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Protein

Retinitis pigmentosa 9 protein homolog

Gene

rp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 114CCHC-typeAdd BLAST19

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinitis pigmentosa 9 protein homolog
Alternative name(s):
Pim-1-associated protein
Short name:
PAP-1
Gene namesi
Name:rp9
Synonyms:Rp9h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2157166 Rp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974291 – 213Retinitis pigmentosa 9 protein homologAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei204Phosphoserine; by PIM1; in vitro1 Publication1
Modified residuei206Phosphoserine; by PIM1; in vitro1 Publication1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP97762
PaxDbiP97762
PeptideAtlasiP97762
PRIDEiP97762

PTM databases

iPTMnetiP97762
PhosphoSitePlusiP97762

Expressioni

Tissue specificityi

Highly expressed in the testis, moderately in the kidney, liver and spleen, and weakly in the skeletal muscle and heart.

Gene expression databases

BgeeiENSMUSG00000032239 Expressed in 287 organ(s), highest expression level in testis
CleanExiMM_RP9
ExpressionAtlasiP97762 baseline and differential
GenevisibleiP97762 MM

Interactioni

Subunit structurei

Binds to PIM1. Binds to ZNHIT4.

Binary interactionsi

WithEntry#Exp.IntActNotes
Cir1Q9DA196EBI-626715,EBI-309693

Protein-protein interaction databases

DIPiDIP-33838N
IntActiP97762, 3 interactors
MINTiP97762
STRINGi10090.ENSMUSP00000034763

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 147PIM1-bindingAdd BLAST147

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 171Poly-Ser6
Compositional biasi176 – 205Lys-richAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 114CCHC-typeAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3794 Eukaryota
ENOG410ZVMR LUCA
GeneTreeiENSGT00510000047055
HOGENOMiHOG000132948
HOVERGENiHBG047374
InParanoidiP97762
KOiK19604
OMAiNKRHEKE
OrthoDBiEOG091G0X0Z
PhylomeDBiP97762
TreeFamiTF329160

Family and domain databases

InterProiView protein in InterPro
IPR034585 PAP-1
PANTHERiPTHR35252 PTHR35252, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P97762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGAGSRRP REPPEHELQR RREQKRRRHD AQQLQQLKHL ESFYEKPPPG
60 70 80 90 100
FIKEDETKPE DCIPDVPGNE HAREFLAHAP TKGLWMPLGR EVKVMQCWRC
110 120 130 140 150
KRYGHRTGDK ECPFFIKGNQ KLEQFRVAHE DPMYDIIREN KRHEKDVRIQ
160 170 180 190 200
QLKQLLEDST SDDDGSSSSS SGDREKRKKR KKKEKHKKRK KEKKKKKKRK
210
HKASKSSESS DSE
Length:213
Mass (Da):25,262
Last modified:May 1, 1997 - v1
Checksum:iEDFA8EEE2130E882
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UGI5Q3UGI5_MOUSE
Retinitis pigmentosa 9 (human)
Rp9 rp9, Rp9h
156Annotation score:
A0A1L1SU01A0A1L1SU01_MOUSE
Retinitis pigmentosa 9 (human)
Rp9
128Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78255 mRNA Translation: BAA11319.1
CCDSiCCDS40564.1
RefSeqiNP_061209.1, NM_018739.2
UniGeneiMm.38235

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239
GeneIDi55934
KEGGimmu:55934
UCSCiuc009ooq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78255 mRNA Translation: BAA11319.1
CCDSiCCDS40564.1
RefSeqiNP_061209.1, NM_018739.2
UniGeneiMm.38235

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-33838N
IntActiP97762, 3 interactors
MINTiP97762
STRINGi10090.ENSMUSP00000034763

PTM databases

iPTMnetiP97762
PhosphoSitePlusiP97762

Proteomic databases

EPDiP97762
PaxDbiP97762
PeptideAtlasiP97762
PRIDEiP97762

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239
GeneIDi55934
KEGGimmu:55934
UCSCiuc009ooq.2 mouse

Organism-specific databases

CTDi6100
MGIiMGI:2157166 Rp9

Phylogenomic databases

eggNOGiKOG3794 Eukaryota
ENOG410ZVMR LUCA
GeneTreeiENSGT00510000047055
HOGENOMiHOG000132948
HOVERGENiHBG047374
InParanoidiP97762
KOiK19604
OMAiNKRHEKE
OrthoDBiEOG091G0X0Z
PhylomeDBiP97762
TreeFamiTF329160

Miscellaneous databases

ChiTaRSiRp9 mouse
PROiPR:P97762
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032239 Expressed in 287 organ(s), highest expression level in testis
CleanExiMM_RP9
ExpressionAtlasiP97762 baseline and differential
GenevisibleiP97762 MM

Family and domain databases

InterProiView protein in InterPro
IPR034585 PAP-1
PANTHERiPTHR35252 PTHR35252, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRP9_MOUSE
AccessioniPrimary (citable) accession number: P97762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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