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Entry version 130 (16 Jan 2019)
Sequence version 1 (01 May 1997)
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Protein

Sodium channel protein

Gene

Scn7a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • sodium channel activity Source: RGD
  • voltage-gated ion channel activity Source: UniProtKB-KW
  • voltage-gated sodium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn7aImported
Synonyms:SCL-11Imported, Scn6aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
61922 Scn7a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei237 – 259HelicalUniRule annotationAdd BLAST23
Transmembranei369 – 393HelicalUniRule annotationAdd BLAST25
Transmembranei528 – 546HelicalUniRule annotationAdd BLAST19
Transmembranei558 – 579HelicalUniRule annotationAdd BLAST22
Transmembranei644 – 665HelicalUniRule annotationAdd BLAST22
Transmembranei729 – 755HelicalUniRule annotationAdd BLAST27
Transmembranei955 – 974HelicalUniRule annotationAdd BLAST20
Transmembranei995 – 1013HelicalUniRule annotationAdd BLAST19
Transmembranei1079 – 1102HelicalUniRule annotationAdd BLAST24
Transmembranei1190 – 1214HelicalUniRule annotationAdd BLAST25
Transmembranei1273 – 1291HelicalUniRule annotationAdd BLAST19
Transmembranei1303 – 1321HelicalUniRule annotationAdd BLAST19
Transmembranei1333 – 1354HelicalUniRule annotationAdd BLAST22
Transmembranei1390 – 1418HelicalUniRule annotationAdd BLAST29
Transmembranei1494 – 1520HelicalUniRule annotationAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3988641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97706

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97706

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P97706 RN

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P97706

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini117 – 404Ion_transInterPro annotationAdd BLAST288
Domaini526 – 751Ion_transInterPro annotationAdd BLAST226
Domaini764 – 948Na_trans_assocInterPro annotationAdd BLAST185
Domaini954 – 1221Ion_transInterPro annotationAdd BLAST268
Domaini1271 – 1518Ion_transInterPro annotationAdd BLAST248

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF4 Eukaryota
ENOG410Y1Z2 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231755

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053100

KEGG Orthology (KO)

