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Protein

Fasciculation and elongation protein zeta-1

Gene

Fez1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.2 Publications

GO - Molecular functioni

  • gamma-tubulin binding Source: Ensembl
  • protein kinase C binding Source: RGD
  • protein N-terminus binding Source: RGD

GO - Biological processi

  • cellular response to growth factor stimulus Source: RGD
  • establishment of cell polarity Source: RGD
  • establishment of mitochondrion localization Source: RGD
  • hippocampus development Source: RGD
  • mitochondrion morphogenesis Source: RGD
  • negative regulation of autophagosome assembly Source: GO_Central
  • positive regulation of anterograde axonal transport of mitochondrion Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of neuron projection development Source: RGD

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-1
Alternative name(s):
Zygin I
Zygin-1
Gene namesi
Name:Fez1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi619708 Fez1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895271 – 393Fasciculation and elongation protein zeta-1Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei317PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.1 Publication
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP97577
PRIDEiP97577

PTM databases

iPTMnetiP97577
PhosphoSitePlusiP97577

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSRNOG00000006075
GenevisibleiP97577 RN

Interactioni

Subunit structurei

Homodimer. Interacts with UBE4B and SAP30L (By similarity). Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 (By similarity). Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation (By similarity). Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon.By similarity

GO - Molecular functioni

  • gamma-tubulin binding Source: Ensembl
  • protein kinase C binding Source: RGD
  • protein N-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi249603, 1 interactor
STRINGi10116.ENSRNOP00000008285

Structurei

3D structure databases

SMRiP97577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili231 – 299Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 98Poly-Glu4

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3919 Eukaryota
ENOG410Z11E LUCA
GeneTreeiENSGT00390000017627
HOGENOMiHOG000019494
HOVERGENiHBG005657
InParanoidiP97577
OMAiEMMSFKS
OrthoDBiEOG091G0AC6
PhylomeDBiP97577
TreeFamiTF313128

Family and domain databases

InterProiView protein in InterPro
IPR011680 FEZ
IPR015642 FEZ_1
PANTHERiPTHR12394 PTHR12394, 1 hit
PTHR12394:SF4 PTHR12394:SF4, 1 hit
PfamiView protein in Pfam
PF07763 FEZ, 1 hit

Sequencei

Sequence statusi: Complete.

P97577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPLVSLDE EFEDIRPCCT EDPEEKPQSL YGTSPHHLED PSLSELENFS
60 70 80 90 100
SEIISFKSME DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL
110 120 130 140 150
RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDTEIHE KEEEDEFIEK
160 170 180 190 200
SENDSGINEE PLLTADQVIE EIEEMMQNSP DPEEEVEVLE EEDGGEISSQ
210 220 230 240 250
ADSVLLQEMQ ALTQTFNNNW SYEGLRHMSG SELTELLDQV EGAIRDFSEE
260 270 280 290 300
LVHQLARRDE LEFEKEVKNS FITVLIEVQN KQKEQRELMK KRRKEKGLSL
310 320 330 340 350
QSSRIEKGNQ MPLKRFSMEG ISNILQSGIR QTFGSSGADR QYLNTVIPYE
360 370 380 390
KKSSPPSVED LQMLTNILFA MKEDNEKVPT LLTDYILKVL CPT
Length:393
Mass (Da):45,244
Last modified:May 1, 1997 - v1
Checksum:i62F1F9552E326C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48249 mRNA Translation: AAC71216.2
U63740 mRNA Translation: AAB40630.1
BC087740 mRNA Translation: AAH87740.1
RefSeqiNP_112328.1, NM_031066.1
XP_017451419.1, XM_017595930.1
UniGeneiRn.5468

Genome annotation databases

EnsembliENSRNOT00000008285; ENSRNOP00000008285; ENSRNOG00000006075
GeneIDi81730
KEGGirno:81730
UCSCiRGD:619708 rat

Similar proteinsi

Entry informationi

Entry nameiFEZ1_RAT
AccessioniPrimary (citable) accession number: P97577
Secondary accession number(s): Q62922
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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