Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P97798 (NEO1_MOUSE)

Protein

Neogenin

Gene

Neo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.1 Publication

GO - Molecular functioni

  • BMP receptor binding Source: BHF-UCL
  • cadherin binding Source: MGI
  • co-receptor binding Source: MGI
  • signaling receptor activity Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neogenin
Gene namesi
Name:Neo1
Synonyms:Ngn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1097159 Neo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini37 – 1136ExtracellularSequence analysisAdd BLAST1100
Transmembranei1137 – 1157HelicalSequence analysisAdd BLAST21
Topological domaini1158 – 1493CytoplasmicSequence analysisAdd BLAST336

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000001504437 – 1493NeogeninAdd BLAST1457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 140PROSITE-ProRule annotation
Disulfide bondi184 ↔ 232PROSITE-ProRule annotation
Glycosylationi221N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi281 ↔ 331PROSITE-ProRule annotation
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi373 ↔ 421PROSITE-ProRule annotation
Glycosylationi501N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi940N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1209PhosphoserineCombined sources1
Modified residuei1225PhosphoserineCombined sources1
Modified residuei1229PhosphothreonineCombined sources1
Modified residuei1433PhosphoserineBy similarity1
Modified residuei1436PhosphothreonineBy similarity1
Modified residuei1464PhosphoserineCombined sources1
Modified residuei1466PhosphoserineBy similarity1
Modified residuei1467PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97798
PaxDbiP97798
PeptideAtlasiP97798
PRIDEiP97798

PTM databases

iPTMnetiP97798
PhosphoSitePlusiP97798
SwissPalmiP97798

Expressioni

Tissue specificityi

Widely expressed.

Developmental stagei

Expressed ubiquitously throughout the mid to late stages of gestation and in adult tissues. Strong expression is observed in the ventral region of the ventricular zone of the E15.5 mouse neural tube, as well as in the ventricular zones of the mesencephalon and rhombencephalon. Isoform 3 and isoform 4 are expressed at higher level compared to other isoforms between E11.5 and E16.5.

Gene expression databases

CleanExiMM_NEO1

Interactioni

Subunit structurei

Interacts with BMP2, BMP4, BMP6, and BMP7 (By similarity). Interacts with RGMA and RGMB. Interacts with MYO10.By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

DIPiDIP-32026N
IntActiP97798, 6 interactors
MINTiP97798
STRINGi10090.ENSMUSP00000063656

Structurei

Secondary structure

11493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP97798
SMRiP97798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 158Ig-like C2-type 1Add BLAST96
Domaini163 – 249Ig-like C2-type 2Add BLAST87
Domaini254 – 347Ig-like C2-type 3Add BLAST94
Domaini352 – 437Ig-like C2-type 4Add BLAST86
Domaini472 – 566Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini572 – 662Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini667 – 762Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini772 – 862Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91
Domaini887 – 986Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini988 – 1085Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1149 – 1153Poly-Val5

Domaini

The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4221 Eukaryota
ENOG410Z913 LUCA
HOGENOMiHOG000230686
HOVERGENiHBG005455
InParanoidiP97798
PhylomeDBiP97798

