Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P97785 (GFRA1_MOUSE)

Entry version 142 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Add a publicationFeedback
Protein

GDNF family receptor alpha-1

Gene

Gfra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-5673001, RAF/MAP kinase cascade
R-MMU-8853659, RET signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GDNF family receptor alpha-1
Short name:
GDNF receptor alpha-1
Short name:
GDNFR-alpha-1
Short name:
GFR-alpha-1
Alternative name(s):
TGF-beta-related neurotrophic factor receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gfra1
Synonyms:Gdnfra, Trnr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1100842, Gfra1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001077925 – 430GDNF family receptor alpha-1Add BLAST406
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000010780431 – 468Removed in mature formSequence analysisAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 87By similarity
Disulfide bondi36 ↔ 42By similarity
Disulfide bondi52 ↔ 72By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 99By similarity
Disulfide bondi154 ↔ 214By similarity
Disulfide bondi161 ↔ 167By similarity
Disulfide bondi178 ↔ 192By similarity
Disulfide bondi187 ↔ 233By similarity
Disulfide bondi216 ↔ 221By similarity
Disulfide bondi243 ↔ 313By similarity
Disulfide bondi250 ↔ 256By similarity
Disulfide bondi267 ↔ 285By similarity
Disulfide bondi277 ↔ 337By similarity
Disulfide bondi315 ↔ 325By similarity
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi430GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P97785

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P97785

PeptideAtlas

More...PeptideAtlasi		P97785

PRoteomics IDEntifications database

More...PRIDEi		P97785

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P97785, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P97785

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P97785

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, in hippocampal neurons (at protein level) (PubMed:23333276). Isoform 1 and isoform 2 are expressed in heart, brain, lung, liver, kidney and testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000025089, Expressed in vestibular membrane of cochlear duct and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P97785, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P97785, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET (By similarity).

Interacts with RET (By similarity).

Interacts with SORL1, either alone or in complex with GDNF. Interaction between SORL1 and GFRA1 leads to GFRA1 internalization, but not degradation (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199904, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P97785

Protein interaction database and analysis system

More...IntActi		P97785, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000026076

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P97785, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P97785

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati25 – 1131Add BLAST89
Repeati150 – 2382Add BLAST89
Repeati239 – 3423Add BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi362 – 369Thr-rich8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQA2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155560

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P97785

KEGG Orthology (KO)

More...KOi		K19895

Identification of Orthologs from Complete Genome Data

More...OMAi		TDVNVWQ

Database of Orthologous Groups

More...OrthoDBi		482696at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P97785

TreeFam database of animal gene trees

More...TreeFami		TF331647

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016017, GDNF/GAS1
IPR037193, GDNF_alpha
IPR003438, GDNF_rcpt
IPR003503, GDNF_rcpt_A1
IPR017372, Glial_neurotroph_fac_rcpt_a1/2

The PANTHER Classification System

More...PANTHERi		PTHR10269, PTHR10269, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02351, GDNF, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038071, GDNF_family_receptor_alpha, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01317, GDNFRALPHA1
PR01316, GDNFRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00907, GDNF, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF110035, SSF110035, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97785-1) [UniParc]FASTAAdd to basket
Also known as: GDNFR-alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFLATLYFVL PLLDLLMSAE VSGGDRLDCV KASDQCLKEQ SCSTKYRTLR 
        60         70         80         90        100
QCVAGKETNF SLTSGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL 
       110        120        130        140        150
RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRAVPFISD VFQQVEHISK 
       160        170        180        190        200
GNNCLDAAKA CNLDDTCKKY RSAYITPCTT SMSNEVCNRR KCHKALRQFF 
       210        220        230        240        250
DKVPAKHSYG MLFCSCRDVA CTERRRQTIV PVCSYEERER PNCLNLQDSC 
       260        270        280        290        300
KTNYICRSRL ADFFTNCQPE SRSVSNCLKE NYADCLLAYS GLIGTVMTPN 
       310        320        330        340        350
YIDSSSLSVA PWCDCSNSGN DLEDCLKFLN FFKDNTCLKN AIQAFGNGSD 
       360        370        380        390        400
VTMWQPAPPV QTTTATTTTA FRIKNKPLGP AGSENEIPTH VLPPCANLQA 
       410        420        430        440        450
QKLKSNVSGS THLCLSDNDY GKDGLAGASS HITTKSMAAP PSCGLSSLPV 
       460 
MVFTALAALL SVSLAETS
Length:468
Mass (Da):51,752
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i997105C2A6DD6446
GO
Isoform 2 (identifier: P97785-2) [UniParc]FASTAAdd to basket
Also known as: GDNFR-beta

The sequence of this isoform differs from the canonical sequence as follows:
     140-144: Missing.

