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Entry version 167 (02 Jun 2021)
Sequence version 5 (16 May 2006)
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Protein

E3 ubiquitin-protein ligase RBBP6

Gene

Rbbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity).

May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788).

Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri260 – 301RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA replication, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RBBP6 (EC:2.3.2.27)
Alternative name(s):
Proliferation potential-related protein
Protein P2P-R
RING-type E3 ubiquitin transferase RBBP6Curated
Retinoblastoma-binding protein 6
p53-associated cellular protein of testis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rbbp6
Synonyms:P2pr, Pact
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:894835, Rbbp6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Early embryonic lethality before 7.5 dpc, accompanied by accumulation of p53 and widespread apoptosis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343551 – 1790E3 ubiquitin-protein ligase RBBP6Add BLAST1790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei130N6-acetyllysineCombined sources1
Modified residuei245PhosphoserineBy similarity1
Modified residuei246PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1
Modified residuei361PhosphoserineCombined sources1
Modified residuei517PhosphoserineBy similarity1
Modified residuei769PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1
Modified residuei773PhosphoserineBy similarity1
Modified residuei781PhosphoserineBy similarity1
Modified residuei816PhosphoserineBy similarity1
Modified residuei862PhosphoserineBy similarity1
Modified residuei874PhosphoserineBy similarity1
Modified residuei958PhosphoserineBy similarity1
Modified residuei985PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1272PhosphothreonineCombined sources1
Modified residuei1278PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1342PhosphoserineBy similarity1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1469PhosphothreonineBy similarity1
Modified residuei1646PhosphoserineBy similarity1
Modified residuei1648PhosphoserineCombined sources1
Modified residuei1651PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P97868

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P97868

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97868

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97868

PeptideAtlas

More...
PeptideAtlasi
P97868

PRoteomics IDEntifications database

More...
PRIDEi
P97868

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
255114 [P97868-1]
255115 [P97868-2]
255116 [P97868-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97868

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97868

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Expressed at lower levels in brain, heart, kidney, liver, lung, skeletal muscle, spleen, thymus and tongue.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is reduced during terminal differentiation. Expression is induced in the G2/M phase of the cell cycle (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030779, Expressed in forelimb bud and 308 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P97868, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MDM2 and YBX1 (By similarity).

Interacts also with p53/TP53 and RB1.

Interacts with NEK6 (By similarity).

Interacts with ZBTB38 (By similarity).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
202817, 3 interactors

Protein interaction database and analysis system

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IntActi
P97868, 3 interactors

Molecular INTeraction database

More...
MINTi
P97868

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000049528

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P97868, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P97868

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97868

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 76DWNNPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni329 – 353DisorderedSequence analysisAdd BLAST25
Regioni374 – 408DisorderedSequence analysisAdd BLAST35
Regioni533 – 599DisorderedSequence analysisAdd BLAST67
Regioni622 – 641DisorderedSequence analysisAdd BLAST20
Regioni648 – 667DisorderedSequence analysisAdd BLAST20
Regioni675 – 797DisorderedSequence analysisAdd BLAST123
Regioni850 – 1292DisorderedSequence analysisAdd BLAST443
Regioni983 – 1139Interaction with RB1Add BLAST157
Regioni1322 – 1790DisorderedSequence analysisAdd BLAST469
Regioni1434 – 1544Interaction with p53Add BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi335 – 352Pro residuesSequence analysisAdd BLAST18
Compositional biasi554 – 599Pro residuesSequence analysisAdd BLAST46
Compositional biasi687 – 730Polar residuesSequence analysisAdd BLAST44
Compositional biasi736 – 767Basic residuesSequence analysisAdd BLAST32
Compositional biasi773 – 787Polar residuesSequence analysisAdd BLAST15
Compositional biasi905 – 930Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi983 – 1030Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi1037 – 1071Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi1084 – 1165Basic and acidic residuesSequence analysisAdd BLAST82
Compositional biasi1175 – 1204Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1220 – 1234Polar residuesSequence analysisAdd BLAST15
Compositional biasi1235 – 1256Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1258 – 1280Polar residuesSequence analysisAdd BLAST23
Compositional biasi1336 – 1361Polar residuesSequence analysisAdd BLAST26
Compositional biasi1362 – 1436Basic and acidic residuesSequence analysisAdd BLAST75
Compositional biasi1449 – 1579Basic and acidic residuesSequence analysisAdd BLAST131
Compositional biasi1647 – 1674Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1675 – 1723Polar residuesSequence analysisAdd BLAST49
Compositional biasi1726 – 1750Basic residuesSequence analysisAdd BLAST25
Compositional biasi1774 – 1790Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a N-terminus DWNN domain, a zinc-finger domain and a C4C4 zinc-binding RING finger domain (By similarity). The ring finger may indeed be a U-box domain (By similarity).By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri260 – 301RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0314, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_239162_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97868

