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Protein

Breast cancer type 2 susceptibility protein homolog

Gene

Brca2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Breast cancer type 2 susceptibility protein homolog
Alternative name(s):
Fanconi anemia group D1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Brca2
Synonyms:Fancd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109337 Brca2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000649851 – 3329Breast cancer type 2 susceptibility protein homologAdd BLAST3329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei435PhosphoserineBy similarity1
Modified residuei481PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei2048PhosphoserineBy similarity1
Modified residuei3214Phosphoserine; by CDK1 and CDK2By similarity1
Modified residuei3241PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3214 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding (By similarity).By similarity
Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P97929

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P97929

MaxQB - The MaxQuant DataBase

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MaxQBi
P97929

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P97929

PeptideAtlas

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PeptideAtlasi
P97929

PRoteomics IDEntifications database

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PRIDEi
P97929

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P97929

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P97929

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highest expression in cerebellum, testis, ileum, appendix, epididymis, ovary and mammary gland. No expression in lung.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the mammary gland, expression increases dramatically during pregnancy.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000041147 Expressed in 215 organ(s), highest expression level in embryo

CleanEx database of gene expression profiles

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CleanExi
MM_BRCA2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P97929 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P97929 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with SEM1, WDR16, USP11, DMC1, ROCK2 and NPM1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with POLH; the interaction is direct. Interacts with the TREX-2 complex subunits PCID2 and SEM1 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
198384, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-972 BRCC ubiquitin ligase complex

Protein interaction database and analysis system

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IntActi
P97929, 2 interactors

Molecular INTeraction database

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MINTi
P97929

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000038576

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIUX-ray3.10A2378-3115[»]
1MJEX-ray3.50A2378-3113[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P97929

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P97929

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P97929

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati981 – 1015BRCA2 1Add BLAST35
Repeati1192 – 1226BRCA2 2Add BLAST35
Repeati1394 – 1428BRCA2 3Add BLAST35
Repeati1491 – 1525BRCA2 4Add BLAST35
Repeati1623 – 1657BRCA2 5Add BLAST35
Repeati1924 – 1958BRCA2 6Add BLAST35
Repeati2004 – 2038BRCA2 7Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40Interaction with PALB2By similarityAdd BLAST40
Regioni628 – 979Interaction with NPM1By similarityAdd BLAST352
Regioni2298 – 2466Interaction with FANCD2By similarityAdd BLAST169
Regioni2402 – 2753Interaction with SEM1By similarityAdd BLAST352

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2603 – 2619Nuclear export signal; masked by interaction with SEM1By similarityAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4751 Eukaryota
ENOG410Y06W LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000139693

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050731

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P97929

KEGG Orthology (KO)

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KOi
K08775

Identification of Orthologs from Complete Genome Data

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OMAi
KAFMEDG

Database of Orthologous Groups

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OrthoDBi
257485at2759

TreeFam database of animal gene trees

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TreeFami
TF105041

Family and domain databases

Conserved Domains Database

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CDDi
cd04493 BRCA2DBD_OB1, 1 hit
cd04495 BRCA2DBD_OB3, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015525 BRCA2
IPR015252 BRCA2_hlx
IPR036315 BRCA2_hlx_sf
IPR015187 BRCA2_OB_1
IPR015188 BRCA2_OB_3
IPR002093 BRCA2_repeat
IPR012340 NA-bd_OB-fold
IPR015205 Tower_dom

The PANTHER Classification System

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PANTHERi
PTHR11289 PTHR11289, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09169 BRCA-2_helical, 1 hit
PF09103 BRCA-2_OB1, 1 hit
PF09104 BRCA-2_OB3, 1 hit
PF00634 BRCA2, 7 hits
PF09121 Tower, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF002397 BRCA2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01341 Tower, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50249 SSF50249, 3 hits
SSF81872 SSF81872, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50138 BRCA2_REPEAT, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P97929-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVEYKRRPT FWEIFKARCS TADLGPISLN WFEELSSEAP PYNSEPPEES
60 70 80 90 100
EYKPHGYEPQ LFKTPQRNPP YHQFASTPIM FKERSQTLPL DQSPFRELGK
110 120 130 140 150
VVASSKHKTH SKKKTKVDPV VDVASPPLKS CLSESPLTLR CTQAVLQREK
160 170 180 190 200
PVVSGSLFYT PKLKEGQTPK PISESLGVEV DPDMSWTSSL ATPPTLSSTV
210 220 230 240 250
LIARDEEARS SVTPADSPAT LKSCFSNHNE SPQKNDRSVP SVIDSENKNQ
260 270 280 290 300
QEAFSQGLGK MLGDSSGKRN SFKDCLRKPI PNILEDGETA VDTSEEDSFS
310 320 330 340 350
LCFPKRRTRN LQKMRMGKTR KKIFSETRTD ELSEEARRQT DDKNSFVFEM
360 370 380 390 400
ELRESDPLDP GVTSQKPFYS QNEEICNEAV QCSDSRWSQS NLSGLNETQT
410 420 430 440 450
GKITLPHISS HSQNISEDFI DMKKEGTGSI TSEKSLPHIS SLPEPEKMFS
460 470 480 490 500
EETVVDKEHE GQHFESLEDS IAGKQMVSRT SQAACLSPSI RKSIFKMREP
510 520 530 540 550
LDETLGTVFS DSMTNSTFTE EHEASACGLG ILTACSQRED SICPSSVDTG
560 570 580 590 600
SWPTTLTDTS ATVKNAGLIS TLKNKKRKFI YSVSDDASLQ GKKLQTHRQL
610 620 630 640 650
ELTNLSAQLE ASAFEVPLTF TNVNSGIPDS SDKKRCLPND PEEPSLTNSF
660 670 680 690 700
GTATSKEISY IHALISQDLN DKEAIVIEEK PQPYTAREAD FLLCLPERTC
710 720 730 740 750
ENDQKSPKVS NGKEKVLVSA CLPSAVQLSS ISFESQENPL GDHNGTSTLK
760 770 780 790 800
LTPSSKLPLS KADMVSREKM CKMPEKLQCE SCKVNIELSK NILEVNEICI
810 820 830 840 850
LSENSKTPGL LPPGENIIEV ASSMKSQFNQ NAKIVIQKDQ KGSPFISEVA
860 870 880 890 900
VNMNSEELFP DSGNNFAFQV TNKCNKPDLG SSVELQEEDL SHTQGPSLKN
910 920 930 940 950
SPMAVDEDVD DAHAAQVLIT KDSDSLAVVH DYTEKSRNNI EQHQKGTEDK
960 970 980 990 1000
DFKSNSSLNM KSDGNSDCSD KWSEFLDPVL NHNFGGSFRT ASNKEIKLSE
1010 1020 1030 1040 1050
HNVKKSKMFF KDIEEQYPTR LACIDIVNTL PLANQKKLSE PHIFDLKSVT
1060 1070 1080 1090 1100
TVSTQSHNQS SVSHEDTDTA PQMLSSKQDF HSNNLTTSQK AEITELSTIL
1110 1120 1130 1140 1150
EESGSQFEFT QFRKPSHIAQ NTSEVPGNQM VVLSTASKEW KDTDLHLPVD
1160 1170 1180 1190 1200
PSVGQTDHSK QFEGSAGVKQ SFPHLLEDTC NKNTSCFLPN INEMEFGGFC
1210 1220 1230 1240 1250
SALGTKLSVS NEALRKAMKL FSDIENSEEP SAKVGPRGFS SSAHHDSVAS
1260 1270 1280 1290 1300
VFKIKKQNTE KSFDEKSSKC QVTLQNNIEM TTCIFVGRNP EKYIKNTKHE
1310 1320 1330 1340 1350
DSYTSSQRNN LENSDGSMSS TSGPVYIHKG DSDLPADQGS KCPESCTQYA
1360 1370 1380 1390 1400
REENTQIKEN ISDLTCLEIM KAEETCMKSS DKKQLPSDKM EQNIKEFNIS
