UniProtKB - P97888 (2ABG_RAT)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Ppp2r2c
Functioni
GO - Molecular functioni
- protein phosphatase regulator activity Source: GO_Central
GO - Biological processi
- peptidyl-serine dephosphorylation Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoformAlternative name(s): PP2A subunit B isoform B55-gamma PP2A subunit B isoform BRgamma PP2A subunit B isoform PR55-gamma PP2A subunit B isoform R2-gamma PP2A subunit B isoform gamma |
Gene namesi | Name:Ppp2r2c |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620920, Ppp2r2c |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Other locations
- protein phosphatase type 2A complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071432 | 1 – 447 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoformAdd BLAST | 447 |
Proteomic databases
jPOSTi | P97888 |
PRIDEi | P97888 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity).
Interacts with IER5 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000007293 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 22 – 61 | WD 1Add BLAST | 40 | |
Repeati | 87 – 128 | WD 2Add BLAST | 42 | |
Repeati | 171 – 209 | WD 3Add BLAST | 39 | |
Repeati | 220 – 260 | WD 4Add BLAST | 41 | |
Repeati | 279 – 317 | WD 5Add BLAST | 39 | |
Repeati | 334 – 375 | WD 6Add BLAST | 42 | |
Repeati | 410 – 446 | WD 7Add BLAST | 37 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354, Eukaryota |
InParanoidi | P97888 |
OMAi | EFRYKSE |
OrthoDBi | 810409at2759 |
PhylomeDBi | P97888 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGEDTDTRKI NHSFLRDHSY VTEADVISTV EFNHTGELLA TGDKGGRVVI
60 70 80 90 100
FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ
110 120 130 140 150
QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV
160 170 180 190 200
PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH
210 220 230 240 250
LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC
260 270 280 290 300
DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
310 320 330 340 350
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYESDCIFD KFECAWNGSD
360 370 380 390 400
SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR
410 420 430 440
RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JWY9 | A0A0G2JWY9_RAT | Serine/threonine-protein phosphatas... | Ppp2r2c | 426 | Annotation score: | ||
A0A0G2K5X0 | A0A0G2K5X0_RAT | Serine/threonine-protein phosphatas... | Ppp2r2c | 320 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38261 mRNA Translation: BAA07413.1 |
RefSeqi | NP_476457.1, NM_057116.1 |
Genome annotation databases
GeneIDi | 117256 |
KEGGi | rno:117256 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38261 mRNA Translation: BAA07413.1 |
RefSeqi | NP_476457.1, NM_057116.1 |
3D structure databases
SMRi | P97888 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000007293 |
Proteomic databases
jPOSTi | P97888 |
PRIDEi | P97888 |
Genome annotation databases
GeneIDi | 117256 |
KEGGi | rno:117256 |
Organism-specific databases
CTDi | 5522 |
RGDi | 620920, Ppp2r2c |
Phylogenomic databases
eggNOGi | KOG1354, Eukaryota |
InParanoidi | P97888 |
OMAi | EFRYKSE |
OrthoDBi | 810409at2759 |
PhylomeDBi | P97888 |
Miscellaneous databases
PROi | PR:P97888 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABG_RAT | |
Accessioni | P97888Primary (citable) accession number: P97888 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families