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Protein

Lysine-specific demethylase hairless

Gene

Hr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi999Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi1001Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi1117Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri594 – 619C6-typeAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase hairless (EC:1.14.11.-)
Gene namesi
Name:Hr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620634 Hr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi563 – 564LL → AA: Decreases RORA protein stability. Strongly decreases RORA protein stability; when associated with 752-L--A-756. 1 Publication2
Mutagenesisi755 – 756LL → AA: Decreases RORA protein stability. Strongly decreases RORA protein stability; when associated with 560-L--A-564. 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838921 – 1181Lysine-specific demethylase hairlessAdd BLAST1181

Proteomic databases

PaxDbiP97609
PRIDEiP97609

PTM databases

CarbonylDBiP97609
iPTMnetiP97609
PhosphoSitePlusiP97609

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015716

Structurei

3D structure databases

ProteinModelPortaliP97609
SMRiP97609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini938 – 1149JmjCPROSITE-ProRule annotationAdd BLAST212

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi560 – 564LXXLL motif 15
Motifi752 – 756LXXLL motif 25

Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors (PubMed:14570920).1 Publication
The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri594 – 619C6-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
HOGENOMiHOG000293150
HOVERGENiHBG000171
InParanoidiP97609
PhylomeDBiP97609

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P97609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLHHGA LCLGEPVPFW
60 70 80 90 100
RGVLSAPDSW LPPGFLQGPK DTLSVVEGEG SRNGERKANW LGSKEGLRWK
110 120 130 140 150
EAMLAHPLAF CGPACPPRYG PLIPEHSSGH PKSDPVAFRP LHCPFLLETK
160 170 180 190 200
ILERAPFWVP TCLPPYLMSS LPPERSYDWP LAPSPWVYSG SQPKVPSAFS
210 220 230 240 250
LGSKGFYHKD PNILRPAKEP LAASESGMLG LAPGGHLQQA CDAEGPSLHQ
260 270 280 290 300
RDGETGAGRQ QNLCPVFLGY PDTVPRTPWP SCPPGLVHTL GNVWAGPGSN
310 320 330 340 350
SFGYQLGPPV TPRCPSPGPP TPPGGCCSSH LPAREGDPGP CRKCQDSPEG
360 370 380 390 400
SSSGPGESSE ERNKAGSRAS PPSHHTKLKK TWLTRHSEQF ECPGGCPGKG
410 420 430 440 450
ESPATGLRAL KRAGSPEVQG ARGPAPKRPS HTFPGTGRQG ARAWQETPET
460 470 480 490 500
STGSKAEAQQ QEEQRGPRDG RIRLRESRLE DTSCQHHLAG VTQCPSCVQA
510 520 530 540 550
AGEVEILTSH SQKSHKLPLE EKPLEEDSCA TSEEGGGSSP EASINKGLAK
560 570 580 590 600
HLLSGLGDRL CRLLRKEREA LAWAQREGQG PAMTEDSPGI PHCCSRCHHG
610 620 630 640 650
LFNTHWRCSH CSHRLCVACG RIAGAGKNRE KTGSREQRTD DCAQEAGHAA
660 670 680 690 700
CSLILTQFVS SQALAELSTV MHQVWAKFDI RGHCFCQVDA RVWAPGDGGQ
710 720 730 740 750
QKEPTEKTPP APQLSCNGDS NRTKDIKEET PDSTESPAED RAGRSPLPCP
760 770 780 790 800
SLCELLASTA VKLCLGHERI HMAFAPVTPA LPSDDRITNI LDSIIAQVVE
810 820 830 840 850
RKIQEKALGP GLRAGSGLRK GLSLPLSPVR TQLSPPGALL WLQEPRPKHG
860 870 880 890 900
FRLFQEHWRQ GQPVLVSGIQ KTLRLSLWGM EALGTLGGQV QTLTALGPPQ
910 920 930 940 950
PTSLDSTAFW KGFSHPEARP KLDEGSVLLL HRPLGDKDES RVENLASSLP
960 970 980 990 1000
LPEYCAHQGK LNLASYLPLG LTLHPLEPQL WAAYGVNSHR GHLGTKNLCV
1010 1020 1030 1040 1050
EVSDLISILV HAEAQLPPWY RAQKDFLSGL DGEGLWSPGS QTSTVWHVFR
1060 1070 1080 1090 1100
AQDAQRIRRF LQMVCPAGAG TLEPGAPGSC YLDSGLRRRL REEWGVSCWT
1110 1120 1130 1140 1150
LLQAPGEAVL VPAGAPHQVQ GLVSTISVTQ HFLSPETSAL SAQLCHQGAS
1160 1170 1180
LPPDHRMLYA QMDRAVFQAV KVAVGTLQEA K
Length:1,181
Mass (Da):127,307
Last modified:July 15, 1998 - v2
Checksum:i834B7029CF8E88F0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7J4G3V7J4_RAT
Hairless homolog (Mouse), isoform C...
Hr hr, rCG_36905
1,207Annotation score:
A0A0G2K5M5A0A0G2K5M5_RAT
Hairless homolog (Mouse), isoform C...
Hr hr, rCG_36905
1,181Annotation score:

Sequence cautioni

The sequence AAC53018 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71293 mRNA Translation: AAC53018.1 Different initiation.
UniGeneiRn.41543

Genome annotation databases

UCSCiRGD:620634 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71293 mRNA Translation: AAC53018.1 Different initiation.
UniGeneiRn.41543

3D structure databases

ProteinModelPortaliP97609
SMRiP97609
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015716

PTM databases

CarbonylDBiP97609
iPTMnetiP97609
PhosphoSitePlusiP97609

Proteomic databases

PaxDbiP97609
PRIDEiP97609

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620634 rat

Organism-specific databases

RGDi620634 Hr

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
HOGENOMiHOG000293150
HOVERGENiHBG000171
InParanoidiP97609
PhylomeDBiP97609

Miscellaneous databases

PROiPR:P97609

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHAIR_RAT
AccessioniPrimary (citable) accession number: P97609
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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