UniProtKB - P97792 (CXAR_MOUSE)
Coxsackievirus and adenovirus receptor homolog
Cxadr
Functioni
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- cell adhesion molecule binding Source: UniProtKB
- cell adhesive protein binding involved in AV node cell-bundle of His cell communication Source: BHF-UCL
- connexin binding Source: UniProtKB
- identical protein binding Source: MGI
- integrin binding Source: MGI
- PDZ domain binding Source: UniProtKB
- signaling receptor binding Source: MGI
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- AV node cell-bundle of His cell adhesion involved in cell communication Source: BHF-UCL
- AV node cell to bundle of His cell communication Source: UniProtKB
- cardiac muscle fiber development Source: MGI
- cell-cell adhesion Source: UniProtKB
- cell-cell junction organization Source: MGI
- defense response to virus Source: MGI
- epithelial structure maintenance Source: UniProtKB
- gamma-delta T cell activation Source: UniProtKB
- germ cell migration Source: UniProtKB
- heart development Source: MGI
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- homotypic cell-cell adhesion Source: UniProtKB
- mitochondrion organization Source: MGI
- negative regulation of cardiac muscle cell proliferation Source: MGI
- neutrophil chemotaxis Source: UniProtKB
- positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
- regulation of AV node cell action potential Source: BHF-UCL
- transepithelial transport Source: MGI
Keywordsi
Molecular function | Receptor |
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202733, Cell surface interactions at the vascular wall |
Names & Taxonomyi
Protein namesi | Recommended name: Coxsackievirus and adenovirus receptor homologShort name: CAR Short name: mCAR |
Gene namesi | Name:Cxadr Synonyms:Car |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1201679, Cxadr |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
- Basolateral cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Other locations
- tight junction By similarity
- adherens junction By similarity
Note: In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.By similarity
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- apicolateral plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- acrosomal vesicle Source: MGI
- adherens junction Source: UniProtKB
- bicellular tight junction Source: UniProtKB
- cell body Source: UniProtKB
- cell junction Source: MGI
- cell-cell junction Source: MGI
- cytoplasm Source: UniProtKB
- filopodium Source: UniProtKB
- growth cone Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- intercalated disc Source: UniProtKB
- membrane raft Source: UniProtKB
- neuromuscular junction Source: MGI
- neuron projection Source: UniProtKB
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 237 | ExtracellularSequence analysisAdd BLAST | 218 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 365 | CytoplasmicSequence analysisAdd BLAST | 107 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Secreted, Tight junctionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000014740 | 20 – 365 | Coxsackievirus and adenovirus receptor homologAdd BLAST | 346 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 120 | Combined sources2 Publications | ||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 146 ↔ 223 | Combined sources2 Publications | ||
Disulfide bondi | 162 ↔ 212 | Combined sources2 Publications | ||
Lipidationi | 259 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 260 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 297 | PhosphoserineCombined sources | 1 | |
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 332 | PhosphoserineBy similarity | 1 | |
Modified residuei | 363 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P97792 |
MaxQBi | P97792 |
PaxDbi | P97792 |
PeptideAtlasi | P97792 |
PRIDEi | P97792 |
PTM databases
GlyConnecti | 2238, 1 N-Linked glycan (1 site) |
GlyGeni | P97792, 2 sites |
iPTMneti | P97792 |
PhosphoSitePlusi | P97792 |
SwissPalmi | P97792 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000022865, Expressed in central nervous system and 318 other tissues |
ExpressionAtlasi | P97792, baseline and differential |
Genevisiblei | P97792, MM |
Interactioni
Subunit structurei
Monomer. May form homodimer.
Interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1.
Interacts with MPDZ; recruits MPDZ to intercellular contact sites.
Interacts with JAML (homodimeric form).
