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UniProtKB - P98066 (TSG6_HUMAN)

Entry version 188 (23 Feb 2022)
Sequence version 2 (21 Jun 2005)
Previous versions | rss
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Protein

Tumor necrosis factor-inducible gene 6 protein

Gene

TNFAIP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major regulator of extracellular matrix organization during tissue remodeling (PubMed:18042364, PubMed:26823460, PubMed:15917224).

Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin (PubMed:20463016, PubMed:15917224, PubMed:16873769).

Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization (PubMed:26468290).

Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling (PubMed:26823460, PubMed:15060082).

Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation (PubMed:27044744).

In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium (PubMed:24501198).

Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts (PubMed:18586671, PubMed:16771708).

Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation (PubMed:18586671).

11 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimally active at pH 6.5-8.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi183CalciumCombined sources1 Publication1
Metal bindingi191CalciumCombined sources1 Publication1
Metal bindingi232CalciumCombined sources1 Publication1
Metal bindingi234Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi235Calcium; via carbonyl oxygenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P98066

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P98066

SIGNOR Signaling Network Open Resource

More...SIGNORi		P98066

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor-inducible gene 6 protein (EC:3.1.1.-1 Publication)
Alternative name(s):
Hyaluronate-binding protein
TNF-stimulated gene 6 protein
Short name:
TSG-61 Publication
Tumor necrosis factor alpha-induced protein 6
Short name:
TNF alpha-induced protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFAIP6
Synonyms:TSG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11898, TNFAIP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600410, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P98066

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000123610

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39H → K: Decreases binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. 1 Publication1
Mutagenesisi41E → K: Has no significant effect on hyaluronan binding to CD44 or hyaluronan-dependent lymphocyte rolling. 1 Publication1
Mutagenesisi46K → Q: Abolishes binding to bikunin. 1 Publication1
Mutagenesisi47Y → F: Abolishes binding to bikunin. Impairs binding to hyaluronan. Retains the ability to bind heavy chains but cannot transfer them onto hyaluronan. Impairs binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. 3 Publications1
Mutagenesisi48K → E: Decreases binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. 1 Publication1
Mutagenesisi55K → A: Decreases binding to heparin. Has normal binding to bikunin. Impairs binding to heparin; when associated with A-69 and A-76. Has no effect on CXCL8-induced neutrophil transmigration; when associated with A-69 and A-76. 2 Publications1
Mutagenesisi64H → K: Increases binding of hyaluronan to CD44. Has no significant effect on hyaluronan-dependent lymphocyte rolling. 1 Publication1
Mutagenesisi69K → A: Decreases binding to heparin. Has normal binding to bikunin. Impairs binding to heparin; when associated with A-55 and A-76. Has no effect on CXCL8-induced neutrophil transmigration; when associated with A-55 and A-76. 2 Publications1
Mutagenesisi76K → A: Decreases binding to heparin. Has normal binding to bikunin. Impairs binding to heparin and decreases the potentiation effect toward bikunin antiprotease activity; when associated with A-55 and A-69. Has no effect on CXCL8-induced neutrophil transmigration; when associated with A-55 and A-69. 2 Publications1
Mutagenesisi89K → A: Decreases binding to heparin. Has normal binding to bikunin. 1 Publication1
Mutagenesisi94Y → F: Abolishes binding to bikunin. Has no effect on transesterification reaction. 2 Publications1
Mutagenesisi105F → V: Impairs binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. 1 Publication1
Mutagenesisi113Y → F: Abolishes binding to bikunin. Impairs binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. Has no effect on transesterification reaction. 3 Publications1
Mutagenesisi183E → S: Reduces the binding affinity to calcium ions. Abolishes the interaction with heavy chain ITIH1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7130

Open Targets

More...OpenTargetsi		ENSG00000123610

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36595

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P98066, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00945, Acetylsalicylic acid
DB00843, Donepezil
DB08818, Hyaluronic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNFAIP6

