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Entry version 125 (18 Sep 2019)
Sequence version 1 (01 May 1997)
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Protein

5'-3' exoribonuclease 1

Gene

Xrn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Exonuclease, Hydrolase, Nuclease, RNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-MMU-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-3' exoribonuclease 1 (EC:3.1.13.-)
Short name:
mXRN1
Alternative name(s):
Protein Dhm2
Strand-exchange protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Xrn1
Synonyms:Dhm2, Exo, Sep1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:891964 Xrn1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000713931 – 17195'-3' exoribonuclease 1Add BLAST1719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1382PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97789

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97789

PeptideAtlas

More...
PeptideAtlasi
P97789

PRoteomics IDEntifications database

More...
PRIDEi
P97789

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97789

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97789

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P97789

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain (spinal cord, dorsal root and superior cervical ganglia, neurons of the cerebrum and brain stem), peripheral nerve fibers in the skin and intestine, spleen, lung, liver, skeletal muscle, kidney and testis.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo between 7 and 17 dpc.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1 (By similarity). Associates with alpha and beta tubulins (PubMed:14580940).

Interacts with DIS3L2 (By similarity).

Interacts with ZC3HAV1 in an RNA-dependent manner (By similarity).

Interacts with ZFP36L1 (By similarity).

Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (By similarity).

Interacts with YTHDC2 (via ANK repeats) (PubMed:29033321).

By similarity2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P97789, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034981

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97789

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2044 Eukaryota
KOG2045 Eukaryota
COG5049 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154879

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97789

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97789

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR041385 SH3_12
IPR040992 XRN1_D1
IPR041412 Xrn1_helical

The PANTHER Classification System

More...
PANTHERi
PTHR12341 PTHR12341, 1 hit
PTHR12341:SF7 PTHR12341:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18129 SH3_12, 1 hit
PF18332 XRN1_D1, 1 hit
PF17846 XRN_M, 1 hit
PF03159 XRN_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006743 Exonuclease_Xnr1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97789-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD
60 70 80 90 100
VHFRISDDKI FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR
110 120 130 140 150
RFRSAKEAED KIKKAIEKGE TLPTEARFDS NCITPGTEFM ARLHEHLKYF
160 170 180 190 200
VNMKISTDKS WQGVTIYFSG HETPGEGEHK IMEFIRSEKA KPDHDPNTRH
210 220 230 240 250
CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA PEETTFHLLH
260 270 280 290 300
LSLMREYIDY EFSALKEKIT FKYDIEKIID DWILMGFLVG NDFIPHLPHL
310 320 330 340 350
HINHDALPLL YGTYIAILPE LGGYINESGH LNLPRFERYL VKLSDFDREH
360 370 380 390 400
FSEVFVDLKW FESKVGNKYL NEAAGAAAEE AKNCKEKRKP KGQENSLSWA
410 420 430 440 450
ALDKSEGEGV ASRDNFEDET EDDDLFETEF RQYKRTYYMT KMGVDVVSDE
460 470 480 490 500
FLANQAACYV QAIQWILHYY YHGVQSWSWY YPYHYAPFLS DIRSISTLKI
510 520 530 540 550
HFELGKPFKP FEQLLAVLPS ASKNLLPTCY QHLMTSEDSP IIEYYPPDFK
560 570 580 590 600
TDLNGKQQEW EAVVLIPFID ETRLLEAMET CNHSLKKEER KRNQHSECLM
610 620 630 640 650
CWYDRDTEFT YSSPWPEKFP AIERCCTRYK MISLDAWRVD INKNKITRVD
660 670 680 690 700
QKALYFCGFP TLKHIKHKFF LKKSGVQVFQ QSSRGENLML EISVNAEPDE
710 720 730 740 750
LRIENIASAV LGKAVFVNWP HLEEARVVAV SDGETKFYIE EPPGTQKVYL
760 770 780 790 800
GKTAPPSKVI QLTDKEQSNW TKEIQGISEQ YLRRKGIIIN ETSAVVYAQL
810 820 830 840 850
LTGRKYQISQ NGEVRLEKQW SKQILPFVYQ TIVKDIRAFD SRFSNIKTLD
860 870 880 890 900
DLFPPRTMVF MLGTPYYGCT GEVQDSGDLI TEGRIRVVFS IPCEPNLDAL
910 920 930 940 950
IQNQHKYSIK YNPGYVLAGR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK
960 970 980 990 1000
ANVGLNLKFN KKNEEVPGYT KKVGNEWMYS SAAEQLLAEY IERAPELFSY
1010 1020 1030 1040 1050
IAKNSQEDVF YEDDIWPGEN ENGAEKVQEI ITWLKGHPVS TLSRSSCDLH
1060 1070 1080 1090 1100
ILDAAIVEKI EEEVEKCKQR KSNKKVRVTV KPHLMYRPLE QQHGVIPDRD
1110 1120 1130 1140 1150
AEFRLFDRVV NVRESFSVPV GLRGTVIGIK GASREADVLF EVLFDEEFPG
1160 1170 1180 1190 1200
GLTIRCSPGR GYRLPTSALV NLSHGSRCET GNQKLTAIVK PQPSVSHCSA
1210 1220 1230 1240 1250
APSGHLGGLN HSPQSPFLPT QVPTKGDDEF CNIWQSLQGA GKTQHLQPTV
1260 1270 1280 1290 1300
QEKGAVLPQE ISQVTEGHKS GFTDHSVRHQ QRKHDSQRKF KEEYKSPKAE
1310 1320 1330 1340 1350
CQSQKLSSKQ TSGGSARCSI KLLKRNESPG TSEAQKVVTS YPNAVHKPPS
1360 1370 1380 1390 1400
GIENFLASLN LSKENEAQLP HHGEPPDEAD LSPQSFAMKG TRMLKEILKI
1410 1420 1430 1440 1450
DSPDTRDSKN DMKKSDNEAT VSSRRDERGV SAHPKPTCHM NKPHGTNEFQ
1460 1470 1480 1490 1500
NVASVDSVCW PGQMPPVSTP VTELSRICSL VGMPQPDFSF LRTTQTMTVC
1510 1520 1530 1540 1550
QVKLSNGLLV HGPQCHSESE AKERAALFAL QQLGSLGVSF PLPPPIFTNY
1560 1570 1580 1590 1600
PPAVPPGAVP PVFTQPTANI MPSSSHLFGS VSWRPPVPVA GNAFHYPSYP
1610 1620 1630 1640 1650
GTMPLAGGVP GGVHSQFIPL QVTKKRVANR KNFENKEAQS SQATPLQTNK
1660 1670 1680 1690 1700
PGSSEATKMT PQESPPASSS SSQAAQPVSS HVETASQGHV GSQPRSAPSS
1710
SKRKSRKLAV NFSVSKPSE
Length:1,719
Mass (Da):194,307
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FE6C888E3FE2459
GO
Isoform 2 (identifier: P97789-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1568-1580: Missing.

