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Protein

Bone morphogenetic protein 1

Gene

Bmp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD) (By similarity). Responsible for the proteolytic activation of lysyl oxidase LOX.By similarity1 Publication

Catalytic activityi

Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.

Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

Activity regulationi

Activity is increased by the procollagen C-endopeptidase enhancer protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi218Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Active sitei219PROSITE-ProRule annotation1
Metal bindingi222Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Metal bindingi228Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor, Hydrolase, Metalloprotease, Protease
Biological processChondrogenesis, Differentiation, Osteogenesis
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-8963896 HDL assembly

Protein family/group databases

MEROPSiM12.005

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 1 (EC:3.4.24.19)
Short name:
BMP-1
Alternative name(s):
Mammalian tolloid protein
Short name:
mTld
Procollagen C-proteinase
Short name:
PCP
Gene namesi
Name:Bmp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:88176 Bmp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000002889126 – 125By similarityAdd BLAST100
ChainiPRO_0000028892126 – 991Bone morphogenetic protein 1Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 324PROSITE-ProRule annotation
Disulfide bondi188 ↔ 210PROSITE-ProRule annotation
Disulfide bondi190 ↔ 191PROSITE-ProRule annotation
Disulfide bondi327 ↔ 353By similarity
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi380 ↔ 402By similarity
Disulfide bondi440 ↔ 466By similarity
Disulfide bondi493 ↔ 515By similarity
Disulfide bondi556 ↔ 568By similarity
Disulfide bondi564 ↔ 577By similarity
Disulfide bondi579 ↔ 592By similarity
Disulfide bondi596 ↔ 622By similarity
Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi649 ↔ 671By similarity
Disulfide bondi712 ↔ 723By similarity
Disulfide bondi719 ↔ 732By similarity
Disulfide bondi734 ↔ 747By similarity
Disulfide bondi752 ↔ 778By similarity
Disulfide bondi805 ↔ 827By similarity
Disulfide bondi865 ↔ 895By similarity
Disulfide bondi922 ↔ 944By similarity
Modified residuei939Omega-N-methylarginineBy similarity1
Modified residuei942Omega-N-methylarginineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Methylation, Zymogen

Proteomic databases

PaxDbiP98063
PeptideAtlasiP98063
PRIDEiP98063

PTM databases

iPTMnetiP98063
PhosphoSitePlusiP98063

Expressioni

Tissue specificityi

At high levels in embryonic maternal deciduum and floor plate region of the neural tube. Less in developing membranous and endochondral bone, submucosa of intestine, dermis of skin and the mesenchyme of spleen and lung.

Gene expression databases

BgeeiENSMUSG00000022098 Expressed in 280 organ(s), highest expression level in entire extraembryonic component
CleanExiMM_BMP1
GenevisibleiP98063 MM

Interactioni

Subunit structurei

Interacts with POSTN, the interaction promotes deposition on the extracellular matrix.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198360, 3 interactors
IntActiP98063, 2 interactors
STRINGi10090.ENSMUSP00000022693

Structurei

3D structure databases

ProteinModelPortaliP98063
SMRiP98063
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 325Peptidase M12APROSITE-ProRule annotationAdd BLAST200
Domaini327 – 439CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini440 – 551CUB 2PROSITE-ProRule annotationAdd BLAST112
Domaini552 – 593EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini596 – 707CUB 3PROSITE-ProRule annotationAdd BLAST112
Domaini708 – 748EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini752 – 864CUB 4PROSITE-ProRule annotationAdd BLAST113
Domaini865 – 981CUB 5PROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiP98063
KOiK05502
OMAiKGFEASH
OrthoDBiEOG091G009U
TreeFamiTF314351

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PF07645 EGF_CA, 1 hit
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS00010 ASX_HYDROXYL, 2 hits
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P98063-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGVARPPLP LLSLPLLLLL LLLPRAGRPL DLADYTYDLG EEDAPELLNY
60 70 80 90 100
KDPCKAAAFL GDIALDEEDL RAFQVQQAAV LRQQTARRPS IKAAGNSSAL
110 120 130 140 150
GGQGTSGQPQ RESRGRWRGR PRSRRAATSR PERVWPDGVI PFVIGGNFTG
160 170 180 190 200
SQRAVFRQAM RHWEKHTCVT FLERTDEDSY IVFTYRPCGC CSYVGRRGGG
210 220 230 240 250
PQAISIGKNC DKFGIVVHEL GHVIGFWHEH TRPDRDRHVS IVRENIQPGQ
260 270 280 290 300
EYNFLKMEVQ EVESLGETYD FDSIMHYARN TFSRGIFLDT IVPKYEVNGV
310 320 330 340 350
KPSIGQRTRL SKGDIAQARK LYKCPACGET LQDSTGNFSS PEYPNGYSAH
360 370 380 390 400
MHCVWRISVT PGEKIILNFT SMDLYRSRLC WYDYVEVRDG FWRKAPLRGR
410 420 430 440 450
FCGGKLPEPI VSTDSRLWVE FRSSSNWVGK GFFAVYEAIC GGDVKKDNGH
460 470 480 490 500
IQSPNYPDDY RPSKVCIWRI QVSEGFHVGL TFQSFEIERH DSCAYDYLEV
510 520 530 540 550
RDGHSESSNL IGRYCGYEKP DDIKSTSSRL WLKFVSDGSI NKAGFAVNFF
560 570 580 590 600
KEVDECSRPN RGGCEQRCLN TLGSYKCSCD PGYELAPDKR RCEAACGGFL
610 620 630 640 650
TKLNGSITSP GWPKEYPPNK NCIWQLVAPT QYRISLQFDF FETEGNDVCK
660 670 680 690 700
YDFVEVRSGL TADSKLHGKF CGSEKPEVIT SQYNNMRVEF KSDNTVSKKG
710 720 730 740 750
FKAHFFSDKD ECSKDNGGCQ QDCVNTFGSY ECQCRSGFVL HDNKHDCKEA
760 770 780 790 800
GCEHKVTSTS GTITSPNWPD KYPSKKECTW AISSTPGHRV KLTFVEMDIE
810 820 830 840 850
SQPECAYDHL EVFDGRDAKA PVLGRFCGSK KPEPVLATGN RMFLRFYSDN
860 870 880 890 900
SVQRKGFQAS HSTECGGQVR ADVKTKDLYS HAQFGDNNYP GGVDCEWVIV
910 920 930 940 950
AEEGYGVELV FQTFEVEEET DCGYDYIELF DGYDSTAPRL GRYCGSGPPE
960 970 980 990
EVYSAGDSVL VKFHSDDTIS KKGFHLRYTS TKFQDTLHSR K
Length:991
Mass (Da):111,666
Last modified:October 3, 2012 - v2
Checksum:iF838441CF1DA9F1A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRJ8A0A2I3BRJ8_MOUSE
Bone morphogenetic protein 1
Bmp1
194Annotation score:
A0A2I3BQB3A0A2I3BQB3_MOUSE
Bone morphogenetic protein 1
Bmp1
57Annotation score:

Sequence cautioni

The sequence AAA37306 differs from that shown. Reason: Frameshift at positions 24 and 61.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti395 – 397APL → VWV in AAA37306 (PubMed:8174772).Curated3
Sequence conflicti519K → N in AAA37306 (PubMed:8174772).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24755 mRNA Translation: AAA37306.1 Frameshift.
AC122268 Genomic DNA No translation available.
BC066062 mRNA Translation: AAH66062.1
CCDSiCCDS36972.1
PIRiI49540
RefSeqiNP_033885.2, NM_009755.3
XP_006518523.1, XM_006518460.3
UniGeneiMm.27757

Genome annotation databases

EnsembliENSMUST00000022693; ENSMUSP00000022693; ENSMUSG00000022098
GeneIDi12153
KEGGimmu:12153
UCSCiuc007uoc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24755 mRNA Translation: AAA37306.1 Frameshift.
AC122268 Genomic DNA No translation available.
BC066062 mRNA Translation: AAH66062.1
CCDSiCCDS36972.1
PIRiI49540
RefSeqiNP_033885.2, NM_009755.3
XP_006518523.1, XM_006518460.3
UniGeneiMm.27757

3D structure databases

ProteinModelPortaliP98063
SMRiP98063
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198360, 3 interactors
IntActiP98063, 2 interactors
STRINGi10090.ENSMUSP00000022693

Protein family/group databases

MEROPSiM12.005

PTM databases

iPTMnetiP98063
PhosphoSitePlusiP98063

Proteomic databases

PaxDbiP98063
PeptideAtlasiP98063
PRIDEiP98063

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022693; ENSMUSP00000022693; ENSMUSG00000022098
GeneIDi12153
KEGGimmu:12153
UCSCiuc007uoc.2 mouse

Organism-specific databases

CTDi649
MGIiMGI:88176 Bmp1

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiP98063
KOiK05502
OMAiKGFEASH
OrthoDBiEOG091G009U
TreeFamiTF314351

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-8963896 HDL assembly

Miscellaneous databases

PROiPR:P98063
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022098 Expressed in 280 organ(s), highest expression level in entire extraembryonic component
CleanExiMM_BMP1
GenevisibleiP98063 MM

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PF07645 EGF_CA, 1 hit
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS00010 ASX_HYDROXYL, 2 hits
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMP1_MOUSE
AccessioniPrimary (citable) accession number: P98063
Secondary accession number(s): Q6NZM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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