Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurensin-1

Gene

Nrsn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth (PubMed:12445626, PubMed:16527258, PubMed:16696124, PubMed:9191101). May play a role in neurite extension (PubMed:26430118).5 Publications

GO - Biological processi

  • nervous system development Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Neurensin-1
Alternative name(s):
Neuro-p24
Vesicular membrane protein of 24 kDa
Short name:
Vesicular membrane protein p24
Gene namesi
Name:Nrsn1Imported
Synonyms:VmpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:894662 Nrsn1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705841 – 196Neurensin-1Add BLAST196

Proteomic databases

PaxDbiP97799
PRIDEiP97799

PTM databases

iPTMnetiP97799
PhosphoSitePlusiP97799

Expressioni

Tissue specificityi

Expressed predominantly in brain. Also weakly expressed in lung and spleen. In brain, expressed strongly in nerve fibers of the cerebral cortex, anterior cerebral nuclei, hypothalamus, amygdaloid complex, brain stem of the metaencephalon and medulla oblongata, and moderately expressed in soma of neurons of the dentate gyrus of the hippocampus and Purkinje cells of the cerebellum.1 Publication

Developmental stagei

Expression is developmentally regulated as axonal fibers innervate, extend collateral fibers and finally attain a stable state. First detected at postnatal day 6 in cell bodies and apical dendrites of pyramidal neurons in the developing cerebral cortex, with expression gradually increasing during postnatal development. In P1 retina, strongly expressed in the optic nerve fiber layer, and weakly expressed in ganglion cells, presumptive amacrine and horizontal cells. At P10, also strongly expressed in other parts of the retina such as the ganglion cells, inner plexiform layer and horizontal cells. Expression decreases as the retina develops further to maturity.2 Publications

Inductioni

By retinoic acid in neuroblastoma Neuro2a cells. Down-regulated following fear conditioning (at protein level) (PubMed:26430118).3 Publications

Gene expression databases

BgeeiENSMUSG00000048978 Expressed in 143 organ(s), highest expression level in telencephalon
CleanExiMM_NRSN1
GenevisibleiP97799 MM

Interactioni

Protein-protein interaction databases

CORUMiP97799

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJHW Eukaryota
ENOG4111HTK LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG053471
InParanoidiP97799
OMAiTEGGYQR
OrthoDBiEOG091G0K9J
PhylomeDBiP97799
TreeFamiTF332090

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029698 Nrsn1
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF6 PTHR14796:SF6, 1 hit

Sequencei

Sequence statusi: Complete.

P97799-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSCSNTCGS RRAQADTEGG YQQRYGVRSY LHQFYEDCTA SIWEYEDDFQ
60 70 80 90 100
IQRSPNRWSS VFWKVGLISG TVFVILGLTV LAVGFLVPPK IEAFGEADFM
110 120 130 140 150
VVDTHAVKYN GALDTCKLAG AVLFCIGGTS MAGCLLMSVF AKSYSKEEKF
160 170 180 190
LQQKFKERIA DIKAHTQPIT KAPGPGDTKI PVTLSRVQNV QPLSAT
Length:196
Mass (Da):21,595
Last modified:May 1, 1997 - v1
Checksum:iF866AB20ADB934BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83206 mRNA Translation: BAA18947.1
AK138191 mRNA Translation: BAE23574.1
AK153741 mRNA Translation: BAE32162.1
AL589766 Genomic DNA Translation: CAI24436.1
BC052019 mRNA Translation: AAH52019.1
CCDSiCCDS26387.1
RefSeqiNP_033539.1, NM_009513.2
XP_011242608.1, XM_011244306.2
XP_017170992.1, XM_017315503.1
UniGeneiMm.4766

Genome annotation databases

EnsembliENSMUST00000057866; ENSMUSP00000055048; ENSMUSG00000048978
ENSMUST00000167305; ENSMUSP00000128979; ENSMUSG00000048978
GeneIDi22360
KEGGimmu:22360
UCSCiuc007pwx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83206 mRNA Translation: BAA18947.1
AK138191 mRNA Translation: BAE23574.1
AK153741 mRNA Translation: BAE32162.1
AL589766 Genomic DNA Translation: CAI24436.1
BC052019 mRNA Translation: AAH52019.1
CCDSiCCDS26387.1
RefSeqiNP_033539.1, NM_009513.2
XP_011242608.1, XM_011244306.2
XP_017170992.1, XM_017315503.1
UniGeneiMm.4766

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP97799

PTM databases

iPTMnetiP97799
PhosphoSitePlusiP97799

Proteomic databases

PaxDbiP97799
PRIDEiP97799

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057866; ENSMUSP00000055048; ENSMUSG00000048978
ENSMUST00000167305; ENSMUSP00000128979; ENSMUSG00000048978
GeneIDi22360
KEGGimmu:22360
UCSCiuc007pwx.2 mouse

Organism-specific databases

CTDi140767
MGIiMGI:894662 Nrsn1

Phylogenomic databases

eggNOGiENOG410IJHW Eukaryota
ENOG4111HTK LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG053471
InParanoidiP97799
OMAiTEGGYQR
OrthoDBiEOG091G0K9J
PhylomeDBiP97799
TreeFamiTF332090

Miscellaneous databases

PROiPR:P97799
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048978 Expressed in 143 organ(s), highest expression level in telencephalon
CleanExiMM_NRSN1
GenevisibleiP97799 MM

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029698 Nrsn1
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF6 PTHR14796:SF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRSN1_MOUSE
AccessioniPrimary (citable) accession number: P97799
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again