UniProtKB - P97751 (VIPR1_MOUSE)
Protein
Vasoactive intestinal polypeptide receptor 1
Gene
Vipr1
Organism
Mus musculus (Mouse)
Status
Functioni
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- peptide hormone binding Source: MGI
- vasoactive intestinal polypeptide receptor activity Source: MGI
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-418555 G alpha (s) signalling events R-MMU-420092 Glucagon-type ligand receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Vasoactive intestinal polypeptide receptor 1Short name: VIP-R-1 Alternative name(s): Pituitary adenylate cyclase-activating polypeptide type II receptor Short name: PACAP type II receptor Short name: PACAP-R-2 Short name: PACAP-R2 VPAC1 |
Gene namesi | Name:Vipr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109272 Vipr1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 143 | ExtracellularSequence analysisAdd BLAST | 113 | |
Transmembranei | 144 – 168 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 169 – 175 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 176 – 195 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 196 – 217 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 218 – 241 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 242 – 255 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 256 – 277 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 278 – 294 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 295 – 318 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 319 – 343 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 344 – 363 | Helical; Name=6Sequence analysisAdd BLAST | 20 | |
Topological domaini | 364 – 375 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 376 – 395 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 396 – 459 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000012856 | 31 – 459 | Vasoactive intestinal polypeptide receptor 1Add BLAST | 429 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 72 | By similarity | ||
Glycosylationi | 58 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 63 ↔ 105 | By similarity | ||
Glycosylationi | 69 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 86 ↔ 122 | By similarity | ||
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 216 ↔ 286 | By similarity | ||
Glycosylationi | 292 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | P97751 |
PaxDbi | P97751 |
PRIDEi | P97751 |
PTM databases
iPTMneti | P97751 |
PhosphoSitePlusi | P97751 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032528 Expressed in 101 organ(s), highest expression level in jejunum |
Genevisiblei | P97751 MM |
Structurei
3D structure databases
ProteinModelPortali | P97751 |
SMRi | P97751 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000156402 |
HOGENOMi | HOG000008249 |
HOVERGENi | HBG008318 |
InParanoidi | P97751 |
KOi | K04589 |
OMAi | VWTIIRI |
OrthoDBi | 651627at2759 |
PhylomeDBi | P97751 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS IPR001571 GPCR_2_VIP_rcpt IPR001771 GPCR_2_VIP_rcpt_1 |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR00249 GPCRSECRETIN PR00491 VASOACTVEIPR PR01154 VIP1RECEPTOR |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P97751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPPSLPPAR WLCVLAGALA CALGPAGSRA ASPHQECEYL QMIEKQRQQC
60 70 80 90 100
LEEAQLENET TGCSKMWDNL TCWPTTPWGQ VVVLDCPLIF QLFSPIHGYN
110 120 130 140 150
ISRNCTEEGW SQLEPGPYHI ACGLNDRASS MDEQQQTEFY DAVKTGYTIG
160 170 180 190 200
YSLSLASLLV AMAILSLFRK LHCTRNYIHM HLFMSFILRA TAVFIKDMAL
210 220 230 240 250
FNNGETDHCS EASVSCKAAV VFFQYCVMAN FFWLLVEGLY LHTLLAVSFF
260 270 280 290 300
SERKYFWGYI LIGWGVPSVF IMIWTIVRIH FEDFGCWDTI INSSLWWIIK
310 320 330 340 350
GPILISILVN FILFICIIRI LVQKLRPPDI GKNDSSPYSR LAKSTLLLIP
360 370 380 390 400
LFGVHYVMFA FFPDNFKAQV KMVFELVVGS FQGFVVAILY CFLNGEVQAE
410 420 430 440 450
LRRKWRRWHL QGVLGWSSKS QHPWGGSNGV SCSTQVSMLT RVSPSARRSS
SFQAEVSLV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 | E → K in BAA81896 (PubMed:10331949).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022860 Genomic DNA Translation: BAA81896.1 AF266282 mRNA Translation: AAF77053.1 AK052465 mRNA Translation: BAC35004.1 S82970 Genomic DNA Translation: AAN86759.1 |
CCDSi | CCDS23633.1 |
RefSeqi | NP_035833.2, NM_011703.4 |
UniGenei | Mm.282007 |
Genome annotation databases
Ensembli | ENSMUST00000035115; ENSMUSP00000035115; ENSMUSG00000032528 |
GeneIDi | 22354 |
KEGGi | mmu:22354 |
UCSCi | uc009sdl.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022860 Genomic DNA Translation: BAA81896.1 AF266282 mRNA Translation: AAF77053.1 AK052465 mRNA Translation: BAC35004.1 S82970 Genomic DNA Translation: AAN86759.1 |
CCDSi | CCDS23633.1 |
RefSeqi | NP_035833.2, NM_011703.4 |
UniGenei | Mm.282007 |
3D structure databases
ProteinModelPortali | P97751 |
SMRi | P97751 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035115 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | P97751 |
PhosphoSitePlusi | P97751 |
Proteomic databases
MaxQBi | P97751 |
PaxDbi | P97751 |
PRIDEi | P97751 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000035115; ENSMUSP00000035115; ENSMUSG00000032528 |
GeneIDi | 22354 |
KEGGi | mmu:22354 |
UCSCi | uc009sdl.2 mouse |
Organism-specific databases
CTDi | 7433 |
MGIi | MGI:109272 Vipr1 |
Phylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000156402 |
HOGENOMi | HOG000008249 |
HOVERGENi | HBG008318 |
InParanoidi | P97751 |
KOi | K04589 |
OMAi | VWTIIRI |
OrthoDBi | 651627at2759 |
PhylomeDBi | P97751 |
TreeFami | TF315710 |
Enzyme and pathway databases
Reactomei | R-MMU-418555 G alpha (s) signalling events R-MMU-420092 Glucagon-type ligand receptors |
Miscellaneous databases
PROi | PR:P97751 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032528 Expressed in 101 organ(s), highest expression level in jejunum |
Genevisiblei | P97751 MM |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS IPR001571 GPCR_2_VIP_rcpt IPR001771 GPCR_2_VIP_rcpt_1 |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR00249 GPCRSECRETIN PR00491 VASOACTVEIPR PR01154 VIP1RECEPTOR |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | VIPR1_MOUSE | |
Accessioni | P97751Primary (citable) accession number: P97751 Secondary accession number(s): Q9JI40, Q9R1T8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | June 20, 2003 | |
Last modified: | February 13, 2019 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries