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Entry version 182 (03 Jul 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Unconventional myosin-VIIa

Gene

Myo7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.3 Publications

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).Curated
Originally predicted to contain a coiled coil domain but proposed to contain a stable SAH domain instead.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi158 – 165ATPCurated8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processHearing, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-VIIa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo7a
Synonyms:Myo7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104510 Myo7a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1189A → E: Strongly reduced affinity for USH1G. 1 Publication1
Mutagenesisi1473F → Q: Reduced affinity for USH1G. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234671 – 2215Unconventional myosin-VIIaAdd BLAST2215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1563PhosphothreonineCombined sources1
Modified residuei1569PhosphoserineCombined sources1
Modified residuei1571PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P97479

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97479

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97479

PeptideAtlas

More...
PeptideAtlasi
P97479

PRoteomics IDEntifications database

More...
PRIDEi
P97479

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97479

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97479

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in mechanosensory stereocilia of cochlea hair cells (at protein level). Expressed in the retina, cochlea, kidney and liver.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the inner ear of the 16.5 day old embryo, expressed only in the cochlear and vestibular sensory hair cells. In addition, expression also occurs in the epithelial cells of the small intestine, hepatocytes, and choroidal plexus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030761 Expressed in 203 organ(s), highest expression level in adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P97479 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P97479 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Might homodimerize in a two headed molecule through the formation of a coiled-coil rod (By similarity).

Identified in a complex with USH1C and USH1G (By similarity).

Interacts with MYRIP (PubMed:12221080).

Interacts with RPE65 (PubMed:21493626).

Interacts with CIB2 (By similarity). May interact with CALM (By similarity).

Interacts with WHRN (PubMed:15590698).

Interacts with PLEKHB1 (via PH domain) (PubMed:15976448).

Interacts with PCDH15 (PubMed:16481439).

Interacts with TWF2 (PubMed:19774077).

Interacts with USH1G (PubMed:21311020).

Interacts with MYH9 (PubMed:27331610).

Interacts (via MyTH4-FERM domains) with cytoplasmic regions of ADGRV1 and USH2A (PubMed:17567809).

Interacts with PDZD7 (via MyTH4-FERM domains) (PubMed:27525485).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201669, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P97479, 5 interactors

Molecular INTeraction database

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MINTi
P97479

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000102745

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P97479

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 741Myosin motorPROSITE-ProRule annotationAdd BLAST677
Domaini745 – 765IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini768 – 788IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini791 – 811IQ 3PROSITE-ProRule annotationAdd BLAST21
Domaini814 – 834IQ 4PROSITE-ProRule annotationAdd BLAST21
Domaini837 – 857IQ 5PROSITE-ProRule annotationAdd BLAST21
Domaini1017 – 1253MyTH4 1PROSITE-ProRule annotationAdd BLAST237
Domaini1258 – 1602FERM 1PROSITE-ProRule annotationAdd BLAST345
Domaini1603 – 1672SH3PROSITE-ProRule annotationAdd BLAST70
Domaini1747 – 1896MyTH4 2PROSITE-ProRule annotationAdd BLAST150
Domaini1902 – 2205FERM 2PROSITE-ProRule annotationAdd BLAST304

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni632 – 639Actin-bindingCurated8
Regioni858 – 935SAHBy similarityAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4229 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155350

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007836

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97479

KEGG Orthology (KO)

