phosphotyrosine; by ABL1 Publication1
Modified residuei1811Phosphoserine1 Publication1
Modified residuei1812Phosphoserine1 Publication1
Modified residuei1814Phosphoserine1 Publication1
Modified residuei1815Phosphoserine1 Publication1
Modified residuei1905Phosphotyrosine; by ABL1 Publication1
Modified residuei2074Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably phosphorylated by the Abl tyrosine kinase. Phosphorylated on tyrosine residues in response to sevenless activation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98081

PRoteomics IDEntifications database

More...
PRIDEi
P98081

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P98081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Uniformly expressed in the embryo from blastoderm through gastrulation. Highly expressed in the mesoderm and CNS during germ-band retraction. CNS expression is later localized to axon bundles. Detected in the embryonic PNS and body wall muscles. Expressed in the eye at the morphogenetic furrow and in developing photoreceptor cells posterior to the furrow.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Embryonic axonogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000414 Expressed in 28 organ(s), highest expression level in second segment of antenna (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P98081 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P98081 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds the SH3 domains of drk via the Pro-rich domain. When phosphorylated, can interact with the SH2 domains of drk. Binds sev via the phosphotyrosine interaction domain (PID).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
65165, 11 interactors

Protein interaction database and analysis system

More...
IntActi
P98081, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0075077

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P98081

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 197PIDPROSITE-ProRule annotationAdd BLAST153
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1631 – 1642Alternate Arg and acidic residuesAdd BLAST12
Repeati1682 – 1692Alternate Arg and acidic residuesAdd BLAST11
Repeati1733 – 1743Alternate Arg and acidic residuesAdd BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1631 – 1743Repeat-rich regionAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi780 – 889Pro-richAdd BLAST110

Keywords - Domaini

Repeat, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3535 Eukaryota
ENOG410XZ1H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168807

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98081

KEGG Orthology (KO)

