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Entry version 133 (16 Oct 2019)
Sequence version 3 (07 Jun 2017)
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Protein

Myelin transcription factor 1-like protein

Gene

Myt1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941).6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri498 – 541CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri542 – 585CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri897 – 940CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri946 – 989CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri999 – 1042CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin transcription factor 1-like protein1 Publication
Short name:
MyT1-L1 Publication
Short name:
MyT1L1 Publication
Alternative name(s):
Neural zinc finger factor 1By similarity
Short name:
NZF-1By similarity
Postmitotic neural gene 1 protein1 Publication
Zinc finger protein Png-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myt1l1 PublicationImported
Synonyms:Kiaa11061 Publication, Nzf1By similarity, Png11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1100511 Myt1l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966741 – 1187Myelin transcription factor 1-like proteinAdd BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97500

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97500

PRoteomics IDEntifications database

More...
PRIDEi
P97500

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97500

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97500

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is restricted to and present throughout the embryonic CNS and developing peripheral neural structures. In the embryonic CNS, expression is restricted to postmitotic neuronal regions. During the neurogenetic period (11 dpc-17 dpc) expression is associated temporally and spatially with the known generation of the first cortical neurons with known gradients of neuron production. Expression continues in developing postmitotic cortical neurons throughout embryonic development and is expressed within 2 days of neuronal induction in P19 cells.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by retinoic acid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000061911 Expressed in 164 organ(s), highest expression level in dorsal striatum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P97500 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIN3B.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058264

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97500

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1058 – 1132Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi83 – 200Asp/Glu-richAdd BLAST118
Compositional biasi688 – 721Ser-richAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri498 – 541CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri542 – 585CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri897 – 940CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri946 – 989CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri999 – 1042CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3803 Eukaryota
ENOG410ZPWS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155671

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234099

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97500

KEGG Orthology (KO)

More...
KOi
K23193

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEDDFPG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97500

TreeFam database of animal gene trees

More...
TreeFami
TF317299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637 SSF103637, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P97500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVDSEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD
110 120 130 140 150
DKEEDDDEEF SEDNDEQGDD DDEDEVDRED EEEIEEEDDE EDDDDEDGDD
160 170 180 190 200
VEEEEEDDDE EEEEEEEEEE NEDHQMSCTR IMQDTDKDDN NNDEYDNYDE
210 220 230 240 250
LVAKSLLNLG KIAEDAAYRA RTESEMNSNT SNSLEDDSDK NENLGRKSEL
260 270 280 290 300
SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN ISDRSYAEGM SQQDSRNMNY
310 320 330 340 350
VMLGKPMNNG LMEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR
360 370 380 390 400
SQPPNMSVRQ HVRQEDDFPG RTPDRSYSDM MNLMRLEEQL SPRSRTFSSC
410 420 430 440 450
AKEDGCHERD DDTTSVNSDR SEEVFDMTKG NLTLLEKAIA LETERAKAMR
460 470 480 490 500
EKMAMDAGRR DNLRSYEDQS PRQLAGEDRK SKSSDSHVKK PYYGKDPSRT
510 520 530 540 550
EKRESKCPTP GCDGTGHVTG LYPHHRSLSG CPHKDRVPPE ILAMHENVLK
560 570 580 590 600
CPTPGCTGRG HVNSNRNSHR SLSGCPIAAA EKLAKAQEKH QSCDVSKSNQ
610 620 630 640 650
ASDRVLRPMC FVKQLEIPQY GYRNNVPTTT PRSNLAKELE KYSKTSFEYN
660 670 680 690 700
SYDNHTYGKR AIAPKVQTRD ISPKGYDDAK RYCKNASPSS STTSSYAPSS
710 720 730 740 750
SSNLSCGGGS SASSTCSKSS FDYTHDMEAA HMAATAILNL STRCREMPQN
760 770 780 790 800
LSTKPQDLCT ARNPDMEVDE NGTLDLSMNK QRPRDSCCPV LTPLEPMSPQ
810 820 830 840 850
QQAVMSSRCF QLSEGDCWDL PVDYTKMKPR RVDEDEPKEI TPEDLDPFQE
860 870 880 890 900
ALEERRYPGE VTIPSPKPKY PQCKESKKDL ITLSGCPLAD KSIRSMLATS
910 920 930 940 950
SQELKCPTPG CDGSGHITGN YASHRSLSGC PRAKKSGIRI AQSKEDKEDQ
960 970 980 990 1000
EPIRCPVPGC DGQGHITGKY ASHRSASGCP LAAKRQKDGY LNGSQFSWKS
1010 1020 1030 1040 1050
VKTEGMSCPT PGCDGSGHVS GSFLTHRSLS GCPRATSAMK KAKLSGEQML
1060 1070 1080 1090 1100
TIKQRASNGI ENDEEIKQLD EEIKELNESN SQMEADMIKL RTQITTMESN
1110 1120 1130 1140 1150
LKTIEEENKV IEQQNESLLH ELANLSQSLI HSLANIQLPH MDPINEQNFD
1160 1170 1180
AYVTTLTEMY TNQDRYQSPE NKALLENIKQ AVRGIQV
Length:1,187
Mass (Da):132,945
Last modified:June 7, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85A1B239FA198F2E
GO
Isoform 2 (identifier: P97500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     494-495: Missing.

