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Entry version 186 (12 Aug 2020)
Sequence version 3 (23 Oct 2007)
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Protein

Kalirin

Gene

Kalrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.3 Publications

Miscellaneous

Called DUO because the encoded protein is closely related to but shorter than TRIO.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2686ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2776Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2663 – 2671ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-193648, NRAGE signals death through JNK
R-RNO-194840, Rho GTPase cycle
R-RNO-3928662, EPHB-mediated forward signaling
R-RNO-416476, G alpha (q) signalling events
R-RNO-416482, G alpha (12/13) signalling events
R-RNO-5687128, MAPK6/MAPK4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kalirin1 Publication (EC:2.7.11.1)
Alternative name(s):
Huntingtin-associated protein-interacting protein
PAM COOH-terminal interactor protein 10
Short name:
P-CIP10
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KalrnImported
Synonyms:Duo, Hapip
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...
RGDi
621865, Kalrn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176786

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809561 – 2959KalirinAdd BLAST2959

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1723PhosphoserineBy similarity1
Modified residuei1726PhosphoserineBy similarity1
Modified residuei1772PhosphoserineCombined sources1
Modified residuei1785PhosphothreonineCombined sources1
Modified residuei1790PhosphoserineCombined sources1
Modified residuei1885PhosphothreonineBy similarity1
Modified residuei2234PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2465 ↔ 2521PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97924

PRoteomics IDEntifications database

More...
PRIDEi
P97924

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97924

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97924

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brain and nervous system. Isoform 6 is highly enriched in the postsynaptic density fraction of the cerebral cortex.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoforms 1 and 7 are prevelant 2 dpp, isoform 6 is not detectable until 2 weeks after birth.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001706, Expressed in frontal cortex and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P97924, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1).

Interacts with FASLG (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P97924

Protein interaction database and analysis system

More...
IntActi
P97924, 7 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000039072

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12959
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97924

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P97924

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 162CRAL-TRIOPROSITE-ProRule annotationAdd BLAST146
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati149 – 290Spectrin 1Sequence analysisAdd BLAST142
Repeati292 – 399Spectrin 2Sequence analysisAdd BLAST108
Repeati400 – 517Spectrin 3Sequence analysisAdd BLAST118
Repeati518 – 621Spectrin 4Sequence analysisAdd BLAST104
Repeati622 – 752Spectrin 5Sequence analysisAdd BLAST131
Repeati753 – 870Spectrin 6Sequence analysisAdd BLAST118
Repeati871 – 977Spectrin 7Sequence analysisAdd BLAST107
Repeati978 – 1101Spectrin 8Sequence analysisAdd BLAST124
Repeati1102 – 1207Spectrin 9Sequence analysisAdd BLAST106
Domaini1254 – 1429DH 1PROSITE-ProRule annotationAdd BLAST176
Domaini1441 – 1553PH 1PROSITE-ProRule annotationAdd BLAST113
Domaini1619 – 1684SH3 1PROSITE-ProRule annotationAdd BLAST66
Domaini1901 – 2076DH 2PROSITE-ProRule annotationAdd BLAST176
Domaini2088 – 2198PH 2PROSITE-ProRule annotationAdd BLAST111
Domaini2293 – 2358SH3 2PROSITE-ProRule annotationAdd BLAST66
Domaini2444 – 2537Ig-like C2-typeAdd BLAST94
Domaini2544 – 2638Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini2657 – 2911Protein kinasePROSITE-ProRule annotationAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi664 – 669Poly-Gln6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032, Eukaryota
KOG0613, Eukaryota
KOG4240, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155248

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97924

KEGG Orthology (KO)

More...
KOi
K15048

Database of Orthologous Groups

More...
OrthoDBi
5761at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97924