More...
KOi
K12475

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028761 Dab
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11232:SF47 PTHR11232:SF47, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00640 PID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179 PID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P98081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKSLVAKLS TASSNLSLAS TFGGGSGAAE ETNYAKHRND PGRFFGDGVQ
60 70 80 90 100
FKAKLIGILE VGEARGDRMC QEALQDLKMA IRAAGEHKQR ITIHVTIDGL
110 120 130 140 150
RLRDEKTGDS LYHHPVHKIS FIAQDMTDSR AFGYIFGSPD SGHRFFGIKT
160 170 180 190 200
DKAASQVVLA MRDLFQVVFE LKKKEIEMAR QQIQGKSLHD HSSQLASLSS
210 220 230 240 250
LKSSGLGGMG LGHSDLASGG ISSGHALTLL GSSLSTTNGT SRLGVSLDVA
260 270 280 290 300
KASGSAAKEV SPESVADLVD LEQELTSLQR GISQMERITP NEPTTSSTGG
310 320 330 340 350
AGHPSLAKSA SEDDPFGDSF IYVPSYSILP PPPDSGRNRH KPPNKTPDAV
360 370 380 390 400
TSLDAMLSPP PGTSSSHGSA SAGLQAADND DDNWLQELDQ QNDVFDTSKV
410 420 430 440 450
VSSSGLGSVL AMAPLASSES TATPTQQLTE VAAGSGPLAD LDIGLSTALG
460 470 480 490 500
NEEQTSTILS LDAFTDLDPL GTGRTRPYVD KKYFFQELKN PPKKLLKELS
510 520 530 540 550
SGSQAGLGLG LSLGQLDGLF PEDSTTISTT TTTATNITAG NPQQNSANTL
560 570 580 590 600
TSTASTAASL GQLLSTVALN PDPLPAPISI PTSISHSITP SAELKLLLGH
610 620 630 640 650
VTNPPNPTGH YYTTEPPTLN SLENPHPPAD PVLLPRDTDP FSPTRKKSDP
660 670 680 690 700
DPFQESDLFA KLDAFEFEAP PAVPAPSIPN LATETKANVF NGPLQVQLPP
710 720 730 740 750
EKELQLQQPP STVRNRPTAS VSALPSGGAL DVISSISNKK MPHLFGQARS
760 770 780 790 800
FGKSGSDIGS SVNMRRLQES DSLSETEAAP EPPPRPDSTP YSEPPPLPPK
810 820 830 840 850
KQFSDLVIRP SPANTTQPPT SGRYEYLNSN VTARRTASSV DAPPIPLPSR
860 870 880 890 900
RVGRSDGCFP GPGRPRKPGH TEDDYLAPLG APPPLLPPPS QGSSARARPQ
910 920 930 940 950
RQASLGRPQD IYENKAEILQ AQAQAQAQAP EVAPSSNTLA PDITLTQLLT
960 970 980 990 1000
LGMDDLAIKL NVPASKLSTM TLVQLTAYLS EYLSSEKSQV HSQERRSSPA
1010 1020 1030 1040 1050
NTAPAPASTA AVFKVNFDQQ TSFVAKFDDT FGEDEPVMPS GSSDSTFVAN
1060 1070 1080 1090 1100
FANFNDAPTP VPTVSPVVAT VPSADRYAVF REIIDQELQQ QQQETDLMGD
1110 1120 1130 1140 1150
LTPPPVDETQ AKEISEGLEV NNVGAELPID ALDVKPAPKI DTKITEVVAQ
1160 1170 1180 1190 1200
AKDRYAALRD IILVENLFDK PAIATDTQPE KEKDLLQDFP EFSDEFNEDH
1210 1220 1230 1240 1250
DLRQIMDHQN VQTHARDRHG LVDSRGFPTE PSSSALTVGD YDEDEDADAG
1260 1270 1280 1290 1300
GESSLDSNEK DAEPVSGQDQ YEKLSTSTQQ LDAAAPALED VQQLQQQSLP
1310 1320 1330 1340 1350
PKQDQKFLSI LTAPGGGTKD DIEIDELMHR AISNLSLDSR DRVSPATSSA
1360 1370 1380 1390 1400
APSRGAPGLH TPSQFNDVST SPIPLQKPGM GPSPVPSQLS AVSQLIDTAT
1410 1420 1430 1440 1450
KQMMGDKDRE KQSWATFDSP KAKGKARLTL PPPPPPASNT SQPDTVESPC
1460 1470 1480 1490 1500
SSDPRDDGWS KQQRRWAKKE RQQTSSSSRD LSPWDDETPE YLKRRQLAAA
1510 1520 1530 1540 1550
QMAHPHQPPM QAPPQHTDRH GYYMRHARRM NSCDEDYDYD GEFVARRDQP
1560 1570 1580 1590 1600
QHQQQQRKFK HGLSRSRDNF ELESPSWYHH PAHHTWSPQE IEQVRVRSFD
1610 1620 1630 1640 1650
RTAYERSSYG PPPPIYDKRG QLRGKYRGDH RDRERERDRD REYRDYARPS
1660 1670 1680 1690 1700
YDFDYENVYE ERGGRSPLAY KPGRGGGDYL YDRERDRDRE RDRKSFDRES
1710 1720 1730 1740 1750
LESYESATRR RRSFGSGNDV YGSLDSRDDY RGDRERDRER DREQMKTRSL
1760 1770 1780 1790 1800
RKPTTTSGKL RISGDIDYEQ DSEQDFQQRS GVRSLQRPNQ LGGDVVLPSN
1810 1820 1830 1840 1850
AVVGPQRLRK SSGSSPWDGE EPALPGQKSW KRPASAAETE RRLAESRRAV
1860 1870 1880 1890 1900
ALGQTPSDGE KERRFRKKTR ARSAKDLATV GAPSASTSAP SRSSYGRGIR
1910 1920 1930 1940 1950
DNYDYICPGQ RNDDDDDDDE DYVDDEPPTD EDKFERLNRR RHEMHQRMLE
1960 1970 1980 1990 2000
SERRQMERHQ PPSLAKLPGQ NRTRGVVANS DYGFVDSYEQ TPTPTPRSNA
2010 2020 2030 2040 2050
SSTGPGGLMM SGGESSAGVT SSKFNFDDGF ESDFNQSSPP PAPAGTASSC
2060 2070 2080 2090 2100
NSTPAGPVSA NANNGGSKSL FRFSNDFSDR EKREQFEMDT PPTSTPPITQ
2110 2120 2130 2140 2150
KLRFDDNVKV SQFDDAAFED DFAKASFDFE KEQAGSATAG AGGSGAMSRK
2160 2170 2180 2190 2200
QNMRTSKLQQ RQELIKKSES VNIFAKKQED PFEDDEFFKS PDQEQAMDQH
2210 2220
NDDTEGGKFQ WSEDANFAKF DENM
Length:2,224
Mass (Da):243,072
Last modified:May 24, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF91939C029292B38
GO
Isoform 2 (identifier: P98081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     463-614: Missing.