Show »
Length:1,185
Mass (Da):132,760
Checksum:iB57B6D9017D4938F
GO
Isoform 3 (identifier: P97500-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-597: Missing.
     598-605: SNQASDRV → MTNRQYFP
     906-925: CPTPGCDGSGHITGNYASHR → LPVQGPSAIDHLLMFSDFLN
     926-1187: Missing.

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):36,771
Checksum:iAD5DED34766D9A20
GO
Isoform 4 (identifier: P97500-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     494-495: Missing.
     906-925: CPTPGCDGSGHITGNYASHR → LPVQGPSAIDHLLMFSDFLN
     926-1187: Missing.

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):55,245
Checksum:i21AA2D3F73328430
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P887A0A1W2P887_MOUSE
Myelin transcription factor 1-like ...
Myt1l
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC53457 differs from that shown. Reason: Frameshift.Curated
The sequence BAC41467 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24 – 25AI → L in AAC53457 (PubMed:9373037).Curated2
Sequence conflicti99M → V in AAC53457 (PubMed:9373037).Curated1
Sequence conflicti127D → AS in AAC53157 (PubMed:9130664).Curated1
Sequence conflicti141E → D in AAC53157 (PubMed:9130664).1
Sequence conflicti141E → D in AAC53457 (PubMed:9373037).1
Sequence conflicti141E → D in BAE48255 (PubMed:21540077).1
Sequence conflicti141E → D in BAC41467 (PubMed:12465718).1
Sequence conflicti141E → D in AAI31678 (PubMed:15489334).1
Sequence conflicti172Missing in AAC53457 (PubMed:9373037).Curated1
Sequence conflicti269L → S in AAC53457 (PubMed:9373037).Curated1
Sequence conflicti305K → R in AAC53457 (PubMed:9373037).Curated1
Sequence conflicti323V → A in AAC53457 (PubMed:9373037).Curated1
Sequence conflicti515T → N in BAC34010 (PubMed:16141072).Curated1
Sequence conflicti650N → K in BAC34010 (PubMed:16141072).Curated1
Sequence conflicti806S → N in BAE48255 (PubMed:21540077).1
Sequence conflicti806S → N in BAC34010 (PubMed:16141072).1
Sequence conflicti806S → N in BAC36413 (PubMed:16141072).1
Sequence conflicti1072E → G in AAC53457 (PubMed:9373037).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157261 – 597Missing in isoform 3. 1 PublicationAdd BLAST597
Alternative sequenceiVSP_0157271 – 426Missing in isoform 4. 1 PublicationAdd BLAST426
Alternative sequenceiVSP_015728494 – 495Missing in isoform 2 and isoform 4. 4 Publications2
Alternative sequenceiVSP_015729598 – 605SNQASDRV → MTNRQYFP in isoform 3. 1 Publication8
Alternative sequenceiVSP_015730906 – 925CPTPG…YASHR → LPVQGPSAIDHLLMFSDFLN in isoform 3 and isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_015731926 – 1187Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U86338 mRNA Translation: AAC53157.1
AF004295 mRNA Translation: AAC53457.1 Frameshift.
AB212898 mRNA Translation: BAE48255.1
AK049967 mRNA Translation: BAC34010.1
AK076608 mRNA Translation: BAC36413.1
AB093283 mRNA Translation: BAC41467.1 Different initiation.
AC154318 Genomic DNA No translation available.
AC154783 Genomic DNA No translation available.
AC159626 Genomic DNA No translation available.
AC166936 Genomic DNA No translation available.
CT025654 Genomic DNA No translation available.
BC131677 mRNA Translation: AAI31678.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS49041.1 [P97500-2]
CCDS49042.1 [P97500-1]

