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Protein

Metabotropic glutamate receptor 1

Gene

Grm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei74GlutamateBy similarity1
Binding sitei165GlutamateBy similarity1
Binding sitei236GlutamateBy similarity1
Binding sitei318GlutamateBy similarity1
Binding sitei409GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-416476 G alpha (q) signalling events
R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-MMU-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metabotropic glutamate receptor 1
Short name:
mGluR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Grm1
Synonyms:Gprc1a, Mglur1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1351338 Grm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 592ExtracellularBy similarityAdd BLAST572
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei593 – 615Helical; Name=1By similarityAdd BLAST23
Topological domaini616 – 629CytoplasmicBy similarityAdd BLAST14
Transmembranei630 – 650Helical; Name=2By similarityAdd BLAST21
Topological domaini651 – 658ExtracellularBy similarity8
Transmembranei659 – 680Helical; Name=3By similarityAdd BLAST22
Topological domaini681 – 703CytoplasmicBy similarityAdd BLAST23
Transmembranei704 – 727Helical; Name=4By similarityAdd BLAST24
Topological domaini728 – 750ExtracellularBy similarityAdd BLAST23
Transmembranei751 – 772Helical; Name=5By similarityAdd BLAST22
Topological domaini773 – 785CytoplasmicBy similarityAdd BLAST13
Transmembranei786 – 807Helical; Name=6By similarityAdd BLAST22
Topological domaini808 – 815ExtracellularBy similarity8
Transmembranei816 – 840Helical; Name=7By similarityAdd BLAST25
Topological domaini841 – 1199CytoplasmicBy similarityAdd BLAST359

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2892

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001292321 – 1199Metabotropic glutamate receptor 1Add BLAST1179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi67 ↔ 109By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140InterchainBy similarity
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi289 ↔ 291By similarity
Disulfide bondi378 ↔ 394By similarity
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi432 ↔ 439By similarity
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi657 ↔ 746By similarity
Glycosylationi747N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei853PhosphoserineCombined sources1
Modified residuei871PhosphothreonineCombined sources1
Modified residuei894PhosphoserineBy similarity1
Modified residuei969PhosphoserineCombined sources1
Modified residuei1097PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1151PhosphothreonineBy similarity1
Modified residuei1154PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97772

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97772

PeptideAtlas

More...
PeptideAtlasi
P97772

PRoteomics IDEntifications database

More...
PRIDEi
P97772

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97772

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97772

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P97772

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019828 Expressed in 111 organ(s), highest expression level in medial dorsal nucleus of thalamus

CleanEx database of gene expression profiles

More...
CleanExi
MM_GRM1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P97772 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200073, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P97772

Protein interaction database and analysis system

More...
IntActi
P97772, 6 interactors

Molecular INTeraction database

More...
MINTi
P97772

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000037255

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P97772

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P97772

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P97772

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni186 – 188Glutamate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1014 – 1041Gln/Pro-richAdd BLAST28
Compositional biasi1073 – 1087Gln/Pro-richAdd BLAST15
Compositional biasi1101 – 1135Asp/Glu-rich (acidic)Add BLAST35
Compositional biasi1147 – 1199Ser-richAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1056 Eukaryota
ENOG410XR6W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153406

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218636

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107965

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97772

KEGG Orthology (KO)

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KOi
K04603

Identification of Orthologs from Complete Genome Data

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OMAi
IRIHSPY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G177R

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97772

TreeFam database of animal gene trees

More...
TreeFami
TF313240

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001256 GPCR_3_mtglu_rcpt_1
IPR019588 Metabotropic_Glu_rcpt_Homer-bd
IPR028082 Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF10606 GluR_Homer-bdg, 1 hit
PF07562 NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00248 GPCRMGR
PR01051 MTABOTROPC1R
PR00593 MTABOTROPICR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01229 GluR_Homer-bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P97772-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRLLLIFFP MIFLEMSILP RMPDRKVLLA GASSQRSVAR MDGDVIIGAL
60 70 80 90 100
FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT
110 120 130 140 150
LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGLNRC LPDGQTLPPG
160 170 180 190 200
RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY
210 220 230 240 250
FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ
260 270 280 290 300
EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL
310 320 330 340 350
SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF
360 370 380 390 400
DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KKVCTGNESL
410 420 430 440 450
EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGYVGLCD AMKPIDGRKL
460 470 480 490 500
LDFLIKSSFV GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW
510 520 530 540 550
HEGVLNIDDY KIQMNKSGMV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC
560 570 580 590 600
KENEFVQDEF TCRACDLGWW PNAELTGCEP ITIRYLEWSD IESIIAIAFS
610 620 630 640 650
CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA
660 670 680 690 700
KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF
710 720 730 740 750
MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN
760 770 780 790 800
LGVVAPVGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA
810 820 830 840 850
FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF
860 870 880 890 900
TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK PGAGNANSNG KSVSWSEPGG
910 920 930 940 950
RQAPKGQHVW QRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDAS
960 970 980 990 1000
TKTLYNVEEE DNTPSTHFSP PSSPSMVVHR RGPPVATTPP LPPHLSAEET
1010 1020 1030 1040 1050
PLFLADSVIP KGLPPPLPQQ QQQPPPQPPP QQPKSLMDQL QGVVTNFGSG
1060 1070 1080 1090 1100
IPDFHAVLAG PGTPGNGLRS LYPPPPPPQH LQMLPLQLST FREEPISPPG
1110 1120 1130 1140 1150
EDDDDDSSER FKLLQEFVYE REGNTEEDDL EEEEDLPAAS KLTPEDSPAL
1160 1170 1180 1190
TPPSPFRDSV ASGSSVPSSP VSESVLCTPP NVTYASVILR DYKQSSSTL
Length:1,199
Mass (Da):133,212
Last modified:April 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE5370AF160CC16E
GO
Isoform 2 (identifier: P97772-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGRQAPKG → KKRQPEFSPSSQCPSAHVQL
     907-1199: Missing.

