UniProtKB - P97821 (CATC_MOUSE)
Protein
Dipeptidyl peptidase 1
Gene
Ctsc
Organism
Mus musculus (Mouse)
Status
Functioni
Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.
Catalytic activityi
- Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro. EC:3.4.14.1
Cofactori
chlorideBy similarityNote: Binds 1 Cl- ion per heavy chain.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 257 | By similarity | 1 | |
Binding sitei | 301 | ChlorideBy similarity | 1 | |
Binding sitei | 303 | Chloride; via amide nitrogenBy similarity | 1 | |
Binding sitei | 346 | ChlorideBy similarity | 1 | |
Active sitei | 404 | By similarity | 1 | |
Active sitei | 426 | By similarity | 1 |
GO - Molecular functioni
- chaperone binding Source: MGI
- chloride ion binding Source: MGI
- cysteine-type endopeptidase activity Source: GO_Central
- cysteine-type peptidase activity Source: MGI
- identical protein binding Source: MGI
- peptidase activator activity involved in apoptotic process Source: MGI
- phosphatase binding Source: MGI
- protein self-association Source: MGI
- serine-type endopeptidase activity Source: UniProtKB
GO - Biological processi
- aging Source: Ensembl
- negative regulation of myelination Source: MGI
- positive regulation of apoptotic signaling pathway Source: MGI
- positive regulation of microglial cell activation Source: MGI
- positive regulation of proteolysis involved in cellular protein catabolic process Source: MGI
- proteolysis Source: UniProtKB
- proteolysis involved in cellular protein catabolic process Source: GO_Central
- response to organic substance Source: MGI
- T cell mediated cytotoxicity Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Ligand | Chloride |
Enzyme and pathway databases
BRENDAi | 3.4.14.1, 3474 |
Reactomei | R-MMU-204005, COPII-mediated vesicle transport R-MMU-2132295, MHC class II antigen presentation R-MMU-5694530, Cargo concentration in the ER R-MMU-6798695, Neutrophil degranulation |
Protein family/group databases
MEROPSi | C01.070 |
Names & Taxonomyi
Protein namesi | Recommended name: Dipeptidyl peptidase 1 (EC:3.4.14.1)Alternative name(s): Cathepsin C Cathepsin J Dipeptidyl peptidase I Short name: DPP-I Short name: DPPI Dipeptidyl transferase Cleaved into the following 3 chains: Alternative name(s): Dipeptidyl peptidase I exclusion domain chain Alternative name(s): Dipeptidyl peptidase I heavy chain Alternative name(s): Dipeptidyl peptidase I light chain |
Gene namesi | Name:Ctsc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109553, Ctsc |
Subcellular locationi
Lysosome
Cytoskeleton
- centrosome Source: MGI
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: MGI
Lysosome
- lysosome Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
LysosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000026346 | 25 – 134 | Dipeptidyl peptidase 1 exclusion domain chainBy similarityAdd BLAST | 110 | |
PropeptideiPRO_0000026347 | 135 – 230 | By similarityAdd BLAST | 96 | |
ChainiPRO_0000026348 | 231 – 393 | Dipeptidyl peptidase 1 heavy chainAdd BLAST | 163 | |
ChainiPRO_0000026349 | 394 – 462 | Dipeptidyl peptidase 1 light chainAdd BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 30 ↔ 118 | By similarity | ||
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 54 ↔ 136 | By similarity | ||
Disulfide bondi | 254 ↔ 297 | By similarity | ||
Glycosylationi | 275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 290 ↔ 330 | By similarity | ||
Disulfide bondi | 320 ↔ 336 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | P97821 |
jPOSTi | P97821 |
PaxDbi | P97821 |
PeptideAtlasi | P97821 |
PRIDEi | P97821 |
PTM databases
GlyGeni | P97821, 3 sites |
iPTMneti | P97821 |
PhosphoSitePlusi | P97821 |
SwissPalmi | P97821 |
Expressioni
Tissue specificityi
Broadly distributed, but higher levels found in lung, liver, kidney and spleen. Lower levels found in testis and brain.