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKPEHDS

Database of Orthologous Groups

More...
OrthoDBi
81368at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97868

TreeFam database of animal gene trees

More...
TreeFami
TF350543

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014891, DWNN_domain
IPR033489, RBBP6
IPR003613, Ubox_domain
IPR025829, Zn_knuckle_CX2CX3GHX4C
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR15439, PTHR15439, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08783, DWNN, 1 hit
PF04564, U-box, 1 hit
PF13696, zf-CCHC_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01180, DWNN, 1 hit
SM00184, RING, 1 hit
SM00343, ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756, SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51282, DWNN, 1 hit
PS50158, ZF_CCHC, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADSDLQITN
60 70 80 90 100
AQTKEEYTDD NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPVMGTTK
110 120 130 140 150
AIDDASASIS LAQLTKTANL AEANASEEDK IKAMMSQSGH EYDPINYMKK
160 170 180 190 200
TLVGPPPPSY TCFRCGKPGH YIKNCPTNGD KNFESGPRIK KSTGIPRSFM
210 220 230 240 250
MEVKDPNMKG AMLTNTGKYA IPTIDAEAYA IGKKEKPPFL PEEPSSSSEE
260 270 280 290 300
DDPIPDELLC LICKDIMTDA VVIPCCGNSY CDECIRTALL ESDEHTCPTC
310 320 330 340 350
HQNDVSPDAL IANKFLRQAV NNFKNETGYT KRLRKQLPPP PPPVPPPRPL
360 370 380 390 400
MQRNLQPLMR SPISRQQDPL MIPVTSSSAH SAPSISSLTS NPSALAPSVS
410 420 430 440 450
GNPSSAPAPV PDITATVSIS VHSEKSDGPF RDSDNKLLPA AALTSEHSKG
460 470 480 490 500
ASSIAITALM EEKGYQVPVL GTPSLLGQSL LHGQLIPTTG PVRINAARPG
510 520 530 540 550
GGRPGWEHSN KLGYLVSPPQ QIRRGERSCY RSINRGRHHS ERSQRTQGPS
560 570 580 590 600
LPATPVFVPV PPPPLYPPPP HTLPLPPGVP PPQFSPQFPP GQPPPAGYSV
610 620 630 640 650
PPPGFPPAPA NISTPWVSSG VQTAHSNTIP TTQAPPLSRE EFYREQRRLK
660 670 680 690 700
EEEKKKSKLD EFTNDFAKEL MEYKKIQKER RRSFSRSKSP YSGSSYSRSS
710 720 730 740 750
YTYSKSRSGS TRSRSYSRSF SRSHSRSYSR SPPYPRRGRG KSRNYRSRSR
760 770 780 790 800
SHGYHRSRSR SPPYRRYHSR SRSPQAFRGQ SPTKRNVPQG ETEREYFNRY
810 820 830 840 850
REVPPPYDIK AYYGRSVDFR DPFEKERYRE WERKYREWYE KYYKGYAVGA
860 870 880 890 900
QPRPSANRED FSPERLLPLN IRNSPFTRGR REDYAAGQSH RNRNLGGNYP
910 920 930 940 950
EKLSTRDSHN AKDNPKSKEK ESENVPGDGK GNKHKKHRKR RKGEESESFL
960 970 980 990 1000
NPELLETSRK CRESSGIDET KTDTLFVLPS RDDATPVRDE PMDAESITFK
1010 1020 1030 1040 1050
SVSDKDKREK DKPKVKSDKT KRKSDGSATA KKDNVLKPSK GPQEKVDGDR
1060 1070 1080 1090 1100
EKSPRSEPPL KKAKEEATKI DSVKPSSSSQ KDEKVTGTPR KAHSKSAKEH
1110 1120 1130 1140 1150
QEAKPAKDEK VKKDCSKDIK SEKPASKDEK AKKPEKNKLL DSKGEKRKRK
1160 1170 1180 1190 1200
TEEKSVDKDF ESSSMKISKV EGTEIVKPSP KRKMEGDVEK LERTPEKDKI
1210 1220 1230 1240 1250
ASSTTPAKKI KLNRETGKKI GNAENASTTK EPSEKLESTS SKIKQEKVKG
1260 1270 1280 1290 1300
KAKRKVAGSE GSSSTLVDYT STSSTGGSPV RKSEEKTDTK RTVIKTMEEY
1310 1320 1330 1340 1350
NNDNTAPAED VIIMIQVPQS KWDKDDFESE EEDVKTTQPI QSVGKPSSII
1360 1370 1380 1390 1400
KNVTTKPSAT AKYTEKESEQ PEKLQKLPKE ASHELMQHEL RSSKGSASSE
1410 1420 1430 1440 1450
KGRAKDREHS GSEKDNPDKR KSGAQPDKES TVDRLSEQGH FKTLSQSSKE
1460 1470 1480 1490 1500
TRTSEKHESV RGSSNKDFTP GRDKKVDYDS RDYSSSKRRD ERGELARRKD
1510 1520 1530 1540 1550
SPPRGKESLS GQKSKLREER DLPKKGAESK KSNSSPPRDK KPHDHKAPYE
1560 1570 1580 1590 1600
TKRPCEETKP VDKNSGKERE KHAAEARNGK ESSGGKLPCI PNPPDPPMEK
1610 1620 1630 1640 1650
ELAAGQVEKS AVKPKPQLSH SSRLSSDLTR ETDEAAFEPD YNESDSESNV
1660 1670 1680 1690 1700
SVKEEEAVAS ISKDLKEKTT EKAKESLTVA TASQPGADRS QSQSSPSVSP
1710 1720 1730 1740 1750
SRSHSPSGSQ TRSHSSSASS AGSQDSKKKK KKKEKKKHKK HKKHKKHKKH
1760 1770 1780 1790
AGADGDVEKS QKHKHKKKKA KKNKDKEKEK DDQKVRSVTV
Length:1,790
Mass (Da):199,587
Last modified:May 16, 2006 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3909C30EB9DD2CE3
GO
Isoform 2 (identifier: P97868-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     653-686: Missing.

