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Protein

WW domain-binding protein 1

Gene

Wbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 1
Short name:
WBP-1
Gene namesi
Name:Wbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104710 Wbp1

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi162Y → A: Abolishes interaction with NEDD4. 1 Publication1
Mutagenesisi176Y → A: Abolishes interaction with NEDD4. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659491 – 304WW domain-binding protein 1Add BLAST304

Proteomic databases

PaxDbiP97764
PRIDEiP97764

PTM databases

PhosphoSitePlusiP97764

Expressioni

Gene expression databases

BgeeiENSMUSG00000030035 Expressed in 290 organ(s), highest expression level in cerebral cortex
CleanExiMM_WBP1
ExpressionAtlasiP97764 baseline and differential
GenevisibleiP97764 MM

Interactioni

Subunit structurei

Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX (By similarity). Interacts with NEDD4.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204545, 2 interactors
ELMiP97764
IntActiP97764, 2 interactors
MINTiP97764
STRINGi10090.ENSMUSP00000032111

Structurei

3D structure databases

ProteinModelPortaliP97764
SMRiP97764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi159 – 162PPxY motif 14
Motifi172 – 176PPxY motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 24Poly-Gln4
Compositional biasi120 – 125Poly-Gln6

Domaini

The PPxY motif 2 mediates interaction with WWOX (By similarity). Both PPxY motifs mediate interaction with NEDD4.By similarity1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWXA Eukaryota
ENOG41104IZ LUCA
GeneTreeiENSGT00530000063663
HOGENOMiHOG000231948
HOVERGENiHBG029355
InParanoidiP97764
OMAiPAHCEGT
OrthoDBiEOG091G0ZU7
PhylomeDBiP97764
TreeFamiTF330726

Family and domain databases

InterProiView protein in InterPro
IPR021684 WBP1-like
PfamiView protein in Pfam
PF11669 WBP-1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97764-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARASSRNSS EEAWGSLQAP QQQQSPAASS LEGAIWRRAG TQTRALDTIL
60 70 80 90 100
YHPQQSHLLR ELCPGVNTQP YLCETGHCCG ETGCCTYYYE LWWFWLLWTV
110 120 130 140 150
LILFSCCCAF RHRRAKLRLQ QQQRQREINL LAYHGACHGA GPVPTGSLLD
160 170 180 190 200
LRLLSAFKPP AYEDVVHHPG TPPPPYTVGP GYPWTTSSEC TRCSSESSCS
210 220 230 240 250
AHLEGTNVEG VSSQQSALPH QEGEPRAGLS PVHIPPSCRY RRLTGDSGIE
260 270 280 290 300
LCPCPDSSEG EPLKEARASA SQPDLEDHSP CALPPDSVSQ VPPMGLASSC

GDIP
Length:304
Mass (Da):33,165
Last modified:November 15, 2002 - v2
Checksum:i2A5C95D34D9D7520
GO
Isoform 2 (identifier: P97764-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-58: Missing.

Show »
Length:269
Mass (Da):29,322
Checksum:iF6F962CB80D499A7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z168D3Z168_MOUSE
WW domain-binding protein 1
Wbp1
288Annotation score:
A0A0N4SUM1A0A0N4SUM1_MOUSE
WW domain-binding protein 1
Wbp1
133Annotation score:
A0A0N4SVJ3A0A0N4SVJ3_MOUSE
WW domain-binding protein 1
Wbp1
195Annotation score:
A0A0N4SVN3A0A0N4SVN3_MOUSE
WW domain-binding protein 1
Wbp1
28Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302 – 304DIP → TSHK in AAB40892 (PubMed:7644498).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00402224 – 58Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40825 mRNA Translation: AAB40892.1
BC005666 mRNA Translation: AAH05666.1
BC019889 mRNA Translation: AAH19889.1
CCDSiCCDS39528.1 [P97764-2]
CCDS39529.1 [P97764-1]
RefSeqiNP_001077392.1, NM_001083923.1 [P97764-2]
NP_058037.2, NM_016757.2 [P97764-1]
UniGeneiMm.1109

Genome annotation databases

EnsembliENSMUST00000032111; ENSMUSP00000032111; ENSMUSG00000030035 [P97764-1]
ENSMUST00000113936; ENSMUSP00000109569; ENSMUSG00000030035 [P97764-2]
GeneIDi22377
KEGGimmu:22377
UCSCiuc009cmo.1 mouse [P97764-1]
uc009cmq.1 mouse [P97764-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40825 mRNA Translation: AAB40892.1
BC005666 mRNA Translation: AAH05666.1
BC019889 mRNA Translation: AAH19889.1
CCDSiCCDS39528.1 [P97764-2]
CCDS39529.1 [P97764-1]
RefSeqiNP_001077392.1, NM_001083923.1 [P97764-2]
NP_058037.2, NM_016757.2 [P97764-1]
UniGeneiMm.1109

3D structure databases

ProteinModelPortaliP97764
SMRiP97764
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204545, 2 interactors
ELMiP97764
IntActiP97764, 2 interactors
MINTiP97764
STRINGi10090.ENSMUSP00000032111

PTM databases

PhosphoSitePlusiP97764

Proteomic databases

PaxDbiP97764
PRIDEiP97764

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032111; ENSMUSP00000032111; ENSMUSG00000030035 [P97764-1]
ENSMUST00000113936; ENSMUSP00000109569; ENSMUSG00000030035 [P97764-2]
GeneIDi22377
KEGGimmu:22377
UCSCiuc009cmo.1 mouse [P97764-1]
uc009cmq.1 mouse [P97764-2]

Organism-specific databases

CTDi23559
MGIiMGI:104710 Wbp1

Phylogenomic databases

eggNOGiENOG410IWXA Eukaryota
ENOG41104IZ LUCA
GeneTreeiENSGT00530000063663
HOGENOMiHOG000231948
HOVERGENiHBG029355
InParanoidiP97764
OMAiPAHCEGT
OrthoDBiEOG091G0ZU7
PhylomeDBiP97764
TreeFamiTF330726

Miscellaneous databases

PROiPR:P97764
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030035 Expressed in 290 organ(s), highest expression level in cerebral cortex
CleanExiMM_WBP1
ExpressionAtlasiP97764 baseline and differential
GenevisibleiP97764 MM

Family and domain databases

InterProiView protein in InterPro
IPR021684 WBP1-like
PfamiView protein in Pfam
PF11669 WBP-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWBP1_MOUSE
AccessioniPrimary (citable) accession number: P97764
Secondary accession number(s): Q8WUP5, Q99J20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: September 12, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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