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Protein

Interleukin-15

Gene

Il15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-RNO-8983432 Interleukin-15 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15
Short name:
IL-15
Gene namesi
Name:Il15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi2887 Il15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000001540330 – 48Sequence analysisAdd BLAST19
ChainiPRO_000001540449 – 162Interleukin-15Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 133By similarity
Disulfide bondi90 ↔ 136By similarity
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97604

Expressioni

Gene expression databases

BgeeiENSRNOG00000003439 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP97604 RN

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP97604
SMRiP97604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000016264
HOGENOMiHOG000113029
HOVERGENiHBG006142
InParanoidiP97604
KOiK05433
OMAiTSIQCYL
OrthoDBiEOG091G0VGG
PhylomeDBiP97604
TreeFamiTF336199

Family and domain databases

Gene3Di1.20.1250.70, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020439 IL-15
IPR003443 IL-15/IL-21_fam
IPR038327 IL-15/IL-21_sf
IPR020466 IL-15_mml
PfamiView protein in Pfam
PF02372 IL15, 1 hit
PRINTSiPR01947 INTLKN15MAML
PR01930 INTRLEUKIN15
SUPFAMiSSF47266 SSF47266, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P97604-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKILKPYMRN TSILYYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW
60 70 80 90 100
IDVRYDLEKI ESLIQFIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH
110 120 130 140 150
EYSNMTLNET VRNVLYLANS TLSSNKNVIE SGCKECEELE ERNFTEFLQS
160
FIHIVQMFIN TS
Length:162
Mass (Da):18,804
Last modified:May 1, 1997 - v1
Checksum:iDA68097A83065AEA
GO
Isoform Short (identifier: P97604-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-96: Missing.

Show »
Length:146
Mass (Da):17,025
Checksum:iB7BB0E0430FAC751
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00266281 – 96Missing in isoform Short. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69272 mRNA Translation: AAB41697.1
AF015719 mRNA Translation: AAB94536.1
AF015718 mRNA Translation: AAB94535.1
RefSeqiNP_037261.1, NM_013129.2 [P97604-1]
XP_008770585.1, XM_008772363.2 [P97604-2]
XP_017456674.1, XM_017601185.1 [P97604-1]
XP_017456675.1, XM_017601186.1 [P97604-1]
XP_017456676.1, XM_017601187.1 [P97604-1]
XP_017456677.1, XM_017601188.1 [P97604-1]
XP_017456678.1, XM_017601189.1 [P97604-1]
UniGeneiRn.2490

Genome annotation databases

EnsembliENSRNOT00000004590; ENSRNOP00000004590; ENSRNOG00000003439 [P97604-1]
GeneIDi25670
KEGGirno:25670

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69272 mRNA Translation: AAB41697.1
AF015719 mRNA Translation: AAB94536.1
AF015718 mRNA Translation: AAB94535.1
RefSeqiNP_037261.1, NM_013129.2 [P97604-1]
XP_008770585.1, XM_008772363.2 [P97604-2]
XP_017456674.1, XM_017601185.1 [P97604-1]
XP_017456675.1, XM_017601186.1 [P97604-1]
XP_017456676.1, XM_017601187.1 [P97604-1]
XP_017456677.1, XM_017601188.1 [P97604-1]
XP_017456678.1, XM_017601189.1 [P97604-1]
UniGeneiRn.2490

3D structure databases

ProteinModelPortaliP97604
SMRiP97604
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP97604

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004590; ENSRNOP00000004590; ENSRNOG00000003439 [P97604-1]
GeneIDi25670
KEGGirno:25670

Organism-specific databases

CTDi3600
RGDi2887 Il15

Phylogenomic databases

GeneTreeiENSGT00390000016264
HOGENOMiHOG000113029
HOVERGENiHBG006142
InParanoidiP97604
KOiK05433
OMAiTSIQCYL
OrthoDBiEOG091G0VGG
PhylomeDBiP97604
TreeFamiTF336199

Enzyme and pathway databases

ReactomeiR-RNO-8983432 Interleukin-15 signaling

Miscellaneous databases

PROiPR:P97604

Gene expression databases

BgeeiENSRNOG00000003439 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP97604 RN

Family and domain databases

Gene3Di1.20.1250.70, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020439 IL-15
IPR003443 IL-15/IL-21_fam
IPR038327 IL-15/IL-21_sf
IPR020466 IL-15_mml
PfamiView protein in Pfam
PF02372 IL15, 1 hit
PRINTSiPR01947 INTLKN15MAML
PR01930 INTRLEUKIN15
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL15_RAT
AccessioniPrimary (citable) accession number: P97604
Secondary accession number(s): O54847
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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