Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth/differentiation factor 10

Gene

Gdf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway (PubMed:22155034). Plays an inhibitory role in the process of adipogenesis (PubMed:21712809).2 Publications

Miscellaneous

3T3-L1 cells endogenously secrete biologically active Gdf10 as a unique complex that contains both the pro-region and the mature region.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processOsteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 10
Short name:
GDF-10
Alternative name(s):
Bone morphogenetic protein 3B
Short name:
BMP-3B
Gene namesi
Name:Gdf10Imported
Synonyms:Bmp3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95684 Gdf10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000003384630 – 366Sequence analysisAdd BLAST337
ChainiPRO_0000033847367 – 476Growth/differentiation factor 10Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi374 ↔ 441By similarity
Disulfide bondi403 ↔ 473By similarity
Disulfide bondi407 ↔ 475By similarity
Disulfide bondi440InterchainBy similarity
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP97737
PaxDbiP97737
PRIDEiP97737

PTM databases

PhosphoSitePlusiP97737

Expressioni

Tissue specificityi

Highly expressed in epididymal adipose tissue, brain, bone and aorta and to a lesser extent in liver and spleen. Expressed at higher levels in preadipocytes than in mature adipocytes (PubMed:21712809). Strongly expressed in glial cells of the cerebellum (PubMed:24963847).4 Publications

Developmental stagei

During embryogenes is expressed most prominently in developing skeletal structures both in the craniofacial region and in the vertebral column.1 Publication

Gene expression databases

BgeeiENSMUSG00000021943 Expressed in 243 organ(s), highest expression level in vault of skull
CleanExiMM_GDF10
GenevisibleiP97737 MM

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region (PubMed:21712809).Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128621

Structurei

3D structure databases

ProteinModelPortaliP97737
SMRiP97737
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOVERGENiHBG004857
InParanoidiP97737
KOiK22674
OMAiTSMQDSE
OrthoDBiEOG091G0WGP
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97737-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGPARISL GSQLLPMVPL LLLLRGAGCG HRGPSWSSLP SAAAGLQGDR
60 70 80 90 100
DSQQSPGDAA AALGPGAQDM VAIHMLRLYE KYNRRGAPPG GGNTVRSFRA
110 120 130 140 150
RLEMIDQKPV YFFNLTSMQD SEMILTAAFH FYSEPPRWPR AREVFCKPRA
160 170 180 190 200
KNASCRLLTP GLPARLHLIF RSLSQNTATQ GLLRGAMALT PPPRGLWQAK
210 220 230 240 250
DISSIIKAAR RDGELLLSAQ LDTGEKDPGV PRPSSHMPYI LVYANDLAIS
260 270 280 290 300
EPNSVAVSLQ RYDPFPAGDF EPGAAPNSSA DPRVRRAAQV SKPLQDNELP
310 320 330 340 350
GLDERPAPAL HAQNFHKHEF WSSPFRALKP RTGRKDRKKK DQDTFTAASS
360 370 380 390 400
QVLDFDEKTM QKARRRQWDE PRVCSRRYLK VDFADIGWNE WIISPKSFDA
410 420 430 440 450
YYCAGACEFP MPKIVRPSNH ATIQSIVRAV GIVPGIPEPC CVPDKMNSLG
460 470
VLFLDENRNA VLKVYPNMSV ETCACR
Length:476
Mass (Da):52,575
Last modified:July 27, 2011 - v2
Checksum:iFCFBD71BDBCE7E50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142R → G in AAB46753 (PubMed:8679252).Curated1
Sequence conflicti333G → A in AAB46753 (PubMed:8679252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82648 mRNA Translation: AAB46753.1
BC058358 mRNA Translation: AAH58358.1
CCDSiCCDS26927.1
RefSeqiNP_665684.2, NM_145741.3
UniGeneiMm.432071

Genome annotation databases

EnsembliENSMUST00000168727; ENSMUSP00000128621; ENSMUSG00000021943
GeneIDi14560
KEGGimmu:14560
UCSCiuc007tab.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82648 mRNA Translation: AAB46753.1
BC058358 mRNA Translation: AAH58358.1
CCDSiCCDS26927.1
RefSeqiNP_665684.2, NM_145741.3
UniGeneiMm.432071

3D structure databases

ProteinModelPortaliP97737
SMRiP97737
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128621

PTM databases

PhosphoSitePlusiP97737

Proteomic databases

MaxQBiP97737
PaxDbiP97737
PRIDEiP97737

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168727; ENSMUSP00000128621; ENSMUSG00000021943
GeneIDi14560
KEGGimmu:14560
UCSCiuc007tab.1 mouse

Organism-specific databases

CTDi2662
MGIiMGI:95684 Gdf10

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOVERGENiHBG004857
InParanoidiP97737
KOiK22674
OMAiTSMQDSE
OrthoDBiEOG091G0WGP
TreeFamiTF316134

Miscellaneous databases

PROiPR:P97737
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021943 Expressed in 243 organ(s), highest expression level in vault of skull
CleanExiMM_GDF10
GenevisibleiP97737 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDF10_MOUSE
AccessioniPrimary (citable) accession number: P97737
Secondary accession number(s): Q6PE07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again