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Protein

Nuclear receptor subfamily 0 group B member 2

Gene

Nr0b2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 0 group B member 2
Alternative name(s):
Orphan nuclear receptor SHP
Small heterodimer partner
Gene namesi
Name:Nr0b2
Synonyms:Shp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621032 Nr0b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002327571 – 260Nuclear receptor subfamily 0 group B member 2Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57Symmetric dimethylarginine; by PRMT5By similarity1

Post-translational modificationi

Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP97947
PRIDEiP97947

PTM databases

PhosphoSitePlusiP97947

Expressioni

Tissue specificityi

Detected in kidney, testis, heart and liver.1 Publication

Gene expression databases

BgeeiENSRNOG00000007229 Expressed in 9 organ(s), highest expression level in liver
GenevisibleiP97947 RN

Interactioni

Subunit structurei

Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2. Interacts with NR1I3 and EID1 (By similarity). Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, PPARA and PPARG. May also interact with HNF4A.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250721, 4 interactors
DIPiDIP-46314N
IntActiP97947, 3 interactors
STRINGi10116.ENSRNOP00000009683

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP97947
SMRiP97947
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97947

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 260NR LBDPROSITE-ProRule annotationAdd BLAST245

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG008136
InParanoidiP97947
KOiK08563
OMAiCQLPPQD
OrthoDBiEOG091G0FGK
PhylomeDBiP97947
TreeFamiTF332386

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequencei

Sequence statusi: Complete.

P97947-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSQSGVCP CQGSASHPTI LYTLLSPGPR TRPMAPASRS HCLCQQHRPV
60 70 80 90 100
RLCAPHRTCR EALDVLGKTV AFLRNLPSFC LLPHEDQRRL LEGCWGPLFL
110 120 130 140 150
LGLAQDTVTF EVAEAPVPSI LKKILLEEPN SGAQGAQPPD PPQPSLAAVQ
160 170 180 190 200
WLQHCLESFW SLELGPKEYA YLKGTILFNP DVPGLHASCH IAHLQQEAHW
210 220 230 240 250
ALCEVLEPWY PASQGRLARI LLMASTLKNI SCTLLVDLFF RPVIGDVDIT
260
ELLEDMLLLR
Length:260
Mass (Da):28,750
Last modified:May 1, 1997 - v1
Checksum:i71C1E09C8B912A79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86839 Genomic DNA Translation: BAA13171.1
D86580 mRNA Translation: BAA13127.1
BC088117 mRNA Translation: AAH88117.1
RefSeqiNP_476474.1, NM_057133.1
UniGeneiRn.10712

Genome annotation databases

EnsembliENSRNOT00000009683; ENSRNOP00000009683; ENSRNOG00000007229
GeneIDi117274
KEGGirno:117274
UCSCiRGD:621032 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86839 Genomic DNA Translation: BAA13171.1
D86580 mRNA Translation: BAA13127.1
BC088117 mRNA Translation: AAH88117.1
RefSeqiNP_476474.1, NM_057133.1
UniGeneiRn.10712

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YP0X-ray1.50B17-28[»]
1ZGYX-ray1.80B115-131[»]
1ZH7X-ray2.50C/D16-26[»]
ProteinModelPortaliP97947
SMRiP97947
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250721, 4 interactors
DIPiDIP-46314N
IntActiP97947, 3 interactors
STRINGi10116.ENSRNOP00000009683

PTM databases

PhosphoSitePlusiP97947

Proteomic databases

PaxDbiP97947
PRIDEiP97947

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009683; ENSRNOP00000009683; ENSRNOG00000007229
GeneIDi117274
KEGGirno:117274
UCSCiRGD:621032 rat

Organism-specific databases

CTDi8431
RGDi621032 Nr0b2

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG008136
InParanoidiP97947
KOiK08563
OMAiCQLPPQD
OrthoDBiEOG091G0FGK
PhylomeDBiP97947
TreeFamiTF332386

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

EvolutionaryTraceiP97947
PROiPR:P97947

Gene expression databases

BgeeiENSRNOG00000007229 Expressed in 9 organ(s), highest expression level in liver
GenevisibleiP97947 RN

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR0B2_RAT
AccessioniPrimary (citable) accession number: P97947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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