More...
KOi
K04839

Database of Orthologous Groups

More...
OrthoDBi
56920at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR028812 Na_channel_a7su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037:SF14 PTHR10037:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P97706-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTSPEPKGL VPFTAESLEL IKNHIAKKCN EEHEEEDLKP SRDIEAGKKL
60 70 80 90 100
PFAYGTLPQG TVSEPLEDVD PYYYVKRNTF MVLNRNRVIF RFNAVSILCT
110 120 130 140 150
LSPLSSLRRA VIKVLVHPLL RLLILISVLT DSILMCMSNL PEWILAVENT
160 170 180 190 200
CLGIYTFEIL VKVIARGIWA GSFSFLGDLW NWLDFSVTLF ELITRSSPLS
210 220 230 240 250
SLPMFKTIRT LRILKIIPLN HGLQSIVVTL VQCLKKLLGA IALALFFLTV
260 270 280 290 300
SSLFGMGLFM GNLKHKCVRW PQEDGNDVMY SGTGSQYHIL ERENFYYMEG
310 320 330 340 350
ARYALLCGNK TDAGLCPEGY MCVKEGSNPD NGFTSFDNFG WALLAMFRLM
360 370 380 390 400
TQDYPELLYH QILYASGKIY MIFFVLISFW FAFYMASLFL GILTMAYEQE
410 420 430 440 450
KQRASEESRD MDSKCHQTVK EFEEEHEGAE LQCIWFYEEV LDLLGLELCI
460 470 480 490 500
KEMETTQIEM KKRSPTSINT TLDILEDTAL GHKEEPETSR KECPLCWYKF
510 520 530 540 550
TKTCFIWKCS PCWIKLNEFA DRIITHPLFD LFLVICIILN ICFLALEHFP
560 570 580 590 600
MSEELMSLLA IGNLVFIGIY TIEMILKIIA MHPYGYFQIS WHIFDSILVV
610 620 630 640 650
LGLTEMLLAD IEEITVFILV PLIFIKLGKY APPFKNLMRI LGRALVALKD
660 670 680 690 700
LVLLVSIFIY FSAVFGMKLF GRSYKDCVCH VDQDCQRQRW HMSDFLHAYV
710 720 730 740 750
TVFRILCGEW IETLWECMEV AGEAWCIPFY MMVILIGNLL ILYLFVGLVS
760 770 780 790 800
SFASYDATTE VSKEAKNLQL AVAWIKMVIN CVLLKILCKE KTVSTEATDQ
810 820 830 840 850
TCDPSVKENI SGHTLSELSN TQTFLRYKDQ SSGTEKTPVT ESESQSLIAS
860 870 880 890 900
PSVSETVPIA SGESDIENLD NKETRSKSAN GSSKEKMKQS SSSECSTVDI
910 920 930 940 950
AISEEEEMVY EHEKSKLHKN GYERKSSAGQ VSRESRNGKI WRNIRKTCCK
960 970 980 990 1000
IVENSWFECF IGLVTLLCTG TLALEDIYIH QRKTIKIFLE YGDMIFAYIF
1010 1020 1030 1040 1050
ILEMLLKWVA YGFKAYFSNN WYKLDFMVVI VLCLSLKGKT REDLNPLPSI
1060 1070 1080 1090 1100
KFLRALRVLS QFERMKVVLR ALIKTTLPAV SVFLVCLMIW LLFSVMGVFL
1110 1120 1130 1140 1150
FAGKFYECID PTRGERFSVF EVMNKSQCEN LVFNESMPWE NAKLNFDNVG
1160 1170 1180 1190 1200
NGFLSLFQVA TFNGWISIMN SAIDSVGVYM QPSFEHSLHM YTYFIIFVVF
1210 1220 1230 1240 1250
GLFLPLCMLI GVIIRNFNKQ KIKQGGSNIF ITVKQKKQYR ALKKLLYADS
1260 1270 1280 1290 1300
QKPAARPRNK FQGFICDVVT HRVFNVVVVL LICFQATTIM IQNDEQSPQI
1310 1320 1330 1340 1350
ETAVFWMNSL FTMLFTLECI LKLTAFRCHY FTSAWNVHDF MVVVFSITGL
1360 1370 1380 1390 1400
LLPLSIGQYF VPPSLVQLLL LSRIIHVLRP GKGPKVFHDL MLPLMLSLPA
1410 1420 1430 1440 1450
LLNIGLLIFL VMFIYAIFGM YNFAYVKKEA GINDVSNFET FGSSMLCLFQ
1460 1470 1480 1490 1500
VTTFSGWDGM LDAIFNSQWS DCDPDKINPG TQVRGDCGSP SVGIFYFVSY
1510 1520 1530 1540 1550
ILISWLIIVN MYVVLIMEFL SIPSKRKNRT LSEDDFRRFF KVWNRFDPDR
1560 1570 1580 1590 1600
TQYIDSTKLS DFAAALDPPL FMAKPNKGQL VAMDLPMAAG DRIHCLDILL
1610 1620 1630 1640 1650
AFTKRVMGKD ERVEKILSEI ESGFMLANPF KITYEPITTT LKRKQEAVSA
1660 1670 1680 1690 1700
TIIQRAYKSY RLRQSDKKIQ DIPEIDDGRE DPNSKGVHSG QIEEKASIQT

QI
Length:1,702
Mass (Da):194,738
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF123DB9ADA2FFCE3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y09164 mRNA Translation: CAA70364.1

NCBI Reference Sequences

More...
RefSeqi
NP_113874.1, NM_031686.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.54541

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:64155

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09164 mRNA Translation: CAA70364.1
RefSeqiNP_113874.1, NM_031686.1
UniGeneiRn.54541

3D structure databases

ProteinModelPortaliP97706
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL3988641

PTM databases

iPTMnetiP97706
PhosphoSitePlusiP97706

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64155
KEGGirno:64155

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6332
RGDi61922 Scn7a

Phylogenomic databases

eggNOGiENOG410INF4 Eukaryota
ENOG410Y1Z2 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100
KOiK04839
OrthoDBi56920at2759

Gene expression databases

GenevisibleiP97706 RN

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028812 Na_channel_a7su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF14 PTHR10037:SF14, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP97706_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97706
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: January 16, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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