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KOi
K10359

Database of Orthologous Groups

More...
OrthoDBi
527681at2759

TreeFam database of animal gene trees

More...
TreeFami
TF335306

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 2 hits
cd13198 FERM_C1_MyoVII, 1 hit
cd13199 FERM_C2_MyoVII, 1 hit
cd01381 MYSc_Myo7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 2 hits
1.25.40.530, 1 hit
2.30.29.30, 3 hits
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR041793 MyoVII_FERM_C1
IPR041794 MyoVII_FERM_C2
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 3 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 2 hits
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 2 hits
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97479-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVILQKGDYV WMDLKSGQEF DVPIGAVVKL CDSGQIQVVD DEDNEHWISP
60 70 80 90 100
QNATHIKPMH PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS
110 120 130 140 150
ILVAVNPYQL LSIYSPEHIR QYTNKKIGEM PPHIFAIADN CYFNMKRNNR
160 170 180 190 200
DQCCIISGES GAGKTESTKL ILQFLAAISG QHSWIEQQVL EATPILEAFG
210 220 230 240 250
NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS RVCRQAPDER
260 270 280 290 300
NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN
310 320 330 340 350
IRSAMKVLMF TDTENWEISK LLAAILHMGN LQYEARTFEN LDACEVLFSP
360 370 380 390 400
SLATAASLLE VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK
410 420 430 440 450
GIYGRLFVWI VEKINAAIYK PPPLEVKNSR RSIGLLDIFG FENFTVNSFE
460 470 480 490 500
QLCINFANEH LQQFFVRHVF KLEQEEYDLE SIDWLHIEFT DNQEALDMIA
510 520 530 540 550
NRPMNVISLI DEESKFPKGT DATMLHKLNS QHKLNANYVP PKNSHETQFG
560 570 580 590 600
INHFAGVVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFIK QIFQADVAMG
610 620 630 640 650
AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH
660 670 680 690 700
LCVRQLRYSG MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQGD
710 720 730 740 750
LRGTCQRMAE AVLGTHDDWQ IGKTKIFLKD HHDMLLEVER DKAITDRVIL
760 770 780 790 800
LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG HHCRKNYELI RLGFLRLQAL
810 820 830 840 850
HRSRKLHKQY RLARQRIIEF QARCRAYLVR KAFRHRLWAV ITVQAYARGM
860 870 880 890 900
IARRLHRRLR VEYQRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER
910 920 930 940 950
LAQLAREDAE RELKEKEEAR RKKELLEQME KARHEPINHS DMVDKMFGFL
960 970 980 990 1000
GTSGSLPGQE GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK
1010 1020 1030 1040 1050
FAKFAATYFQ GTTTHSYTRR PLKQPLLYHD DEGDQLAALA VWITILRFMG
1060 1070 1080 1090 1100
DLPEPKYHTA MSDGSEKIPV MTKIYETLGK KTYKRELQAL QGEGETQLPE
1110 1120 1130 1140 1150
GQKKTSVRHK LVHLTLKKKS KLTEEVTKRL NDGESTVQGN SMLEDRPTSN
1160 1170 1180 1190 1200
LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG
1210 1220 1230 1240 1250
CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ
1260 1270 1280 1290 1300
ATKSKKPIML PVTFMDGTTK TLLTDSATTA RELCNALADK ISLKDRFGFS
1310 1320 1330 1340 1350
LYIALFDKVS SLGSGSDHVM DAISQCEQYA KEQGAQERNA PWRLFFRKEV
1360 1370 1380 1390 1400
FTPWHNPSED NVATNLIYQQ VVRGVKFGEY RCEKEDDLAE LASQQYFVDY
1410 1420 1430 1440 1450
GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK KGIYAQRRTD
1460 1470 1480 1490 1500
SQKVKEDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF
1510 1520 1530 1540 1550
VDEQEQVLLE LSFPEIMAVS SSRECRVLLS LGCSDLGCAT CQSGRAGLTP
1560 1570 1580 1590 1600
AGPCSPCWSC RGTKMMAPSF TLATIKGDEY TFTSSNAEDI RDLVVTFLEG
1610 1620 1630 1640 1650
LRKRSKYVVA LQDNPNPAGE ESGFLSFAKG DLIILDHDTG EQVMNSGWAN
1660 1670 1680 1690 1700
GINERTKQRG DFPTDCVYVM PTVTLPPREI VALVTMTPDQ RQDVVRLLQL
1710 1720 1730 1740 1750
RTAEPEVRAK PYTLEEFSYD YFRPPPKHTL SRVMVSKARG KDRLWSHTRE
1760 1770 1780 1790 1800
PLKQALLKKI LGSEELSQEA CMAFVAVLKY MGDYPSKRMR SVNELTDQIF
1810 1820 1830 1840 1850
EWALKAEPLK DEAYVQILKQ LTDNHIRYSE ERGWELLWLC TGLFPPSNIL
1860 1870 1880 1890 1900
LPHVQRFLQS RKHCPLAIDC LQRLQKALRN GSRKYPPHLV EVEAIQHKTT
1910 1920 1930 1940 1950
QIFHKVYFPD DTDEAFEVES STKAKDFCQN IASRLLLKSS EGFSLFVKIA
1960 1970 1980 1990 2000
DKVISVPEND FFFDFVRHLT DWIKKARPIK DGIVPSLTYQ VFFMKKLWTT
2010 2020 2030 2040 2050
TVPGKDPMAD SIFHYYQELP KYLRGYHKCT REEVLQLGAL IYRVKFEEDK
2060 2070 2080 2090 2100
SYFPSIPKLL RELVPQDLIR QVSPDDWKRS IVAYFNKHAG KSKEEAKLAF
2110 2120 2130 2140 2150
LKLIFKWPTF GSAFFEVKQT TEPNFPEILL IAINKYGVSL IDPRTKDILT
2160 2170 2180 2190 2200
THPFTKISNW SSGNTYFHIT IGNLVRGSKL LCETSLGYKM DDLLTSYISQ
2210
MLTAMSKQRN SRSGR
Length:2,215
Mass (Da):254,939
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD942FC7674B75EC7
GO
Isoform 2 (identifier: P97479-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1523-1560: Missing.