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033024 Neogenin
IPR010560 Neogenin_C
PANTHERiPTHR44146:SF1 PTHR44146:SF1, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97798-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEREAGRL LCTSSSRRCC PPPPLLLLLP LLLLLGRPAS GAAATKSGPR 
        60         70         80         90        100
RQSQGASVRT FTPFYFLVEP VDTLSVRGSS VILNCSAYSE PSPNIEWKKD 
       110        120        130        140        150
GTFLNLESDD RRQLLPDGSL FISNVVHSKH NKPDEGFYQC VATVDNLGTI 
       160        170        180        190        200
VSRTAKLTVA GLPRFTSQPE PSSVYVGNSA ILNCEVNADL VPFVRWEQNR 
       210        220        230        240        250
QPLLLDDRIV KLPSGTLVIS NATEGDGGLY RCIVESGGPP KFSDEAELKV 
       260        270        280        290        300
LQDPEEIVDL VFLMRPSSMM KVTGQSAVLP CVVSGLPAPV VRWMKNEEVL 
       310        320        330        340        350
DTESSGRLVL LAGGCLEISD VTEDDAGTYF CIADNGNKTV EAQAELTVQV 
       360        370        380        390        400
PPGFLKQPAN IYAHESMDIV FECEVTGKPT PTVKWVKNGD VVIPSDNFKI 
       410        420        430        440        450
VKEHNLQVLG LVKSDEGFYQ CIAENDVGNA QAGAQLIILE HDVAIPTLPP 
       460        470        480        490        500
TSLTSATTDH LAPATTGPLP SAPRDVVASL VSTRFIKLTW RTPASDPHGD 
       510        520        530        540        550
NLTYSVFYTK EGVDRERVEN TSQPGEMQVT IQNLMPATVY IFKVMAQNKH 
       560        570        580        590        600
GSGESSAPLR VETQPEVQLP GPAPNIRAYA TSPTSITVTW ETPLSGNGEI 
       610        620        630        640        650
QNYKLYYMEK GTDKEQDIDV SSHSYTINGL KKYTEYSFRV VAYNKHGPGV 
       660        670        680        690        700
STQDVAVRTL SDVPSAAPQN LSLEVRNSKS IVIHWQPPSS TTQNGQITGY 
       710        720        730        740        750
KIRYRKASRK SDVTETLVTG TQLSQLIEGL DRGTEYNFRV AALTVNGTGP 
       760        770        780        790        800
ATDWLSAETF ESDLDETRVP EVPSSLHVRP LVTSIVVSWT PPENQNIVVR 
       810        820        830        840        850
GYAIGYGIGS PHAQTIKVDY KQRYYTIENL DPSSHYVITL KAFNNVGEGI 
       860        870        880        890        900
PLYESAVTRP HTDTSEVDLF VINAPYTPVP DPTPMMPPVG VQASILSHDT 
       910        920        930        940        950
IRITWADNSL PKHQKITDSR YYTVRWKTNI PANTKYKNAN ATTLSYLVTG 
       960        970        980        990       1000
LKPNTLYEFS VMVTKGRRSS TWSMTAHGAT FELVPTSPPK DVTVVSKEGK 
      1010       1020       1030       1040       1050
PRTIIVNWQP PSEANGKITG YIIYYSTDVN AEIHDWVIEP VVGNRLTHQI 
      1060       1070       1080       1090       1100
QELTLDTPYY FKIQARNSKG MGPMSEAVQF RTPKADSSDK MPNDQALGSA 
      1110       1120       1130       1140       1150
GKGSRLPDLG SDYKPPMSGS NSPHGSPTSP LDSNMLLVII VSVGVITIVV 
      1160       1170       1180       1190       1200
VVVIAVFCTR RTTSHQKKKR AACKSVNGSH KYKGNCKDVK PPDLWIHHER 
      1210       1220       1230       1240       1250
LELKPIDKSP DPNPVMTDTP IPRNSQDITP VDNSMDSNIH QRRNSYRGHE 
      1260       1270       1280       1290       1300
SEDSMSTLAG RRGMRPKMMM PFDSQPPQPV ISAHPIHSLD NPHHHFHSSS 
      1310       1320       1330       1340       1350
LASPARSHLY HPSSPWPIGT SMSLSDRANS TESVRNTPST DTMPASSSQT 
      1360       1370       1380       1390       1400
CCTDHQDPEG ATSSSYLASS QEEDSGQSLP TAHVRPSHPL KSFAVPAIPP 
      1410       1420       1430       1440       1450
PGPPLYDPAL PSTPLLSQQA LEPSTFHSVK TASIGTLGRS RPPMPVVVPS 
      1460       1470       1480       1490 
APEVQETTRM LEDSESSYEP DELTKEMAHL EGLMKDLNAI TTA
Length:1,493
Mass (Da):163,160
Last modified:May 1, 1997 - v1
Checksum:i441DE919D5E17C0E
GO
Isoform 2 (identifier: P97798-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     442-461: Missing.

Show »
Length:1,473
Mass (Da):161,128
Checksum:iB830117BB889871A
GO
Isoform 3 (identifier: P97798-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-878: Missing.

Note: Expression developmentally regulated.
Show »
Length:1,477
Mass (Da):161,397
Checksum:i3248E1E198F0AB6E
GO
Isoform 4 (identifier: P97798-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1086-1096: Missing.

Note: Expression developmentally regulated.
Show »
Length:1,482
Mass (Da):161,971
Checksum:i705C7C3FBB8A4CC1
GO
Isoform 5 (identifier: P97798-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1279-1331: Missing.

Note: Expression developmentally regulated.
Show »
Length:1,440
Mass (Da):157,418
Checksum:iD8818C1E884DC0D3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QK04E9QK04_MOUSE
Neogenin
Neo1
1,492Annotation score:
Q7TQG5Q7TQG5_MOUSE
Neogenin
Neo1
1,465Annotation score:
A0A1L1SRD6A0A1L1SRD6_MOUSE
Neogenin
Neo1
405Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002594442 – 461Missing in isoform 2. CuratedAdd BLAST20
Alternative sequenceiVSP_002595863 – 878Missing in isoform 3. CuratedAdd BLAST16
Alternative sequenceiVSP_0025961086 – 1096Missing in isoform 4. CuratedAdd BLAST11
Alternative sequenceiVSP_0025971279 – 1331Missing in isoform 5. CuratedAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09535 mRNA Translation: CAA70727.1
UniGeneiMm.42249

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09535 mRNA Translation: CAA70727.1
UniGeneiMm.42249

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BQ6X-ray2.30A/B883-1133[»]
4BQ7X-ray6.60A/B883-1133[»]
4BQ8X-ray2.80A883-1083[»]
4BQ9X-ray2.91A/B883-1083[»]
4BQBX-ray2.70A/B/C/D883-1133[»]
4BQCX-ray3.20A/B883-1133[»]
4PLNX-ray3.20C/D765-980[»]
4UI2X-ray3.15A883-1133[»]
ProteinModelPortaliP97798
SMRiP97798
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-32026N
IntActiP97798, 6 interactors
MINTiP97798
STRINGi10090.ENSMUSP00000063656

PTM databases

iPTMnetiP97798
PhosphoSitePlusiP97798
SwissPalmiP97798

Proteomic databases

MaxQBiP97798
PaxDbiP97798
PeptideAtlasiP97798
PRIDEiP97798

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1097159 Neo1

Phylogenomic databases

eggNOGiKOG4221 Eukaryota
ENOG410Z913 LUCA
HOGENOMiHOG000230686
HOVERGENiHBG005455
InParanoidiP97798
PhylomeDBiP97798

Miscellaneous databases

ChiTaRSiNeo1 mouse
PROiPR:P97798
SOURCEiSearch...

Gene expression databases

CleanExiMM_NEO1

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033024 Neogenin
IPR010560 Neogenin_C
PANTHERiPTHR44146:SF1 PTHR44146:SF1, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNEO1_MOUSE
AccessioniPrimary (citable) accession number: P97798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again