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 1 hit
cd00160, RhoGEF, 2 hits
cd00170, SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR028569, Kalirin
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF49, PTHR22826:SF49, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00650, CRAL_TRIO, 1 hit
PF00041, fn3, 1 hit
PF07679, I-set, 1 hit
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit
PF00621, RhoGEF, 2 hits
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00220, S_TKc, 1 hit
SM00516, SEC14, 1 hit
SM00326, SH3, 2 hits
SM00150, SPEC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 2 hits
SSF48726, SSF48726, 1 hit
SSF49265, SSF49265, 1 hit
SSF50044, SSF50044, 2 hits
SSF52087, SSF52087, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50010, DH_2, 2 hits
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50002, SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P97924-1) [UniParc]FASTAAdd to basket
Also known as: Kalirin-12A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLSGSFRND GLKASDVLPI LKEKVAFVSG GRDKRGGPIL TFPARTNHDR
60 70 80 90 100
IRQEDLRKLV TNLASVPSED VCKRGFTVII DMRGSKWDLI KPLLKTLQEA
110 120 130 140 150
FPAEIHVALI IKPDNFWQKQ KTNFGSSKFI FETSMVSVEG LTKLVDPSQL
160 170 180 190 200
TEEFDGSLDY NHEEWIELRL SLEEFFNSAV HLLSRLEDLQ EMLARKEFPV
210 220 230 240 250
DVEGSRRLID EHTQLKKKVL KAPVEELDRE GQRLLQCIRC SDGFSGRNCI
260 270 280 290 300
PGSADFQSLV PKITSLLDKL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD
310 320 330 340 350
AEKMFDWISH NKELFLQSHT EIGVSYQHAL DLQTQHNHFA MNSMNAYVNI
360 370 380 390 400
NRIMSVASRL SEAGHYASQQ IKQISTQLDQ EWKSFAAALD ERSTILAMSA
410 420 430 440 450
VFHQKAEQFL SGVDAWCKMC SEGGLPSEMQ DLELAIHHHQ SLYEQVTQAY
460 470 480 490 500
TEVSQDGKAL LDVLQRPLSP GNSESLTATA NYSKAVHQVL DVVHEVLHHQ
510 520 530 540 550
RRLESIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA FLSKHTGVGK
560 570 580 590 600
SLHRARALQK RHDDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYKA
610 620 630 640 650
ARHLEVRIQD FVRRVEQRKL LLDMSVSFHT HTKELWTWME DLQKEVLEDV
660 670 680 690 700
CADSVDAVQE LIKQFQQQQT ATLDATLNVI KEGEDLIQQL RSAPPSLGEP
710 720 730 740 750
TEARDSAVSN NKTPHSSSIS HIESVLQQLD DAQVQMEELF HERKIKLDIF
760 770 780 790 800
LQLRIFEQYT IEVTAELDAW NEDLLRQMND FNTEDLTLAE QRLQRHTERK
810 820 830 840 850
LAMNNMTFEV IQQGQDLHQY IMEVQASGIE LICEKDVDLA AQVQELLEFL
860 870 880 890 900
HEKQHELELN AEQTHKRLEQ CLQLRHLQAE VKQVLGWIRN GESMLNASLV
910 920 930 940 950
NASSLSEAEQ LQREHEQFQL AIEKTHQSAL QVQQKAEALL QAGHYDADAI
960 970 980 990 1000
RECAEKVALH WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYR
1010 1020 1030 1040 1050
RDEDWCGGRD KLGPAAEMDH VIPLLSKHLE QKEAFLKACT LARRNAEVFL
1060 1070 1080 1090 1100
KYIHRNNVSM PSVASHTRGP EQQVKAILSE LLQRENRVLH FWTLKKRRLD
1110 1120 1130 1140 1150
QCQQYVVFER SAKQALDWIQ ETGEYYLSTH TSTGETTEET QELLKEYGEF
1160 1170 1180 1190 1200
