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Entry version 160 (22 Apr 2020)
Sequence version 1 (01 May 1997)
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Protein

Telomerase protein component 1

Gene

Tep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (By similarity). Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (PubMed:11149928). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle (PubMed:11149928).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1177 – 1184ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Telomerase protein component 1
Alternative name(s):
Telomerase-associated protein 1
Short name:
Telomerase protein 1
p240
p80 telomerase homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tep1
Synonyms:Tp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109573 Tep1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509831 – 2629Telomerase protein component 1Add BLAST2629

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P97499

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97499

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97499

PeptideAtlas

More...
PeptideAtlasi
P97499

PRoteomics IDEntifications database

More...
PRIDEi
P97499

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97499

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97499

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000006281 Expressed in jejunum and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P97499 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P97499 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associated component of the telomerase holoenzyme complex (By similarity).

Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs) (PubMed:11149928, PubMed:9020079). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (PubMed:11149928, PubMed:9020079).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P97499, 1 interactor

Molecular INTeraction database

More...
MINTi
P97499

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000006444

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P97499 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 30TEP1 N-terminal 1Add BLAST30
Repeati31 – 60TEP1 N-terminal 2Add BLAST30
Repeati61 – 90TEP1 N-terminal 3Add BLAST30
Repeati91 – 120TEP1 N-terminal 4Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini227 – 685TROVEPROSITE-ProRule annotationAdd BLAST459
Domaini1171 – 1578NACHTPROSITE-ProRule annotationAdd BLAST408
Repeati1420 – 1462WD 1Add BLAST43
Repeati1681 – 1720WD 2Add BLAST40
Repeati1723 – 1761WD 3Add BLAST39
Repeati1764 – 1803WD 4Add BLAST40
Repeati1805 – 1844WD 5Add BLAST40
Repeati1847 – 1886WD 6Add BLAST40
Repeati1889 – 1930WD 7Add BLAST42
Repeati1932 – 1971WD 8Add BLAST40
Repeati1974 – 2013WD 9Add BLAST40
Repeati2015 – 2054WD 10Add BLAST40
Repeati2067 – 2106WD 11Add BLAST40
Repeati2113 – 2151WD 12Add BLAST39
Repeati2154 – 2191WD 13Add BLAST38
Repeati2193 – 2241WD 14Add BLAST49
Repeati2244 – 2282WD 15Add BLAST39
Repeati2285 – 2324WD 16Add BLAST40
Repeati2326 – 2362WD 17Add BLAST37
Repeati2375 – 2424WD 18Add BLAST50
Repeati2467 – 2507WD 19Add BLAST41
Repeati2555 – 2592WD 20Add BLAST38
Repeati2594 – 2628WD 21Add BLAST35

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3602 Eukaryota
KOG4155 Eukaryota
ENOG410XP3K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000342_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97499

KEGG Orthology (KO)

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KOi
K11127

Identification of Orthologs from Complete Genome Data

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OMAi
PKCLFVG

Database of Orthologous Groups

More...
OrthoDBi
29963at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97499

