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Protein

Heat shock protein beta-6

Gene

Hspb6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-6
Short name:
HspB6
Alternative name(s):
Heat shock 20 kDa-like protein p20
Gene namesi
Name:Hspb6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621554 Hspb6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259401 – 162Heat shock protein beta-6Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.1 Publication
Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97541
PRIDEiP97541

PTM databases

iPTMnetiP97541
PhosphoSitePlusiP97541

Expressioni

Tissue specificityi

Widely expressed. High expression in muscle tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000020922
GenevisibleiP97541 RN

Interactioni

Subunit structurei

Homodimer (PubMed:19646995). Small heat shock proteins form high molecular mass oligomers containing variable number of monomers; these oligomers display a very flexible quaternary structure easily exchanging their subunits. Heterooligomer with HSPB1; formed through oligomerization of HSPB1:HSBP6 dimers; subunit exchange leads to formation of at least two different heterooligomeric complexes, differing in variable quantities of HSPB1 and HSPB6 homodimers in addition to HSPB1:HSPB6 heterodimers. Heterooligomer with CRYAB; large heterooligomers consist of CRYAB homodimers and HSPB5:HSPB6 heterodimers but lacking HSPB6 homodimers. Interacts with BAG3. Interacts (phosphorylated) with YWHAZ. Interacts with PDE4A and PDE4D; required for maintenance of the non-phosphorylated state of HSPB6 under basal conditions. Interacts with KDR. Interacts with PRKD1 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • chaperone binding Source: Ensembl
  • protein homodimerization activity Source: UniProtKB
  • unfolded protein binding Source: Ensembl

Protein-protein interaction databases

BioGridi251372, 1 interactor
STRINGi10116.ENSRNOP00000028401

Structurei

Secondary structure

1162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi74 – 79Combined sources6
Helixi85 – 87Combined sources3
Beta strandi88 – 93Combined sources6
Beta strandi96 – 105Combined sources10
Beta strandi113 – 122Combined sources10
Beta strandi133 – 136Combined sources4
Beta strandi140 – 146Combined sources7

3D structure databases

ProteinModelPortaliP97541
SMRiP97541
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97541

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 162sHSPPROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 72Involved in stabilization of the HSPB1:HSBP6 heterodimerBy similarityAdd BLAST72

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiP97541
KOiK09545
OMAiAFAPYYL
OrthoDBiEOG091G0USC
PhylomeDBiP97541
TreeFamiTF105049

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P97541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIRVPVQPS WLRRASAPLP GFSTPGRLFD QRFGEGLLEA ELASLCPAAI
60 70 80 90 100
APYYLRAPSV ALPTAQVPTD PGYFSVLLDV KHFSPEEISV KVVGDHVEVH
110 120 130 140 150
ARHEERPDEH GFIAREFHRR YRLPPGVDPA AVTSALSPEG VLSIQATPAS
160
AQASLPSPPA AK
Length:162
Mass (Da):17,505
Last modified:May 1, 1997 - v1
Checksum:i91561D8813EBFC98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29960 mRNA Translation: BAA06227.1
PIRiA53814
RefSeqiNP_620242.1, NM_138887.1
UniGeneiRn.3201

Genome annotation databases

EnsembliENSRNOT00000028401; ENSRNOP00000028401; ENSRNOG00000020922
GeneIDi192245
KEGGirno:192245
UCSCiRGD:621554 rat

Similar proteinsi

Entry informationi

Entry nameiHSPB6_RAT
AccessioniPrimary (citable) accession number: P97541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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