2 PublicationsBinary interactionsi
Hide detailsP97792
With | #Exp. | IntAct |
---|---|---|
Actb [P60710] | 6 | EBI-7429264,EBI-353957 |
Isoform 1 [P97792-1]
With | #Exp. | IntAct |
---|---|---|
RXRA [P19793] from Homo sapiens. | 2 | EBI-15903843,EBI-78598 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- cell adhesion molecule binding Source: UniProtKB
- cell adhesive protein binding involved in AV node cell-bundle of His cell communication Source: BHF-UCL
- connexin binding Source: UniProtKB
- identical protein binding Source: MGI
- integrin binding Source: MGI
- PDZ domain binding Source: UniProtKB
- signaling receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198986, 2 interactors |
CORUMi | P97792 |
DIPi | DIP-41457N |
IntActi | P97792, 4 interactors |
MINTi | P97792 |
STRINGi | 10090.ENSMUSP00000023572 |
Miscellaneous databases
RNActi | P97792, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P97792 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P97792 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 136 | Ig-like C2-type 1Add BLAST | 117 | |
Domaini | 141 – 228 | Ig-like C2-type 2Add BLAST | 88 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 360 – 365 | PDZ-bindingBy similarity | 6 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSG0, Eukaryota |
GeneTreei | ENSGT00940000154829 |
HOGENOMi | CLU_040549_0_0_1 |
InParanoidi | P97792 |
OMAi | ICNEIRE |
OrthoDBi | 896005at2759 |
PhylomeDBi | P97792 |
TreeFami | TF330875 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARLLCFVLL CGIADFTSGL SITTPEQRIE KAKGETAYLP CKFTLSPEDQ
60 70 80 90 100
GPLDIEWLIS PSDNQIVDQV IILYSGDKIY DNYYPDLKGR VHFTSNDVKS
110 120 130 140 150
GDASINVTNL QLSDIGTYQC KVKKAPGVAN KKFLLTVLVK PSGTRCFVDG
160 170 180 190 200
SEEIGNDFKL KCEPKEGSLP LQFEWQKLSD SQTMPTPWLA EMTSPVISVK
210 220 230 240 250
NASSEYSGTY SCTVQNRVGS DQCMLRLDVV PPSNRAGTIA GAVIGTLLAL
260 270 280 290 300
VLIGAILFCC HRKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS
310 320 330 340 350
SLGSMSPSNM EGYSKTQYNQ VPSEDFERAP QSPTLAPAKV AAPNLSRMGA
360
VPVMIPAQSK DGSIV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A338P6N1 | A0A338P6N1_MOUSE | Coxsackievirus and adenovirus recep... | Cxadr | 136 | Annotation score: | ||
A0A338P6U1 | A0A338P6U1_MOUSE | Coxsackievirus and adenovirus recep... | Cxadr | 52 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014827 | 139 – 164 | VKPSG…LKCEP → GKSSFLLSTGVEWGGGAELQ GGREGG in isoform 3. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_014828 | 165 – 365 | Missing in isoform 3. 1 PublicationAdd BLAST | 201 | |
Alternative sequenceiVSP_014829 | 340 – 365 | VAAPN…DGSIV → FKYAYKTDGITVV in isoform 2. 3 PublicationsAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90715 mRNA Translation: AAC53148.1 Y10320 mRNA Translation: CAA71368.1 Y11929 mRNA Translation: CAA72679.1 AK004908 mRNA Translation: BAB23660.2 AK145569 mRNA Translation: BAE26518.1 BC004680 mRNA Translation: AAH04680.1 BC016457 mRNA Translation: AAH16457.1 |
CCDSi | CCDS28276.1 [P97792-1] CCDS37379.1 [P97792-2] CCDS88952.1 [P97792-3] |
RefSeqi | NP_001020363.1, NM_001025192.3 [P97792-1] NP_001263192.1, NM_001276263.1 [P97792-3] NP_034118.1, NM_009988.4 [P97792-2] XP_006522946.1, XM_006522883.3 [P97792-1] XP_006522947.1, XM_006522884.3 [P97792-2] |