TreeFam database of animal gene trees

More...
TreeFami
TF328424

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025139 DUF4062
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
IPR008850 TEP1_N
IPR008858 TROVE_dom
IPR037214 TROVE_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13271 DUF4062, 1 hit
PF05729 NACHT, 1 hit
PF05386 TEP1_N, 4 hits
PF05731 TROVE, 1 hit
PF00400 WD40, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140864 SSF140864, 1 hit
SSF50978 SSF50978, 4 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50837 NACHT, 1 hit
PS51226 TEP1_N, 4 hits
PS50988 TROVE, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 8 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P97499-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLCGHVPG HSDILSLKNR CLTMLPDLQP LEKIHGHRSV HSDILSLENQ
60 70 80 90 100
CLTMLSDLQP TERIDGHISV HPDILSLENR CLTMLPDLQP LEKLCGHMSS
110 120 130 140 150
HPDVLSLENQ CLATLPTVKS TALTSPLLQG LHISHTAQAD LHSLKTSNCL
160 170 180 190 200
LPELPTKKTP CFSEELDLPP GPRALKSMSA TAQVQEVALG QWCVSKEKEF
210 220 230 240 250
QEEESTEVPM PLYSLSLEEE EVEAPVLKLT SGDSGFHPET TDQVLQEKKM
260 270 280 290 300
ALLTLLCSAL ASNVNVKDAS DLTRASILEV CSALASLEPE FILKASLYAR
310 320 330 340 350
QQLNLRDIAN TVLAVAALLP ACRPHVRRYY SAIVHLPSDW IQVAEFYQSL
360 370 380 390 400
AEGDEKKLVS LPACLRAAMT DKFAEFDEYQ LAKYNPRKHR SKRRSRQPPR
410 420 430 440 450
PQKTERPFSE RGKCFPKSLW PLKNEQITFE AAYNAMPEKN RLPRFTLKKL
460 470 480 490 500
VEYLHIHKPA QHVQALLGYR YPATLELFSR SHLPGPWESS RAGQRMKLRR
510 520 530 540 550
PETWERELSL RGNKASVWEE LIDNGKLPFM AMLRNLCNLL RTGISARHHE
560 570 580 590 600
LVLQRLQHEK SVVHSRQFPF RFLNAHDSID KLEAQLRSKA SPFPSNTTLM
610 620 630 640 650
KRIMIRNSKK NRRPASRKHL CTLTRRQLRA AMTIPVMYEQ LKREKLRLHK
660 670 680 690 700
ARQWNCDVEL LERYRQALET AVNLSVKHNL SPMPGRTLLV YLTDANADRL
710 720 730 740 750
CPKSHSQGPP LNYVLLLIGM MVARAEQVTV CLCGGGFVKT PVLTADEGIL
760 770 780 790 800
KTAIKLQAQV QELEGNDEWP LDTFGKYLLS LAVQRTPIDR VILFGQRMDT
810 820 830 840 850
ELLKVAKQII WQHVNSKCLF VGVLLQKTQY ISPNLNPNDV TLSGCTDGIL
860 870 880 890 900
KFIAEHGASR LLEHVGQLDK LFKIPPPPGK TQAPSLRPLE ENIPGPLGPI
910 920 930 940 950
SQHGWRNIRL FISSTFRDMH GERDLLMRSV LPALQARVFP HRISLHAIDL
960 970 980 990 1000
RWGITEEETR RNRQLEVCLG EVENSQLFVG ILGSRYGYIP PSYDLPDHPH
1010 1020 1030 1040 1050
FHWTHEYPSG RSVTEMEVMQ FLNRGQRSQP SAQALIYFRD PDFLSSVPDA
1060 1070 1080 1090 1100
WKPDFISESE EAAHRVSELK RYLHEQKEVT CRSYSCEWGG VAAGRPYTGG
1110 1120 1130 1140 1150
LEEFGQLVLQ DVWSMIQKQH LQPGAQLEQP TSISEDDLIQ TSFQQLKTPT
1160 1170 1180 1190 1200
SPARPRLLQD TVQQLLLPHG RLSLVTGQAG QGKTAFLASL VSALKVPDQP
1210 1220 1230 1240 1250
NEPPFVFFHF AAARPDQCLA LNLLRRLCTH LRQKLGELSA LPSTYRGLVW
1260 1270 1280 1290 1300
ELQQKLLLKF AQSLQPAQTL VLIIDGADKL VDRNGQLISD WIPKSLPRRV
1310 1320 1330 1340 1350
HLVLSVSSDS GLGETLQQSQ GAYVVALGSL VPSSRAQLVR EELALYGKRL
1360 1370 1380 1390 1400
EESPFNNQMR LLLAKQGSSL PLYLHLVTDY LRLFTLYEQV SERLRTLPAT
1410 1420 1430 1440 1450
LPLLLQHILS TLEQEHGHDV LPQALTALEV TRSGLTVDQL HAILSTWLIL
1460 1470 1480 1490 1500
PKETKSWEEV LAASHSGNPF PLCPFAYLVQ SLRSLLGEGP VERPGARLCL
1510 1520 1530 1540 1550
SDGPLRTTIK RRYGKRLGLE KTAHVLIAAH LWKTCDPDAS GTFRSCPPEA
1560 1570 1580 1590 1600
LKDLPYHLLQ SGNHGLLAEF LTNLHVVAAY LEVGLVPDLL EAHVLYASSK
1610 1620 1630 1640 1650
PEANQKLPAA DVAVFHTFLR QQASLLTQYP LLLLQQAASQ PEESPVCCQA
1660 1670 1680 1690 1700
PLLTQRWHDQ FTLKWINKPQ TLKGQQSLSL TMSSSPTAVA FSPNGQRAAV
1710 1720 1730 1740 1750
GTASGTIYLL NLKTWQEEKA VVSGCDGISS FAFLSDTALF LTTFDGHLEL
1760 1770 1780 1790 1800
WDLQHGCWVF QTKAHQYQIT GCCLSPDRRL LATVCLGGYL KLWDTVRGQL
1810 1820 1830 1840 1850
AFQYTHPKSL NCVAFHPEGQ VVATGSWAGS ITFFQADGLK VTKELGAPGP
1860 1870 1880 1890 1900
SVCSLAFNKP GKIVAVGRID GTVELWAWQE GARLAAFPAQ CGCVSAVLFL
1910 1920 1930 1940 1950
HAGDRFLTAG EDGKAQLWSG FLGRPRGCLG SLPLSPALSV ALNPDGDQVA
1960 1970 1980 1990 2000
VGYREDGINI YKISSGSQGP QHQELNVAVS ALVWLSPSVL VSGAEDGSLH
2010 2020 2030 2040 2050
GWMFKGDSLH SLWLLSRYQK PVLGLAASRE LMAAASEDFT VRLWPRQLLT
2060 2070 2080 2090 2100
QPHVHAVELP CCAELRGHEG PVCCCSFSPD GGILATAGRD RNLLCWDMKI
2110 2120 2130 2140 2150
AQAPLLIHTF SSCHRDWITG CAWTKDNILV SCSSDGSVGL WNPEAGQQLG
2160 2170 2180 2190 2200
QFSGHQSAVS AVVAVEEHIV SVSRDGTLKV WDHQGVELTS IPAHSGPISQ
2210 2220 2230 2240 2250
CAAALEPRPG GQPGSELLVV TVGLDGATKL WHPLLVCQIR TLQGHSGPVT
2260 2270 2280 2290 2300
AAAASEASGL LLTSDDSSVQ LWQIPKEADD SYKPRSSVAI TAVAWAPDGS
2310 2320 2330 2340 2350
MVVSGNEAGE LTLWQQAKAV ATAQAPGRVS HLIWYSANSF FVLSANENVS
2360 2370 2380 2390 2400
EWQVGLRKGS TSTSSSLHLK RVLQEDWGVL TGLGLAPDGQ SLILMKEDVE
2410 2420 2430 2440 2450
LLEMKPGSIP SSICRRYGVH SSILCTSKEY GLFYLQQGDS GLLSILEQKE
2460 2470 2480 2490 2500
SGEFEEILDF NLNLNNPNGS PVSITQAKPE SESSLLCATS DGMLWNLSEC
2510 2520 2530 2540 2550
TSEGEWIVDN IWQKKAKKPK TQTLETELSP HSELDFSIDC WIDPTNLKAQ
2560 2570 2580 2590 2600
QCKKIHLGSV TALHVLPGLL VTASKDRDVK LWERPSMQLL GLFRCEGPVS
2610 2620
CLEPWMEPSS PLQLAVGDTQ GNLYFLSWE
Length:2,629
Mass (Da):291,460
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62F73691F900A77B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BR80A0A2I3BR80_MOUSE
Telomerase protein component 1
Tep1
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ06A0A2I3BQ06_MOUSE
Telomerase protein component 1
Tep1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRB1A0A2I3BRB1_MOUSE
Telomerase protein component 1
Tep1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U86137 mRNA Translation: AAC53043.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36907.1

