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Protein

Eotaxin

Gene

Ccl11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3644 Ccl11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000519824 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94O-linked (GalNAc...) threonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97545

Expressioni

Gene expression databases

BgeeiENSRNOG00000007335
GenevisibleiP97545 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009756

Structurei

3D structure databases

ProteinModelPortaliP97545
SMRiP97545
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiP97545
KOiK16597
OMAiRITNNRC
OrthoDBiEOG091G14KV
PhylomeDBiP97545
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSTALLFL LLTATSFTSQ VLAHPGSIPT SCCFTMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTKLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,851
Last modified:May 1, 1997 - v1
Checksum:i77375B4A038B3F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08358 mRNA Translation: CAA69645.1
U96637 mRNA Translation: AAB65775.1
RefSeqiNP_062078.1, NM_019205.1
UniGeneiRn.10632

Genome annotation databases

EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335
GeneIDi29397
KEGGirno:29397

Similar proteinsi

Entry informationi

Entry nameiCCL11_RAT
AccessioniPrimary (citable) accession number: P97545
Secondary accession number(s): O08780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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