Rgs14

Functionⁱ

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance.6 Publications

GO - Molecular functionⁱ

GDP-dissociation inhibitor activity Source: UniProtKB
G-protein alpha-subunit binding Source: MGI
GTPase activating protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10926822
- 17635935
GTPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10926822
microtubule binding Source: UniProtKB
protein kinase binding Source: MGI
receptor signaling complex scaffold activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB
chromosome segregation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15525537
G-protein coupled receptor signaling pathway
Source: MGI
Traceable author statementⁱ
- 11342430
intracellular signal transduction Source: InterPro
learning
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20837545
long-term memory
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20837545
long-term synaptic potentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 20837545
mitotic cell cycle
Source: MGI
Inferred from mutant phenotypeⁱ
- 15525537
negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
negative regulation of G-protein coupled receptor protein signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 10926822
negative regulation of MAP kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20837545
negative regulation of synaptic plasticity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20837545
nucleocytoplasmic transport
Source: UniProtKB
Inferred from direct assayⁱ
- 15520006
platelet-derived growth factor receptor signaling pathway Source: UniProtKB
positive regulation of GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10926822
positive regulation of neurogenesis Source: UniProtKB
regulation of DNA-templated transcription in response to stress
Source: UniProtKB
Inferred from direct assayⁱ
- 15520006
regulation of G-protein coupled receptor protein signaling pathway Source: MGI
response to oxidative stress Source: UniProtKB
spindle organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15525537
visual learning Source: UniProtKB
zygote asymmetric cell division
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15525537

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, GTPase activation, Signal transduction inhibitor
Biological process	Cell cycle, Cell division

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 14 Short name: RGS14 Alternative name(s): RAP1/RAP2-interacting protein Short name: RPIP1
Gene namesⁱ	Name:Rgs14
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:1859709 Rgs14

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Disruption phenotypeⁱ

No visible phenotype. Mice show an enhancement of postsynaptic long-term potentiation (LTP) responses in the CA2 neurons of the hippocampus that is correlated with an increase of spatial learning and object recognition memory (OMR).2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	92 – 93	EN → AA: Inhibits GAP activity. Does not inhibit interaction with GNAI1 in the centrosomes. Reduces the down-regulation of G(i)-dependent signaling. Does not affect subcellular location and does not promote gene transcription activation. Inhibits strongly the down-regulation of G(i)-dependent signaling; when associated with F-519. Inhibits the interaction with GNAI1 in the centrosomes; when associated with A-518. 3 Publications	2
Mutagenesisⁱ	261	S → A: Does not affect subcellular location; when associated with A-497. 1 Publication	1
Mutagenesisⁱ	336	R → L: Reduces interaction with RABGEF1 and RAP2A. Strongly reduces interaction with RAP2A; when associated with L-409. 3 Publications	1
Mutagenesisⁱ	409	H → L: Does not reduce interaction with RAP2A. Strongly reduces interaction with RAP2A; when associated with L-336. 2 Publications	1
Mutagenesisⁱ	497	T → A: Does not affect subcellular location; when associated with A-261. 1 Publication	1
Mutagenesisⁱ	506 – 507	LL → AA: Strongly expressed in the nucleus, mainly associated with PML nuclear bodies but not with centrosomes. Promotes gene transcription activation. 1 Publication	2
Mutagenesisⁱ	518	Q → A: Inhibits GDI activity. Does not inhibit interaction with GNAI1 in the centrosomes, does not affect subcellular location and does not promote gene transcription activation. Inhibits interaction with GNAI1 in the centrosomes; when associated with A-92-93-A. 2 Publications	1
Mutagenesisⁱ	519	R → F: Reduces interaction with GNAI1 and GNAI2. Inhibits strongly the down-regulation of G(i)-dependent signaling; when associated with A-92-93-A. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204218	1 – 547	Regulator of G-protein signaling 14Add BLAST		547

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	20	PhosphoserineBy similarity	1
Modified residueⁱ	42	PhosphoserineBy similarity	1
Modified residueⁱ	45	PhosphoserineBy similarity	1
Modified residueⁱ	143	PhosphoserineBy similarity	1
Modified residueⁱ	199	PhosphoserineCombined sources	1
Modified residueⁱ	203	PhosphoserineBy similarity	1
Modified residueⁱ	218	PhosphoserineBy similarity	1
Modified residueⁱ	249	PhosphothreonineCombined sources	1
Modified residueⁱ	289	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P97492
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P97492
PaxDbⁱ	P97492
PeptideAtlas More...PeptideAtlasⁱ	P97492
PRIDEⁱ	P97492

PTM databases

iPTMnetⁱ	P97492
PhosphoSitePlusⁱ	P97492

Expressionⁱ

Tissue specificityⁱ

Expressed in pyramidal neurons of the CA1, CA2 and fasciola cinerea (FC) subregions of the hippocampus and in the olfactory cortex (at protein level). Expressed in brain, spleen, heart, liver, lung, kidney, skin and thymus (at protein level). Expressed in granular layer of the cerebellum, forbrain, striatum, layer V of the cortex, olfactory cortex, tubercules, subthalamic and hippocampus, particularly in the CA2 region, to a lesser extent in the CA1 region and the external layer of the dentate gyrus. Expressed in neurons.4 Publications