Show »
Length:1,756
Mass (Da):195,310
Checksum:iE3C0F009CC28107E
GO
Isoform 3 (identifier: P97868-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-123: IDDASASISLAQLTKTANLAEA → VCKNTITLFLHNCFYLYNVSVT
     124-1756: Missing.

Show »
Length:157
Mass (Da):17,888
Checksum:i39B749141C9B2FA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P6W1A0A338P6W1_MOUSE
E3 ubiquitin-protein ligase RBBP6
Rbbp6
1,759Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J165A0A0R4J165_MOUSE
E3 ubiquitin-protein ligase RBBP6
Rbbp6
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZU8D3YZU8_MOUSE
E3 ubiquitin-protein ligase RBBP6
Rbbp6
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNZ1A0A0U1RNZ1_MOUSE
E3 ubiquitin-protein ligase RBBP6
Rbbp6
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC72432 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254I → F in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti317 – 318RQ → GR in AAC72432 (PubMed:9037032).Curated2
Sequence conflicti341P → H in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti418S → F in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti421V → S in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti580P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti595P → T in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti615 – 622PWVSSGVQ → ACFSPGVP in AAC72432 (PubMed:9037032).Curated8
Sequence conflicti629I → M in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti636P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti647R → K in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti689S → F in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti703Y → D in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti789Q → R in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti940R → Q in BAE36255 (PubMed:16141072).Curated1
Sequence conflicti941R → RNEE in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti956 – 958ETS → GKF in AAC72432 (PubMed:9037032).Curated3
Sequence conflicti963E → G in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti978L → F in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti982D → E in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1012K → N in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti1290K → T in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1316Q → H in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1564N → I in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1581E → D in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1591P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1596P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1604A → V in AAC72432 (PubMed:9037032).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018285102 – 123IDDAS…NLAEA → VCKNTITLFLHNCFYLYNVS VT in isoform 3. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_018286124 – 1756Missing in isoform 3. 2 PublicationsAdd BLAST1633
Alternative sequenceiVSP_018287653 – 686Missing in isoform 2. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK045635 mRNA Translation: BAC32441.1
AK079129 mRNA Translation: BAC37553.1
AK081261 mRNA Translation: BAC38179.1
AK144758 mRNA Translation: BAE26051.1
AK160656 mRNA Translation: BAE35944.1
AK161231 mRNA Translation: BAE36255.1
AC125221 Genomic DNA No translation available.
BC025874 mRNA Translation: AAH25874.1
U83913 mRNA Translation: AAC72432.1 Frameshift.
U28789 mRNA Translation: AAB49620.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52387.1 [P97868-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42727