1410 1420 1430 1440 1450
FQTASGKNTR VSKESLNKSV NIFNRETDEL TVISDSLNSK ILHGINKDKM
1460 1470 1480 1490 1500
HTSCHKKAIS IKKVFEDHFP IVTVSQLPAQ QHPEYEIEST KEPTLLSFHT
1510 1520 1530 1540 1550
ASGKKVKIMQ ESLDKVKNLF DETQYVRKTA SFSQGSKPLK DSKKELTLAY
1560 1570 1580 1590 1600
EKIEVTASKC EEMQNFVSKE TEMLPQQNYH MYRQTENLKT SNGTSSKVQE
1610 1620 1630 1640 1650
NIENNVEKNP RICCICQSSY PVTEDSALAY YTEDSRKTCV RESSLSKGRK
1660 1670 1680 1690 1700
WLREQGDKLG TRNTIKIECV KEHTEDFAGN ASYEHSLVII RTEIDTNHVS
1710 1720 1730 1740 1750
ENQVSTLLSD PNVCHSYLSQ SSFCHCDDMH NDSGYFLKNK IDSDVPPDMK
1760 1770 1780 1790 1800
NAEGNTISPR VSATKERNLH PQTINEYCVQ KLETNTSPHA NKDVAIDPSL
1810 1820 1830 1840 1850
LDSRNCKVGS LVFITAHSQE TERTKEIVTD NCYKIVEQNR QSKPDTCQTS
1860 1870 1880 1890 1900
CHKVLDDSKD FICPSSSGDV CINSRKDSFC PHNEQILQHN QSMSGLKKAA
1910 1920 1930 1940 1950
TPPVGLETWD TSKSIREPPQ AAHPSRTYGI FSTASGKAIQ VSDASLEKAR
1960 1970 1980 1990 2000
QVFSEMDGDA KQLSSMVSLE GNEKPHHSVK RENSVVHSTQ GVLSLPKPLP
2010 2020 2030 2040 2050
GNVNSSVFSG FSTAGGKLVT VSESALHKVK GMLEEFDLIR TEHTLQHSPI
2060 2070 2080 2090 2100
PEDVSKILPQ PCAEIRTPEY PVNSKLQKTY NDKSSLPSNY KESGSSGNTQ
2110 2120 2130 2140 2150
SIEVSLQLSQ MERNQDTQLV LGTKVSHSKA NLLGKEQTLP QNIKVKTDEM
2160 2170 2180 2190 2200
KTFSDVPVKT NVGEYYSKES ENYFETEAVE SAKAFMEDDE LTDSEQTHAK
2210 2220 2230 2240 2250
CSLFTCPQNE TLFNSRTRKR GGVTVDAVGQ PPIKRSLLNE FDRIIESKGK
2260 2270 2280 2290 2300
SLTPSKSTPD GTVKDRSLFT HHMSLEPVTC GPFCSSKERQ GAQRPHLTSP
2310 2320 2330 2340 2350
AQELLSKGHP WRHSALEKSP SSPIVSILPA HDVSATRTER TRHSGKSTKV
2360 2370 2380 2390 2400
FVPPFKMKSQ FHGDEHFNSK NVNLEGKNQK STDGDREDGN DSHVRQFNKD
2410 2420 2430 2440 2450
LMSSLQSARD LQDMRIKNKE RRHLRLQPGS LYLTKSSTLP RISLQAAVGD
2460 2470 2480 2490 2500
RAPSACSPKQ LYIYGVSKEC INVNSKNAEY FQFDIQDHFG KEDLCAGKGF
2510 2520 2530 2540 2550
QLADGGWLIP SNDGKAGKEE FYRALCDTPG VDPKLISSIW VANHYRWIVW
2560 2570 2580 2590 2600
KLAAMEFAFP KEFANRCLNP ERVLLQLKYR YDVEIDNSRR SALKKILERD
2610 2620 2630 2640 2650
DTAAKTLVLC ISDIISPSTK VSETSGGKTS GEDANKVDTI ELTDGWYAVR
2660 2670 2680 2690 2700
AQLDPPLMAL VKSGKLTVGQ KIITQGAELV GSPDACAPLE APDSLRLKIS
2710 2720 2730 2740 2750
ANSTRPARWH SRLGFFRDPR PFPLPLSSLF SDGGNVGCVD IIVQRVYPLQ
2760 2770 2780 2790 2800
WVEKTVSGLY IFRSEREEEK EALRFAEAQQ KKLEALFTKV HTEFKDHEED
2810 2820 2830 2840 2850
TTQRCVLSRT LTRQQVHALQ DGAELYAAVQ YASDPDHLEA CFSEEQLRAL
2860 2870 2880 2890 2900
NNYRQMLNDK KQARIQSEFR KALESAEKEE GLSRDVTTVW KLRVTSYKKK
2910 2920 2930 2940 2950
EKSALLSIWR PSSDLSSLLT EGKRYRIYHL AVSKSKSKFE RPSIQLTATK
2960 2970 2980 2990 3000
RTQYQQLPVS SETLLQVYQP RESLHFSRLS DPAFQPPCSE VDVVGVVVSV
3010 3020 3030 3040 3050
VKPIGLAPLV YLSDECLNLL VVKFGIDLNE DIKPRVLIAA SNLQCQPEST
3060 3070 3080 3090 3100
SGVPTLFAGH FSIFSASPKE AYFQEKVNNL KHAIENIDTF YKEAEKKLIH
3110 3120 3130 3140 3150
