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Protein

Galectin-7

Gene

Lgals7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Gene namesi
Name:Lgals7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61951 Lgals7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769421 – 136Galectin-7Add BLAST136

Proteomic databases

PaxDbiP97590
PRIDEiP97590

Expressioni

Gene expression databases

BgeeiENSRNOG00000020380
ExpressionAtlasiP97590 baseline and differential
GenevisibleiP97590 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027620

Structurei

3D structure databases

ProteinModelPortaliP97590
SMRiP97590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 136GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 76Beta-galactoside bindingSequence analysis7

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00760000119105
HOGENOMiHOG000293279
HOVERGENiHBG006255
InParanoidiP97590
KOiK10092
OMAiHSAHVSH
PhylomeDBiP97590

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030640 Galectin_7
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF107 PTHR11346:SF107, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

P97590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATHHKTPL PQGVRLGTVM RIRGVVPDQA GRFHVNLLCG EEQEADAALH
60 70 80 90 100
FNPRLDTSEV VFNTKQQGKW GREERGTGIP FQRGQPFEVL IITTEEGFKT
110 120 130
VIGDDEYLHF HHRMPSSNVR SVEVGGDVQL HSVKIF
Length:136
Mass (Da):15,285
Last modified:January 23, 2007 - v4
Checksum:i460D2CD3191BF294
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 5SATH → M (PubMed:9697310).Curated4
Sequence conflicti47A → C in AAB40658 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67883 mRNA Translation: AAB40658.1
AF036941 mRNA Translation: AAB88871.1
RefSeqiNP_072104.2, NM_022582.2
XP_006228732.1, XM_006228670.3
UniGeneiRn.6336

Genome annotation databases

EnsembliENSRNOT00000084393; ENSRNOP00000068607; ENSRNOG00000020380
GeneIDi29518
KEGGirno:29518
UCSCiRGD:61951 rat

Similar proteinsi

Entry informationi

Entry nameiLEG7_RAT
AccessioniPrimary (citable) accession number: P97590
Secondary accession number(s): O54958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 128 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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