Show »
Length:2,072
Mass (Da):227,214
Checksum:iE2EF798ADACFE401
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JI13E1JI13_DROME
Disabled, isoform F
Dab cDNA C, CG9695, dab, Dmel\CG9695, CG9695
2,360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PI84M9PI84_DROME
Disabled, isoform H
Dab cDNA C, CG9695, dab, Dmel\CG9695, CG9695
2,146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NDT7M9NDT7_DROME
Disabled, isoform C
Dab cDNA C, CG9695, dab, Dmel\CG9695, CG9695
2,047Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NG14M9NG14_DROME
Disabled, isoform E
Dab cDNA C, CG9695, dab, Dmel\CG9695, CG9695
2,071Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PCU3M9PCU3_DROME
Disabled, isoform I
Dab cDNA C, CG9695, dab, Dmel\CG9695, CG9695
2,149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NEC1M9NEC1_DROME
Disabled, isoform D
Dab cDNA C, CG9695, dab, Dmel\CG9695, CG9695
2,200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PFS5M9PFS5_DROME
Disabled, isoform G
Dab cDNA C, CG9695, dab, Dmel\CG9695, CG9695
2,336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB08527 differs from that shown. Intron retention.Curated
The sequence AAB08527 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti620N → T in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti885 – 886LL → SW in AAB08527 (PubMed:7680635).Curated2
Sequence conflicti1061V → M in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1126 – 1127EL → DV in AAB08527 (PubMed:7680635).Curated2
Sequence conflicti1158 – 1159LR → RG in AAB08527 (PubMed:7680635).Curated2
Sequence conflicti1241Y → D in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1294L → Q in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1297Q → QQ in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1594V → A in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1693R → P in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1787R → L in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1803V → A in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti1808 – 1809LR → FA in AAB08527 (PubMed:7680635).Curated2
Sequence conflicti1978A → V in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti2039Missing in AAB08527 (PubMed:7680635).Curated1
Sequence conflicti2089D → E in AAB08527 (PubMed:7680635).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004185463 – 614Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L08845 mRNA Translation: AAB08527.1 Sequence problems.
AE014296 Genomic DNA Translation: AAF49424.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A46299

NCBI Reference Sequences

More...
RefSeqi
NP_524119.2, NM_079395.4 [P98081-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0075318; FBpp0075077; FBgn0000414 [P98081-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9695

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08845 mRNA Translation: AAB08527.1 Sequence problems.
AE014296 Genomic DNA Translation: AAF49424.2
PIRiA46299
RefSeqiNP_524119.2, NM_079395.4 [P98081-1]

3D structure databases

SMRiP98081
ModBaseiSearch...

Protein-protein interaction databases

BioGridi65165, 11 interactors
IntActiP98081, 4 interactors
STRINGi7227.FBpp0075077

PTM databases

iPTMnetiP98081

Proteomic databases

PaxDbiP98081
PRIDEiP98081

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075318; FBpp0075077; FBgn0000414 [P98081-1]
GeneIDi39866
KEGGidme:Dmel_CG9695

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39866
FlyBaseiFBgn0000414 Dab

Phylogenomic databases

eggNOGiKOG3535 Eukaryota
ENOG410XZ1H LUCA
GeneTreeiENSGT00940000168807
InParanoidiP98081
KOiK12475

Enzyme and pathway databases

ReactomeiR-DME-190873 Gap junction degradation
R-DME-196025 Formation of annular gap junctions
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
SignaLinkiP98081

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39866

Protein Ontology

More...
PROi
PR:P98081

Gene expression databases

BgeeiFBgn0000414 Expressed in 28 organ(s), highest expression level in second segment of antenna (Drosophila)
ExpressionAtlasiP98081 baseline and differential
GenevisibleiP98081 DM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR028761 Dab
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR11232:SF47 PTHR11232:SF47, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAB_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98081
Secondary accession number(s): Q9VV93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 24, 2005
Last modified: July 3, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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