Show »
Length:906
Mass (Da):101,710
Checksum:iB9223F00A9C6851C
GO
Isoform 3 (identifier: P97772-3) [UniParc]FASTAAdd to basket
Also known as: E55

The sequence of this isoform differs from the canonical sequence as follows:
     317-321: SDGWA → RDSRN
     322-1199: Missing.

Show »
Length:321
Mass (Da):35,852
Checksum:i9DC2B123A5211A2C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007184317 – 321SDGWA → RDSRN in isoform 3. 1 Publication5
Alternative sequenceiVSP_007185322 – 1199Missing in isoform 3. 1 PublicationAdd BLAST878
Alternative sequenceiVSP_007186887 – 906NSNGK…QAPKG → KKRQPEFSPSSQCPSAHVQL in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_007187907 – 1199Missing in isoform 2. 2 PublicationsAdd BLAST293

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF320126 mRNA Translation: AAG41991.2
BC067057 mRNA Translation: AAH67057.1
BC079566 mRNA Translation: AAH79566.1
U89891 mRNA Translation: AAB48099.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23696.1 [P97772-1]
CCDS48499.1 [P97772-2]

NCBI Reference Sequences

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RefSeqi
NP_001107805.1, NM_001114333.2 [P97772-2]
NP_058672.1, NM_016976.3 [P97772-1]
XP_006512612.1, XM_006512549.3 [P97772-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.391904
Mm.482986

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044306; ENSMUSP00000037255; ENSMUSG00000019828 [P97772-1]
ENSMUST00000105560; ENSMUSP00000101189; ENSMUSG00000019828 [P97772-2]
ENSMUST00000105561; ENSMUSP00000101190; ENSMUSG00000019828 [P97772-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
14816

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:14816

UCSC genome browser

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UCSCi
uc007ejh.2 mouse [P97772-2]
uc007eji.2 mouse [P97772-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320126 mRNA Translation: AAG41991.2
BC067057 mRNA Translation: AAH67057.1
BC079566 mRNA Translation: AAH79566.1
U89891 mRNA Translation: AAB48099.1
CCDSiCCDS23696.1 [P97772-1]
CCDS48499.1 [P97772-2]
RefSeqiNP_001107805.1, NM_001114333.2 [P97772-2]
NP_058672.1, NM_016976.3 [P97772-1]
XP_006512612.1, XM_006512549.3 [P97772-1]
UniGeneiMm.391904
Mm.482986

3D structure databases

ProteinModelPortaliP97772
SMRiP97772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200073, 9 interactors
CORUMiP97772
IntActiP97772, 6 interactors
MINTiP97772
STRINGi10090.ENSMUSP00000037255

Chemistry databases

BindingDBiP97772
ChEMBLiCHEMBL2892

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiP97772
PhosphoSitePlusiP97772
SwissPalmiP97772

Proteomic databases

MaxQBiP97772
PaxDbiP97772
PeptideAtlasiP97772
PRIDEiP97772

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044306; ENSMUSP00000037255; ENSMUSG00000019828 [P97772-1]
ENSMUST00000105560; ENSMUSP00000101189; ENSMUSG00000019828 [P97772-2]
ENSMUST00000105561; ENSMUSP00000101190; ENSMUSG00000019828 [P97772-2]
GeneIDi14816
KEGGimmu:14816
UCSCiuc007ejh.2 mouse [P97772-2]
uc007eji.2 mouse [P97772-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2911
MGIiMGI:1351338 Grm1

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00940000153406
HOGENOMiHOG000218636
HOVERGENiHBG107965
InParanoidiP97772
KOiK04603
OMAiIRIHSPY
OrthoDBiEOG091G177R
PhylomeDBiP97772
TreeFamiTF313240

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

Protein Ontology

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PROi
PR:P97772

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019828 Expressed in 111 organ(s), highest expression level in medial dorsal nucleus of thalamus
CleanExiMM_GRM1
GenevisibleiP97772 MM

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001256 GPCR_3_mtglu_rcpt_1
IPR019588 Metabotropic_Glu_rcpt_Homer-bd
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF10606 GluR_Homer-bdg, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01051 MTABOTROPC1R
PR00593 MTABOTROPICR
SMARTiView protein in SMART
SM01229 GluR_Homer-bdg, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRM1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97772
Secondary accession number(s): Q6AXG4, Q9EPV6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 11, 2003
Last modified: December 5, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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