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Protein

SHC-transforming protein 2

Gene

SHC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).By similarity

Miscellaneous

PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-167044 Signalling to RAS
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5673001 RAF/MAP kinase cascade
SignaLinkiP98077
SIGNORiP98077

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 2
Alternative name(s):
Protein Sck
SHC-transforming protein B
Src homology 2 domain-containing-transforming protein C2
Short name:
SH2 domain protein C2
Gene namesi
Name:SHC2
Synonyms:SCK, SHCB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000129946.10
HGNCiHGNC:29869 SHC2
MIMi605217 gene
neXtProtiNX_P98077

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi25759
OpenTargetsiENSG00000129946
PharmGKBiPA134971076

Chemistry databases

ChEMBLiCHEMBL3299

Polymorphism and mutation databases

BioMutaiSHC2
DMDMi193806386

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977321 – 582SHC-transforming protein 2Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338Phosphotyrosine1 Publication1
Modified residuei339Phosphotyrosine1 Publication1
Modified residuei414Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosines by the Trk receptors.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP98077
MaxQBiP98077
PaxDbiP98077
PeptideAtlasiP98077
PRIDEiP98077
ProteomicsDBi57785

PTM databases

iPTMnetiP98077
PhosphoSitePlusiP98077

Expressioni

Tissue specificityi

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.1 Publication

Gene expression databases

BgeeiENSG00000129946
CleanExiHS_SHC2
ExpressionAtlasiP98077 baseline and differential
GenevisibleiP98077 HS

Organism-specific databases

HPAiHPA006136

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117302, 9 interactors
IntActiP98077, 6 interactors
MINTiP98077
STRINGi9606.ENSP00000264554

Chemistry databases

BindingDBiP98077

Structurei

3D structure databases

ProteinModelPortaliP98077
SMRiP98077
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 329PIDPROSITE-ProRule annotationAdd BLAST183
Domaini487 – 578SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni330 – 486CH1Add BLAST157

Domaini

The PID domain mediates binding to the TrkA receptor.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00390000018860
HOGENOMiHOG000231974
HOVERGENiHBG050121
InParanoidiP98077
KOiK17447
OMAiPRMPQWK
OrthoDBiEOG091G04DC
PhylomeDBiP98077
TreeFamiTF315807

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029591 SHC2
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF5 PTHR10337:SF5, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

P98077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGPGGRAP PAPPAPPEPE APTTFCALLP RMPQWKFAAP GGFLGRGPAA
60 70 80 90 100
ARAAGASGGA DPQPEPAGPG GVPALAAAVL GACEPRCAAP CPLPALSRCR
110 120 130 140 150
GAGSRGSRGG RGAAGSGDAA AAAEWIRKGS FIHKPAHGWL HPDARVLGPG
160 170 180 190 200
VSYVVRYMGC IEVLRSMRSL DFNTRTQVTR EAINRLHEAV PGVRGSWKKK
210 220 230 240 250
APNKALASVL GKSNLRFAGM SISIHISTDG LSLSVPATRQ VIANHHMPSI
260 270 280 290 300
SFASGGDTDM TDYVAYVAKD PINQRACHIL ECCEGLAQSI ISTVGQAFEL
310 320 330 340 350
RFKQYLHSPP KVALPPERLA GPEESAWGDE EDSLEHNYYN SIPGKEPPLG
360 370 380 390 400
GLVDSRLALT QPCALTALDQ GPSPSLRDAC SLPWDVGSTG TAPPGDGYVQ
410 420 430 440 450
ADARGPPDHE EHLYVNTQGL DAPEPEDSPK KDLFDMRPFE DALKLHECSV
460 470 480 490 500
AAGVTAAPLP LEDQWPSPPT RRAPVAPTEE QLRQEPWYHG RMSRRAAERM
510 520 530 540 550
LRADGDFLVR DSVTNPGQYV LTGMHAGQPK HLLLVDPEGV VRTKDVLFES
560 570 580
ISHLIDHHLQ NGQPIVAAES ELHLRGVVSR EP
Length:582
Mass (Da):61,916
Last modified:July 1, 2008 - v4
Checksum:iF640AC298DA37B68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45 – 56GRGPA…RAAGA → IRGSNAQKVVGASG in BAA25798 (PubMed:9507002).CuratedAdd BLAST12
Sequence conflicti61D → G in BAA25798 (PubMed:9507002).Curated1
Sequence conflicti65E → D in BAA25798 (PubMed:9507002).Curated1
Sequence conflicti96 – 125LSRCR…AAAEW → MAFAGLASHVWWWRPSSQNR IWFRRGSPEF (PubMed:8760305).CuratedAdd BLAST30
Sequence conflicti114A → P (PubMed:7527937).Curated1
Sequence conflicti188E → I (PubMed:8760305).Curated1
Sequence conflicti226I → T (PubMed:8760305).Curated1
Sequence conflicti272I → E (PubMed:8760305).Curated1
Sequence conflicti440Missing (PubMed:8760305).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008988 Genomic DNA No translation available.
AC138433 Genomic DNA No translation available.
AC006124 Genomic DNA No translation available.
AB001451 mRNA Translation: BAA25798.1
AL360254 mRNA Translation: CAB96175.1
CCDSiCCDS45891.1
RefSeqiNP_036567.2, NM_012435.2
UniGeneiHs.30965

Genome annotation databases

EnsembliENST00000264554; ENSP00000264554; ENSG00000129946
GeneIDi25759
KEGGihsa:25759
UCSCiuc002loq.4 human

Similar proteinsi

Entry informationi

Entry nameiSHC2_HUMAN
AccessioniPrimary (citable) accession number: P98077
Secondary accession number(s): O60230, Q9NPL5, Q9UCX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 1, 2008
Last modified: July 18, 2018
This is version 154 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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