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Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

Cacng1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.1 Publication

GO - Molecular functioni

  • calcium channel regulator activity Source: UniProtKB
  • voltage-gated calcium channel activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:Cacng1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2249 Cacng1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicCurated10
Transmembranei11 – 29HelicalBy similarityAdd BLAST19
Topological domaini30 – 109ExtracellularCuratedAdd BLAST80
Transmembranei110 – 130HelicalBy similarityAdd BLAST21
Topological domaini131 – 135CytoplasmicCurated5
Transmembranei136 – 156HelicalBy similarityAdd BLAST21
Topological domaini157 – 180ExtracellularCuratedAdd BLAST24
Transmembranei181 – 205HelicalBy similarityAdd BLAST25
Topological domaini206 – 223CytoplasmicCuratedAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646721 – 223Voltage-dependent calcium channel gamma-1 subunitAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 81By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97707
PRIDEiP97707

Expressioni

Tissue specificityi

Skeletal muscle.1 Publication

Interactioni

Subunit structurei

Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (Probable). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004349

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0I Eukaryota
ENOG4111J5G LUCA
HOGENOMiHOG000293219
HOVERGENiHBG003868
InParanoidiP97707
KOiK04866
PhylomeDBiP97707

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005421 VDCC_g1su
IPR008368 VDCC_gsu
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01601 VDCCGAMMA1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P97707-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQTKTAKVR VTLFFILAGG VLAMVAVVTD HWAVLSPHLE HHNETCVAAH
60 70 80 90 100
FGLWRICTTW VAMHNQDKNC DGTIPAGEKN CSYFRHFNPG ESSEIFEFTT
110 120 130 140 150
QKEYSISAAA IAIFSLGFII IGSICAFLSF GNKRDYLLRP ASMFYAFAGL
160 170 180 190 200
CLIVSVEVMR QSVKRMIDSE DTVWIEYYYS WSFACACAGF TLLFLGGLFL
210 220
LLFSLPRMPQ NPWESCMDTE SEH
Length:223
Mass (Da):25,119
Last modified:May 1, 1997 - v1
Checksum:iA9EA30B625E41CCC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V6E5G3V6E5_RAT
Voltage-dependent calcium channel g...
Cacng1 rCG_34582
223Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09453 mRNA Translation: CAA70602.1
RefSeqiNP_062128.1, NM_019255.1
UniGeneiRn.24079

Genome annotation databases

GeneIDi29658
KEGGirno:29658
UCSCiRGD:2249 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09453 mRNA Translation: CAA70602.1
RefSeqiNP_062128.1, NM_019255.1
UniGeneiRn.24079

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004349

Proteomic databases

PaxDbiP97707
PRIDEiP97707

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29658
KEGGirno:29658
UCSCiRGD:2249 rat

Organism-specific databases

CTDi786
RGDi2249 Cacng1

Phylogenomic databases

eggNOGiENOG410IH0I Eukaryota
ENOG4111J5G LUCA
HOGENOMiHOG000293219
HOVERGENiHBG003868
InParanoidiP97707
KOiK04866
PhylomeDBiP97707

Miscellaneous databases

PROiPR:P97707

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005421 VDCC_g1su
IPR008368 VDCC_gsu
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01601 VDCCGAMMA1
ProtoNetiSearch...

Entry informationi

Entry nameiCCG1_RAT
AccessioniPrimary (citable) accession number: P97707
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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