Developmental stageⁱ

Expressed in germinal vesicle oocytes, not in metaphase II oocytes. Expressed in embryo from 8.5 through 16.5 dpc (at protein level). Expressed in the zygote through to the blastocyst stage. Expressed in area lateral to the rhombencephalic floor plate at 12 dpc. Expressed in the anterior region of the brain, including the telencephalic olfactive nuclei and the hippocampus anlage at 17 dpc.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000052087 Expressed in 198 organ(s), highest expression level in Ammon's horn
CleanExⁱ	MM_RGS14
ExpressionAtlasⁱ	P97492 baseline and differential
Genevisibleⁱ	P97492 MM

Interactionⁱ

Subunit structureⁱ

Interacts with GNAI1 and GNAI2 (PubMed:15112653, PubMed:17635935). Interacts with GNAI3 (By similarity). Interacts with GNAO1 (PubMed:10926822). Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization (By similarity). Interacts with RABGEF1; the interactions is GTP-dependent (PubMed:10926822, PubMed:15112653). Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI (PubMed:10926822, PubMed:15112653). Associates with microtubules (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIC8A (via C-terminus). Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially). Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF. Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially) (By similarity).By similarity3 Publications

GO - Molecular functionⁱ

G-protein alpha-subunit binding Source: MGI
GTPase activating protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10926822
- 17635935
microtubule binding Source: UniProtKB
protein kinase binding Source: MGI
receptor signaling complex scaffold activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	206175, 1 interactor
IntActⁱ	P97492, 2 interactors
Molecular INTeraction database More...MINTⁱ	P97492
STRINGⁱ	10090.ENSMUSP00000068731

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	375 – 392	Combined sources	18
Beta strandⁱ	394 – 397	Combined sources	4
Turnⁱ	398 – 402	Combined sources	5
Helixⁱ	403 – 406	Combined sources	4
Turnⁱ	407 – 410	Combined sources	4
Turnⁱ	413 – 415	Combined sources	3
Helixⁱ	433 – 435	Combined sources	3
Beta strandⁱ	436 – 439	Combined sources	4
Beta strandⁱ	441 – 443	Combined sources	3
Beta strandⁱ	451 – 454	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P97492
SMRⁱ	P97492
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P97492

EvolutionaryTraceⁱ

P97492

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	67 – 184	RGSPROSITE-ProRule annotationAdd BLAST	118
Domainⁱ	303 – 374	RBD 1PROSITE-ProRule annotationAdd BLAST	72
Domainⁱ	376 – 446	RBD 2PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	500 – 522	GoLocoPROSITE-ProRule annotationAdd BLAST	23

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	300 – 427	Necessary for interaction with RABGEF11 PublicationAdd BLAST		128

Domainⁱ

The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.By similarity

The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3.By similarity

The RBD domains are necessary for localization to the nucleus and centrosomes.By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000049111
HOVERGENⁱ	HBG061568
InParanoidⁱ	P97492
KEGG Orthology (KO) More...KOⁱ	K17706
OMAⁱ	TGKRQTC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
TreeFamⁱ	TF328814

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08743 RGS_RGS14, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR003109 GoLoco_motif IPR003116 RBD_dom IPR016137 RGS IPR030776 RGS14 IPR037881 RGS14_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR10845:SF179 PTHR10845:SF179, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02188 GoLoco, 1 hit PF02196 RBD, 2 hits PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00390 GoLoco, 1 hit SM00455 RBD, 2 hits SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit SSF54236 SSF54236, 2 hits
PROSITEⁱ	View protein in PROSITE PS50877 GOLOCO, 1 hit PS50898 RBD, 2 hits PS50132 RGS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P97492-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGKPKHLGV PNGRMVLAVS DGELTSTAGS QAQGEGRGSS LSIHSLPSGP 
        60         70         80         90        100
SSPFSTEEQP VASWAQSFER LLQDPRGLAY FTEFLKKEFS AENVTFWKAC 
       110        120        130        140        150
ERFQQIPASD TKQLAQEAHN IYHEFLSSQA LSPVNIDRQA WLSEEVLAQP 
       160        170        180        190        200
RPDMFRAQQL QIFNLMKFDS YARFVKSPLY QECLLAEAEG RPLREPGSSH 
       210        220        230        240        250
LGSPDTARKK PKLKPGKSLP LGVEELGQLP LAEGPCGRPL RKSFRREMTG 
       260        270        280        290        300
GAMNSALRRE SQGSLNSSAS LDLGFLAFVS SKSESHRKSL GSGESESESR 
       310        320        330        340        350
PGKYCCVYLP DGTASLALAR PGLTIRDMLA GICEKRGLSL PDIKVYLVGN 
       360        370        380        390        400
EQKALVLDQD CTVLADQEVR LENRITFQLE LVGLERVVRI SAKPTKRLQE 
       410        420        430        440        450
ALQPILAKHG LSLDQVVLHR PGEKQPMDLE NPVSSVASQT LVLDTPPDAK 
       460        470        480        490        500
MSEARSISPC RSQGCLPRTQ TKDSHLPPSS SSLLVEDASS STGNRQTCDI 
       510        520        530        540 
EGLVELLNRV QSSGAHDQRG LLRKEDLVLP EFLQLPSQRP GSREAPP

