Caspase-7

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-. EC:3.4.22.60

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• aspartic-type endopeptidase activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• cysteine-type endopeptidase activity Source: UniProtKBInferred from direct assayⁱ
  • "Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity."
    Demon D., Van Damme P., Vanden Berghe T., Deceuninck A., Van Durme J., Verspurten J., Helsens K., Impens F., Wejda M., Schymkowitz J., Rousseau F., Madder A., Vandekerckhove J., Declercq W., Gevaert K., Vandenabeele P.
    Mol. Cell Proteomics 8:2700-2714(2009) [PubMed] [Europe PMC] [Abstract]
• cysteine-type endopeptidase activity involved in apoptotic process Source: MGIInferred from direct assayⁱ
  • "Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD."
    Berube C., Boucher L.M., Ma W., Wakeham A., Salmena L., Hakem R., Yeh W.C., Mak T.W., Benchimol S.
    Proc. Natl. Acad. Sci. U.S.A. 102:14314-14320(2005) [PubMed] [Europe PMC] [Abstract]
• cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: MGI
• cysteine-type peptidase activity Source: MGI
• peptidase activity Source: MGI

GO - Biological processⁱ

• aging Source: Ensembl
• apoptotic process Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Caspases 3 and 7: key mediators of mitochondrial events of apoptosis."
    Lakhani S.A., Masud A., Kuida K., Porter G.A. Jr., Booth C.J., Mehal W.Z., Inayat I., Flavell R.A.
    Science 311:847-851(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to staurosporine Source: MGI
• execution phase of apoptosis Source: MGIInferred from genetic interactionⁱ
  • "Caspases 3 and 7: key mediators of mitochondrial events of apoptosis."
    Lakhani S.A., Masud A., Kuida K., Porter G.A. Jr., Booth C.J., Mehal W.Z., Inayat I., Flavell R.A.
    Science 311:847-851(2006) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from genetic interactionⁱ
  • "Caspases 3 and 7: key mediators of mitochondrial events of apoptosis."
    Lakhani S.A., Masud A., Kuida K., Porter G.A. Jr., Booth C.J., Mehal W.Z., Inayat I., Flavell R.A.
    Science 311:847-851(2006) [PubMed] [Europe PMC] [Abstract]
• leukocyte apoptotic process Source: Ensembl
• neuron apoptotic process Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• protein processing Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• proteolysis Source: MGI
• response to UV Source: MGIInferred from genetic interactionⁱ
  • "Caspases 3 and 7: key mediators of mitochondrial events of apoptosis."
    Lakhani S.A., Masud A., Kuida K., Porter G.A. Jr., Booth C.J., Mehal W.Z., Inayat I., Flavell R.A.
    Science 311:847-851(2006) [PubMed] [Europe PMC] [Abstract]
• striated muscle cell differentiation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MTDDQDCAAE LEKVDSSSED GVDAKPDRSS IISSILLKKK RNASAGPVRT 
        60         70         80         90        100
GRDRVPTYLY RMDFQKMGKC IIINNKNFDK ATGMDVRNGT DKDAGALFKC 
       110        120        130        140        150
FQNLGFEVTV HNDCSCAKMQ DLLRKASEED HSNSACFACV LLSHGEEDLI 
       160        170        180        190        200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG 
       210        220        230        240        250
PINDIDANPR NKIPVEADFL FAYSTVPGYY SWRNPGKGSW FVQALCSILN 
       260        270        280        290        300
EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP RFNEKKQIPC MVSMLTKELY 

FSR                                                    

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Peptidase families
   Classification of peptidase families and list of entries
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot