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Entry version 175 (03 Jul 2019)
Sequence version 2 (08 May 2019)
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Protein

Tyrosine-protein phosphatase non-receptor type substrate 1

Gene

Sirpa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2172127 DAP12 interactions
R-MMU-391160 Signal regulatory protein family interactions
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type substrate 1
Short name:
SHP substrate 1
Short name:
SHPS-1
Alternative name(s):
Brain Ig-like molecule with tyrosine-based activation motifs
Short name:
Bit
CD172 antigen-like family member A
Inhibitory receptor SHPS-1
MyD-1 antigen
Signal-regulatory protein alpha-1
Short name:
Sirp-alpha-1
Short name:
mSIRP-alpha1
p84
CD_antigen: CD172a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sirpa
Synonyms:Bit, Myd1, Ptpns1, Shps1, Sirp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108563 Sirpa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 373ExtracellularSequence analysisAdd BLAST342
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 511CytoplasmicSequence analysisAdd BLAST117

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Add BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001494232 – 513Tyrosine-protein phosphatase non-receptor type substrate 1Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 121PROSITE-ProRule annotation
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi171 ↔ 229PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi274 ↔ 332PROSITE-ProRule annotation
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei440Phosphotyrosine; by Tyr-kinasesSequence analysis1
Modified residuei464Phosphotyrosine; by Tyr-kinasesSequence analysis1
Modified residuei481Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei505Phosphotyrosine; by Tyr-kinasesBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.5 Publications
Phosphorylated on tyrosine residues.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97797

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97797

PeptideAtlas

More...
PeptideAtlasi
P97797

PRoteomics IDEntifications database

More...
PRIDEi
P97797

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2714

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97797

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97797

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in cerebral cortex, brain, spinal cord, cerebellum and spleen, and at much lower levels in kidney, thymus, heart, lung and liver. Within the cerebellum, highly expressed throughout the molecular layer, and in synaptic glomeruli in the granule cell layer. Detected in neurons of the hippocampus and dentate gyrus, and in olfactory bulb. Not detected in Purkinje cells. Highly expressed in the plexiform layers, optic fiber layer and the outer segments of the photoreceptor layer in the retina. Highly expressed in macrophages. Isoform 3 is detected at very low levels in all tissues tested.4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in the CNS of embryos from day 7 to 17.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037902 Expressed in 296 organ(s), highest expression level in stroma of bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P97797 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202490, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P97797

Protein interaction database and analysis system

More...
IntActi
P97797, 5 interactors

Molecular INTeraction database

More...
MINTi
P97797

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099491

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1513
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97797

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P97797

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 137Ig-like V-typeAdd BLAST106
Domaini149 – 248Ig-like C1-type 1Add BLAST100
Domaini255 – 343Ig-like C1-type 2Add BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi440 – 443SH2-bindingSequence analysis4
Motifi450 – 455SH3-bindingSequence analysis6
Motifi464 – 467SH2-bindingSequence analysis4
Motifi481 – 484SH2-bindingSequence analysis4
Motifi505 – 508SH2-bindingSequence analysis4

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKYM Eukaryota
ENOG410YKK2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186656

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97797

KEGG Orthology (KO)

More...
KOi
K06551

Database of Orthologous Groups

More...
OrthoDBi
904196at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97797-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAGPAPGR LGPLLLCLLL SASCFCTGAT GKELKVTQPE KSVSVAAGDS
60 70 80 90 100
TVLNCTLTSL LPVGPIRWYR GVGPSRLLIY SFAGEYVPRI RNVSDTTKRN
110 120 130 140 150
NMDFSIRISN VTPADAGIYY CVKFQKGSSE PDTEIQSGGG TEVYVLAKPS
160 170 180 190 200
PPEVSGPADR GIPDQKVNFT CKSHGFSPRN ITLKWFKDGQ ELHPLETTVN
210 220 230 240 250
PSGKNVSYNI SSTVRVVLNS MDVNSKVICE VAHITLDRSP LRGIANLSNF
260 270 280 290 300
IRVSPTVKVT QQSPTSMNQV NLTCRAERFY PEDLQLIWLE NGNVSRNDTP
310 320 330 340 350
KNLTKNTDGT YNYTSLFLVN SSAHREDVVF TCQVKHDQQP AITRNHTVLG
360 370 380 390 400
FAHSSDQGSM QTFPDNNATH NWNVFIGVGV ACALLVVLLM AALYLLRIKQ
410 420 430 440 450
KKAKGSTSST RLHEPEKNAR EITQVQSLIQ DTNDINDITY ADLNLPKEKK
460 470 480 490 500
PAPRAPEPNN HTEYASIETG KVPRPEDTLT YADLDMVHLS RAQPAPKPEP
510
SFSEYASVQV QRK
Length:513
Mass (Da):56,414
Last modified:May 8, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3C483B0DC99BD9A
GO
Isoform 2 (identifier: P97797-2) [UniParc]FASTAAdd to basket
Also known as: a', Large

The sequence of this isoform differs from the canonical sequence as follows:
     425-428: Missing.

Show »
Length:509
Mass (Da):55,986
Checksum:iCF5A6EC9404C14CF
GO
Isoform 3 (identifier: P97797-3) [UniParc]FASTAAdd to basket
Also known as: b, Small

The sequence of this isoform differs from the canonical sequence as follows:
     147-364: Missing.

Show »
Length:295
Mass (Da):32,163
Checksum:iB43CF97461EAFEE0
GO
Isoform 4 (identifier: P97797-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-364: Missing.
     425-428: Missing.

Show »
Length:291
Mass (Da):31,735
Checksum:i32292DB33466E613
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P6I8Q6P6I8_MOUSE
Signal-regulatory protein alpha
Sirpa Ptpns1, mCG_9902
509Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CX65E0CX65_MOUSE
Tyrosine-protein phosphatase non-re...
Sirpa
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ANC1A2ANC1_MOUSE
Tyrosine-protein phosphatase non-re...
Sirpa
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6Missing in CAA71375 (Ref. 7) Curated1
Sequence conflicti10R → L in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti29A → V in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti29A → V in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti29A → V in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti29A → V in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti29A → V in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti29A → V in CAA71375 (Ref. 7) Curated1
Sequence conflicti32K → T in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti34L → V in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti52V → I in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti57L → V in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti67R → K in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti67R → K in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti67R → K in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti67R → K in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti67R → K in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti67R → K in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti67R → K in CAA71375 (Ref. 7) Curated1
Sequence conflicti74 – 77PSRL → KAGC in CAA71375 (Ref. 7) Curated4
Sequence conflicti74P → Q in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti74P → Q in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti74P → Q in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti74P → Q in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti74P → Q in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti74P → Q in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti74P → Q in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti83A → T in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti83A → T in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti83A → T in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti83A → T in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti83A → T in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti83A → T in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti83A → T in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti83A → T in CAA71375 (Ref. 7) Curated1
Sequence conflicti86Y → H in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti86Y → H in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti86Y → H in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti86Y → H in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti86Y → H in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti86Y → H in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti86Y → H in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti86Y → H in CAA71375 (Ref. 7) Curated1
Sequence conflicti87V → F in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti87V → F in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti87V → F in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti87V → F in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti87V → F in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti87V → F in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti87V → F in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti87V → F in CAA71375 (Ref. 7) Curated1
Sequence conflicti90I → V in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti90I → V in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti90I → V in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti90I → V in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti90I → V in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti90I → V in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti90I → V in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti90I → V in CAA71375 (Ref. 7) Curated1
Sequence conflicti91R → T in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti91R → T in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti91R → T in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti91R → T in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti91R → T in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti91R → T in CAA71375 (Ref. 7) Curated1
Sequence conflicti96T → A in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti96T → A in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti96T → A in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti96T → A in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti96T → A in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti96T → A in CAA71375 (Ref. 7) Curated1
Sequence conflicti114A → E in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti114A → E in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti114A → E in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti114A → E in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti114A → E in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti114A → E in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti114A → E in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti114A → E in CAA71375 (Ref. 7) Curated1
Sequence conflicti118I → T in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti118I → T in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti118I → T in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti118I → T in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti118I → T in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti118I → T in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti118I → T in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti118I → T in CAA71375 (Ref. 7) Curated1
Sequence conflicti126K → R in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti126K → R in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti128S → P in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti128S → P in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti128S → P in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti128S → P in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti128S → P in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti128S → P in CAA71375 (Ref. 7) Curated1
Sequence conflicti154 – 156VSG → YPV in CAA71375 (Ref. 7) Curated3
Sequence conflicti164D → Y in CAA71375 (Ref. 7) Curated1
Sequence conflicti194P → H in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti194P → H in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti194P → H in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti194P → H in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti194P → H in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti194P → H in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti224N → H in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti224N → H in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti224N → H in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti224N → H in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti224N → H in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti224N → H in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti224N → H in CAA71375 (Ref. 7) Curated1
Sequence conflicti263S → P in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti276A → D in CAA71375 (Ref. 7) Curated1
Sequence conflicti351F → L in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti351F → L in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti351F → L in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti351F → L in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti351F → L in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti351F → L in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti351F → L in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti351F → L in CAA71375 (Ref. 7) Curated1
Sequence conflicti365D → G in BAA13520 (PubMed:9070220).Curated1
Sequence conflicti365D → G in BAA13521 (PubMed:9070220).Curated1
Sequence conflicti365D → G in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti365D → G in AAB92591 (PubMed:9348339).Curated1
Sequence conflicti365D → G in BAA89289 (PubMed:10585853).Curated1
Sequence conflicti365D → G in BAA89290 (PubMed:10585853).Curated1
Sequence conflicti365D → G in AAK56107 (PubMed:11471062).Curated1
Sequence conflicti365D → G in CAA71375 (Ref. 7) Curated1
Sequence conflicti448 – 458EKKPAPRAPEP → RRKPAPGSLEFL in CAA71375 (Ref. 7) CuratedAdd BLAST11
Sequence conflicti490S → N in BAA20376 (PubMed:9073522).Curated1
Sequence conflicti490S → N in AAB92591 (PubMed:9348339).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007031147 – 364Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST218
Alternative sequenceiVSP_007032425 – 428Missing in isoform 2 and isoform 4. 5 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D87967 mRNA Translation: BAA13520.1
D87968 mRNA Translation: BAA13521.1
D85785 mRNA Translation: BAA20376.1
U89694 mRNA Translation: AAB92591.1
AF072543 mRNA Translation: AAC24886.1
AF072544 mRNA Translation: AAC24887.1
AB024507 Genomic DNA Translation: BAA89290.1
AB018194 mRNA Translation: BAA76555.1
AB024507 Genomic DNA Translation: BAA89289.1
AF332079 mRNA Translation: AAK56107.1
AF332080 mRNA Translation: AAK56108.1
Y10349 mRNA Translation: CAA71375.1
AL808126 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28242.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16729.1 [P97797-2]
CCDS50708.1 [P97797-4]
CCDS71142.1 [P97797-1]
CCDS71143.1 [P97797-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5288
JC5289

NCBI Reference Sequences

More...
RefSeqi
NP_001171118.1, NM_001177647.2 [P97797-4]
NP_001277948.1, NM_001291019.1 [P97797-1]
NP_001277949.1, NM_001291020.1 [P97797-1]
NP_001277950.1, NM_001291021.1 [P97797-3]
NP_031573.2, NM_007547.4 [P97797-2]
XP_006499049.1, XM_006498986.3 [P97797-1]
XP_017172050.1, XM_017316561.1
XP_017172057.1, XM_017316568.1 [P97797-3]
XP_017172058.1, XM_017316569.1 [P97797-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000049262; ENSMUSP00000049022; ENSMUSG00000037902 [P97797-1]
ENSMUST00000099113; ENSMUSP00000096713; ENSMUSG00000037902 [P97797-3]
ENSMUST00000103202; ENSMUSP00000099491; ENSMUSG00000037902 [P97797-2]
ENSMUST00000103203; ENSMUSP00000099492; ENSMUSG00000037902 [P97797-2]
ENSMUST00000160276; ENSMUSP00000125004; ENSMUSG00000037902 [P97797-4]
ENSMUST00000161620; ENSMUSP00000124048; ENSMUSG00000037902 [P97797-1]
ENSMUST00000179001; ENSMUSP00000137611; ENSMUSG00000037902 [P97797-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19261

UCSC genome browser

More...
UCSCi
uc008mhz.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87967 mRNA Translation: BAA13520.1
D87968 mRNA Translation: BAA13521.1
D85785 mRNA Translation: BAA20376.1
U89694 mRNA Translation: AAB92591.1
AF072543 mRNA Translation: AAC24886.1
AF072544 mRNA Translation: AAC24887.1
AB024507 Genomic DNA Translation: BAA89290.1
AB018194 mRNA Translation: BAA76555.1
AB024507 Genomic DNA Translation: BAA89289.1
AF332079 mRNA Translation: AAK56107.1
AF332080 mRNA Translation: AAK56108.1
Y10349 mRNA Translation: CAA71375.1
AL808126 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28242.1
CCDSiCCDS16729.1 [P97797-2]
CCDS50708.1 [P97797-4]
CCDS71142.1 [P97797-1]
CCDS71143.1 [P97797-3]
PIRiJC5288
JC5289
RefSeqiNP_001171118.1, NM_001177647.2 [P97797-4]
NP_001277948.1, NM_001291019.1 [P97797-1]
NP_001277949.1, NM_001291020.1 [P97797-1]
NP_001277950.1, NM_001291021.1 [P97797-3]
NP_031573.2, NM_007547.4 [P97797-2]
XP_006499049.1, XM_006498986.3 [P97797-1]
XP_017172050.1, XM_017316561.1
XP_017172057.1, XM_017316568.1 [P97797-3]
XP_017172058.1, XM_017316569.1 [P97797-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YZ1X-ray1.40A/B32-146[»]
SMRiP97797
ModBaseiSearch...

Protein-protein interaction databases

BioGridi202490, 9 interactors
CORUMiP97797
IntActiP97797, 5 interactors
MINTiP97797
STRINGi10090.ENSMUSP00000099491

PTM databases

GlyConnecti2714
iPTMnetiP97797
PhosphoSitePlusiP97797

Proteomic databases

MaxQBiP97797
PaxDbiP97797
PeptideAtlasiP97797
PRIDEiP97797

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P97797
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049262; ENSMUSP00000049022; ENSMUSG00000037902 [P97797-1]
ENSMUST00000099113; ENSMUSP00000096713; ENSMUSG00000037902 [P97797-3]
ENSMUST00000103202; ENSMUSP00000099491; ENSMUSG00000037902 [P97797-2]
ENSMUST00000103203; ENSMUSP00000099492; ENSMUSG00000037902 [P97797-2]
ENSMUST00000160276; ENSMUSP00000125004; ENSMUSG00000037902 [P97797-4]
ENSMUST00000161620; ENSMUSP00000124048; ENSMUSG00000037902 [P97797-1]
ENSMUST00000179001; ENSMUSP00000137611; ENSMUSG00000037902 [P97797-2]
GeneIDi19261
KEGGimmu:19261
UCSCiuc008mhz.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140885
MGIiMGI:108563 Sirpa

Phylogenomic databases

eggNOGiENOG410IKYM Eukaryota
ENOG410YKK2 LUCA
GeneTreeiENSGT00960000186656
InParanoidiP97797
KOiK06551
OrthoDBi904196at2759

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2172127 DAP12 interactions
R-MMU-391160 Signal regulatory protein family interactions
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiP97797

Protein Ontology

More...
PROi
PR:P97797

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037902 Expressed in 296 organ(s), highest expression level in stroma of bone marrow
ExpressionAtlasiP97797 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHPS1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97797
Secondary accession number(s): A0A0R4J1Z7
, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 8, 2019
Last modified: July 3, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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