Domain mapping of disease mutations (DMDM)

More...DMDMi		68067717

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 171 PublicationAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002669218 – 277Tumor necrosis factor-inducible gene 6 proteinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 127PROSITE-ProRule annotation
Disulfide bondi82 ↔ 103PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 161PROSITE-ProRule annotation
Disulfide bondi188 ↔ 210PROSITE-ProRule annotation
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P98066

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P98066

PeptideAtlas

More...PeptideAtlasi		P98066

PRoteomics IDEntifications database

More...PRIDEi		P98066

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57783

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P98066, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P98066

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P98066

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level) (PubMed:16873769). Expressed in mesenchymal stem cells (PubMed:16771708). Found in the synovial fluid of patients with rheumatoid arthritis.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in peripheral blood mononuclear cells, high endothelial venules, airway epithelium and submucosal gland in response to inflammatory cytokine TNF (PubMed:1730767, PubMed:16873769). Down-regulated upon differentiation of mesenchymal stem cells to osteoblasts (PubMed:16771708).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123610, Expressed in layer of synovial tissue and 198 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P98066, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000123610, Tissue enriched (urinary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via Link domain) with inter-alpha-inhibitor (I-alpha-I) component bikunin (PubMed:15917224).

Interacts with ITIH2/HC2; this interaction is required for transesterification of the HC to hyaluronan (PubMed:20463016).

Interacts (via Link and CUB domains) with ITIH1 (PubMed:26468290). Chondroitin sulfate may be required for the stability of the complex (PubMed:7516184).

Interacts (via Link domain) with various C-X-C and C-C chemokines including PF4, CXCL8, CXCL11, CXCL12, CCL2, CCL7, CCL19, CCL21, and CCL27; this interaction interferes with chemokine binding to glycosaminoglycans (PubMed:24501198, PubMed:27044744).

Interacts (primarily via Link domain) with BMP2; this interaction is inhibited by hyaluronan (PubMed:16771708).

Interacts (via both Link and CUB domains) with TNFSF11 (PubMed:18586671).

Interacts (via CUB domain) with FN1 (via type III repeats 9-14); this interaction enhances fibronectin fibril assembly. TNFAIP6 may act as a bridging molecule between FN1 and THBS1 (PubMed:18042364).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112984, 25 interactors

Protein interaction database and analysis system

More...IntActi		P98066, 25 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000243347

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P98066, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P98066

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P98066

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P98066

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 129LinkPROSITE-ProRule annotationAdd BLAST94
Domaini135 – 247CUBPROSITE-ProRule annotationAdd BLAST113

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Link domain interacts with various extracellular matrix components, including heparin, heparan sulfates, hyaluronan and I-alpha-I complex (PubMed:15917224, PubMed:15060082). It is required for binding to various chemokines (PubMed:27044744).3 Publications
The CUB domain is necessary for calcium ion binding and transesterification reaction (PubMed:26468290). It is required for binding to FN1 (PubMed:18042364).2 Publications

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1218, Eukaryota
KOG3714, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_092089_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P98066

Identification of Orthologs from Complete Genome Data

More...OMAi		YDDIHGF

Database of Orthologous Groups

More...OrthoDBi		934805at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P98066

TreeFam database of animal gene trees

More...TreeFami		TF334173

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.290, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000859, CUB_dom
IPR000538, Link_dom
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 1 hit
PF00193, Xlink, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 1 hit
SM00445, LINK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 1 hit
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 1 hit
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P98066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT 
        60         70         80         90        100
YAEAKAVCEF EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG 
       110        120        130        140        150
PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKQIFKSPG 
       160        170        180        190        200
FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF DLEDDPGCLA DYVEIYDSYD 
       210        220        230        240        250
DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF QIKYVAMDPV 
       260        270 
SKSSQGKNTS TTSTGNKNFL AGRFSHL
Length:277
Mass (Da):31,203
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2B3AEB76353A782
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013005144Q → R2 PublicationsCorresponds to variant dbSNP:rs1046668Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M31165 mRNA Translation: AAB00792.1
AJ421518 mRNA Translation: CAD13434.1
AJ419936 mRNA Translation: CAD12353.1
AC009311 Genomic DNA Translation: AAY15067.1
CH471058 Genomic DNA Translation: EAX11511.1
BC030205 mRNA Translation: AAH30205.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2193.1

