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UniProtKB - P97949 (P97949_RAT)
Protein
Submitted name:
Antigen peptide transporter 1
Gene
Tap1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- This reaction proceeds in the forwardARBA annotation direction.
Cofactori
Mg2+ARBA annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 515 – 522 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type peptide antigen transporter activity Source: Ensembl
- ADP binding Source: Ensembl
- ATP binding Source: UniProtKB-UniRule
- MHC class Ib protein binding Source: Ensembl
- MHC class I protein binding Source: Ensembl
- peptide antigen binding Source: Ensembl
- TAP2 binding Source: Ensembl
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of endogenous peptide antigen via MHC class I Source: Ensembl
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: InterPro
- cytosol to endoplasmic reticulum transport Source: Ensembl
- defense response Source: Ensembl
Keywordsi
Biological process | Adaptive immunityARBA annotation, Immunity, TransportARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, MagnesiumARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Antigen peptide transporter 1ImportedSubmitted name: Tap1 proteinImportedSubmitted name: Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)Imported |
Gene namesi | Name:Tap1Imported Synonyms:Arrb2-psImported, Hla-dmaImported, Hla-dmbImported, Psmb9Imported, RT1-BaImported, RT1-BbImported, RT1-DaImported, RT1-Db1Imported, RT1-Db2Imported, RT1-DObImported, tap1Imported, Tap2Imported, TesbImported ORF Names:rCG_61064Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3817, Tap1 |
Subcellular locationi
Cytoskeleton
- centriolar satellite Source: Ensembl
Endoplasmic reticulum
- TAP complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 90 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 110 – 131 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 164 – 185 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 205 – 226 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 291 – 318 | HelicalSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5014102145 | 27 – 725 | Sequence analysisAdd BLAST | 699 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000000457, Expressed in thymus and 21 other tissues |
Interactioni
GO - Molecular functioni
- MHC class Ib protein binding Source: Ensembl
- MHC class I protein binding Source: Ensembl
- TAP2 binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 166 – 447 | ABC transmembrane type-1InterPro annotationAdd BLAST | 282 | |
Domaini | 480 – 719 | ABC transporterInterPro annotationAdd BLAST | 240 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification]ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159023 |
HOGENOMi | CLU_000604_84_3_1 |
OMAi | LGIMLWG |
OrthoDBi | 684058at2759 |
TreeFami | TF105197 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR013305, ABC_Tap-like IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase IPR013306, Tap1/ABCB2 IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF249, PTHR24221:SF249, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR00958, 3a01208, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P97949-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAHAWPTAA LLLLLVDWLL LRPVLPGIFS LLVPEVPLLR VWAVGLSRWA
60 70 80 90 100
ILGLGVRGVL GVTAGARGWL AALQPLVAAL GLALPGLASF RKLSAWGALR
110 120 130 140 150
EGDNAGLLHW NSRLDAFVLS YVAALPAAAL WHKLGGFWAP SGHKGAGDML
160 170 180 190 200
CRMLGFLDSK KGRLHLVLVL LILSCLGEMA IPFFTGRITD WILQDKTAPS
210 220 230 240 250
FARNMWLMCI LTVASTALEF AGDGIYNITM GHMHSRVHGE VFRAVLHQET
260 270 280 290 300
GFFLKNPTGS ITSRVTEDTS NVCESISDKL NLFLWYLGRG LCLLAFMIWG
310 320 330 340 350
SFYLTVVTLL SLPLLFLLPR RLGKVYQSLA VKVQESLAKS TQVALEALSA
360 370 380 390 400
MPTVRSFANE EGEAQKFRQK LEEMKPLNKK EALAYVTEVW TMSVSGMLLK
410 420 430 440 450
VGILYLGGQL VVRGAVSSGN LVSFVLYQLQ FTRAVEVLLS IYPSMQKSVG
460 470 480 490 500
ASEKIFEYLD RTPCSPLSGS LAPLNMKGLV KFQDVSFAYP NHPNVQVLQG
510 520 530 540 550
LTFTLYPGKV TALVGPNGSG KSTVAALLQN LYQPTGGKVL LDGELLVQYD
560 570 580 590 600
HHYLHTQVAA VGQEPLLFGR SFRENIAYGL TRTPTMEEIT AVAMESGAHD
610 620 630 640 650
FISGFPQGYD TEVGETGNQL SGGQRQAVAL ARALIRKPRL LILDDATSAL
660 670 680 690 700
DAGNQLRVQR LLYESPEWAS RTVLLITQQL SLAERAHHIL FLKEGSVCEQ
710 720
GTHLQLMERG GCYRSMVEAL AAPSD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP36370 | TAP1_RAT | Antigen peptide transporter 1 | Tap1 Abcb2, Mtp1 | 725 | Annotation score: | ||
A0A0G2JY71 | A0A0G2JY71_RAT | Antigen peptide transporter 1 | Tap1 | 82 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098547 Genomic DNA No translation available. Y10230 mRNA Translation: CAA71279.1 Y10234 mRNA Translation: CAA71283.1 BX883043 Genomic DNA Translation: CAE83941.1 CH473988 Genomic DNA Translation: EDL96810.1 |
RefSeqi | NP_114444.2, NM_032055.4 |
Genome annotation databases
Ensembli | ENSRNOT00000000529; ENSRNOP00000000529; ENSRNOG00000000457 |
GeneIDi | 24811 |
KEGGi | rno:24811 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098547 Genomic DNA No translation available. Y10230 mRNA Translation: CAA71279.1 Y10234 mRNA Translation: CAA71283.1 BX883043 Genomic DNA Translation: CAE83941.1 CH473988 Genomic DNA Translation: EDL96810.1 |
RefSeqi | NP_114444.2, NM_032055.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSRNOT00000000529; ENSRNOP00000000529; ENSRNOG00000000457 |
GeneIDi | 24811 |
KEGGi | rno:24811 |
Organism-specific databases
CTDi | 6890 |
RGDi | 3817, Tap1 |
Phylogenomic databases
GeneTreei | ENSGT00940000159023 |
HOGENOMi | CLU_000604_84_3_1 |
OMAi | LGIMLWG |
OrthoDBi | 684058at2759 |
TreeFami | TF105197 |
Gene expression databases
Bgeei | ENSRNOG00000000457, Expressed in thymus and 21 other tissues |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR013305, ABC_Tap-like IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase IPR013306, Tap1/ABCB2 IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF249, PTHR24221:SF249, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR00958, 3a01208, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P97949_RAT | |
Accessioni | P97949Primary (citable) accession number: P97949 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 1997 |
Last sequence update: | May 1, 1997 | |
Last modified: | January 19, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |