UniProtKB - P97576 (GRPE1_RAT)
Protein
GrpE protein homolog 1, mitochondrial
Gene
Grpel1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
GO - Molecular functioni
- adenyl-nucleotide exchange factor activity Source: GO_Central
- ATPase activator activity Source: RGD
- ATPase binding Source: RGD
- chaperone binding Source: InterPro
- identical protein binding Source: RGD
- protein homodimerization activity Source: InterPro
- unfolded protein binding Source: RGD
GO - Biological processi
- protein folding Source: InterPro
- protein import into mitochondrial matrix Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Names & Taxonomyi
Protein namesi | Recommended name: GrpE protein homolog 1, mitochondrialAlternative name(s): Mt-GrpE#1 |
Gene namesi | Name:Grpel1 Synonyms:Grepel1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70947, Grpel1 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: RGD
- mitochondrion Source: RGD
- PAM complex, Tim23 associated import motor Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 27 | Mitochondrion1 PublicationAdd BLAST | 27 | |
ChainiPRO_0000013051 | 28 – 217 | GrpE protein homolog 1, mitochondrialAdd BLAST | 190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 94 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 94 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 100 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 120 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 215 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 215 | N6-succinyllysine; alternateBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P97576 |
PaxDbi | P97576 |
PRIDEi | P97576 |
PTM databases
iPTMneti | P97576 |
PhosphoSitePlusi | P97576 |
SwissPalmi | P97576 |
Expressioni
Tissue specificityi
Ubiquitous. Particularly abundant in heart, kidney and liver.
Gene expression databases
Bgeei | ENSRNOG00000006593, Expressed in heart and 21 other tissues |
ExpressionAtlasi | P97576, baseline and differential |
Genevisiblei | P97576, RN |
Interactioni
Subunit structurei
Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity).
By similarityGO - Molecular functioni
- ATPase binding Source: RGD
- chaperone binding Source: InterPro
- identical protein binding Source: RGD
- protein homodimerization activity Source: InterPro
- unfolded protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249476, 3 interactors |
STRINGi | 10116.ENSRNOP00000008930 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GrpE family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3003, Eukaryota |
GeneTreei | ENSGT00390000005589 |
HOGENOMi | CLU_057217_0_1_1 |
InParanoidi | P97576 |
PhylomeDBi | P97576 |
TreeFami | TF105284 |
Family and domain databases
CDDi | cd00446, GrpE, 1 hit |
Gene3Di | 2.30.22.10, 1 hit 3.90.20.20, 1 hit |
HAMAPi | MF_01151, GrpE, 1 hit |
InterProi | View protein in InterPro IPR000740, GrpE IPR013805, GrpE_coiled_coil IPR009012, GrpE_head |
PANTHERi | PTHR21237, PTHR21237, 1 hit |
Pfami | View protein in Pfam PF01025, GrpE, 1 hit |
PRINTSi | PR00773, GRPEPROTEIN |
SUPFAMi | SSF51064, SSF51064, 1 hit SSF58014, SSF58014, 1 hit |
PROSITEi | View protein in PROSITE PS01071, GRPE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97576-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARCVRLAR RSLPALALSF RPSPRLLCTA TKQKNNGQNL EEDLGHCEPK
60 70 80 90 100
TDPSSADKTL LEEKVKLEEQ LKETMEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQGFCKD LLEVADILEK ATQSVPKEEV SNNNPHLKSL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LRLDPIGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK
210
LHGRTLRPAL VGVVKDA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JZA2 | A0A0G2JZA2_RAT | GrpE protein homolog | Grpel1 | 230 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62940 mRNA Translation: AAC53534.1 BC097312 mRNA Translation: AAH97312.1 |
RefSeqi | NP_077813.1, NM_024487.4 |
Genome annotation databases
Ensembli | ENSRNOT00000008932; ENSRNOP00000008930; ENSRNOG00000006593 |
GeneIDi | 79563 |
KEGGi | rno:79563 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62940 mRNA Translation: AAC53534.1 BC097312 mRNA Translation: AAH97312.1 |
RefSeqi | NP_077813.1, NM_024487.4 |
3D structure databases
SMRi | P97576 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249476, 3 interactors |
STRINGi | 10116.ENSRNOP00000008930 |
PTM databases
iPTMneti | P97576 |
PhosphoSitePlusi | P97576 |
SwissPalmi | P97576 |
Proteomic databases
jPOSTi | P97576 |
PaxDbi | P97576 |
PRIDEi | P97576 |
Genome annotation databases
Ensembli | ENSRNOT00000008932; ENSRNOP00000008930; ENSRNOG00000006593 |
GeneIDi | 79563 |
KEGGi | rno:79563 |
Organism-specific databases
CTDi | 80273 |
RGDi | 70947, Grpel1 |
Phylogenomic databases
eggNOGi | KOG3003, Eukaryota |
GeneTreei | ENSGT00390000005589 |
HOGENOMi | CLU_057217_0_1_1 |
InParanoidi | P97576 |
PhylomeDBi | P97576 |
TreeFami | TF105284 |
Miscellaneous databases
PROi | PR:P97576 |
Gene expression databases
Bgeei | ENSRNOG00000006593, Expressed in heart and 21 other tissues |
ExpressionAtlasi | P97576, baseline and differential |
Genevisiblei | P97576, RN |
Family and domain databases
CDDi | cd00446, GrpE, 1 hit |
Gene3Di | 2.30.22.10, 1 hit 3.90.20.20, 1 hit |
HAMAPi | MF_01151, GrpE, 1 hit |
InterProi | View protein in InterPro IPR000740, GrpE IPR013805, GrpE_coiled_coil IPR009012, GrpE_head |
PANTHERi | PTHR21237, PTHR21237, 1 hit |
Pfami | View protein in Pfam PF01025, GrpE, 1 hit |
PRINTSi | PR00773, GRPEPROTEIN |
SUPFAMi | SSF51064, SSF51064, 1 hit SSF58014, SSF58014, 1 hit |
PROSITEi | View protein in PROSITE PS01071, GRPE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRPE1_RAT | |
Accessioni | P97576Primary (citable) accession number: P97576 Secondary accession number(s): Q4QRA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families