VLEGDSPKWS TPNKDPTREP HAASTCCASD LLGSGGQFLR ISPTGQQSYQ
3160 3170 3180 3190 3200
SPLSHCTLKG KSMPLAHSAQ MAAKSWSGEN EIDDPKTCRK RRALDFLSRL
3210 3220 3230 3240 3250
PLPSPVSPIC TFVSPAAQKA FQPPRSCGTK YATPIKKEPS SPRRRTPFQK
3260 3270 3280 3290 3300
TSGVSLPDCD SVADEELALL STQALTPDSV GGNEQAFPGD STRNPQPAQR
3310 3320
PDQQVGPRSR KESLRDCRGD SSEKLAVES
Length:3,329
Mass (Da):370,664
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50A32E8BADE2CF7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YVI7A0A0J9YVI7_MOUSE
Breast cancer type 2 susceptibility...
Brca2
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1038L → I in AAB48306 (PubMed:9063750).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti44S → F in strain: C57BL/6 and 129/Sv. 1
Natural varianti340T → P in strain: 129/Sv. 1
Natural varianti377N → H in strain: C57BL/6. 1
Natural varianti407H → P in strain: C57BL/6. 1
Natural varianti661I → V in strain: C57BL/6. 1
Natural varianti739P → H in strain: C57BL/6. 1
Natural varianti1198 – 1199GF → RI in strain: C57BL/6. 2
Natural varianti1257Q → P in strain: C57BL/6. 1
Natural varianti1392Q → R in strain: C57BL/6. 1
Natural varianti1520 – 1521FD → CG in strain: C57BL/6. 2
Natural varianti1583R → W in strain: C57BL/6. 1
Natural varianti1613C → W in strain: C57BL/6. 1
Natural varianti1686S → R in strain: C57BL/6. 1
Natural varianti1799S → F in strain: 129/Sv. 1
Natural varianti1881P → L in strain: C57BL/6. 1
Natural varianti1894S → F in strain: 129/Sv. 1
Natural varianti2141Q → K in strain: C57BL/6. 1
Natural varianti2392S → R in strain: C57BL/6. 1
Natural varianti2605K → Q in strain: C57BL/6. 1
Natural varianti2648A → P in strain: C57BL/6. 1
Natural varianti2717R → C in strain: 129/Sv. 1
Natural varianti2729L → M in strain: 129/Sv. 1
Natural varianti2814Q → H in strain: C57BL/6. 1
Natural varianti2827A → P in strain: C57BL/6. 1
Natural varianti2907S → I in strain: 129/Sv. 1
Natural varianti2929H → L in strain: 129/Sv. 1
Natural varianti3058A → G in strain: C57BL/6. 1
Natural varianti3071A → G in strain: C57BL/6. 1
Natural varianti3081K → E in strain: C57BL/6. 1
Natural varianti3089T → S in strain: C57BL/6. 1
Natural varianti3105 – 3109DSPKW → SQSQV in strain: C57BL/6. 5
Natural varianti3220A → G in strain: 129/Sv. 1
Natural varianti3238E → K in strain: 129/Sv. 1
Natural varianti3243Missing in strain: C57BL/6. 1
Natural varianti3245R → K in strain: 129/Sv. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U82270 mRNA Translation: AAB48306.1
U65594 mRNA Translation: AAC23702.1
U89652 mRNA Translation: AAB71377.1
AC154885 Genomic DNA No translation available.
U72947 mRNA Translation: AAB40720.1
U89503 Genomic DNA Translation: AAC53276.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39411.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T30835
T30904
T42205