Protein sequence database of the Protein Information Resource

More...PIRi		A41735

NCBI Reference Sequences

More...RefSeqi		NP_009046.2, NM_007115.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000243347; ENSP00000243347; ENSG00000123610

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7130

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000243347.5; ENSP00000243347.3; NM_007115.4; NP_009046.2

UCSC genome browser

More...UCSCi		uc002txk.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31165 mRNA Translation: AAB00792.1
AJ421518 mRNA Translation: CAD13434.1
AJ419936 mRNA Translation: CAD12353.1
AC009311 Genomic DNA Translation: AAY15067.1
CH471058 Genomic DNA Translation: EAX11511.1
BC030205 mRNA Translation: AAH30205.1
CCDSiCCDS2193.1
PIRiA41735
RefSeqiNP_009046.2, NM_007115.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O7BNMR-T36-133[»]
1O7CNMR-T36-133[»]
2N40NMR-A36-133[»]
2PF5X-ray1.90A/B/C/D/E36-133[»]
2WNOX-ray2.30A129-277[»]
BMRBiP98066
SMRiP98066
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112984, 25 interactors
IntActiP98066, 25 interactors
STRINGi9606.ENSP00000243347

Chemistry databases

DrugBankiDB00945, Acetylsalicylic acid
DB00843, Donepezil
DB08818, Hyaluronic acid

PTM databases

GlyGeniP98066, 2 sites
iPTMnetiP98066
PhosphoSitePlusiP98066

Genetic variation databases

BioMutaiTNFAIP6
DMDMi68067717

Proteomic databases

MassIVEiP98066
PaxDbiP98066
PeptideAtlasiP98066
PRIDEiP98066
ProteomicsDBi57783

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33651, 195 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		7130

Genome annotation databases

EnsembliENST00000243347; ENSP00000243347; ENSG00000123610
GeneIDi7130
KEGGihsa:7130
MANE-SelectiENST00000243347.5; ENSP00000243347.3; NM_007115.4; NP_009046.2
UCSCiuc002txk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7130
DisGeNETi7130

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNFAIP6
HGNCiHGNC:11898, TNFAIP6
HPAiENSG00000123610, Tissue enriched (urinary)
MIMi600410, gene
neXtProtiNX_P98066
OpenTargetsiENSG00000123610
PharmGKBiPA36595
VEuPathDBiHostDB:ENSG00000123610

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1218, Eukaryota
KOG3714, Eukaryota
GeneTreeiENSGT00940000157201
HOGENOMiCLU_092089_0_0_1
InParanoidiP98066
OMAiYDDIHGF
OrthoDBi934805at2759
PhylomeDBiP98066
TreeFamiTF334173

Enzyme and pathway databases

PathwayCommonsiP98066
ReactomeiR-HSA-6798695, Neutrophil degranulation
SignaLinkiP98066
SIGNORiP98066

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7130, 10 hits in 1041 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNFAIP6, human
EvolutionaryTraceiP98066

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TSG-6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7130
PharosiP98066, Tbio

Protein Ontology

More...PROi		PR:P98066
RNActiP98066, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123610, Expressed in layer of synovial tissue and 198 other tissues
GenevisibleiP98066, HS

Family and domain databases

CDDicd00041, CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000859, CUB_dom
IPR000538, Link_dom
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF00193, Xlink, 1 hit
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00445, LINK, 1 hit
SUPFAMiSSF49854, SSF49854, 1 hit
SSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSG6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98066
Secondary accession number(s): Q53TI7, Q8WWI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 21, 2005
Last modified: February 23, 2022
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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