RVPAKQTKEK VKLLIQLADS FVEKGHIHAT EIRKWVTTVD KHYRDFSLRM
1210 1220 1230 1240 1250
GKYRYTLEKA LGVNTEDNKD LELDIIPASL SDREVKLRDA NHEVNEEKRK
1260 1270 1280 1290 1300
SARKKEFIMA ELLQTEKAYV RDLHECLETY LWEMTSGVEE IPPGILNKEH
1310 1320 1330 1340 1350
IIFGNIQEIY DFHNNIFLKE LEKYEQLPED VGHCFVTWAD KFQMYVTYCK
1360 1370 1380 1390 1400
NKPDSNQLIL EHAGTFFDEI QQRHGLANSI SSYLIKPVQR VTKYQLLLKE
1410 1420 1430 1440 1450
LLTCCEEGKG ELKDGLEVML SVPKKANDAM HVSMLEGFDE NLDVQGELIL
1460 1470 1480 1490 1500
QDAFQVWDPK SLIRKGRERH LFLFEISLVF SKEIKDSSGH TKYVYKNKLL
1510 1520 1530 1540 1550
TSELGVTEHV EGDPCKFALW SGRTPSSDNK TVLKASNIET KQEWIKNIRE
1560 1570 1580 1590 1600
VIQERIIHLK GALKEPIQLP KTPAKLRNNS KRDGVEDGDS QGDGSSQPDT
1610 1620 1630 1640 1650
ISIASRTSQN TVESDKLSGG CELTVVLQDF SAAHSSELSI QVGQTVELLE
1660 1670 1680 1690 1700
RPSERPGWCL VRTTERSPPQ EGLVPSSTLC ISHSRSSVEM DCFFPLVKDS
1710 1720 1730 1740 1750
YSHSSGENGG KSESVANLQS QPSLNSIHSS PGPKRSTNTL KKWLTSPVRR
1760 1770 1780 1790 1800
LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS ADEKSKKGWG
1810 1820 1830 1840 1850
EDEPDEESHT PLPPPMKIFD NDPTQDEMSS LLAARQAPTD VPTAADLVSA
1860 1870 1880 1890 1900
IEKLVKSKLT LEGGSYRGSL KDPTVCLNEG MAPPTPPRNL EEEQKAKALR
1910 1920 1930 1940 1950
GRMFVLNELV QTEKDYVKDL GIVVEGFMKR IEEKGVPEDM RGKEKIVFGN
1960 1970 1980 1990 2000
IHQIYDWHKD FFLAELEKCI QEQDRLAQLF IKHERKLHIY VWYCQNKPRS
2010 2020 2030 2040 2050
EYIVAEYDAY FEEVKQEINQ RLTLSDFLIK PIQRITKYQL LLKDFLRYSE
2060 2070 2080 2090 2100
KAGLECSDIE KAVELMCLVP KRCNDMMNLG RLQGFEGTLT AQGKLLQQDT
2110 2120 2130 2140 2150
FYVIELDAGM QSRTKERRVF LFEQIVIFSE LLRKGSLTPG YMFKRSIKMN
2160 2170 2180 2190 2200
YLVLEEDVDD DPCKFALMNR ETSERVILQA ANSDIQQAWV QDINQVLETQ
2210 2220 2230 2240 2250
RDFLNALQSP IEYQRKERST AVIRSQPPRV PQASPRPYSS VPVGSEKPPK
2260 2270 2280 2290 2300
GSSYNPPLPP LKISTSNGSP GFDYHQPGDK FDASKQNDLG GCNGTSTMAV
2310 2320 2330 2340 2350
IKDYYALKEN EICVSQGEVV QVLAVNQQNM CLVYQPASDH SPAAEGWVPG
2360 2370 2380 2390 2400
SILAPLTKAT APAESSDESI KKSCSWHTLR MRKRADVENT GKNEATGPRK
2410 2420 2430 2440 2450
PKDILGNKAS VKETNSSEES ECDDLDPNTS MEILNPNFIQ EVAPEFLVPL
2460 2470 2480 2490 2500
VDVTCLLGDT VLLQCKACGR PKPTITWKGP DQNILDTDNS SATYTISSCD
2510 2520 2530 2540 2550
SGESTLKICN LMPQDSGIYT CIATNDHGTA STSATVKVQG VPAAPNRPIA
2560 2570 2580 2590 2600
QERSCTSVIL RWLPPASTGN CTISGYTVEY REEGSQVWQQ SVASTLDTYL
2610 2620 2630 2640 2650
VIEDLSPGCP YQFRVSASNP WGISLPSEPS EFVHLPEYDA AADGATISWK
2660 2670 2680 2690 2700
ENFDSAYTEL NEIGRGRFSI VKKCIHKATR KDVAVKFVSK KMKKKEQAAH
2710 2720 2730 2740 2750
EAALLQHLQH PQYVTLHDTY ESPTSYILIL ELMDDGRLLD YLMNHDELME
2760 2770 2780 2790 2800
EKVAFYIRDI MEALQYLHNC RVAHLDIKPE NLLIDLRIPV PRVKLIDLED
2810 2820 2830 2840 2850
AVQISGHFHI HHLLGNPEFA APEVIQGIPV SLGTDIWSIG VLTYVMLSGV
2860 2870 2880 2890 2900
SPFLDESKEE TCINVCRVDF SFPHEYFCGV SNAARDFINV ILQEDFRRRP
2910 2920 2930 2940 2950
TAATCLQHPW LQPHNGSYSK IPLDTSRLAC FIERRKHQND VRPIPNVKSY