NCBI Reference Sequences

More...
RefSeqi
NP_001074470.1, NM_001081001.2
NP_033895.2, NM_009765.3
XP_017176117.1, XM_017320628.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.236256

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044620; ENSMUSP00000038576; ENSMUSG00000041147
ENSMUST00000202313; ENSMUSP00000144150; ENSMUSG00000041147

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12190

UCSC genome browser

More...
UCSCi
uc009aty.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82270 mRNA Translation: AAB48306.1
U65594 mRNA Translation: AAC23702.1
U89652 mRNA Translation: AAB71377.1
AC154885 Genomic DNA No translation available.
U72947 mRNA Translation: AAB40720.1
U89503 Genomic DNA Translation: AAC53276.1
CCDSiCCDS39411.1
PIRiT30835
T30904
T42205
RefSeqiNP_001074470.1, NM_001081001.2
NP_033895.2, NM_009765.3
XP_017176117.1, XM_017320628.1
UniGeneiMm.236256

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIUX-ray3.10A2378-3115[»]
1MJEX-ray3.50A2378-3113[»]
ProteinModelPortaliP97929
SMRiP97929
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198384, 7 interactors
ComplexPortaliCPX-972 BRCC ubiquitin ligase complex
IntActiP97929, 2 interactors
MINTiP97929
STRINGi10090.ENSMUSP00000038576

PTM databases

iPTMnetiP97929
PhosphoSitePlusiP97929

Proteomic databases

EPDiP97929
jPOSTiP97929
MaxQBiP97929
PaxDbiP97929
PeptideAtlasiP97929
PRIDEiP97929

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044620; ENSMUSP00000038576; ENSMUSG00000041147
ENSMUST00000202313; ENSMUSP00000144150; ENSMUSG00000041147
GeneIDi12190
KEGGimmu:12190
UCSCiuc009aty.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
675
MGIiMGI:109337 Brca2

Phylogenomic databases

eggNOGiKOG4751 Eukaryota
ENOG410Y06W LUCA
GeneTreeiENSGT00390000003602
HOGENOMiHOG000139693
HOVERGENiHBG050731
InParanoidiP97929
KOiK08775
OMAiKAFMEDG
OrthoDBi257485at2759
TreeFamiTF105041

Enzyme and pathway databases

ReactomeiR-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Miscellaneous databases

EvolutionaryTraceiP97929

Protein Ontology

More...
PROi
PR:P97929

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041147 Expressed in 215 organ(s), highest expression level in embryo
CleanExiMM_BRCA2
ExpressionAtlasiP97929 baseline and differential
GenevisibleiP97929 MM

Family and domain databases

CDDicd04493 BRCA2DBD_OB1, 1 hit
cd04495 BRCA2DBD_OB3, 1 hit
InterProiView protein in InterPro
IPR015525 BRCA2
IPR015252 BRCA2_hlx
IPR036315 BRCA2_hlx_sf
IPR015187 BRCA2_OB_1
IPR015188 BRCA2_OB_3
IPR002093 BRCA2_repeat
IPR012340 NA-bd_OB-fold
IPR015205 Tower_dom
PANTHERiPTHR11289 PTHR11289, 1 hit
PfamiView protein in Pfam
PF09169 BRCA-2_helical, 1 hit
PF09103 BRCA-2_OB1, 1 hit
PF09104 BRCA-2_OB3, 1 hit
PF00634 BRCA2, 7 hits
PF09121 Tower, 1 hit
PIRSFiPIRSF002397 BRCA2, 1 hit
SMARTiView protein in SMART
SM01341 Tower, 1 hit
SUPFAMiSSF50249 SSF50249, 3 hits
SSF81872 SSF81872, 1 hit
PROSITEiView protein in PROSITE
PS50138 BRCA2_REPEAT, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRCA2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97929
Secondary accession number(s): F8VPU5, O35922, P97383
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2012
Last modified: January 16, 2019
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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