UniProtKB - P97700 (M2OM_RAT)
Protein
Mitochondrial 2-oxoglutarate/malate carrier protein
Gene
Slc25a11
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (PubMed:5083502, PubMed:3355813). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (By similarity).By similarity1 Publication1 Publication
GO - Molecular functioni
- alpha-ketoglutarate transmembrane transporter activity Source: RGD
- antiporter activity Source: GO_Central
- malate transmembrane transporter activity Source: GO_Central
- oxaloacetate transmembrane transporter activity Source: GO_Central
- succinate transmembrane transporter activity Source: GO_Central
- sulfate transmembrane transporter activity Source: GO_Central
- thiosulfate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- malate transmembrane transport Source: GO_Central
- oxaloacetate transport Source: GO_Central
- phosphate ion transmembrane transport Source: GO_Central
- succinate transmembrane transport Source: GO_Central
- sulfate transport Source: GO_Central
- thiosulfate transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-RNO-70263, Gluconeogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial 2-oxoglutarate/malate carrier proteinShort name: OGCP Alternative name(s): Solute carrier family 25 member 11 |
Gene namesi | Name:Slc25a11 Synonyms:Slc20a4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708476, Slc25a11 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: RGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 24 – 42 | Helical; Name=1Sequence analysisAdd BLAST | 19 | |
Transmembranei | 83 – 101 | Helical; Name=2Sequence analysisAdd BLAST | 19 | |
Transmembranei | 119 – 140 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Transmembranei | 183 – 202 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Transmembranei | 222 – 240 | Helical; Name=5Sequence analysisAdd BLAST | 19 | |
Transmembranei | 281 – 300 | Helical; Name=6Sequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000090627 | 2 – 314 | Mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST | 313 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 6 | PhosphoserineBy similarity | 1 | |
Modified residuei | 57 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 73 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 102 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 256 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P97700 |
PaxDbi | P97700 |
PRIDEi | P97700 |
PTM databases
iPTMneti | P97700 |
PhosphoSitePlusi | P97700 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 249007, 2 interactors |
IntActi | P97700, 2 interactors |
STRINGi | 10116.ENSRNOP00000005144 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 23 – 108 | Solcar 1Add BLAST | 86 | |
Repeati | 117 – 208 | Solcar 2Add BLAST | 92 | |
Repeati | 217 – 306 | Solcar 3Add BLAST | 90 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0759, Eukaryota |
InParanoidi | P97700 |
OrthoDBi | 892773at2759 |
PhylomeDBi | P97700 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97700-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAATASPGAG RMDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVXNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKALIGMTAG ATGAFVGPPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALIR IAREEGVPTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCAIMISG LVTTAASMPV DIVKTRIQNM
260 270 280 290 300
RMIDEKPEYK NGLDVLLKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6H5 | G3V6H5_RAT | Mitochondrial 2-oxoglutarate/malate... | Slc25a11 rCG_32730 | 314 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U84727 mRNA Translation: AAB41797.1 |
RefSeqi | NP_071793.1, NM_022398.2 |
Genome annotation databases
GeneIDi | 64201 |
KEGGi | rno:64201 |
UCSCi | RGD:708476, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U84727 mRNA Translation: AAB41797.1 |
RefSeqi | NP_071793.1, NM_022398.2 |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249007, 2 interactors |
IntActi | P97700, 2 interactors |
STRINGi | 10116.ENSRNOP00000005144 |
PTM databases
iPTMneti | P97700 |
PhosphoSitePlusi | P97700 |
Proteomic databases
jPOSTi | P97700 |
PaxDbi | P97700 |
PRIDEi | P97700 |
Genome annotation databases
GeneIDi | 64201 |
KEGGi | rno:64201 |
UCSCi | RGD:708476, rat |
Organism-specific databases
CTDi | 8402 |
RGDi | 708476, Slc25a11 |
Phylogenomic databases
eggNOGi | KOG0759, Eukaryota |
InParanoidi | P97700 |
OrthoDBi | 892773at2759 |
PhylomeDBi | P97700 |
Enzyme and pathway databases
Reactomei | R-RNO-70263, Gluconeogenesis |
Miscellaneous databases
PROi | PR:P97700 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M2OM_RAT | |
Accessioni | P97700Primary (citable) accession number: P97700 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families