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Protein

Jun dimerization protein 2

Gene

Jdp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • positive regulation of histone deacetylation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Jun dimerization protein 2
Gene namesi
Name:Jdp2
Synonyms:Jundm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1932093 Jdp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi148T → A: Blocks phosphorylation by MAPK8. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003311311 – 163Jun dimerization protein 2Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei148Phosphothreonine; by MAPK82 Publications1

Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.2 Publications
Polyubiquitinated; probably by IRF2BP1.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP97875
PaxDbiP97875
PeptideAtlasiP97875
PRIDEiP97875

PTM databases

iPTMnetiP97875
PhosphoSitePlusiP97875

Expressioni

Tissue specificityi

Ubiquitously expressed in all adult tissues tested as well in embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000034271
ExpressionAtlasiP97875 baseline and differential
GenevisibleiP97875 MM

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer. Interacts with IRF2BP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219888, 14 interactors
ELMiP97875
STRINGi10090.ENSMUSP00000059724

Structurei

3D structure databases

ProteinModelPortaliP97875
SMRiP97875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 135bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 96Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni100 – 128Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110847
HOGENOMiHOG000034126
HOVERGENiHBG057870
InParanoidiP97875
KOiK09033
OMAiXESERLE
OrthoDBiEOG091G0M4N
PhylomeDBiP97875
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029819 JDP2
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF10 PTHR23351:SF10, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P97875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL
60 70 80 90 100
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL
110 120 130 140 150
QRESERLELM NAELKTQIEE LKLERQQLIL MLNRHRPTCI VRTDSVRTPE
160
SEGNPLLEQL DKK
Length:163
Mass (Da):18,675
Last modified:June 1, 1998 - v2
Checksum:iA8AB65A7D20564F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077438 mRNA Translation: BAB83764.1
BC019780 mRNA Translation: AAH19780.1
CCDSiCCDS26060.1
RefSeqiNP_001191981.1, NM_001205052.1
NP_001191982.1, NM_001205053.1
NP_112149.2, NM_030887.2
UniGeneiMm.103560

Genome annotation databases

EnsembliENSMUST00000050687; ENSMUSP00000059724; ENSMUSG00000034271
ENSMUST00000171754; ENSMUSP00000129985; ENSMUSG00000034271
ENSMUST00000177587; ENSMUSP00000136823; ENSMUSG00000034271
GeneIDi81703
KEGGimmu:81703
UCSCiuc007ohb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiJDP2_MOUSE
AccessioniPrimary (citable) accession number: P97875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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