Length:547

Mass (Da):59,847

Last modified:July 27, 2011 - v2

Checksum:ⁱ51BDE89E58F1E2C3

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RCH4	D6RCH4_MOUSE		Regulator of G-protein-signaling 14 Regulator of G-protein-signaling 14	Rgs14	82	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	209	Missing in BAB22436 (PubMed:16141072).Curated		1
Sequence conflictⁱ	431	N → T in AAB41893 (Ref. 1) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85055 mRNA Translation: AAB41893.1 CT009762 Genomic DNA No translation available. BC030321 mRNA Translation: AAH30321.1 AK002891 mRNA Translation: BAB22436.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36674.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058038.2, NM_016758.3
UniGeneⁱ	Mm.1426

Genome annotation databases

Ensemblⁱ	ENSMUST00000063771; ENSMUSP00000068731; ENSMUSG00000052087
GeneIDⁱ	51791
KEGGⁱ	mmu:51791
UCSC genome browser More...UCSCⁱ	uc007qqq.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97492	Regulator of G-protein signaling 14	)	RAT		544	UniRef90_P97492
UPI0005ABA817		MOUSE		551
UPI000A317CE2		MUSCR		547
UPI000A30EEB3		MUSPA		546
Rgs14 protein		RAT		375
+1

Protein	Similar proteins		Species	Score	Length	Source
P97492	Regulator of G-protein signaling 14	)	RAT		544	UniRef50_P97492
Regulator of G-protein signaling 14		FUKDA		570
Uncharacterized protein		CAVPO		570
Regulator of G-protein signaling 14		HETGA		565
Uncharacterized protein		CERAT		592
+149

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

A balanced mind - Issue 132 of October 2011

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85055 mRNA Translation: AAB41893.1 CT009762 Genomic DNA No translation available. BC030321 mRNA Translation: AAH30321.1 AK002891 mRNA Translation: BAB22436.1
CCDSⁱ	CCDS36674.1
RefSeqⁱ	NP_058038.2, NM_016758.3
UniGeneⁱ	Mm.1426

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WFY	NMR	-	A	366-456	[»]
ProteinModelPortalⁱ	P97492
SMRⁱ	P97492
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	206175, 1 interactor
IntActⁱ	P97492, 2 interactors
MINTⁱ	P97492
STRINGⁱ	10090.ENSMUSP00000068731

PTM databases

iPTMnetⁱ	P97492
PhosphoSitePlusⁱ	P97492

Proteomic databases

EPDⁱ	P97492
MaxQBⁱ	P97492
PaxDbⁱ	P97492
PeptideAtlasⁱ	P97492
PRIDEⁱ	P97492

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000063771; ENSMUSP00000068731; ENSMUSG00000052087
GeneIDⁱ	51791
KEGGⁱ	mmu:51791
UCSCⁱ	uc007qqq.2 mouse

Organism-specific databases

CTDⁱ	10636
MGIⁱ	MGI:1859709 Rgs14

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000049111
HOVERGENⁱ	HBG061568
InParanoidⁱ	P97492
KOⁱ	K17706
OMAⁱ	TGKRQTC
OrthoDBⁱ	EOG091G0BDG
TreeFamⁱ	TF328814

Miscellaneous databases

ChiTaRSⁱ	Rgs16 mouse
EvolutionaryTraceⁱ	P97492
Protein Ontology More...PROⁱ	PR:P97492
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000052087 Expressed in 198 organ(s), highest expression level in Ammon's horn
CleanExⁱ	MM_RGS14
ExpressionAtlasⁱ	P97492 baseline and differential
Genevisibleⁱ	P97492 MM

Family and domain databases

CDDⁱ	cd08743 RGS_RGS14, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR003109 GoLoco_motif IPR003116 RBD_dom IPR016137 RGS IPR030776 RGS14 IPR037881 RGS14_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR10845:SF179 PTHR10845:SF179, 1 hit
Pfamⁱ	View protein in Pfam PF02188 GoLoco, 1 hit PF02196 RBD, 2 hits PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00390 GoLoco, 1 hit SM00455 RBD, 2 hits SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit SSF54236 SSF54236, 2 hits
PROSITEⁱ	View protein in PROSITE PS50877 GOLOCO, 1 hit PS50898 RBD, 2 hits PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS14_MOUSE
Accessionⁱ	P97492Primary (citable) accession number: P97492 Secondary accession number(s): Q8K2R4, Q9DCD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	July 27, 2011
	Last modified:	September 12, 2018
	This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - P97492 (RGS14_MOUSE)

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Regulator of G-protein signaling 14

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Plasma membrane

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