NCBI Reference Sequences

More...
RefSeqi
NP_035377.2, NM_011247.2 [P97868-1]
NP_778188.1, NM_175023.3
XP_006507533.1, XM_006507470.3 [P97868-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000052135; ENSMUSP00000049528; ENSMUSG00000030779 [P97868-1]
ENSMUST00000071590; ENSMUSP00000071519; ENSMUSG00000030779 [P97868-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19647

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19647

UCSC genome browser

More...
UCSCi
uc009jow.2, mouse [P97868-3]
uc009joy.2, mouse [P97868-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045635 mRNA Translation: BAC32441.1
AK079129 mRNA Translation: BAC37553.1
AK081261 mRNA Translation: BAC38179.1
AK144758 mRNA Translation: BAE26051.1
AK160656 mRNA Translation: BAE35944.1
AK161231 mRNA Translation: BAE36255.1
AC125221 Genomic DNA No translation available.
BC025874 mRNA Translation: AAH25874.1
U83913 mRNA Translation: AAC72432.1 Frameshift.
U28789 mRNA Translation: AAB49620.1
CCDSiCCDS52387.1 [P97868-1]
PIRiT42727
RefSeqiNP_035377.2, NM_011247.2 [P97868-1]
NP_778188.1, NM_175023.3
XP_006507533.1, XM_006507470.3 [P97868-2]

3D structure databases

BMRBiP97868
SMRiP97868
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202817, 3 interactors
IntActiP97868, 3 interactors
MINTiP97868
STRINGi10090.ENSMUSP00000049528

PTM databases

iPTMnetiP97868
PhosphoSitePlusiP97868

Proteomic databases

EPDiP97868
jPOSTiP97868
MaxQBiP97868
PaxDbiP97868
PeptideAtlasiP97868
PRIDEiP97868
ProteomicsDBi255114 [P97868-1]
255115 [P97868-2]
255116 [P97868-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26070, 350 antibodies

The DNASU plasmid repository

More...
DNASUi
19647

Genome annotation databases

EnsembliENSMUST00000052135; ENSMUSP00000049528; ENSMUSG00000030779 [P97868-1]
ENSMUST00000071590; ENSMUSP00000071519; ENSMUSG00000030779 [P97868-2]
GeneIDi19647
KEGGimmu:19647
UCSCiuc009jow.2, mouse [P97868-3]
uc009joy.2, mouse [P97868-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5930
MGIiMGI:894835, Rbbp6

Phylogenomic databases

eggNOGiKOG0314, Eukaryota
GeneTreeiENSGT00940000157561
HOGENOMiCLU_239162_0_0_1
InParanoidiP97868
OMAiKKPEHDS
OrthoDBi81368at2759
PhylomeDBiP97868
TreeFamiTF350543

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
19647, 25 hits in 51 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rbbp6, mouse

Protein Ontology

More...
PROi
PR:P97868
RNActiP97868, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030779, Expressed in forelimb bud and 308 other tissues
GenevisibleiP97868, MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR014891, DWNN_domain
IPR033489, RBBP6
IPR003613, Ubox_domain
IPR025829, Zn_knuckle_CX2CX3GHX4C
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR15439, PTHR15439, 2 hits
PfamiView protein in Pfam
PF08783, DWNN, 1 hit
PF04564, U-box, 1 hit
PF13696, zf-CCHC_2, 1 hit
SMARTiView protein in SMART
SM01180, DWNN, 1 hit
SM00184, RING, 1 hit
SM00343, ZnF_C2HC, 1 hit
SUPFAMiSSF57756, SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS51282, DWNN, 1 hit
PS50158, ZF_CCHC, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBBP6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97868
Secondary accession number(s): P70287
, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: June 2, 2021
This is version 167 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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