UniProtKB - P97807 (FUMH_MOUSE)

BLAST

>sp|P97807|FUMH_MOUSE Fumarate hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Fh PE=1 SV=3
MYRALRLLARSRRLLRVPSAGAAVSGEATTLPRCAPNVARMASQNSFRVEFDTFGELKVP
TDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFGILKRAAAEVNQEYGLDPKIASAIMKA
ADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNK
SQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLT
LGQEFSGYVQQVQYAMVRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGL
PFVTAPNKFEALAAHDALVELSGAMNTAACSLMKIANDIRFLGSGPRSGLGELILPENEP
GSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLL
GDASVSFTDNCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLK
ETAIELGYLTAEQFDEWVKPKDMLGPK

Align

Format
Add to basket Added to basket
History
Entry version 168 (12 Sep 2018)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Fumarate hydratase, mitochondrial

Gene

Fh

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors (By similarity).By similarity

Catalytic activityⁱ

(S)-malate = fumarate + H₂O.

Pathwayⁱ: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from fumarate.
Proteins known to be involved in this subpathway in this organism are:

Fumarate hydratase, mitochondrial (Fh)

This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from fumarate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	144	SubstrateBy similarity		1

GO - Molecular functionⁱ

fumarate hydratase activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fumarate metabolic process Source: MGI
homeostasis of number of cells within a tissue
Source: MGI
Inferred from mutant phenotypeⁱ
- 17418408
malate metabolic process Source: MGI
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 27554470
tricarboxylic acid cycle Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	Tricarboxylic acid cycle

Enzyme and pathway databases

Reactomeⁱ	R-MMU-71403 Citric acid cycle (TCA cycle)
UniPathwayⁱ	UPA00223;UER01007

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fumarate hydratase, mitochondrial (EC:4.2.1.2) Short name: Fumarase Alternative name(s): EF-3
Gene namesⁱ	Name:Fh Synonyms:Fh1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:95530 Fh1

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Transit peptideⁱ	1 – 41	MitochondrionBy similarityAdd BLAST	41
ChainⁱPRO_0000010323	42 – 507	Fumarate hydratase, mitochondrialAdd BLAST	466
Isoform Cytoplasmic (identifier: P97807-2)
Initiator methionineⁱ		RemovedBy similarity

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	58	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	58	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	63	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	63	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	77	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	77	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	82	PhosphothreonineCombined sources	1
Modified residueⁱ	112	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	112	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	119	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	119	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	210	N6-acetyllysineCombined sources	1
Modified residueⁱ	220	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	220	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	289	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	289	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	363	PhosphoserineCombined sources	1
Modified residueⁱ	464	N6-succinyllysineCombined sources	1
Modified residueⁱ	470	N6-succinyllysineCombined sources	1
Modified residueⁱ	499	N6-acetyllysineCombined sources	1
Isoform Cytoplasmic (identifier: P97807-2)
Modified residueⁱ	2	N-acetylalanine By similarityBy similarity	1

Post-translational modificationⁱ

Isoform Cytoplasmic is acetylated at position 2.By similarity

Acetylation of Lys-474 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P97807
PaxDbⁱ	P97807
PeptideAtlas More...PeptideAtlasⁱ	P97807
PRIDEⁱ	P97807

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00759940 P97807

REPRODUCTION-2DPAGEⁱ

IPI00759940
P97807

PTM databases

iPTMnetⁱ	P97807
PhosphoSitePlusⁱ	P97807
SwissPalmⁱ	P97807

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000026526 Expressed in 306 organ(s), highest expression level in brown adipose tissue
CleanExⁱ	MM_FH1
ExpressionAtlasⁱ	P97807 baseline and differential
Genevisibleⁱ	P97807 MM

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

BioGridⁱ	199665, 3 interactors
IntActⁱ	P97807, 6 interactors
Molecular INTeraction database More...MINTⁱ	P97807
STRINGⁱ	10090.ENSMUSP00000027810

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97807
SMRⁱ	P97807
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	173 – 176	B siteBy similarity		4
Regionⁱ	183 – 185	Substrate bindingBy similarity		3

Sequence similaritiesⁱ

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1317 Eukaryota COG0114 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002779
HOGENOMⁱ	HOG000061736
HOVERGENⁱ	HBG002183
InParanoidⁱ	P97807
KEGG Orthology (KO) More...KOⁱ	K01679
OMAⁱ	VSFTDNC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05UL
TreeFamⁱ	TF300441

