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UniProtKB - P97926 (OXYR_MOUSE)
Protein
Oxytocin receptor
Gene
Oxtr
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- oxytocin receptor activity Source: MGI
- peptide binding Source: GO_Central
- peptide hormone binding Source: MGI
- vasopressin receptor activity Source: GO_Central
GO - Biological processi
- digestive tract development Source: Ensembl
- eating behavior Source: MGI
- ERK1 and ERK2 cascade Source: MGI
- estrous cycle Source: Ensembl
- female pregnancy Source: GO_Central
- G protein-coupled receptor signaling pathway Source: MGI
- heart development Source: Ensembl
- maternal behavior Source: MGI
- maternal process involved in parturition Source: GO_Central
- memory Source: MGI
- negative regulation of gastric acid secretion Source: MGI
- positive regulation of blood pressure Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of norepinephrine secretion Source: MGI
- positive regulation of penile erection Source: MGI
- positive regulation of synapse assembly Source: MGI
- positive regulation of synaptic transmission, GABAergic Source: MGI
- positive regulation of synaptic transmission, glutamatergic Source: MGI
- positive regulation of uterine smooth muscle contraction Source: MGI
- positive regulation of vasoconstriction Source: GO_Central
- regulation of digestive system process Source: MGI
- regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
- response to amphetamine Source: MGI
- response to anoxia Source: MGI
- response to cocaine Source: Ensembl
- response to cytokine Source: Ensembl
- response to estradiol Source: Ensembl
- response to peptide hormone Source: Ensembl
- response to progesterone Source: Ensembl
- response to steroid hormone Source: MGI
- response to xenobiotic stimulus Source: Ensembl
- sleep Source: MGI
- social behavior Source: MGI
- sperm ejaculation Source: MGI
- suckling behavior Source: MGI
- telencephalon development Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-388479, Vasopressin-like receptors R-MMU-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Oxytocin receptorShort name: OT-R |
Gene namesi | Name:Oxtr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109147, Oxtr |
VEuPathDBi | HostDB:ENSMUSG00000049112 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- apical plasma membrane Source: MGI
- integral component of plasma membrane Source: GO_Central
Other locations
- adherens junction Source: MGI
- microvillus Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 64 – 74 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 75 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 98 – 113 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 114 – 135 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 136 – 154 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 202 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 203 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 226 – 274 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 275 – 293 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 294 – 308 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 309 – 331 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 332 – 388 | CytoplasmicSequence analysisAdd BLAST | 57 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070000 | 1 – 388 | Oxytocin receptorAdd BLAST | 388 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 112 ↔ 187 | PROSITE-ProRule annotation | ||
Modified residuei | 365 | PhosphoserineBy similarity | 1 | |
Modified residuei | 367 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P97926 |
PRIDEi | P97926 |
ProteomicsDBi | 294414 |
PTM databases
GlyGeni | P97926, 2 sites |
iPTMneti | P97926 |
PhosphoSitePlusi | P97926 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000049112, Expressed in white adipose tissue and 128 other tissues |
ExpressionAtlasi | P97926, baseline and differential |
Genevisiblei | P97926, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000051132 |
Chemistry databases
BindingDBi | P97926 |
Miscellaneous databases
RNActi | P97926, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 354 – 388 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 358 – 388 | Polar residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230440 |
HOGENOMi | CLU_009579_15_3_1 |
InParanoidi | P97926 |
OMAi | YVIFSWL |
OrthoDBi | 890925at2759 |
PhylomeDBi | P97926 |
TreeFami | TF106499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002062, Oxytocn_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24241:SF89, PTHR24241:SF89, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00665, OXYTOCINR PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97926-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASVP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGSDAAGG
260 270 280 290 300
AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD
310 320 330 340 350
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY
360 370 380
LKGSRPGETS ISKKSNSSTF VLSRRSSSQR SCSQPSSA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SVY6 | A0A0N4SVY6_MOUSE | Oxytocin receptor | Oxtr | 75 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 375 | R → C in BAA18995 (PubMed:9027321).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86599 mRNA Translation: BAA18995.1 D86631 Genomic DNA Translation: BAA18996.1 AC153594 Genomic DNA No translation available. |
CCDSi | CCDS39588.1 |
RefSeqi | NP_001074616.1, NM_001081147.1 XP_006505786.1, XM_006505723.1 |
Genome annotation databases
Ensembli | ENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112 |
GeneIDi | 18430 |
KEGGi | mmu:18430 |
UCSCi | uc009deb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86599 mRNA Translation: BAA18995.1 D86631 Genomic DNA Translation: BAA18996.1 AC153594 Genomic DNA No translation available. |
CCDSi | CCDS39588.1 |
RefSeqi | NP_001074616.1, NM_001081147.1 XP_006505786.1, XM_006505723.1 |
3D structure databases
SMRi | P97926 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000051132 |
Chemistry databases
BindingDBi | P97926 |
ChEMBLi | CHEMBL3243907 |
GuidetoPHARMACOLOGYi | 369 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P97926, 2 sites |
iPTMneti | P97926 |
PhosphoSitePlusi | P97926 |
Proteomic databases
PaxDbi | P97926 |
PRIDEi | P97926 |
ProteomicsDBi | 294414 |
Protocols and materials databases
Antibodypediai | 10144, 383 antibodies from 35 providers |
DNASUi | 18430 |
Genome annotation databases
Ensembli | ENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112 |
GeneIDi | 18430 |
KEGGi | mmu:18430 |
UCSCi | uc009deb.1, mouse |
Organism-specific databases
CTDi | 5021 |
MGIi | MGI:109147, Oxtr |
VEuPathDBi | HostDB:ENSMUSG00000049112 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230440 |
HOGENOMi | CLU_009579_15_3_1 |
InParanoidi | P97926 |
OMAi | YVIFSWL |
OrthoDBi | 890925at2759 |
PhylomeDBi | P97926 |
TreeFami | TF106499 |
Enzyme and pathway databases
Reactomei | R-MMU-388479, Vasopressin-like receptors R-MMU-416476, G alpha (q) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 18430, 1 hit in 64 CRISPR screens |
PROi | PR:P97926 |
RNActi | P97926, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049112, Expressed in white adipose tissue and 128 other tissues |
ExpressionAtlasi | P97926, baseline and differential |
Genevisiblei | P97926, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002062, Oxytocn_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24241:SF89, PTHR24241:SF89, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00665, OXYTOCINR PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OXYR_MOUSE | |
Accessioni | P97926Primary (citable) accession number: P97926 Secondary accession number(s): F8VQ78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | October 16, 2013 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families