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Protein

Endothelial cell-specific molecule 1

Gene

Esm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-specific molecule 1
Short name:
ESM-1
Alternative name(s):
PG25
Gene namesi
Name:Esm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi71013 Esm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001439622 – 184Endothelial cell-specific molecule 1Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi157O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and dermatan sulfate.By similarity

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP97682
PRIDEiP97682

Expressioni

Tissue specificityi

Pineal gland specific.

Gene expression databases

BgeeiENSRNOG00000010797 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP97682 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014559

Structurei

3D structure databases

ProteinModelPortaliP97682
SMRiP97682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 102IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000018810
HOGENOMiHOG000273901
HOVERGENiHBG005610
InParanoidiP97682
OMAiSTKYAVD
OrthoDBiEOG091G0M9A
PhylomeDBiP97682

Family and domain databases

InterProiView protein in InterPro
IPR038850 ESM1
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
PANTHERiPTHR15428 PTHR15428, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97682-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLLLLTTL LIPLHLGMAW SAKYAVDCPE HCDNTECRSS LRCKRTVLDD
60 70 80 90 100
CGCCQVCAAG PGETCYRTVS GMDGVKCGPG LKCHFYSEED DFGDEFGVCK
110 120 130 140 150
DCPYGTFGMD CKETCNCQSG ICDRVTGRCL DFPFFQYAAA KSPSRTSASQ
160 170 180
TERDAASGDG NAVREEIGDR NAARPSVMKW LNPR
Length:184
Mass (Da):20,075
Last modified:May 1, 1997 - v1
Checksum:i58549D713E88E189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80818 mRNA Translation: AAB39192.1
BC070888 mRNA Translation: AAH70888.1
RefSeqiNP_072126.1, NM_022604.2
UniGeneiRn.6376

Genome annotation databases

EnsembliENSRNOT00000014559; ENSRNOP00000014559; ENSRNOG00000010797
GeneIDi64536
KEGGirno:64536

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80818 mRNA Translation: AAB39192.1
BC070888 mRNA Translation: AAH70888.1
RefSeqiNP_072126.1, NM_022604.2
UniGeneiRn.6376

3D structure databases

ProteinModelPortaliP97682
SMRiP97682
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014559

Proteomic databases

PaxDbiP97682
PRIDEiP97682

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014559; ENSRNOP00000014559; ENSRNOG00000010797
GeneIDi64536
KEGGirno:64536

Organism-specific databases

CTDi11082
RGDi71013 Esm1

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000018810
HOGENOMiHOG000273901
HOVERGENiHBG005610
InParanoidiP97682
OMAiSTKYAVD
OrthoDBiEOG091G0M9A
PhylomeDBiP97682

Miscellaneous databases

PROiPR:P97682

Gene expression databases

BgeeiENSRNOG00000010797 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP97682 RN

Family and domain databases

InterProiView protein in InterPro
IPR038850 ESM1
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
PANTHERiPTHR15428 PTHR15428, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESM1_RAT
AccessioniPrimary (citable) accession number: P97682
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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