IVNRVNQGT
Note: Produced by alternative splicing.
Length:2,959
Mass (Da):336,587
Last modified:October 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A3C6770D1CBCC1F
GO
Isoform 2 (identifier: P97924-2) [UniParc]FASTAAdd to basket
Also known as: Kalirin-8B, P-CIP10B

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MNPPEGASEEGGAADSDVDAFFRT
     1860-1899: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSRV...HPDFVYSNCI
     1900-2959: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:1,919
Mass (Da):218,841
Checksum:iE4DBB818E890F453
GO
Isoform 3 (identifier: P97924-3) [UniParc]FASTAAdd to basket
Also known as: Kalirin-8A, P-CIP10A

The sequence of this isoform differs from the canonical sequence as follows:
     1860-1899: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSRV...HPDFVYSNCI
     1900-2959: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:1,899
Mass (Da):216,819
Checksum:iE3545E4CB9F59A1E
GO
Isoform 4 (identifier: P97924-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     923-923: E → ESLFHATSLQ

Note: Produced by alternative splicing.Curated
Show »
Length:2,968
Mass (Da):337,572
Checksum:i6B8B3C0E9FD8CDDC
GO
Isoform 5 (identifier: P97924-5) [UniParc]FASTAAdd to basket
Also known as: Delta Kalirin-7

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     1617-1636: LSGGCELTVVLQDFSAAHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2959: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 6.Curated
Show »
Length:1,013
Mass (Da):116,939
Checksum:i8C24887FBE316B64
GO
Isoform 6 (identifier: P97924-6) [UniParc]FASTAAdd to basket
Also known as: Kalirin-7, Kalirin-7c, HAPIP

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     1617-1636: LSGGCELTVVLQDFSAAHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2959: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:1,654
Mass (Da):191,116
Checksum:iC2C267C2226EF596
GO
Isoform 7 (identifier: P97924-7) [UniParc]FASTAAdd to basket
Also known as: Kalirin-9A

The sequence of this isoform differs from the canonical sequence as follows:
     2372-2376: KSCSW → TLLKP
     2377-2959: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:2,376
Mass (Da):271,353
Checksum:i3AEC5B08F483E75C
GO
Isoform 8 (identifier: P97924-8) [UniParc]FASTAAdd to basket
Also known as: Kalirin-4a

The sequence of this isoform differs from the canonical sequence as follows:
     705-718: DSAVSNNKTPHSSS → SAWAVIPVGNASG
     719-2959: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:717
Mass (Da):81,973
Checksum:i08AB2C8397ED9654
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LZV1F1LZV1_RAT
Non-specific serine/threonine prote...
Kalrn
2,977Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46T → S in AAT39517 (PubMed:15950621).Curated1
Sequence conflicti62N → Y in AAT39517 (PubMed:15950621).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0288931 – 623Missing in isoform 5. 1 PublicationAdd BLAST623
Alternative sequenceiVSP_0288911 – 4MVLS → MNPPEGASEEGGAADSDVDA FFRT in isoform 2. 2 Publications4
Alternative sequenceiVSP_0288921 – 4MVLS → MTDRFWDQWYLWYLRLLRLL DR in isoform 6. 1 Publication4
Alternative sequenceiVSP_028894705 – 718DSAVS…PHSSS → SAWAVIPVGNASG in isoform 8. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_028895719 – 2959Missing in isoform 8. 1 PublicationAdd BLAST2241
Alternative sequenceiVSP_028896923E → ESLFHATSLQ in isoform 4. 1 Publication1
Alternative sequenceiVSP_0288971617 – 1636LSGGC…AAHSS → DGNLVPRWHLGPGDPFSTYV in isoform 5 and isoform 6. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0288981637 – 2959Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST1323
Alternative sequenceiVSP_0288991860 – 1899TLEGG…KAKAL → VSGHAGGSRVLPLTSMWLPG PQLGPQISYLHPDFVYSNCI in isoform 2 and isoform 3. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_0289001900 – 2959Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST1060
Alternative sequenceiVSP_0289012372 – 2376KSCSW → TLLKP in isoform 7. 1 Publication5
Alternative sequenceiVSP_0289022377 – 2959Missing in isoform 7. 1 PublicationAdd BLAST583

