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Protein

Stanniocalcin-1

Gene

Stc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: RGD
  • cellular response to cAMP Source: RGD
  • cellular response to glucocorticoid stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • chondrocyte proliferation Source: Ensembl
  • decidualization Source: RGD
  • embryo implantation Source: RGD
  • endothelial cell morphogenesis Source: Ensembl
  • growth plate cartilage axis specification Source: Ensembl
  • negative regulation of calcium ion transport Source: Ensembl
  • negative regulation of endothelial cell migration Source: Ensembl
  • negative regulation of renal phosphate excretion Source: Ensembl
  • ossification Source: RGD
  • positive regulation of calcium ion import Source: Ensembl
  • regulation of anion transport Source: Ensembl
  • regulation of cardiac muscle cell contraction Source: Ensembl
  • response to organic cyclic compound Source: RGD
  • response to vitamin D Source: RGD

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-1
Short name:
STC-1
Gene namesi
Name:Stc1
Synonyms:Stc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi621776 Stc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000003330119 – 33Sequence analysisAdd BLAST15
ChainiPRO_000003330234 – 247Stanniocalcin-1Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 59By similarity
Disulfide bondi54 ↔ 74By similarity
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi65 ↔ 114By similarity
Disulfide bondi98 ↔ 128By similarity
Disulfide bondi135 ↔ 170By similarity
Disulfide bondi202InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97574

Expressioni

Gene expression databases

BgeeiENSRNOG00000015075
GenevisibleiP97574 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020728

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH10 Eukaryota
ENOG410YPCI LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000008670
HOVERGENiHBG003575
InParanoidiP97574
OMAiCSVAKRN
OrthoDBiEOG091G0HC1
PhylomeDBiP97574
TreeFamiTF324693

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQNSAVILA LVISAAAAHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL
60 70 80 90 100
QVGCGAFACL ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA
110 120 130 140 150
NGITSKVFLA IRRCSTFQRM IAEVQEDCYS KLNVCSIAKR NPEAITEVIQ
160 170 180 190 200
LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD SLMEKIGPNM ASLFHILQTD
210 220 230 240
HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEGDSPSHIK RTSQENA
Length:247
Mass (Da):27,507
Last modified:May 1, 1997 - v1
Checksum:iDAC2FD08575A513B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62667 mRNA Translation: AAB39541.1
BC078803 mRNA Translation: AAH78803.1
RefSeqiNP_112385.1, NM_031123.2
UniGeneiRn.10647

Genome annotation databases

EnsembliENSRNOT00000020728; ENSRNOP00000020728; ENSRNOG00000015075
GeneIDi81801
KEGGirno:81801
UCSCiRGD:621776 rat

Similar proteinsi

Entry informationi

Entry nameiSTC1_RAT
AccessioniPrimary (citable) accession number: P97574
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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