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01362 Fumarase_classII, 1 hit
Gene3Dⁱ	1.10.275.10, 1 hit
HAMAPⁱ	MF_00743 FumaraseC, 1 hit
InterProⁱ	View protein in InterPro IPR005677 Fum_hydII IPR024083 Fumarase/histidase_N IPR018951 Fumarase_C_C IPR020557 Fumarate_lyase_CS IPR000362 Fumarate_lyase_fam IPR022761 Fumarate_lyase_N IPR008948 L-Aspartase-like
PANTHERⁱ	PTHR11444 PTHR11444, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10415 FumaraseC_C, 1 hit PF00206 Lyase_1, 1 hit
PRINTSⁱ	PR00149 FUMRATELYASE
SUPFAMⁱ	SSF48557 SSF48557, 1 hit
TIGRFAMsⁱ	TIGR00979 fumC_II, 1 hit
PROSITEⁱ	View protein in PROSITE PS00163 FUMARATE_LYASES, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform Mitochondrial (identifier: P97807-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRALRLLAR SRRLLRVPSA GAAVSGEATT LPRCAPNVAR MASQNSFRVE 
        60         70         80         90        100
FDTFGELKVP TDKYYGAQTV RSTMNFKIGG ATERMPIPVI QAFGILKRAA 
       110        120        130        140        150
AEVNQEYGLD PKIASAIMKA ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV 
       160        170        180        190        200
NEVISNRAIE MLGGELGSKK PVHPNDHVNK SQSSNDTFPT AMHIAAAVEV 
       210        220        230        240        250
HKVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT LGQEFSGYVQ 
       260        270        280        290        300
QVQYAMVRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL 
       310        320        330        340        350
PFVTAPNKFE ALAAHDALVE LSGAMNTAAC SLMKIANDIR FLGSGPRSGL 
       360        370        380        390        400
GELILPENEP GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF 
       410        420        430        440        450
ELNVFKPMMI KNVLHSARLL GDASVSFTDN CVVGIQANTE RINKLMNESL 
       460        470        480        490        500
MLVTALNPHI GYDKAAKIAK TAHKNGSTLK ETAIELGYLT AEQFDEWVKP 

KDMLGPK

Length:507

Mass (Da):54,357

Last modified:July 27, 2011 - v3

Checksum:ⁱ2F24F7B089608ABE

Isoform Cytoplasmic (identifier: P97807-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-40: Missing.

« Hide

        10         20         30         40         50
MASQNSFRVE FDTFGELKVP TDKYYGAQTV RSTMNFKIGG ATERMPIPVI 
        60         70         80         90        100
QAFGILKRAA AEVNQEYGLD PKIASAIMKA ADEVAEGKLN DHFPLVVWQT 
       110        120        130        140        150
GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK SQSSNDTFPT 
       160        170        180        190        200
AMHIAAAVEV HKVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT 
       210        220        230        240        250
LGQEFSGYVQ QVQYAMVRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV 
       260        270        280        290        300
AAKVAALTGL PFVTAPNKFE ALAAHDALVE LSGAMNTAAC SLMKIANDIR 
       310        320        330        340        350
FLGSGPRSGL GELILPENEP GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA 
       360        370        380        390        400
VTVGGSNGHF ELNVFKPMMI KNVLHSARLL GDASVSFTDN CVVGIQANTE 
       410        420        430        440        450
RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK ETAIELGYLT 
       460 
AEQFDEWVKP KDMLGPK

Show »

Length:467

Mass (Da):50,053

Checksum:ⁱ95ECA9B728E029AF

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	H3BKG7	H3BKG7_MOUSE		Fumarate hydratase 1 Fumarate hydratase 1	Fh1	167	Annotation score:
	H3BJV5	H3BJV5_MOUSE		Fumarate hydratase 1 Fumarate hydratase 1	Fh1	61	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	183	S → N in AK002379 (PubMed:16141072).Curated		1
Sequence conflictⁱ	236	A → T in AK002379 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018967	1 – 40	Missing in isoform Cytoplasmic. CuratedAdd BLAST		40

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002379 mRNA No translation available. AK147000 mRNA Translation: BAE27597.1 CH466555 Genomic DNA Translation: EDL13210.1 BC006048 mRNA Translation: AAH06048.1 U72679 mRNA Translation: AAB51039.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15547.1 [P97807-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_034339.2, NM_010209.2 [P97807-1]
UniGeneⁱ	Mm.41502

