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Protein

Heart- and neural crest derivatives-expressed protein 1

Gene

Hand1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heart- and neural crest derivatives-expressed protein 1
Alternative name(s):
Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
Short name:
eHAND
Gene namesi
Name:Hand1
Synonyms:Ehand
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621206 Hand1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271871 – 216Heart- and neural crest derivatives-expressed protein 1Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107Phosphothreonine; by PLK4By similarity1
Modified residuei109Phosphoserine; by PLK4By similarity1

Post-translational modificationi

Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97832

PTM databases

iPTMnetiP97832

Expressioni

Gene expression databases

BgeeiENSRNOG00000002582 Expressed in 2 organ(s), highest expression level in colon
GenevisibleiP97832 RN

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003486

Structurei

3D structure databases

ProteinModelPortaliP97832
SMRiP97832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 146bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 17Poly-His9
Compositional biasi66 – 71Poly-Ala6

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000232082
HOVERGENiHBG051880
InParanoidiP97832
KOiK09071
OMAiRPYFQSW
OrthoDBiEOG091G0MSL
PhylomeDBiP97832
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P97832-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLVGSYAHH HHHHHSHPPH PMLHEPFLFG PASRCHQERP YFQSWLLSPA
60 70 80 90 100
DAAPDFPAGG PPPTTAVAAA AYGPDARPSQ SPGRLEALGG RLPRRKGSGP
110 120 130 140 150
KKERRRTESI NSAFAELREC IPNVPADTKL SKIKTLRLAT SYIAYLMDVL
160 170 180 190 200
AKDAQAGDPE AFKAELKKTD GGRESKRKRE SPQQHEGLPP ALGPSEKRIK
210
GRTGWPQQVW ALELNQ
Length:216
Mass (Da):23,810
Last modified:May 1, 1999 - v2
Checksum:iFD047598350C9BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08140 mRNA Translation: CAA69334.1
BC097324 mRNA Translation: AAH97324.1
RefSeqiNP_067603.1, NM_021592.2
UniGeneiRn.39340

Genome annotation databases

EnsembliENSRNOT00000003486; ENSRNOP00000003486; ENSRNOG00000002582
GeneIDi59112
KEGGirno:59112
UCSCiRGD:621206 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08140 mRNA Translation: CAA69334.1
BC097324 mRNA Translation: AAH97324.1
RefSeqiNP_067603.1, NM_021592.2
UniGeneiRn.39340

3D structure databases

ProteinModelPortaliP97832
SMRiP97832
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003486

PTM databases

iPTMnetiP97832

Proteomic databases

PaxDbiP97832

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003486; ENSRNOP00000003486; ENSRNOG00000002582
GeneIDi59112
KEGGirno:59112
UCSCiRGD:621206 rat

Organism-specific databases

CTDi9421
RGDi621206 Hand1

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000232082
HOVERGENiHBG051880
InParanoidiP97832
KOiK09071
OMAiRPYFQSW
OrthoDBiEOG091G0MSL
PhylomeDBiP97832
TreeFamiTF315153

Miscellaneous databases

PROiPR:P97832

Gene expression databases

BgeeiENSRNOG00000002582 Expressed in 2 organ(s), highest expression level in colon
GenevisibleiP97832 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHAND1_RAT
AccessioniPrimary (citable) accession number: P97832
Secondary accession number(s): Q4V8L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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