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Protein

FXYD domain-containing ion transport regulator 5

Gene

Fxyd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • cadherin binding Source: MGI
  • ion channel activity Source: InterPro
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 5
Alternative name(s):
EF-8
Ion channel homolog RIC
Oncoprotein-induced protein 2
Gene namesi
Name:Fxyd5
Synonyms:Oit2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1201785 Fxyd5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 145ExtracellularSequence analysisAdd BLAST124
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 178CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000038899622 – 178FXYD domain-containing ion transport regulator 5Add BLAST157

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP97808
PaxDbiP97808
PeptideAtlasiP97808
PRIDEiP97808

PTM databases

iPTMnetiP97808
PhosphoSitePlusiP97808
SwissPalmiP97808

Expressioni

Tissue specificityi

Spleen, lung, skeletal muscle, and testis.

Developmental stagei

Exhibits biphasic expression during development.

Gene expression databases

BgeeiENSMUSG00000009687 Expressed in 224 organ(s), highest expression level in blood
CleanExiMM_FXYD5
ExpressionAtlasiP97808 baseline and differential
GenevisibleiP97808 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124203

Structurei

3D structure databases

ProteinModelPortaliP97808
SMRiP97808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 134Pro-richAdd BLAST47

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCU8 Eukaryota
ENOG4111E7R LUCA
GeneTreeiENSGT00410000026316
HOGENOMiHOG000112679
HOVERGENiHBG051678
InParanoidiP97808
KOiK13362
OMAiPFFYDED
PhylomeDBiP97808
TreeFamiTF338182

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989 PD005989, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P97808-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSSRLCLL TIVALILPSR GQTPKKPTSI FTADQTSATT RDNVPDPDQT
60 70 80 90 100
SPGVQTTPLI WTREEATGSQ TAAQTETQQL TKMATSNPVS DPGPHTSSKK
110 120 130 140 150
GTPAVSRIEP LSPSKNFMPP SYIEHPLDSN ENNPFYYDDT TLRKRGLLVA
160 170
AVLFITGIII LTSGKCRQLS QFCLNRHR
Length:178
Mass (Da):19,454
Last modified:November 24, 2009 - v3
Checksum:i466FBF1E05D861C5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WJA1F8WJA1_MOUSE
FXYD domain-containing ion transpor...
Fxyd5
179Annotation score:
E0CXN1E0CXN1_MOUSE
FXYD domain-containing ion transpor...
Fxyd5
185Annotation score:
F6TWM7F6TWM7_MOUSE
FXYD domain-containing ion transpor...
Fxyd5
127Annotation score:
E0CYX7E0CYX7_MOUSE
FXYD domain-containing ion transpor...
Fxyd5
111Annotation score:
E0CXM5E0CXM5_MOUSE
FXYD domain-containing ion transpor...
Fxyd5
117Annotation score:
A0A0J9YUX0A0A0J9YUX0_MOUSE
FXYD domain-containing ion transpor...
Fxyd5
108Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72680 mRNA Translation: AAB51040.1
AK003068 mRNA Translation: BAB22545.1
CCDSiCCDS21121.1
RefSeqiNP_001104543.1, NM_001111073.2
NP_001274142.1, NM_001287213.1
NP_032787.1, NM_008761.4
UniGeneiMm.1870

Genome annotation databases

EnsembliENSMUST00000159924; ENSMUSP00000124219; ENSMUSG00000009687
ENSMUST00000161684; ENSMUSP00000125285; ENSMUSG00000009687
ENSMUST00000161805; ENSMUSP00000125398; ENSMUSG00000009687
ENSMUST00000162087; ENSMUSP00000125065; ENSMUSG00000009687
ENSMUST00000162116; ENSMUSP00000124203; ENSMUSG00000009687
GeneIDi18301
KEGGimmu:18301
UCSCiuc009ghp.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72680 mRNA Translation: AAB51040.1
AK003068 mRNA Translation: BAB22545.1
CCDSiCCDS21121.1
RefSeqiNP_001104543.1, NM_001111073.2
NP_001274142.1, NM_001287213.1
NP_032787.1, NM_008761.4
UniGeneiMm.1870

3D structure databases

ProteinModelPortaliP97808
SMRiP97808
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124203

PTM databases

iPTMnetiP97808
PhosphoSitePlusiP97808
SwissPalmiP97808

Proteomic databases

EPDiP97808
PaxDbiP97808
PeptideAtlasiP97808
PRIDEiP97808

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159924; ENSMUSP00000124219; ENSMUSG00000009687
ENSMUST00000161684; ENSMUSP00000125285; ENSMUSG00000009687
ENSMUST00000161805; ENSMUSP00000125398; ENSMUSG00000009687
ENSMUST00000162087; ENSMUSP00000125065; ENSMUSG00000009687
ENSMUST00000162116; ENSMUSP00000124203; ENSMUSG00000009687
GeneIDi18301
KEGGimmu:18301
UCSCiuc009ghp.3 mouse

Organism-specific databases

CTDi53827
MGIiMGI:1201785 Fxyd5

Phylogenomic databases

eggNOGiENOG410JCU8 Eukaryota
ENOG4111E7R LUCA
GeneTreeiENSGT00410000026316
HOGENOMiHOG000112679
HOVERGENiHBG051678
InParanoidiP97808
KOiK13362
OMAiPFFYDED
PhylomeDBiP97808
TreeFamiTF338182

Miscellaneous databases

ChiTaRSiFxyd5 mouse
PROiPR:P97808
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009687 Expressed in 224 organ(s), highest expression level in blood
CleanExiMM_FXYD5
ExpressionAtlasiP97808 baseline and differential
GenevisibleiP97808 MM

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989 PD005989, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFXYD5_MOUSE
AccessioniPrimary (citable) accession number: P97808
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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