Genome annotation databases

Ensemblⁱ	ENSMUST00000027810; ENSMUSP00000027810; ENSMUSG00000026526 [P97807-1]
GeneIDⁱ	14194
KEGGⁱ	mmu:14194
UCSC genome browser More...UCSCⁱ	uc007dtn.2 mouse [P97807-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97807	Fumarate hydratase, mitochondrial	)	HUMAN		510	UniRef90_P07954
Fumarate hydratase, mitochondrial		MACFA		510
Fumarate hydratase, mitochondrial		RAT		507
fumarate hydratase, mitochondrial		TARSY		596
Fumarate hydratase, mitochondrial		PIG		512
+121

Protein	Similar proteins		Species	Score	Length	Source
P97807	Fumarate hydratase, mitochondrial	)	HUMAN		510	UniRef50_P07954
Fumarate hydratase, mitochondrial		MACFA		510
Fumarate hydratase, mitochondrial		RAT		507
fumarate hydratase, mitochondrial		TARSY		596
Fumarate hydratase, mitochondrial		PIG		512
+128

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002379 mRNA No translation available. AK147000 mRNA Translation: BAE27597.1 CH466555 Genomic DNA Translation: EDL13210.1 BC006048 mRNA Translation: AAH06048.1 U72679 mRNA Translation: AAB51039.1
CCDSⁱ	CCDS15547.1 [P97807-1]
RefSeqⁱ	NP_034339.2, NM_010209.2 [P97807-1]
UniGeneⁱ	Mm.41502

3D structure databases

ProteinModelPortalⁱ	P97807
SMRⁱ	P97807
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199665, 3 interactors
IntActⁱ	P97807, 6 interactors
MINTⁱ	P97807
STRINGⁱ	10090.ENSMUSP00000027810

PTM databases

iPTMnetⁱ	P97807
PhosphoSitePlusⁱ	P97807
SwissPalmⁱ	P97807

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00759940 P97807

REPRODUCTION-2DPAGEⁱ

IPI00759940
P97807

Proteomic databases

MaxQBⁱ	P97807
PaxDbⁱ	P97807
PeptideAtlasⁱ	P97807
PRIDEⁱ	P97807

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027810; ENSMUSP00000027810; ENSMUSG00000026526 [P97807-1]
GeneIDⁱ	14194
KEGGⁱ	mmu:14194
UCSCⁱ	uc007dtn.2 mouse [P97807-1]

Organism-specific databases

CTDⁱ	14194
MGIⁱ	MGI:95530 Fh1

Phylogenomic databases

eggNOGⁱ	KOG1317 Eukaryota COG0114 LUCA
GeneTreeⁱ	ENSGT00390000002779
HOGENOMⁱ	HOG000061736
HOVERGENⁱ	HBG002183
InParanoidⁱ	P97807
KOⁱ	K01679
OMAⁱ	VSFTDNC
OrthoDBⁱ	EOG091G05UL
TreeFamⁱ	TF300441

Enzyme and pathway databases

UniPathwayⁱ	UPA00223;UER01007
Reactomeⁱ	R-MMU-71403 Citric acid cycle (TCA cycle)

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P97807
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026526 Expressed in 306 organ(s), highest expression level in brown adipose tissue
CleanExⁱ	MM_FH1
ExpressionAtlasⁱ	P97807 baseline and differential
Genevisibleⁱ	P97807 MM

Family and domain databases

CDDⁱ	cd01362 Fumarase_classII, 1 hit
Gene3Dⁱ	1.10.275.10, 1 hit
HAMAPⁱ	MF_00743 FumaraseC, 1 hit
InterProⁱ	View protein in InterPro IPR005677 Fum_hydII IPR024083 Fumarase/histidase_N IPR018951 Fumarase_C_C IPR020557 Fumarate_lyase_CS IPR000362 Fumarate_lyase_fam IPR022761 Fumarate_lyase_N IPR008948 L-Aspartase-like
PANTHERⁱ	PTHR11444 PTHR11444, 1 hit
Pfamⁱ	View protein in Pfam PF10415 FumaraseC_C, 1 hit PF00206 Lyase_1, 1 hit
PRINTSⁱ	PR00149 FUMRATELYASE
SUPFAMⁱ	SSF48557 SSF48557, 1 hit
TIGRFAMsⁱ	TIGR00979 fumC_II, 1 hit
PROSITEⁱ	View protein in PROSITE PS00163 FUMARATE_LYASES, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FUMH_MOUSE
Accessionⁱ	P97807Primary (citable) accession number: P97807 Secondary accession number(s): Q3UIA9, Q99JL0, Q9DCX0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	July 27, 2011
	Last modified:	September 12, 2018
	This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P97807 (FUMH_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Fumarate hydratase, mitochondrial

Fh

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Other locations

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: tricarboxylic acid cycle

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