Protein sequence database of the Protein Information Resource

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PIRi
T30987

NCBI Reference Sequences

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RefSeqi
NP_033377.1, NM_009351.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000006444; ENSMUSP00000006444; ENSMUSG00000006281

Database of genes from NCBI RefSeq genomes

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GeneIDi
21745

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21745

UCSC genome browser

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UCSCi
uc007tlt.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86137 mRNA Translation: AAC53043.1
CCDSiCCDS36907.1
PIRiT30987
RefSeqiNP_033377.1, NM_009351.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiP97499, 1 interactor
MINTiP97499
STRINGi10090.ENSMUSP00000006444

PTM databases

iPTMnetiP97499
PhosphoSitePlusiP97499

Proteomic databases

EPDiP97499
MaxQBiP97499
PaxDbiP97499
PeptideAtlasiP97499
PRIDEiP97499

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
6875 92 antibodies

Genome annotation databases

EnsembliENSMUST00000006444; ENSMUSP00000006444; ENSMUSG00000006281
GeneIDi21745
KEGGimmu:21745
UCSCiuc007tlt.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7011
MGIiMGI:109573 Tep1

Phylogenomic databases

eggNOGiKOG3602 Eukaryota
KOG4155 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00940000161338
HOGENOMiCLU_000342_0_0_1
InParanoidiP97499
KOiK11127
OMAiPKCLFVG
OrthoDBi29963at2759
PhylomeDBiP97499
TreeFamiTF328424

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tep1 mouse

Protein Ontology

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PROi
PR:P97499
RNActiP97499 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000006281 Expressed in jejunum and 225 other tissues
ExpressionAtlasiP97499 baseline and differential
GenevisibleiP97499 MM

Family and domain databases

Gene3Di2.130.10.10, 5 hits
InterProiView protein in InterPro
IPR025139 DUF4062
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
IPR008850 TEP1_N
IPR008858 TROVE_dom
IPR037214 TROVE_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF13271 DUF4062, 1 hit
PF05729 NACHT, 1 hit
PF05386 TEP1_N, 4 hits
PF05731 TROVE, 1 hit
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 16 hits
SUPFAMiSSF140864 SSF140864, 1 hit
SSF50978 SSF50978, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50837 NACHT, 1 hit
PS51226 TEP1_N, 4 hits
PS50988 TROVE, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 8 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97499
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 1997
Last modified: April 22, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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