Show »
Length:2,177
Mass (Da):251,097
Checksum:iB11BA144AE43B63D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5MJ56Q5MJ56_MOUSE
Myosin VIIa isoform 2
Myo7a
2,172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J113A0A0R4J113_MOUSE
Unconventional myosin-VIIa
Myo7a
2,166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPX7A0A0U1RPX7_MOUSE
Unconventional myosin-VIIa
Myo7a
2,164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YUT5D3YUT5_MOUSE
Unconventional myosin-VIIa
Myo7a
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPT3A0A0U1RPT3_MOUSE
Unconventional myosin-VIIa
Myo7a
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85L → R in AAB40708 (PubMed:7870172).Curated1
Sequence conflicti238E → S in AAB40708 (PubMed:7870172).Curated1
Sequence conflicti589I → V in AAB40708 (PubMed:7870172).Curated1
Sequence conflicti682V → G in AAB40708 (PubMed:7870172).Curated1
Sequence conflicti1156F → L in AAB40708 (PubMed:7870172).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti241R → P in sh-1. 1
Natural varianti502R → P in sh-1. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0422381523 – 1560Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U81453 mRNA Translation: AAB40708.1
AC115022 Genomic DNA No translation available.
AC119880 Genomic DNA No translation available.
AC157792 Genomic DNA No translation available.
AY821853 mRNA Translation: AAV87212.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40026.1 [P97479-2]
CCDS57565.1 [P97479-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T30870

NCBI Reference Sequences

More...
RefSeqi
NP_001243010.1, NM_001256081.1 [P97479-1]
NP_001243012.1, NM_001256083.1
NP_032689.2, NM_008663.2 [P97479-2]
XP_011239993.1, XM_011241691.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000107127; ENSMUSP00000102744; ENSMUSG00000030761 [P97479-2]
ENSMUST00000107128; ENSMUSP00000102745; ENSMUSG00000030761 [P97479-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17921

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17921

UCSC genome browser

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UCSCi
uc009ijy.2 mouse [P97479-2]
uc009ijz.2 mouse [P97479-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81453 mRNA Translation: AAB40708.1
AC115022 Genomic DNA No translation available.
AC119880 Genomic DNA No translation available.
AC157792 Genomic DNA No translation available.
AY821853 mRNA Translation: AAV87212.1
CCDSiCCDS40026.1 [P97479-2]
CCDS57565.1 [P97479-1]
PIRiT30870
RefSeqiNP_001243010.1, NM_001256081.1 [P97479-1]
NP_001243012.1, NM_001256083.1
NP_032689.2, NM_008663.2 [P97479-2]
XP_011239993.1, XM_011241691.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PVLX-ray2.80A965-1687[»]
5WSTX-ray2.10A/B866-932[»]
5WSUX-ray3.00C/D834-935[»]
5WSVX-ray2.33B/D828-870[»]
SMRiP97479
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201669, 6 interactors
IntActiP97479, 5 interactors
MINTiP97479
STRINGi10090.ENSMUSP00000102745

PTM databases

iPTMnetiP97479
PhosphoSitePlusiP97479

Proteomic databases

jPOSTiP97479
MaxQBiP97479
PaxDbiP97479
PeptideAtlasiP97479
PRIDEiP97479

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P97479
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107127; ENSMUSP00000102744; ENSMUSG00000030761 [P97479-2]
ENSMUST00000107128; ENSMUSP00000102745; ENSMUSG00000030761 [P97479-1]
GeneIDi17921
KEGGimmu:17921
UCSCiuc009ijy.2 mouse [P97479-2]
uc009ijz.2 mouse [P97479-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4647
MGIiMGI:104510 Myo7a

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155350
HOGENOMiHOG000007836
InParanoidiP97479
KOiK10359
OrthoDBi527681at2759
TreeFamiTF335306

Enzyme and pathway databases

ReactomeiR-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Myo7a mouse

Protein Ontology

More...
PROi
PR:P97479

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030761 Expressed in 203 organ(s), highest expression level in adrenal gland
ExpressionAtlasiP97479 baseline and differential
GenevisibleiP97479 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 2 hits
cd13198 FERM_C1_MyoVII, 1 hit
cd13199 FERM_C2_MyoVII, 1 hit
cd01381 MYSc_Myo7, 1 hit
Gene3Di1.20.80.10, 2 hits
1.25.40.530, 1 hit
2.30.29.30, 3 hits
2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR041793 MyoVII_FERM_C1
IPR041794 MyoVII_FERM_C2
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 3 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 2 hits
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 2 hits
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO7A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97479
Secondary accession number(s): E9QLP7, Q5MJ57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: July 3, 2019
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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