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Protein

Dipeptidyl peptidase 1

Gene

Ctsc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

chlorideBy similarityNote: Binds 1 Cl- ion per heavy chain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei257By similarity1
Binding sitei301ChlorideBy similarity1
Binding sitei303Chloride; via amide nitrogenBy similarity1
Binding sitei346ChlorideBy similarity1
Active sitei404By similarity1
Active sitei426By similarity1

GO - Molecular functioni

GO - Biological processi

  • aging Source: Ensembl
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of proteolysis involved in cellular protein catabolic process Source: MGI
  • proteolysis Source: UniProtKB
  • proteolysis involved in cellular protein catabolic process Source: GO_Central
  • response to organic substance Source: MGI
  • T cell mediated cytotoxicity Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandChloride

Enzyme and pathway databases

BRENDAi3.4.14.1 3474
ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-2132295 MHC class II antigen presentation
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC01.070

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 1 (EC:3.4.14.1)
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name:
DPP-I
Short name:
DPPI
Dipeptidyl transferase
Cleaved into the following 3 chains:
Alternative name(s):
Dipeptidyl peptidase I exclusion domain chain
Alternative name(s):
Dipeptidyl peptidase I heavy chain
Alternative name(s):
Dipeptidyl peptidase I light chain
Gene namesi
Name:Ctsc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109553 Ctsc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3454
GuidetoPHARMACOLOGYi2344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002634625 – 134Dipeptidyl peptidase 1 exclusion domain chainBy similarityAdd BLAST110
PropeptideiPRO_0000026347135 – 230By similarityAdd BLAST96
ChainiPRO_0000026348231 – 393Dipeptidyl peptidase 1 heavy chainAdd BLAST163
ChainiPRO_0000026349394 – 462Dipeptidyl peptidase 1 light chainAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi30 ↔ 118By similarity
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 136By similarity
Disulfide bondi254 ↔ 297By similarity
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 330By similarity
Disulfide bondi320 ↔ 336By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP97821
PaxDbiP97821
PeptideAtlasiP97821
PRIDEiP97821

PTM databases

iPTMnetiP97821
PhosphoSitePlusiP97821
SwissPalmiP97821

Expressioni

Tissue specificityi

Broadly distributed, but higher levels found in lung, liver, kidney and spleen. Lower levels found in testis and brain.

Gene expression databases

BgeeiENSMUSG00000030560
CleanExiMM_CTSC
ExpressionAtlasiP97821 baseline and differential
GenevisibleiP97821 MM

Interactioni

Subunit structurei

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97821, 1 interactor
MINTiP97821
STRINGi10090.ENSMUSP00000032779

Chemistry databases

BindingDBiP97821

Structurei

3D structure databases

ProteinModelPortaliP97821
SMRiP97821
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140859
HOGENOMiHOG000068022
HOVERGENiHBG005248
InParanoidiP97821
KOiK01275
OMAiYDDFLHY
OrthoDBiEOG091G06TT
PhylomeDBiP97821
TreeFamiTF313225

Family and domain databases

Gene3Di2.40.128.80, 1 hit
InterProiView protein in InterPro
IPR014882 CathepsinC_exc
IPR036496 CathepsinC_exc_dom_sf
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08773 CathepsinC_exc, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
SSF75001 SSF75001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS
60 70 80 90 100
DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNWACFVGK KVESHIEKVN
160 170 180 190 200
MNAAHLGGLQ ERYSERLYTH NHNFVKAINT VQKSWTATAY KEYEKMSLRD
210 220 230 240 250
LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ GVNYVSPVRN
260 270 280 290 300
QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG
310 320 330 340 350
FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF
360 370 380 390 400
YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE
410 420 430 440 450
LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE
460
SIAVAAIPIP KL
Length:462
Mass (Da):52,376
Last modified:May 1, 1997 - v1
Checksum:i56574B38D7DF4710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89269 mRNA Translation: AAB49457.1
U74683 mRNA Translation: AAB58400.3
BC067063 mRNA Translation: AAH67063.1
CCDSiCCDS21438.1
RefSeqiNP_034112.3, NM_009982.5
UniGeneiMm.322945
Mm.483300
Mm.89295

Genome annotation databases

EnsembliENSMUST00000032779; ENSMUSP00000032779; ENSMUSG00000030560
GeneIDi13032
KEGGimmu:13032
UCSCiuc009ifu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCATC_MOUSE
AccessioniPrimary (citable) accession number: P97821
Secondary accession number(s): O08853
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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