Genome annotation databases
Ensembli | ENSMUST00000023572; ENSMUSP00000023572; ENSMUSG00000022865 [P97792-1] ENSMUST00000114229; ENSMUSP00000109867; ENSMUSG00000022865 [P97792-2] ENSMUST00000231356; ENSMUSP00000156281; ENSMUSG00000022865 [P97792-3] |
GeneIDi | 13052 |
KEGGi | mmu:13052 |
UCSCi | uc007zsm.2, mouse [P97792-3] uc007zsn.2, mouse [P97792-1] uc007zso.2, mouse [P97792-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90715 mRNA Translation: AAC53148.1 Y10320 mRNA Translation: CAA71368.1 Y11929 mRNA Translation: CAA72679.1 AK004908 mRNA Translation: BAB23660.2 AK145569 mRNA Translation: BAE26518.1 BC004680 mRNA Translation: AAH04680.1 BC016457 mRNA Translation: AAH16457.1 |
CCDSi | CCDS28276.1 [P97792-1] CCDS37379.1 [P97792-2] CCDS88952.1 [P97792-3] |
RefSeqi | NP_001020363.1, NM_001025192.3 [P97792-1] NP_001263192.1, NM_001276263.1 [P97792-3] NP_034118.1, NM_009988.4 [P97792-2] XP_006522946.1, XM_006522883.3 [P97792-1] XP_006522947.1, XM_006522884.3 [P97792-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JZ7 | X-ray | 2.19 | A | 20-233 | [»] | |
3MJ7 | X-ray | 2.80 | B | 18-236 | [»] | |
SMRi | P97792 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198986, 2 interactors |
CORUMi | P97792 |
DIPi | DIP-41457N |
IntActi | P97792, 4 interactors |
MINTi | P97792 |
STRINGi | 10090.ENSMUSP00000023572 |
PTM databases
GlyConnecti | 2238, 1 N-Linked glycan (1 site) |
GlyGeni | P97792, 2 sites |
iPTMneti | P97792 |
PhosphoSitePlusi | P97792 |
SwissPalmi | P97792 |
Proteomic databases
jPOSTi | P97792 |
MaxQBi | P97792 |
PaxDbi | P97792 |
PeptideAtlasi | P97792 |
PRIDEi | P97792 |
Protocols and materials databases
Antibodypediai | 1120, 447 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023572; ENSMUSP00000023572; ENSMUSG00000022865 [P97792-1] ENSMUST00000114229; ENSMUSP00000109867; ENSMUSG00000022865 [P97792-2] ENSMUST00000231356; ENSMUSP00000156281; ENSMUSG00000022865 [P97792-3] |
GeneIDi | 13052 |
KEGGi | mmu:13052 |
UCSCi | uc007zsm.2, mouse [P97792-3] uc007zsn.2, mouse [P97792-1] uc007zso.2, mouse [P97792-2] |
Organism-specific databases
CTDi | 1525 |
MGIi | MGI:1201679, Cxadr |
Phylogenomic databases
eggNOGi | ENOG502QSG0, Eukaryota |
GeneTreei | ENSGT00940000154829 |
HOGENOMi | CLU_040549_0_0_1 |
InParanoidi | P97792 |
OMAi | ICNEIRE |
OrthoDBi | 896005at2759 |
PhylomeDBi | P97792 |
TreeFami | TF330875 |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202733, Cell surface interactions at the vascular wall |
Miscellaneous databases
BioGRID-ORCSi | 13052, 0 hits in 17 CRISPR screens |
ChiTaRSi | Cxadr, mouse |
EvolutionaryTracei | P97792 |
PROi | PR:P97792 |
RNActi | P97792, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022865, Expressed in central nervous system and 318 other tissues |
ExpressionAtlasi | P97792, baseline and differential |
Genevisiblei | P97792, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXAR_MOUSE | |
Accessioni | P97792Primary (citable) accession number: P97792 Secondary accession number(s): O09052 Q9DBJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references