Show »
Length:463
Mass (Da):51,134
Checksum:iEAF2A1522622C037
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RDD4D6RDD4_MOUSE
GDNF family receptor alpha-1
Gfra1
419Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YUD5D3YUD5_MOUSE
GDNF family receptor alpha-1
Gfra1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3C9D3Z3C9_MOUSE
GDNF family receptor alpha-1
Gfra1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YWL3D3YWL3_MOUSE
GDNF family receptor alpha-1
Gfra1
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C7ZN00A0A1C7ZN00_MOUSE
GDNF family receptor alpha-1
Gfra1
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366T → M in BAA19185 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041630140 – 144Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF014117 mRNA Translation: AAB86599.1
AF015172 mRNA Translation: AAB86600.1
AB000800 mRNA Translation: BAA19185.1
CH466585 Genomic DNA Translation: EDL01795.1
CH466585 Genomic DNA Translation: EDL01796.1
BC054378 mRNA Translation: AAH54378.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38028.1 [P97785-1]
CCDS70967.1 [P97785-2]

NCBI Reference Sequences

More...RefSeqi		NP_001272386.1, NM_001285457.2 [P97785-2]
NP_034409.1, NM_010279.3 [P97785-1]
XP_006526744.1, XM_006526681.1 [P97785-1]
XP_006526745.1, XM_006526682.1 [P97785-1]
XP_006526746.1, XM_006526683.3 [P97785-1]
XP_006526747.1, XM_006526684.1 [P97785-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000026076; ENSMUSP00000026076; ENSMUSG00000025089 [P97785-1]
ENSMUST00000129100; ENSMUSP00000117196; ENSMUSG00000025089 [P97785-2]
ENSMUST00000152507; ENSMUSP00000120333; ENSMUSG00000025089 [P97785-1]
ENSMUST00000169850; ENSMUSP00000130128; ENSMUSG00000025089 [P97785-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		14585

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:14585

UCSC genome browser

More...UCSCi		uc008ial.2, mouse [P97785-2]
uc008ian.2, mouse [P97785-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014117 mRNA Translation: AAB86599.1
AF015172 mRNA Translation: AAB86600.1
AB000800 mRNA Translation: BAA19185.1
CH466585 Genomic DNA Translation: EDL01795.1
CH466585 Genomic DNA Translation: EDL01796.1
BC054378 mRNA Translation: AAH54378.1
CCDSiCCDS38028.1 [P97785-1]
CCDS70967.1 [P97785-2]
RefSeqiNP_001272386.1, NM_001285457.2 [P97785-2]
NP_034409.1, NM_010279.3 [P97785-1]
XP_006526744.1, XM_006526681.1 [P97785-1]
XP_006526745.1, XM_006526682.1 [P97785-1]
XP_006526746.1, XM_006526683.3 [P97785-1]
XP_006526747.1, XM_006526684.1 [P97785-1]

3D structure databases

SMRiP97785
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199904, 4 interactors
CORUMiP97785
IntActiP97785, 1 interactor
STRINGi10090.ENSMUSP00000026076

PTM databases

GlyGeniP97785, 3 sites
iPTMnetiP97785
PhosphoSitePlusiP97785

Proteomic databases

MaxQBiP97785
PaxDbiP97785
PeptideAtlasiP97785
PRIDEiP97785

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18697, 422 antibodies

Genome annotation databases

EnsembliENSMUST00000026076; ENSMUSP00000026076; ENSMUSG00000025089 [P97785-1]
ENSMUST00000129100; ENSMUSP00000117196; ENSMUSG00000025089 [P97785-2]
ENSMUST00000152507; ENSMUSP00000120333; ENSMUSG00000025089 [P97785-1]
ENSMUST00000169850; ENSMUSP00000130128; ENSMUSG00000025089 [P97785-1]
GeneIDi14585
KEGGimmu:14585
UCSCiuc008ial.2, mouse [P97785-2]
uc008ian.2, mouse [P97785-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2674
MGIiMGI:1100842, Gfra1

Phylogenomic databases

eggNOGiENOG502QQA2, Eukaryota
GeneTreeiENSGT00940000155560
InParanoidiP97785
KOiK19895
OMAiTDVNVWQ
OrthoDBi482696at2759
PhylomeDBiP97785
TreeFamiTF331647

Enzyme and pathway databases

ReactomeiR-MMU-5673001, RAF/MAP kinase cascade
R-MMU-8853659, RET signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		14585, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Gfra1, mouse

Protein Ontology

More...PROi		PR:P97785
RNActiP97785, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000025089, Expressed in vestibular membrane of cochlear duct and 257 other tissues
ExpressionAtlasiP97785, baseline and differential
GenevisibleiP97785, MM

Family and domain databases

InterProiView protein in InterPro
IPR016017, GDNF/GAS1
IPR037193, GDNF_alpha
IPR003438, GDNF_rcpt
IPR003503, GDNF_rcpt_A1
IPR017372, Glial_neurotroph_fac_rcpt_a1/2
PANTHERiPTHR10269, PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351, GDNF, 3 hits
PIRSFiPIRSF038071, GDNF_family_receptor_alpha, 1 hit
PRINTSiPR01317, GDNFRALPHA1
PR01316, GDNFRECEPTOR
SMARTiView protein in SMART
SM00907, GDNF, 3 hits
SUPFAMiSSF110035, SSF110035, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGFRA1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97785
Secondary accession number(s): O35246, O35252
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again