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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

Batf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: RGD
  • DNA-binding transcription factor activity Source: InterPro
  • protein heterodimerization activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Alternative name(s):
Jun dimerization protein 1
Short name:
JDP-1
Gene namesi
Name:Batf3
Synonyms:Jdp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620501 Batf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261081 – 133Basic leucine zipper transcriptional factor ATF-like 3Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97876

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248847, 1 interactor
STRINGi10116.ENSRNOP00000004962

Structurei

3D structure databases

ProteinModelPortaliP97876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 91bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 55Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni56 – 84Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
HOGENOMiHOG000236325
HOVERGENiHBG096186
InParanoidiP97876
KOiK09034
PhylomeDBiP97876

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029818 p21SNFT
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF13 PTHR23351:SF13, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P97876-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGPPAGGV LQSSVAAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT
60 70 80 90 100
QKSDKLHEEH ESLEQENSVL RREIAKLKEE LRHLTEALKE HEKMCPLLLC
110 120 130
PMNFVQLRPD PVASWSAHDA PDHPSFIWLG TLV
Length:133
Mass (Da):15,129
Last modified:May 1, 1997 - v1
Checksum:i0A38C37121EB06F2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V6G9G3V6G9_RAT
Basic leucine zipper transcriptiona...
Batf3
133Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53450 Genomic DNA Translation: AAB49921.1
RefSeqiNP_068637.1, NM_021865.1
UniGeneiRn.211982

Genome annotation databases

GeneIDi60462
KEGGirno:60462

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53450 Genomic DNA Translation: AAB49921.1
RefSeqiNP_068637.1, NM_021865.1
UniGeneiRn.211982

3D structure databases

ProteinModelPortaliP97876
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248847, 1 interactor
STRINGi10116.ENSRNOP00000004962

Proteomic databases

PaxDbiP97876

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60462
KEGGirno:60462

Organism-specific databases

CTDi55509
RGDi620501 Batf3

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
HOGENOMiHOG000236325
HOVERGENiHBG096186
InParanoidiP97876
KOiK09034
PhylomeDBiP97876

Miscellaneous databases

PROiPR:P97876

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029818 p21SNFT
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF13 PTHR23351:SF13, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBATF3_RAT
AccessioniPrimary (citable) accession number: P97876
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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