Show »
Length:1,706
Mass (Da):192,978
Checksum:i53CD8A860D36DC3C
GO
Isoform 3 (identifier: P97789-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1436-1436: P → PSKKL
     1661-1719: PQESPPASSS...VNFSVSKPSE → EFPGWVHLPVTSLTYGLWWRLPG

Show »
Length:1,687
Mass (Da):191,416
Checksum:i9805496C9820F4DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VQ87F8VQ87_MOUSE
5'-3' exoribonuclease 1
Xrn1
1,723Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQN7A0A087WQN7_MOUSE
5'-3' exoribonuclease 1
Xrn1
1,719Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQ18A0A087WQ18_MOUSE
5'-3' exoribonuclease 1
Xrn1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WNV6A0A087WNV6_MOUSE
5'-3' exoribonuclease 1
Xrn1
969Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99G → A in BAA21563 (PubMed:9218715).Curated1
Sequence conflicti172E → D in BAE25024 (PubMed:16141072).Curated1
Sequence conflicti193D → G in BAE25024 (PubMed:16141072).Curated1
Sequence conflicti1085M → L in BAA21563 (PubMed:9218715).Curated1
Sequence conflicti1243T → I in BAA21563 (PubMed:9218715).Curated1
Sequence conflicti1261I → L in BAE41404 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0166961436P → PSKKL in isoform 3. 1 Publication1
Alternative sequenceiVSP_0166971568 – 1580Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0166981661 – 1719PQESP…SKPSE → EFPGWVHLPVTSLTYGLWWR LPG in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D88026 mRNA Translation: BAA21563.1
X91617 mRNA Translation: CAA62819.1
X91617 mRNA Translation: CAA62820.1
AK142311 mRNA Translation: BAE25024.1
AK162848 mRNA Translation: BAE37081.1
AK169840 mRNA Translation: BAE41404.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS81053.1 [P97789-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T30174
T30175
T30244

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88026 mRNA Translation: BAA21563.1
X91617 mRNA Translation: CAA62819.1
X91617 mRNA Translation: CAA62820.1
AK142311 mRNA Translation: BAE25024.1
AK162848 mRNA Translation: BAE37081.1
AK169840 mRNA Translation: BAE41404.1
CCDSiCCDS81053.1 [P97789-1]
PIRiT30174
T30175
T30244

3D structure databases

SMRiP97789
ModBaseiSearch...

Protein-protein interaction databases

IntActiP97789, 2 interactors
STRINGi10090.ENSMUSP00000034981

PTM databases

iPTMnetiP97789
PhosphoSitePlusiP97789
SwissPalmiP97789

Proteomic databases

MaxQBiP97789
PaxDbiP97789
PeptideAtlasiP97789
PRIDEiP97789

Organism-specific databases

MGIiMGI:891964 Xrn1

Phylogenomic databases

eggNOGiKOG2044 Eukaryota
KOG2045 Eukaryota
COG5049 LUCA
HOGENOMiHOG000154879
InParanoidiP97789
PhylomeDBiP97789

Enzyme and pathway databases

ReactomeiR-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-MMU-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Xrn1 mouse

Protein Ontology

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PROi
PR:P97789

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR041385 SH3_12
IPR040992 XRN1_D1
IPR041412 Xrn1_helical
PANTHERiPTHR12341 PTHR12341, 1 hit
PTHR12341:SF7 PTHR12341:SF7, 1 hit
PfamiView protein in Pfam
PF18129 SH3_12, 1 hit
PF18332 XRN1_D1, 1 hit
PF17846 XRN_M, 1 hit
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRN1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97789
Secondary accession number(s): O35651
, P97790, Q3TE44, Q3TRE9, Q3UQL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1997
Last modified: September 18, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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