Protein sequence database of the Protein Information Resource

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PIRi
T30189
T46608

NCBI Reference Sequences

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RefSeqi
NP_001087244.1, NM_001093775.1 [P97500-1]
XP_011242129.1, XM_011243827.2 [P97500-1]
XP_011242131.1, XM_011243829.2
XP_017170459.1, XM_017314970.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000021009; ENSMUSP00000021009; ENSMUSG00000061911 [P97500-2]
ENSMUST00000049784; ENSMUSP00000058264; ENSMUSG00000061911 [P97500-1]
ENSMUST00000218198; ENSMUSP00000151919; ENSMUSG00000061911 [P97500-3]
ENSMUST00000218583; ENSMUSP00000151588; ENSMUSG00000061911 [P97500-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17933

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17933

UCSC genome browser

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UCSCi
uc007ngi.1 mouse [P97500-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86338 mRNA Translation: AAC53157.1
AF004295 mRNA Translation: AAC53457.1 Frameshift.
AB212898 mRNA Translation: BAE48255.1
AK049967 mRNA Translation: BAC34010.1
AK076608 mRNA Translation: BAC36413.1
AB093283 mRNA Translation: BAC41467.1 Different initiation.
AC154318 Genomic DNA No translation available.
AC154783 Genomic DNA No translation available.
AC159626 Genomic DNA No translation available.
AC166936 Genomic DNA No translation available.
CT025654 Genomic DNA No translation available.
BC131677 mRNA Translation: AAI31678.1
CCDSiCCDS49041.1 [P97500-2]
CCDS49042.1 [P97500-1]
PIRiT30189
T46608
RefSeqiNP_001087244.1, NM_001093775.1 [P97500-1]
XP_011242129.1, XM_011243827.2 [P97500-1]
XP_011242131.1, XM_011243829.2
XP_017170459.1, XM_017314970.1

3D structure databases

SMRiP97500
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058264

PTM databases

iPTMnetiP97500
PhosphoSitePlusiP97500

Proteomic databases

MaxQBiP97500
PaxDbiP97500
PRIDEiP97500

Genome annotation databases

EnsembliENSMUST00000021009; ENSMUSP00000021009; ENSMUSG00000061911 [P97500-2]
ENSMUST00000049784; ENSMUSP00000058264; ENSMUSG00000061911 [P97500-1]
ENSMUST00000218198; ENSMUSP00000151919; ENSMUSG00000061911 [P97500-3]
ENSMUST00000218583; ENSMUSP00000151588; ENSMUSG00000061911 [P97500-2]
GeneIDi17933
KEGGimmu:17933
UCSCiuc007ngi.1 mouse [P97500-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23040
MGIiMGI:1100511 Myt1l

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG3803 Eukaryota
ENOG410ZPWS LUCA
GeneTreeiENSGT00940000155671
HOGENOMiHOG000234099
InParanoidiP97500
KOiK23193
OMAiPEDDFPG
PhylomeDBiP97500
TreeFamiTF317299

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Myt1l mouse

Protein Ontology

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PROi
PR:P97500

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000061911 Expressed in 164 organ(s), highest expression level in dorsal striatum
ExpressionAtlasiP97500 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits
SUPFAMiSSF103637 SSF103637, 6 hits
PROSITEiView protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYT1L_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97500
Secondary accession number(s): A2RRK5
, D3Z1P7, O08996, Q33DP0, Q8C643, Q8C7L4, Q8CHB4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 7, 2017
Last modified: October 16, 2019
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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