Gene expression databases
Bgeei | ENSMUSG00000030560, Expressed in lymph node and 302 other tissues |
Genevisiblei | P97821, MM |
Interactioni
Subunit structurei
Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
By similarityGO - Molecular functioni
- chaperone binding Source: MGI
- identical protein binding Source: MGI
- phosphatase binding Source: MGI
- protein self-association Source: MGI
Protein-protein interaction databases
BioGRIDi | 198969, 1 interactor |
IntActi | P97821, 1 interactor |
MINTi | P97821 |
STRINGi | 10090.ENSMUSP00000032779 |
Chemistry databases
BindingDBi | P97821 |
Miscellaneous databases
RNActi | P97821, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1543, Eukaryota |
GeneTreei | ENSGT00940000155787 |
HOGENOMi | CLU_048219_0_0_1 |
InParanoidi | P97821 |
OMAi | FVTPVRN |
OrthoDBi | 1275401at2759 |
PhylomeDBi | P97821 |
TreeFami | TF313225 |
Family and domain databases
CDDi | cd02621, Peptidase_C1A_CathepsinC, 1 hit |
Gene3Di | 2.40.128.80, 1 hit |
InterProi | View protein in InterPro IPR039412, CatC IPR014882, CathepsinC_exc IPR036496, CathepsinC_exc_dom_sf IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C |
Pfami | View protein in Pfam PF08773, CathepsinC_exc, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF75001, SSF75001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P97821-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS
60 70 80 90 100
DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNWACFVGK KVESHIEKVN
160 170 180 190 200
MNAAHLGGLQ ERYSERLYTH NHNFVKAINT VQKSWTATAY KEYEKMSLRD
210 220 230 240 250
LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ GVNYVSPVRN
260 270 280 290 300
QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG
310 320 330 340 350
FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF
360 370 380 390 400
YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE
410 420 430 440 450
LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE
460
SIAVAAIPIP KL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U7T5 | Q3U7T5_MOUSE | Dipeptidyl peptidase 1 | Ctsc | 137 | Annotation score: | ||
D3Z220 | D3Z220_MOUSE | Dipeptidyl peptidase 1 | Ctsc | 254 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89269 mRNA Translation: AAB49457.1 U74683 mRNA Translation: AAB58400.3 BC067063 mRNA Translation: AAH67063.1 |
CCDSi | CCDS21438.1 |
RefSeqi | NP_034112.3, NM_009982.5 |
Genome annotation databases
Ensembli | ENSMUST00000032779; ENSMUSP00000032779; ENSMUSG00000030560 |
GeneIDi | 13032 |
KEGGi | mmu:13032 |
UCSCi | uc009ifu.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89269 mRNA Translation: AAB49457.1 U74683 mRNA Translation: AAB58400.3 BC067063 mRNA Translation: AAH67063.1 |
CCDSi | CCDS21438.1 |
RefSeqi | NP_034112.3, NM_009982.5 |
3D structure databases
SMRi | P97821 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198969, 1 interactor |
IntActi | P97821, 1 interactor |
MINTi | P97821 |
STRINGi | 10090.ENSMUSP00000032779 |
Chemistry databases
BindingDBi | P97821 |
ChEMBLi | CHEMBL3454 |
GuidetoPHARMACOLOGYi | 2344 |
Protein family/group databases
MEROPSi | C01.070 |
PTM databases
GlyGeni | P97821, 3 sites |
iPTMneti | P97821 |
PhosphoSitePlusi | P97821 |
SwissPalmi | P97821 |
Proteomic databases
EPDi | P97821 |
jPOSTi | P97821 |
PaxDbi | P97821 |
PeptideAtlasi | P97821 |
PRIDEi | P97821 |
Protocols and materials databases
Antibodypediai | 31473, 267 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032779; ENSMUSP00000032779; ENSMUSG00000030560 |
GeneIDi | 13032 |
KEGGi | mmu:13032 |
UCSCi | uc009ifu.2, mouse |
Organism-specific databases
CTDi | 1075 |
MGIi | MGI:109553, Ctsc |
Phylogenomic databases
eggNOGi | KOG1543, Eukaryota |
GeneTreei | ENSGT00940000155787 |
HOGENOMi | CLU_048219_0_0_1 |
InParanoidi | P97821 |
OMAi | FVTPVRN |
OrthoDBi | 1275401at2759 |
PhylomeDBi | P97821 |
TreeFami | TF313225 |
Enzyme and pathway databases
BRENDAi | 3.4.14.1, 3474 |
Reactomei | R-MMU-204005, COPII-mediated vesicle transport R-MMU-2132295, MHC class II antigen presentation R-MMU-5694530, Cargo concentration in the ER R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 13032, 2 hits in 17 CRISPR screens |
ChiTaRSi | Ctsc, mouse |
PROi | PR:P97821 |
RNActi | P97821, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030560, Expressed in lymph node and 302 other tissues |
Genevisiblei | P97821, MM |
Family and domain databases
CDDi | cd02621, Peptidase_C1A_CathepsinC, 1 hit |
Gene3Di | 2.40.128.80, 1 hit |
InterProi | View protein in InterPro IPR039412, CatC IPR014882, CathepsinC_exc IPR036496, CathepsinC_exc_dom_sf IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C |
Pfami | View protein in Pfam PF08773, CathepsinC_exc, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF75001, SSF75001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATC_MOUSE | |
Accessioni | P97821Primary (citable) accession number: P97821 Secondary accession number(s): O08853 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | May 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries