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Protein

Cytochrome c oxidase subunit 2

Gene

cbaB

Organism
Thermus thermophilus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Caution

The sequence shown here has been extracted from PDB entry 2CUA.Curated

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Copper A1
Metal bindingi116Copper A1
Metal bindingi120Copper A1
Metal bindingi124Copper A1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene namesi
Name:cbaB
Synonyms:ctaC
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183721‹1 – 135Cytochrome c oxidase subunit 2Add BLAST›135

Interactioni

Protein-protein interaction databases

IntActiP98052, 1 interactor

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP98052
SMRiP98052
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP98052

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiENOG4105NAA Bacteria
COG1622 LUCA

Family and domain databases

CDDicd13913 ba3_CcO_II_C, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR034214 Ba3_CcO_II_C
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit

Sequencei

Sequence statusi: Fragment.

P98052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AYTLATHTAG VIPAGKLERV DPTTVRQEGP WADPAQAVVQ TGPNQYTVYV
60 70 80 90 100
LAFAFGYQPN PIEVPQGAEI VFKITSPDVI HGFHVEGTNI NVEVLPGEVS
110 120 130
TVRYTFKRPG EYRIICNQYC GLGHQNMFGT IVVKE
Length:135
Mass (Da):14,804
Last modified:May 24, 2005 - v2
Checksum:i786895A803A52FAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30B1-135[»]
2CUAX-ray1.60A/B1-135[»]
2FWLNMR-B1-135[»]
2LLNNMR-A11-135[»]
5U7NX-ray2.30A/B/C/D/E/F/G/H1-135[»]
ProteinModelPortaliP98052
SMRiP98052
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP98052, 1 interactor

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105NAA Bacteria
COG1622 LUCA

Miscellaneous databases

EvolutionaryTraceiP98052

Family and domain databases

CDDicd13913 ba3_CcO_II_C, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR034214 Ba3_CcO_II_C
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_THETH
AccessioniPrimary (citable) accession number: P98052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: January 31, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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