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U88156 mRNA Translation: AAB66366.1
U88157 mRNA Translation: AAB66367.1
AF230644 mRNA Translation: AAF69144.1
AF229255 mRNA Translation: AAF66014.1
AF232668 mRNA Translation: AAF66018.1
AF232669 mRNA Translation: AAF66019.1
AY621095 mRNA Translation: AAT39517.1
U94189 mRNA Translation: AAC15790.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T32732
T42098

NCBI Reference Sequences

More...
RefSeqi
NP_114451.2, NM_032062.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000016340; ENSRNOP00000016340; ENSRNOG00000001706 [P97924-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84009

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:84009

UCSC genome browser

More...
UCSCi
RGD:621865, rat [P97924-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88156 mRNA Translation: AAB66366.1
U88157 mRNA Translation: AAB66367.1
AF230644 mRNA Translation: AAF69144.1
AF229255 mRNA Translation: AAF66014.1
AF232668 mRNA Translation: AAF66018.1
AF232669 mRNA Translation: AAF66019.1
AY621095 mRNA Translation: AAT39517.1
U94189 mRNA Translation: AAC15790.1
PIRiT32732
T42098
RefSeqiNP_114451.2, NM_032062.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U3ONMR-A1617-1686[»]
2KR9NMR-A1253-1432[»]
5O33X-ray1.64B1253-1432[»]
SMRiP97924
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

CORUMiP97924
IntActiP97924, 7 interactors
STRINGi10116.ENSRNOP00000039072

Chemistry databases

ChEMBLiCHEMBL2176786

PTM databases

iPTMnetiP97924
PhosphoSitePlusiP97924

Proteomic databases

PaxDbiP97924
PRIDEiP97924

Genome annotation databases

EnsembliENSRNOT00000016340; ENSRNOP00000016340; ENSRNOG00000001706 [P97924-5]
GeneIDi84009
KEGGirno:84009
UCSCiRGD:621865, rat [P97924-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8997
RGDi621865, Kalrn

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
KOG0613, Eukaryota
KOG4240, Eukaryota
GeneTreeiENSGT00940000155248
InParanoidiP97924
KOiK15048
OrthoDBi5761at2759
PhylomeDBiP97924

Enzyme and pathway databases

ReactomeiR-RNO-193648, NRAGE signals death through JNK
R-RNO-194840, Rho GTPase cycle
R-RNO-3928662, EPHB-mediated forward signaling
R-RNO-416476, G alpha (q) signalling events
R-RNO-416482, G alpha (12/13) signalling events
R-RNO-5687128, MAPK6/MAPK4 signaling

Miscellaneous databases

EvolutionaryTraceiP97924

Protein Ontology

More...
PROi
PR:P97924

Gene expression databases

BgeeiENSRNOG00000001706, Expressed in frontal cortex and 22 other tissues
ExpressionAtlasiP97924, baseline and differential

Family and domain databases

CDDicd00063, FN3, 1 hit
cd00160, RhoGEF, 2 hits
cd00170, SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR028569, Kalirin
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR22826:SF49, PTHR22826:SF49, 3 hits
PfamiView protein in Pfam
PF00650, CRAL_TRIO, 1 hit
PF00041, fn3, 1 hit
PF07679, I-set, 1 hit
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit
PF00621, RhoGEF, 2 hits
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 4 hits
SMARTiView protein in SMART
SM00060, FN3, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00220, S_TKc, 1 hit
SM00516, SEC14, 1 hit
SM00326, SH3, 2 hits
SM00150, SPEC, 7 hits
SUPFAMiSSF48065, SSF48065, 2 hits
SSF48726, SSF48726, 1 hit
SSF49265, SSF49265, 1 hit
SSF50044, SSF50044, 2 hits
SSF52087, SSF52087, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50010, DH_2, 2 hits
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50002, SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKALRN_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97924
Secondary accession number(s): O70135
, Q6IV51, Q9JIF1, Q9JIF2, Q9JIG0, Q9JIH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 23, 2007
Last modified: August 12, 2020
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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